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The map label for this gene is pth [H]

Identifier: 138893725

GI number: 138893725

Start: 56122

End: 56682

Strand: Direct

Name: pth [H]

Synonym: GTNG_0046

Alternate gene names: 138893725

Gene position: 56122-56682 (Clockwise)

Preceding gene: 138893724

Following gene: 138893726

Centisome position: 1.58

GC content: 47.95

Gene sequence:

>561_bases
TTGAAGCTGTTTGTCGGGCTCGGAAACCCGGGCAAGGAGTATGAACAAACGCGCCATAACATCGGTTTTTTCGTCATTGA
TGAGTTGGCTAAACGTTGGAACGTTTCGTTGAAAACCGCTAAATTCCGTGGCTTGTTCGGAACGGCTTCCGTTTTCGGCG
AAAAAGTGGCATTATGCAAACCTTTAACATATATGAATTTATCAGGGGAATGTGTTTGCCCGCTCATCGACTTCTACGAT
ATTGCCGTCGACGATGTTATTATTATATACGATGACCTCGATCTCCCGCCGGGGAAAATCCGCCTTCGTCTAAAAGGAGG
CTCCGGTGGTCATAATGGTGTCAAGTCGATCATTCACCATCTTGGCACGGAGCAGTTTAAGCGCATTCGCATCGGCATCG
GTCGGCCAACAAATGGGCAACCAGTTGCTGATTACGTACTTAGCCGTTTTACGGAAGAAGAAAAGCCAGCGGTAATGGAA
GCTGTTTTGCGGGCTGCCGATGCGTGTGAACAGGCAGTGACGACACCGTTTATCCAAGTGATGAATGACTTTAACGAGTG
A

Upstream 100 bases:

>100_bases
TGAGGCTGAAGAAGGAAGAGAAACGACGCCAGAAGGATGATAGACGTAACCGTTTCGGTTACGTCTTTTGTAGTATCATG
TACAGAGAGGAGCACGGCCA

Downstream 100 bases:

>100_bases
ATATTTTCCTCTGAACTGGTACACAATGTGAGTACGGAAGGCGCGAGGCATTGACTTCGCCTGCCTTGCGGACGGAACAG
TCCAGTGAGGAGGTTTGCTC

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 186; Mature: 186

Protein sequence:

>186_residues
MKLFVGLGNPGKEYEQTRHNIGFFVIDELAKRWNVSLKTAKFRGLFGTASVFGEKVALCKPLTYMNLSGECVCPLIDFYD
IAVDDVIIIYDDLDLPPGKIRLRLKGGSGGHNGVKSIIHHLGTEQFKRIRIGIGRPTNGQPVADYVLSRFTEEEKPAVME
AVLRAADACEQAVTTPFIQVMNDFNE

Sequences:

>Translated_186_residues
MKLFVGLGNPGKEYEQTRHNIGFFVIDELAKRWNVSLKTAKFRGLFGTASVFGEKVALCKPLTYMNLSGECVCPLIDFYD
IAVDDVIIIYDDLDLPPGKIRLRLKGGSGGHNGVKSIIHHLGTEQFKRIRIGIGRPTNGQPVADYVLSRFTEEEKPAVME
AVLRAADACEQAVTTPFIQVMNDFNE
>Mature_186_residues
MKLFVGLGNPGKEYEQTRHNIGFFVIDELAKRWNVSLKTAKFRGLFGTASVFGEKVALCKPLTYMNLSGECVCPLIDFYD
IAVDDVIIIYDDLDLPPGKIRLRLKGGSGGHNGVKSIIHHLGTEQFKRIRIGIGRPTNGQPVADYVLSRFTEEEKPAVME
AVLRAADACEQAVTTPFIQVMNDFNE

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=168, Percent_Identity=32.7380952380952, Blast_Score=100, Evalue=1e-21,
Organism=Escherichia coli, GI1787455, Length=184, Percent_Identity=42.3913043478261, Blast_Score=125, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6321983, Length=192, Percent_Identity=29.6875, Blast_Score=75, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 20662; Mature: 20662

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1 ; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLFVGLGNPGKEYEQTRHNIGFFVIDELAKRWNVSLKTAKFRGLFGTASVFGEKVALCK
CEEEEECCCCCHHHHHHHHCCCHHHHHHHHHHHCCEEEEHHHCCCHHHHHHHHHHHHHHC
PLTYMNLSGECVCPLIDFYDIAVDDVIIIYDDLDLPPGKIRLRLKGGSGGHNGVKSIIHH
CCEEECCCCCEEHHHHHHHHHHHCCEEEEEECCCCCCCEEEEEEECCCCCCHHHHHHHHH
LGTEQFKRIRIGIGRPTNGQPVADYVLSRFTEEEKPAVMEAVLRAADACEQAVTTPFIQV
HCHHHHHHEEEECCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
MNDFNE
HHHCCC
>Mature Secondary Structure
MKLFVGLGNPGKEYEQTRHNIGFFVIDELAKRWNVSLKTAKFRGLFGTASVFGEKVALCK
CEEEEECCCCCHHHHHHHHCCCHHHHHHHHHHHCCEEEEHHHCCCHHHHHHHHHHHHHHC
PLTYMNLSGECVCPLIDFYDIAVDDVIIIYDDLDLPPGKIRLRLKGGSGGHNGVKSIIHH
CCEEECCCCCEEHHHHHHHHHHHCCEEEEEECCCCCCCEEEEEEECCCCCCHHHHHHHHH
LGTEQFKRIRIGIGRPTNGQPVADYVLSRFTEEEKPAVMEAVLRAADACEQAVTTPFIQV
HCHHHHHHEEEECCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
MNDFNE
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA