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The map label for this gene is fpg

Identifier: 13508119

GI number: 13508119

Start: 457147

End: 457980

Strand: Direct

Name: fpg

Synonym: MPN380

Alternate gene names: 13508119

Gene position: 457147-457980 (Clockwise)

Preceding gene: 13508118

Following gene: 13508120

Centisome position: 56.0

GC content: 35.97

Gene sequence:

>834_bases
ATGCCTGAACTACCTGAAGTTGCCACTGTAATTACCGAACTTAAGAGCTGTGTTTTAAACAAACCTGTCAAGCAAGTTAA
GGTTCACTTAGACAAGGTGTTGAAAAATACTAATGTCAAGCAGCTTAACGATGCGTTAGTCAACCACAGCTTTGTGGACA
TTAAGCGCCGCGGCAAGTACATTATTTTTTGTTTAAGTAACGGTTTGTTTTTAGTGTCACACTTACGCATGGAAGGCAAA
TATTTCTTTGAAGCTAAAGGCAGTCAGTTTGACTTAAACCATGTTTTAGTCGAGTTTTTATTCCAAGATGGTGATCAACT
TAACTATCATGATACGCGTCAATTTGGTACCTTTCACTTGTTCAATAGATATCAGTTTGAAAACGCACGTGAATTGAACA
AATTAGCACTCGATCCCTTAGATCAGGAATTTAACCATCAAGCGATCTTTAACAAAGGCCATAAGTCCAACAAGAAGATT
AAAACCTTTATTTTAGATCAGACCAACATTAGCGGTATTGGCAATATTTACGCTGATGAAATTTTGTTTGCAAGTAAGAT
TCACCCTGAAACTTTAGCTAAAAATTTGAACTTATCGCAGTATCAGCTAATTTGTCAAAATGCAACTGATATTTTAAAGA
AAGCAGTTGAAATGAAGGGTACTACCATTGGCACTTTTACCTTTAAAAAAGATCATACCGGTGGTTACCAACACTTCTTG
AAAATTCATGGCAAAAAGGGGAAGCAATGTCAAAGCTGTAACACCACTATTATTAAGAAAAAGATTAATGGTCGGGGCAG
CTATATTTGTGAAAAGTGTCAAATACAGCGTTAA

Upstream 100 bases:

>100_bases
TTGTCCACGCTGCTTTAAAACCAATCGATAAACAAGCTTTATTAGAGCTTTTAGATAAATATGGCATTAAAGCACTAGCG
CAAAAATTTAGTCAACTGTA

Downstream 100 bases:

>100_bases
TGGTTAACTGTTCCAGTTAATGCCAGAATTATGGCTTTATAAAAAAGAGCTTAAATATCTTAAACTTAAGCTCTTTTTGA
TCACTTAAATTCACCATAAA

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM

Number of amino acids: Translated: 277; Mature: 276

Protein sequence:

>277_residues
MPELPEVATVITELKSCVLNKPVKQVKVHLDKVLKNTNVKQLNDALVNHSFVDIKRRGKYIIFCLSNGLFLVSHLRMEGK
YFFEAKGSQFDLNHVLVEFLFQDGDQLNYHDTRQFGTFHLFNRYQFENARELNKLALDPLDQEFNHQAIFNKGHKSNKKI
KTFILDQTNISGIGNIYADEILFASKIHPETLAKNLNLSQYQLICQNATDILKKAVEMKGTTIGTFTFKKDHTGGYQHFL
KIHGKKGKQCQSCNTTIIKKKINGRGSYICEKCQIQR

Sequences:

>Translated_277_residues
MPELPEVATVITELKSCVLNKPVKQVKVHLDKVLKNTNVKQLNDALVNHSFVDIKRRGKYIIFCLSNGLFLVSHLRMEGK
YFFEAKGSQFDLNHVLVEFLFQDGDQLNYHDTRQFGTFHLFNRYQFENARELNKLALDPLDQEFNHQAIFNKGHKSNKKI
KTFILDQTNISGIGNIYADEILFASKIHPETLAKNLNLSQYQLICQNATDILKKAVEMKGTTIGTFTFKKDHTGGYQHFL
KIHGKKGKQCQSCNTTIIKKKINGRGSYICEKCQIQR
>Mature_276_residues
PELPEVATVITELKSCVLNKPVKQVKVHLDKVLKNTNVKQLNDALVNHSFVDIKRRGKYIIFCLSNGLFLVSHLRMEGKY
FFEAKGSQFDLNHVLVEFLFQDGDQLNYHDTRQFGTFHLFNRYQFENARELNKLALDPLDQEFNHQAIFNKGHKSNKKIK
TFILDQTNISGIGNIYADEILFASKIHPETLAKNLNLSQYQLICQNATDILKKAVEMKGTTIGTFTFKKDHTGGYQHFLK
IHGKKGKQCQSCNTTIIKKKINGRGSYICEKCQIQR

