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The map label for this gene is purH [H]

Identifier: 138893923

GI number: 138893923

Start: 275114

End: 276652

Strand: Direct

Name: purH [H]

Synonym: GTNG_0247

Alternate gene names: 138893923

Gene position: 275114-276652 (Clockwise)

Preceding gene: 138893922

Following gene: 138893924

Centisome position: 7.75

GC content: 52.37

Gene sequence:

>1539_bases
ATGGCAGTCAAACGAGCATTAATCAGCGTGTCTAATAAAGAAGGGATCATTCCGTTTGCAAAACAACTAACCGAACTCGG
CATCGAAATCATTTCGACTGGCGGGACGAAACGGGCACTCGAGGACGCTGGGATTTCGGTGATCTCGATTTCCAATGTCA
CCGGGTTTCCGGAAATTTTAGACGGGCGTGTGAAAACGTTGCATCCGGCCATTCATGGCGGTATTTTGGCGATTCGTAGC
GATGAGCGCCATCAAGCAGCGCTAGCGGAGCATGGCATCCGCCTGATCGATTTGGTCGTCGTCAACTTGTACCCGTTCCA
GCAAACGATCGCGAAACCGGACGTAACGCTTGCTGAGGCGATTGAGAATATCGATATTGGCGGTCCGACTATGGTGCGCG
CGGCAGCGAAAAACTATGCCGATGTCGCCATCGTCGTCGATCCGGCTGATTACCCGACGATAATTGAGGAGCTGAAAACA
AACGGATCGATCCAAGCGGAAACGCGGCAAAAATTGGCGGCGAAAGCGTTCCGCCATACGGCAGCGTATGATGCGATGAT
TGCCGAGTATTTGACCAATCTCACCGGAGAGGAGTACCCGGAAACGCTCACCGTCACCTACACGAAAAAGCAATCGTTGC
GCTATGGCGAAAATCCGCATCAATCAGCGTCGTTTTATGCCAAACCGCTCGGTGCGGCTTTCTCGATTGCGCAAGCGAAA
CAGCTGCACGGAAAAGATCTATCGTATAACAACATTAACGATGCCAATGCGGCCATCAACCTTGTTCGTGAGTTTCAGGA
GCCAGCCGTAGTGGCGATCAAACATATGAACCCGTGCGGCGTTGGTGTCGGTGCGACGCTTCTTGAGGCATTTACAAAAG
CGTACGAGGCCGATCCGGTGTCCATTTTCGGTGGAATTATTGCGGTGAACCGTGAAGTGGACAAAGAAACGGCCGAGCGA
ATGCATGACATCTTTTTGGAAATCGTCATCGCTCCATCATTTAGTGACGAGGCGCTCGCCATTTTGACGAAAAAGAAAAA
TATCCGTCTGTTGACGCTTGATTTTGCGGCGGCAGACGTCAAGGAAAAAATGCTTGTTTCGGTAAGCGGTGGCTTGCTCG
TTCAAGATGCGGATACGTACACGCTTGAGGACGCTGAGTGGAATGTTGTCACGAAGCGCCAACCGACCGAAGCGGAATGC
GAACAGCTTCGCTTTGCTTGGAACGTTGTGAAACATGTGAAATCCAACGCCATCGTGCTGGCGAAAAACGGCATGACCGT
TGGCGTTGGCGCCGGGCAAATGAACCGAGTTGGCGCAGCGAAGATTGCGATTGAACAAGCGGGAGAGCAGGCGGCAGGCG
CGGTGCTTGCATCAGACGCCTTTTTCCCGATGGACGACACTGTTGAAGCGGCAGCGAAAGCCGGCATTACGGCCATCATC
CAACCGGGCGGCTCGATTCGTGACGCTGATTCGATCCGCAAAGCAAATGAGTACGGCATTGCCATGGTGTTTACTGGTGT
TCGCCATTTCAAACATTAA

Upstream 100 bases:

>100_bases
CTTGAGGCACGCATCCATGCGGTTGAACATGAGTTATACCCGGCGGTGTTGCGCATGCTGTTAGGGGAAACGGAACAACA
AGAAGAAAGGATCGAGAAGA

Downstream 100 bases:

>100_bases
ACGGCGGCAAAAAGGGGAGGAAGATGATGAACATTCTCGTAGTCGGACGCGGCGGGCGTGAGCATGCGATCGCCTGGAAG
GTGGCGCAAAGCCCGCTTGC

Product: bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase

Products: NA

Alternate protein names: Phosphoribosylaminoimidazolecarboxamide formyltransferase; AICAR transformylase; IMP cyclohydrolase; ATIC; IMP synthase; Inosinicase [H]

Number of amino acids: Translated: 512; Mature: 511

Protein sequence:

