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The map label for this gene is manB [H]

Identifier: 138894012

GI number: 138894012

Start: 384567

End: 385976

Strand: Direct

Name: manB [H]

Synonym: GTNG_0338

Alternate gene names: 138894012

Gene position: 384567-385976 (Clockwise)

Preceding gene: 138894011

Following gene: 138894013

Centisome position: 10.83

GC content: 54.04

Gene sequence:

>1410_bases
ATGAATACGTCGATAACGAAACCGTTCGCATGGCCAACACACGTATTTAAAGAGTATGACATTCGCGGGCGTGCCGGCGA
GGAACTTGATGAGTCGTTTGCTTATTGGCTTGGACGGGCCTTTGCTGAAATGATGCAAAATGAGGGCGAACGGAAGGCGG
TTGTTGCCCATGACAACCGCCTGTCGTCGCCGGCGCTGCATCGATCGTTGAAAAACGGGTTGCTTGATGGCGGCTGTGAT
GTCATCGATATTGGGCTTTCGACGACACCGATGTTTTACTACAGCTTATACAACACGGACATTTCATGTGGCATGATCGT
TACCGCAAGCCACAACCCAGGCGATGAGAACGGATTTAAAATCGCCATGGGAAAAACAACGATTTATGGCGAACGCATTC
AAGCGCTGCGAAAGGCGATGGAGCGGCTAAGCCAACAACAGGCACAACCCGAAGTGACGCGGGGGCGTGAGGAAACGCTT
GACCTGGTCCCGGCATATATCAAGATGTTGAAGGAGAAAATTCAGCTCGGTCCACGTCAGCTGAAAGTCGTTGTCGACTG
CGGCAACGGCACCCCGTCGATCATTGCGCCAAAAGTGCTCAAAGAATGGGGCTGTGATGTCATCCCGCTCTATTGTGAAT
CCGATCCGACGTTCCCGAATCACCATCCTGACCCGGTTGTGCCGGAAAACTTAGCTGATTTGATCAAAACGGTGCGCAAG
GAGCAGGCGGATCTAGGCATCGCATTTGACGGTGACGGCGACCGGATCGGTATCGTGGATGAAACGGGCACGATCCGCTG
GGGCGACCAACTGATGGTATTGTTCTGGCGTGATATTCTCAAGCGCCATCCGGGAGCTGAGGCGCCGGTTGAGGTAAAAT
GTTCGCAAGCGCTCGTAGAAGAAATTGAGCGGCTCGGCGGCCGGCCGTTTTTCCACCGTACCGGTCATTCACACGTAAAA
GCGACGTTGCGCCGCCGACCGGCCATTCCGTTTGCCGGCGAGATGTCCGGGCACTTATTCTTCAATGATGAATTTTATGG
TTACGATGACGCCTTGTACGCTGCGGGACGGCTGCTTCGCCTCTTGTCGCATGACAAGCGCCCACTCTCTGAGTGGTTTG
CTGATGTGCCGTATTATGTGGCGACGCCGGAAACGCGTGTCACCTGCCCAGAGGAGAAAAAACCGGTGGCCATCGACGCT
GTGAAAAAACGGTTTGCCAGCCGTTATCCGGTCGTCGATGTCGACGGTGCTCGTATTCAATTCCGTGAAGGCTGGGGATT
GGTGCGTCCTTCGAACACGCAACCGATTCTTGTCTTGCGCGCTGAAGCGAAGACGGAAGAAGCGTTGGCGGAGATTAAAC
GGCAGTTGGCTGATTGTTTGCATACGCTCGAGCTTCACGTCAATTGGTAA

Upstream 100 bases:

>100_bases
GGTCCGAACGGTCCGAACCCAAATCGAGGGGCGGAGTCAACACTATCATACTTATTAACAGCAGCAATCGCTCAATCGAT
TTCGGTGGAGGTGGTTTTCG

Downstream 100 bases:

>100_bases
CTTTGCTTTTGTCCAGATCGATGTGCCTACTTGTTCGTTATCTTAGATAGCAGCTATTTTTCCGGCGTCGGCCGCCCGTT
CCATAGGGCGCCGCGCCGGA

Product: phosphomannomutase

Products: NA

Alternate protein names: PMM / PGM [H]

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MNTSITKPFAWPTHVFKEYDIRGRAGEELDESFAYWLGRAFAEMMQNEGERKAVVAHDNRLSSPALHRSLKNGLLDGGCD
VIDIGLSTTPMFYYSLYNTDISCGMIVTASHNPGDENGFKIAMGKTTIYGERIQALRKAMERLSQQQAQPEVTRGREETL
DLVPAYIKMLKEKIQLGPRQLKVVVDCGNGTPSIIAPKVLKEWGCDVIPLYCESDPTFPNHHPDPVVPENLADLIKTVRK
EQADLGIAFDGDGDRIGIVDETGTIRWGDQLMVLFWRDILKRHPGAEAPVEVKCSQALVEEIERLGGRPFFHRTGHSHVK
ATLRRRPAIPFAGEMSGHLFFNDEFYGYDDALYAAGRLLRLLSHDKRPLSEWFADVPYYVATPETRVTCPEEKKPVAIDA
VKKRFASRYPVVDVDGARIQFREGWGLVRPSNTQPILVLRAEAKTEEALAEIKRQLADCLHTLELHVNW

Sequences:

>Translated_469_residues
MNTSITKPFAWPTHVFKEYDIRGRAGEELDESFAYWLGRAFAEMMQNEGERKAVVAHDNRLSSPALHRSLKNGLLDGGCD
VIDIGLSTTPMFYYSLYNTDISCGMIVTASHNPGDENGFKIAMGKTTIYGERIQALRKAMERLSQQQAQPEVTRGREETL
DLVPAYIKMLKEKIQLGPRQLKVVVDCGNGTPSIIAPKVLKEWGCDVIPLYCESDPTFPNHHPDPVVPENLADLIKTVRK
EQADLGIAFDGDGDRIGIVDETGTIRWGDQLMVLFWRDILKRHPGAEAPVEVKCSQALVEEIERLGGRPFFHRTGHSHVK
ATLRRRPAIPFAGEMSGHLFFNDEFYGYDDALYAAGRLLRLLSHDKRPLSEWFADVPYYVATPETRVTCPEEKKPVAIDA
VKKRFASRYPVVDVDGARIQFREGWGLVRPSNTQPILVLRAEAKTEEALAEIKRQLADCLHTLELHVNW
>Mature_469_residues
MNTSITKPFAWPTHVFKEYDIRGRAGEELDESFAYWLGRAFAEMMQNEGERKAVVAHDNRLSSPALHRSLKNGLLDGGCD
VIDIGLSTTPMFYYSLYNTDISCGMIVTASHNPGDENGFKIAMGKTTIYGERIQALRKAMERLSQQQAQPEVTRGREETL
DLVPAYIKMLKEKIQLGPRQLKVVVDCGNGTPSIIAPKVLKEWGCDVIPLYCESDPTFPNHHPDPVVPENLADLIKTVRK
EQADLGIAFDGDGDRIGIVDETGTIRWGDQLMVLFWRDILKRHPGAEAPVEVKCSQALVEEIERLGGRPFFHRTGHSHVK
ATLRRRPAIPFAGEMSGHLFFNDEFYGYDDALYAAGRLLRLLSHDKRPLSEWFADVPYYVATPETRVTCPEEKKPVAIDA
VKKRFASRYPVVDVDGARIQFREGWGLVRPSNTQPILVLRAEAKTEEALAEIKRQLADCLHTLELHVNW

Specific function: The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to it

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI290463102, Length=211, Percent_Identity=30.3317535545024, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI21361621, Length=211, Percent_Identity=30.3317535545024, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1788361, Length=450, Percent_Identity=33.7777777777778, Blast_Score=213, Evalue=3e-56,
Organism=Escherichia coli, GI1789566, Length=456, Percent_Identity=27.6315789473684, Blast_Score=127, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2; =5.4.2.8 [H]

Molecular weight: Translated: 52854; Mature: 52854

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTSITKPFAWPTHVFKEYDIRGRAGEELDESFAYWLGRAFAEMMQNEGERKAVVAHDNR
CCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
LSSPALHRSLKNGLLDGGCDVIDIGLSTTPMFYYSLYNTDISCGMIVTASHNPGDENGFK
CCCHHHHHHHHHCCCCCCCCEEEECCCCCCEEEEEEECCCCCCCEEEEECCCCCCCCCEE
IAMGKTTIYGERIQALRKAMERLSQQQAQPEVTRGREETLDLVPAYIKMLKEKIQLGPRQ
EEECCCCHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCEE
LKVVVDCGNGTPSIIAPKVLKEWGCDVIPLYCESDPTFPNHHPDPVVPENLADLIKTVRK
EEEEEECCCCCCCCCCHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHH
EQADLGIAFDGDGDRIGIVDETGTIRWGDQLMVLFWRDILKRHPGAEAPVEVKCSQALVE
HHHCCEEEECCCCCEEEEEECCCCEEECCHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHH
EIERLGGRPFFHRTGHSHVKATLRRRPAIPFAGEMSGHLFFNDEFYGYDDALYAAGRLLR
HHHHHCCCCCEECCCHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHH
LLSHDKRPLSEWFADVPYYVATPETRVTCPEEKKPVAIDAVKKRFASRYPVVDVDGARIQ
HHHCCCCCHHHHHHCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEECCCCEEE
FREGWGLVRPSNTQPILVLRAEAKTEEALAEIKRQLADCLHTLELHVNW
EECCCCEECCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHEEEECC
>Mature Secondary Structure
MNTSITKPFAWPTHVFKEYDIRGRAGEELDESFAYWLGRAFAEMMQNEGERKAVVAHDNR
CCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
LSSPALHRSLKNGLLDGGCDVIDIGLSTTPMFYYSLYNTDISCGMIVTASHNPGDENGFK
CCCHHHHHHHHHCCCCCCCCEEEECCCCCCEEEEEEECCCCCCCEEEEECCCCCCCCCEE
IAMGKTTIYGERIQALRKAMERLSQQQAQPEVTRGREETLDLVPAYIKMLKEKIQLGPRQ
EEECCCCHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCEE
LKVVVDCGNGTPSIIAPKVLKEWGCDVIPLYCESDPTFPNHHPDPVVPENLADLIKTVRK
EEEEEECCCCCCCCCCHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHH
EQADLGIAFDGDGDRIGIVDETGTIRWGDQLMVLFWRDILKRHPGAEAPVEVKCSQALVE
HHHCCEEEECCCCCEEEEEECCCCEEECCHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHH
EIERLGGRPFFHRTGHSHVKATLRRRPAIPFAGEMSGHLFFNDEFYGYDDALYAAGRLLR
HHHHHCCCCCEECCCHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHH
LLSHDKRPLSEWFADVPYYVATPETRVTCPEEKKPVAIDAVKKRFASRYPVVDVDGARIQ
HHHCCCCCHHHHHHCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEECCCCEEE
FREGWGLVRPSNTQPILVLRAEAKTEEALAEIKRQLADCLHTLELHVNW
EECCCCEECCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1903398; 10984043; 7515870; 10481091; 8050998; 11716469; 11839312 [H]