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger

Homologues:

Organism=Escherichia coli, GI1790066, Length=278, Percent_Identity=29.4964028776978, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1786932, Length=278, Percent_Identity=23.021582733813, Blast_Score=73, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FPG_MYCPN (P75402)

Other databases:

- EMBL:   U00089
- PIR:   S73783
- RefSeq:   NP_110068.1
- ProteinModelPortal:   P75402
- SMR:   P75402
- IntAct:   P75402
- GeneID:   876793
- GenomeReviews:   U00089_GR
- KEGG:   mpn:MPN380
- HOGENOM:   HBG690070
- OMA:   FLKVHTK
- ProtClustDB:   PRK01103
- BioCyc:   MPNE272634:MPN380-MONOMER
- BRENDA:   3.2.2.23
- BRENDA:   4.2.99.18
- HAMAP:   MF_00103
- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663
- SMART:   SM00898
- TIGRFAMs:   TIGR00577

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS; SSF81624 Form_DNAglyc_cat; SSF46946 Ribosomal_H2TH

EC number: =3.2.2.23; =4.2.99.18

Molecular weight: Translated: 31855; Mature: 31724

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: PS51068 FPG_CAT; PS01242 ZF_FPG_1; PS51066 ZF_FPG_2

Important sites: ACT_SITE 2-2 ACT_SITE 3-3 ACT_SITE 59-59 ACT_SITE 265-265 BINDING 94-94 BINDING 113-113

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVATVITELKSCVLNKPVKQVKVHLDKVLKNTNVKQLNDALVNHSFVDIKRRGKY
CCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCHHEEHCCCCCE
IIFCLSNGLFLVSHLRMEGKYFFEAKGSQFDLNHVLVEFLFQDGDQLNYHDTRQFGTFHL
EEEECCCCEEEEHHHHHCCEEEEEECCCEECHHHHHHHHHHCCCCCCCCCHHHHCCCEEE
FNRYQFENARELNKLALDPLDQEFNHQAIFNKGHKSNKKIKTFILDQTNISGIGNIYADE
HHHHCCCCHHHHHHHHCCCCCHHCCCHHHHCCCCCCCCEEEEEEEECCCCCCCCHHHHHH
ILFASKIHPETLAKNLNLSQYQLICQNATDILKKAVEMKGTTIGTFTFKKDHTGGYQHFL
HHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHH
KIHGKKGKQCQSCNTTIIKKKINGRGSYICEKCQIQR
EEECCCCCCCCCCCCEEEEEECCCCCCEEEHHCCCCC
>Mature Secondary Structure 
PELPEVATVITELKSCVLNKPVKQVKVHLDKVLKNTNVKQLNDALVNHSFVDIKRRGKY
CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCHHEEHCCCCCE
IIFCLSNGLFLVSHLRMEGKYFFEAKGSQFDLNHVLVEFLFQDGDQLNYHDTRQFGTFHL
EEEECCCCEEEEHHHHHCCEEEEEECCCEECHHHHHHHHHHCCCCCCCCCHHHHCCCEEE
FNRYQFENARELNKLALDPLDQEFNHQAIFNKGHKSNKKIKTFILDQTNISGIGNIYADE
HHHHCCCCHHHHHHHHCCCCCHHCCCHHHHCCCCCCCCEEEEEEEECCCCCCCCHHHHHH
ILFASKIHPETLAKNLNLSQYQLICQNATDILKKAVEMKGTTIGTFTFKKDHTGGYQHFL
HHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHH
KIHGKKGKQCQSCNTTIIKKKINGRGSYICEKCQIQR
EEECCCCCCCCCCCCEEEEEECCCCCCEEEHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8948633