>512_residues
MAVKRALISVSNKEGIIPFAKQLTELGIEIISTGGTKRALEDAGISVISISNVTGFPEILDGRVKTLHPAIHGGILAIRS
DERHQAALAEHGIRLIDLVVVNLYPFQQTIAKPDVTLAEAIENIDIGGPTMVRAAAKNYADVAIVVDPADYPTIIEELKT
NGSIQAETRQKLAAKAFRHTAAYDAMIAEYLTNLTGEEYPETLTVTYTKKQSLRYGENPHQSASFYAKPLGAAFSIAQAK
QLHGKDLSYNNINDANAAINLVREFQEPAVVAIKHMNPCGVGVGATLLEAFTKAYEADPVSIFGGIIAVNREVDKETAER
MHDIFLEIVIAPSFSDEALAILTKKKNIRLLTLDFAAADVKEKMLVSVSGGLLVQDADTYTLEDAEWNVVTKRQPTEAEC
EQLRFAWNVVKHVKSNAIVLAKNGMTVGVGAGQMNRVGAAKIAIEQAGEQAAGAVLASDAFFPMDDTVEAAAKAGITAII
QPGGSIRDADSIRKANEYGIAMVFTGVRHFKH

Sequences:

>Translated_512_residues
MAVKRALISVSNKEGIIPFAKQLTELGIEIISTGGTKRALEDAGISVISISNVTGFPEILDGRVKTLHPAIHGGILAIRS
DERHQAALAEHGIRLIDLVVVNLYPFQQTIAKPDVTLAEAIENIDIGGPTMVRAAAKNYADVAIVVDPADYPTIIEELKT
NGSIQAETRQKLAAKAFRHTAAYDAMIAEYLTNLTGEEYPETLTVTYTKKQSLRYGENPHQSASFYAKPLGAAFSIAQAK
QLHGKDLSYNNINDANAAINLVREFQEPAVVAIKHMNPCGVGVGATLLEAFTKAYEADPVSIFGGIIAVNREVDKETAER
MHDIFLEIVIAPSFSDEALAILTKKKNIRLLTLDFAAADVKEKMLVSVSGGLLVQDADTYTLEDAEWNVVTKRQPTEAEC
EQLRFAWNVVKHVKSNAIVLAKNGMTVGVGAGQMNRVGAAKIAIEQAGEQAAGAVLASDAFFPMDDTVEAAAKAGITAII
QPGGSIRDADSIRKANEYGIAMVFTGVRHFKH
>Mature_511_residues
AVKRALISVSNKEGIIPFAKQLTELGIEIISTGGTKRALEDAGISVISISNVTGFPEILDGRVKTLHPAIHGGILAIRSD
ERHQAALAEHGIRLIDLVVVNLYPFQQTIAKPDVTLAEAIENIDIGGPTMVRAAAKNYADVAIVVDPADYPTIIEELKTN
GSIQAETRQKLAAKAFRHTAAYDAMIAEYLTNLTGEEYPETLTVTYTKKQSLRYGENPHQSASFYAKPLGAAFSIAQAKQ
LHGKDLSYNNINDANAAINLVREFQEPAVVAIKHMNPCGVGVGATLLEAFTKAYEADPVSIFGGIIAVNREVDKETAERM
HDIFLEIVIAPSFSDEALAILTKKKNIRLLTLDFAAADVKEKMLVSVSGGLLVQDADTYTLEDAEWNVVTKRQPTEAECE
QLRFAWNVVKHVKSNAIVLAKNGMTVGVGAGQMNRVGAAKIAIEQAGEQAAGAVLASDAFFPMDDTVEAAAKAGITAIIQ
PGGSIRDADSIRKANEYGIAMVFTGVRHFKH

Specific function: De novo purine biosynthesis; ninth step. De novo purine biosynthesis; tenth step. [C]

COG id: COG0138

COG function: function code F; AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purH family [H]

Homologues:

Organism=Homo sapiens, GI20127454, Length=472, Percent_Identity=38.3474576271186, Blast_Score=281, Evalue=1e-75,
Organism=Escherichia coli, GI1790439, Length=525, Percent_Identity=53.5238095238095, Blast_Score=538, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI71985564, Length=474, Percent_Identity=36.0759493670886, Blast_Score=259, Evalue=3e-69,
Organism=Caenorhabditis elegans, GI71985574, Length=311, Percent_Identity=27.0096463022508, Blast_Score=81, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323768, Length=476, Percent_Identity=38.655462184874, Blast_Score=273, Evalue=7e-74,
Organism=Saccharomyces cerevisiae, GI6323056, Length=470, Percent_Identity=37.8723404255319, Blast_Score=265, Evalue=1e-71,
Organism=Drosophila melanogaster, GI24649832, Length=476, Percent_Identity=38.2352941176471, Blast_Score=284, Evalue=1e-76,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002695
- InterPro:   IPR013982
- InterPro:   IPR016193
- InterPro:   IPR011607 [H]

