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The map label for this gene is pmsR

Identifier: 13508346

GI number: 13508346

Start: 727599

End: 728072

Strand: Direct

Name: pmsR

Synonym: MPN607

Alternate gene names: 13508346

Gene position: 727599-728072 (Clockwise)

Preceding gene: 13508317

Following gene: 13508362

Centisome position: 89.12

GC content: 39.87

Gene sequence:

>474_bases
ATGAAACAAATCTATTTTGGTGGTGGCTGTTTTTGGGGTACCCAAAAGTATTTTGATCTGATTAAGGGTGTCCAAAAGAC
CAGTGTGGGCTACCTCAATTCCAACATGAAAAATCCCACTTACGAACAAGTATGTAGTGGGCAGACCAACGCAGTGGAAG
CAGTGTTCGTTGAATATGATGAAAACAAGGTAAGCTTAAACGAACTTATTGATGCTTTCTTTAAGGTCATTGATCCCACC
ATTAGAAACCGTCAGGGTAATGATATTGGTACCCAGTACCGTACCGGAGTTTATTGGGTAGATCCCCAAGACGAGCAGTT
AATTACGCAAAAGTTTAGGGAACTACAGGCCAATTATCCAAAACCAATTGTGACGGAAAACCGTGCAATGGAAAACTATT
TTTTAGCAGAAGAGTACCACCAGGATTACTTAAAGAAAAATCCTCATGGTTACTGTCACATTAAATTTGACTAG

Upstream 100 bases:

>100_bases
AAAGATCAGCAATCTTGAAAAGATCGGTTCCAGTTTGTGCACTCATATGACGCTTCTAACTAATATTTACTTAAATTATA
TTGACCAATAAATTTAGGAA

Downstream 100 bases:

>100_bases
TTAAAGACTTCTGGGTTTTTCACAAACAGGAATGCCTTAATGATGTTGTAGCAATAGTCATTAATCCGTTCAATGTGTTT
CACCGACAGAATTAAGTCAA

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase

Number of amino acids: Translated: 157; Mature: 157

Protein sequence:

>157_residues
MKQIYFGGGCFWGTQKYFDLIKGVQKTSVGYLNSNMKNPTYEQVCSGQTNAVEAVFVEYDENKVSLNELIDAFFKVIDPT
IRNRQGNDIGTQYRTGVYWVDPQDEQLITQKFRELQANYPKPIVTENRAMENYFLAEEYHQDYLKKNPHGYCHIKFD

Sequences:

>Translated_157_residues
MKQIYFGGGCFWGTQKYFDLIKGVQKTSVGYLNSNMKNPTYEQVCSGQTNAVEAVFVEYDENKVSLNELIDAFFKVIDPT
IRNRQGNDIGTQYRTGVYWVDPQDEQLITQKFRELQANYPKPIVTENRAMENYFLAEEYHQDYLKKNPHGYCHIKFD
>Mature_157_residues
MKQIYFGGGCFWGTQKYFDLIKGVQKTSVGYLNSNMKNPTYEQVCSGQTNAVEAVFVEYDENKVSLNELIDAFFKVIDPT
IRNRQGNDIGTQYRTGVYWVDPQDEQLITQKFRELQANYPKPIVTENRAMENYFLAEEYHQDYLKKNPHGYCHIKFD

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family

Homologues:

Organism=Homo sapiens, GI6912516, Length=153, Percent_Identity=42.483660130719, Blast_Score=122, Evalue=9e-29,
Organism=Homo sapiens, GI208609995, Length=153, Percent_Identity=42.483660130719, Blast_Score=122, Evalue=1e-28,
Organism=Homo sapiens, GI208609993, Length=114, Percent_Identity=40.3508771929825, Blast_Score=76, Evalue=1e-14,
Organism=Escherichia coli, GI1790665, Length=153, Percent_Identity=37.9084967320261, Blast_Score=111, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6320881, Length=158, Percent_Identity=38.6075949367089, Blast_Score=107, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24664627, Length=139, Percent_Identity=30.9352517985612, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI45553131, Length=136, Percent_Identity=30.1470588235294, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24664631, Length=139, Percent_Identity=30.2158273381295, Blast_Score=70, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MSRA_MYCPN (P75188)

Other databases:

- EMBL:   U00089
- PIR:   S73561
- RefSeq:   NP_110296.1
- ProteinModelPortal:   P75188
- SMR:   P75188
- GeneID:   876738
- GenomeReviews:   U00089_GR
- KEGG:   mpn:MPN607
- HOGENOM:   HBG748152
- OMA:   EAIFQRI
- ProtClustDB:   PRK14054
- BioCyc:   MPNE272634:MPN607-MONOMER
- BRENDA:   1.8.4.11
- HAMAP:   MF_01401
- InterPro:   IPR002569
- Gene3D:   G3DSA:3.30.1060.10
- TIGRFAMs:   TIGR00401

Pfam domain/function: PF01625 PMSR; SSF55068 MsrA

EC number: =1.8.4.11

Molecular weight: Translated: 18379; Mature: 18379

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: NA

Important sites: ACT_SITE 10-10

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQIYFGGGCFWGTQKYFDLIKGVQKTSVGYLNSNMKNPTYEQVCSGQTNAVEAVFVEYD
CCEEEECCEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCEEEEEEEEC
ENKVSLNELIDAFFKVIDPTIRNRQGNDIGTQYRTGVYWVDPQDEQLITQKFRELQANYP
CCEECHHHHHHHHHHHHCHHHCCCCCCCCCCEECCCEEEECCCCHHHHHHHHHHHHCCCC
KPIVTENRAMENYFLAEEYHQDYLKKNPHGYCHIKFD
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEC
>Mature Secondary Structure
MKQIYFGGGCFWGTQKYFDLIKGVQKTSVGYLNSNMKNPTYEQVCSGQTNAVEAVFVEYD
CCEEEECCEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCEEEEEEEEC
ENKVSLNELIDAFFKVIDPTIRNRQGNDIGTQYRTGVYWVDPQDEQLITQKFRELQANYP
CCEECHHHHHHHHHHHHCHHHCCCCCCCCCCEECCCEEEECCCCHHHHHHHHHHHHCCCC
KPIVTENRAMENYFLAEEYHQDYLKKNPHGYCHIKFD
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8948633