Pfam domain/function: PF01808 AICARFT_IMPCHas; PF02142 MGS [H]

EC number: =2.1.2.3; =3.5.4.10 [H]

Molecular weight: Translated: 55089; Mature: 54957

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVKRALISVSNKEGIIPFAKQLTELGIEIISTGGTKRALEDAGISVISISNVTGFPEIL
CCCHHHHHEECCCCCCCHHHHHHHHCCCEEEECCCCHHHHHHCCEEEEEECCCCCCHHHH
DGRVKTLHPAIHGGILAIRSDERHQAALAEHGIRLIDLVVVNLYPFQQTIAKPDVTLAEA
CCCHHHHCHHHHCCEEEEECCCHHHHHHHHCCCEEEEEEEECCCCHHHHHCCCCCHHHHH
IENIDIGGPTMVRAAAKNYADVAIVVDPADYPTIIEELKTNGSIQAETRQKLAAKAFRHT
HHHCCCCCCHHHHHHHCCCCCEEEEECCCCCHHHHHHHHCCCCEEHHHHHHHHHHHHHHH
AAYDAMIAEYLTNLTGEEYPETLTVTYTKKQSLRYGENPHQSASFYAKPLGAAFSIAQAK
HHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
QLHGKDLSYNNINDANAAINLVREFQEPAVVAIKHMNPCGVGVGATLLEAFTKAYEADPV
HHCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCH
SIFGGIIAVNREVDKETAERMHDIFLEIVIAPSFSDEALAILTKKKNIRLLTLDFAAADV
HHCCCEEEECCHHHHHHHHHHHHHHEEEEEECCCCCCEEEEEEECCCEEEEEEECHHHHH
KEKMLVSVSGGLLVQDADTYTLEDAEWNVVTKRQPTEAECEQLRFAWNVVKHVKSNAIVL
HHHEEEEECCCEEEECCCCEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEE
AKNGMTVGVGAGQMNRVGAAKIAIEQAGEQAAGAVLASDAFFPMDDTVEAAAKAGITAII
EECCEEEEECCCCCCCCCHHHHHHHHCCCHHHCEEEECCCCCCCCHHHHHHHHCCCEEEE
QPGGSIRDADSIRKANEYGIAMVFTGVRHFKH
CCCCCCCCHHHHHHHHHCCEEEEEHHHHHHCC
>Mature Secondary Structure 
AVKRALISVSNKEGIIPFAKQLTELGIEIISTGGTKRALEDAGISVISISNVTGFPEIL
CCHHHHHEECCCCCCCHHHHHHHHCCCEEEECCCCHHHHHHCCEEEEEECCCCCCHHHH
DGRVKTLHPAIHGGILAIRSDERHQAALAEHGIRLIDLVVVNLYPFQQTIAKPDVTLAEA
CCCHHHHCHHHHCCEEEEECCCHHHHHHHHCCCEEEEEEEECCCCHHHHHCCCCCHHHHH
IENIDIGGPTMVRAAAKNYADVAIVVDPADYPTIIEELKTNGSIQAETRQKLAAKAFRHT
HHHCCCCCCHHHHHHHCCCCCEEEEECCCCCHHHHHHHHCCCCEEHHHHHHHHHHHHHHH
AAYDAMIAEYLTNLTGEEYPETLTVTYTKKQSLRYGENPHQSASFYAKPLGAAFSIAQAK
HHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
QLHGKDLSYNNINDANAAINLVREFQEPAVVAIKHMNPCGVGVGATLLEAFTKAYEADPV
HHCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCH
SIFGGIIAVNREVDKETAERMHDIFLEIVIAPSFSDEALAILTKKKNIRLLTLDFAAADV
HHCCCEEEECCHHHHHHHHHHHHHHEEEEEECCCCCCEEEEEEECCCEEEEEEECHHHHH
KEKMLVSVSGGLLVQDADTYTLEDAEWNVVTKRQPTEAECEQLRFAWNVVKHVKSNAIVL
HHHEEEEECCCEEEECCCCEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEE
AKNGMTVGVGAGQMNRVGAAKIAIEQAGEQAAGAVLASDAFFPMDDTVEAAAKAGITAII
EECCEEEEECCCCCCCCCHHHHHHHHCCCHHHCEEEECCCCCCCCHHHHHHHHCCCEEEE
QPGGSIRDADSIRKANEYGIAMVFTGVRHFKH
CCCCCCCCHHHHHHHHHCCEEEEEHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA