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The map label for this gene is 13508111

Identifier: 13508111

GI number: 13508111

Start: 444341

End: 446116

Strand: Direct

Name: 13508111

Synonym: MPN372

Alternate gene names: NA

Gene position: 444341-446116 (Clockwise)

Preceding gene: 13508109

Following gene: 13508116

Centisome position: 54.43

GC content: 41.55

Gene sequence:

>1776_bases
ATGCCAAATCCTGTTAGATTTGTTTACCGTGTTGATTTGAGAAGCCCTGAAGAAATTTTTGAACATGGCTTTTCAACTTT
AGGTGATGTGAGAAATTTCTTTGAACACATTCTCTCCACTAATTTTGGTAGAAGCTATTTTATTTCCACTTCAGAAACAC
CCACAGCAGCTATTCGCTTCTTTGGTAGCTGGTTACGGGAATATGTACCAGAGCACCCCAGAAGGGCTTACTTATATGAA
ATTCGTGCCGACCAACACTTTTACAATGCCCGCGCCACTGGGGAGAACTTGTTAGATTTAATGCGTCAAAGACAAGTAGT
ATTTGACTCTGGTGATCGAGAAATGGCACAAATGGGAATTAGAGCTTTACGCACTTCCTTTGCGTATCAACGTGAATGGT
TTACCGATGGTCCAATTGCAGCAGCTAATGTCCGTAGTGCTTGACTAGTAGATGCTGTTCCCGTTGAACCTGGTCATGCT
CACCACCCGGCTGGTCGTGTTGTAGAGACTACTAGAATTAATGAACCGGAAATGCACAACCCTCATTATCAAGAGCTGCA
AACCCAAGCCAATGATCAACCATGATTGCCAACACCAGGAATAGCTACTCCTGTACATTTATCAATTCCCCAAGCAGCTT
CCGTTGCTGATGTTTCGGAAGGTACTTCCGCTTCGCTATCGTTTGCGTGCCCTGATTGAAGTCCACCTTCTAGTAATGGT
GAAAATCCGCTAGACAAATGCATTGCGGAAAAGATTGATAACTATAACCTACAATCCTTACCACAGTACGCTAGCAGTGT
AAAGGAACTGGAAGATACACCAGTATACCTAAGGGGAATTAAAACGCAAAAAACCTTTATGTTACAAGCAGATCCGCAAA
ATAACAATGTCTTTTTGGTCGAAGTAAACCCCAAACAAAAGTCCAGCTTTCCCCAAACCATCTTCTTTTGGGATGTTTAT
CAACGAATTTGTCTCAAGGATTTAACTGGTGCACAAATCAGTCTTTCGCTTACTGCCTTTACTACTCAGTATGCTGGTCA
GCTCAAAGTGCACCTTAGTGTTAGCGCGGTTAATGCCGTGAACCAAAAGTGAAAAATGACACCGCAAGACATTGCAATAA
CTCAGTTTCGGGTCTCCTCTGAACTGTTAGGTCAAACTGAAAATGGCTTGTTCTGAAATACCAAGAGTGGTGGTTCACAA
CACGATTTGTATGTATGTCCTTTGAAAAATCCACCTAGTGATTTGGAAGAATTACAAATAATTGTTGATGAATGTACTAC
CCATGCGCAGTTTGTTACTATGCGTGCAGCTAGCACCTTCTTTGTTGATGTTCAGCTAGGCTGGTATTGAAGGGGTTATT
ACTATACCCCACAATTAAGTGGTTGATCTTATCAGATGAAAACACCAGATGGACAGATATTCTATGATCTAAAAACTTCG
AAAATCTTCTTTGTCCAGGACAACCAAAACGTGTTCTTTCTCCATAATAAACTCAACAAACAAACTGGTTACAGCTGGGA
TTGAGTAGAATGGCTAAAACATGACATGAATGAGGACAAAGACGAAAACTTTAAATGGTACTTTTCGCGTGATGACCTTA
CCATTCCTTCCGTTGAAGGGCTTAACTTCCGCCACATTCGCTGTTACGCTGACAACCAGCAGTTAAAGGTGATCATAAGC
GGTTCACGTTGGGGCGGTTGGTACTCCACTTACGATAAAGTTGAAAGTAATGTCGAAGATAAGATTTTGGTCAAAGATGG
TTTTGATCGCTTTTAG

Upstream 100 bases:

>100_bases
ACTTGGATCCCAAGGTGATGGTGGATAATTACTGTTAACAATTTTTTTAGAAAAAGGCAGTTTTTGAAGTTTTTAATTTG
TAAAATTTCATTTTTTAAAA

Downstream 100 bases:

>100_bases
CGATTAAGCTTTAACGTCACTGTTTTGCTCTAATGTTAGAAGCAAAGATCTTGTCGACAAACTCGTTGCGCTTGCGGTAA
CGACGTACTACTAAATAAGT

Product: toxin subunit s1

Products: NA

Alternate protein names: ADP-ribosyltransferase CARDS; CARDX TX [H]

Number of amino acids: Translated: 591; Mature: 590

Protein sequence:

>591_residues
MPNPVRFVYRVDLRSPEEIFEHGFSTLGDVRNFFEHILSTNFGRSYFISTSETPTAAIRFFGSWLREYVPEHPRRAYLYE
IRADQHFYNARATGENLLDLMRQRQVVFDSGDREMAQMGIRALRTSFAYQREWFTDGPIAAANVRSAWLVDAVPVEPGHA
HHPAGRVVETTRINEPEMHNPHYQELQTQANDQPWLPTPGIATPVHLSIPQAASVADVSEGTSASLSFACPDWSPPSSNG
ENPLDKCIAEKIDNYNLQSLPQYASSVKELEDTPVYLRGIKTQKTFMLQADPQNNNVFLVEVNPKQKSSFPQTIFFWDVY
QRICLKDLTGAQISLSLTAFTTQYAGQLKVHLSVSAVNAVNQKWKMTPQDIAITQFRVSSELLGQTENGLFWNTKSGGSQ
HDLYVCPLKNPPSDLEELQIIVDECTTHAQFVTMRAASTFFVDVQLGWYWRGYYYTPQLSGWSYQMKTPDGQIFYDLKTS
KIFFVQDNQNVFFLHNKLNKQTGYSWDWVEWLKHDMNEDKDENFKWYFSRDDLTIPSVEGLNFRHIRCYADNQQLKVIIS
GSRWGGWYSTYDKVESNVEDKILVKDGFDRF

Sequences:

>Translated_591_residues
MPNPVRFVYRVDLRSPEEIFEHGFSTLGDVRNFFEHILSTNFGRSYFISTSETPTAAIRFFGSWLREYVPEHPRRAYLYE
IRADQHFYNARATGENLLDLMRQRQVVFDSGDREMAQMGIRALRTSFAYQREWFTDGPIAAANVRSA*LVDAVPVEPGHA
HHPAGRVVETTRINEPEMHNPHYQELQTQANDQP*LPTPGIATPVHLSIPQAASVADVSEGTSASLSFACPD*SPPSSNG
ENPLDKCIAEKIDNYNLQSLPQYASSVKELEDTPVYLRGIKTQKTFMLQADPQNNNVFLVEVNPKQKSSFPQTIFFWDVY
QRICLKDLTGAQISLSLTAFTTQYAGQLKVHLSVSAVNAVNQK*KMTPQDIAITQFRVSSELLGQTENGLF*NTKSGGSQ
HDLYVCPLKNPPSDLEELQIIVDECTTHAQFVTMRAASTFFVDVQLGWY*RGYYYTPQLSG*SYQMKTPDGQIFYDLKTS
KIFFVQDNQNVFFLHNKLNKQTGYSWD*VEWLKHDMNEDKDENFKWYFSRDDLTIPSVEGLNFRHIRCYADNQQLKVIIS
GSRWGGWYSTYDKVESNVEDKILVKDGFDRF
>Mature_590_residues
PNPVRFVYRVDLRSPEEIFEHGFSTLGDVRNFFEHILSTNFGRSYFISTSETPTAAIRFFGSWLREYVPEHPRRAYLYEI
RADQHFYNARATGENLLDLMRQRQVVFDSGDREMAQMGIRALRTSFAYQREWFTDGPIAAANVRSA*LVDAVPVEPGHAH
HPAGRVVETTRINEPEMHNPHYQELQTQANDQP*LPTPGIATPVHLSIPQAASVADVSEGTSASLSFACPD*SPPSSNGE
NPLDKCIAEKIDNYNLQSLPQYASSVKELEDTPVYLRGIKTQKTFMLQADPQNNNVFLVEVNPKQKSSFPQTIFFWDVYQ
RICLKDLTGAQISLSLTAFTTQYAGQLKVHLSVSAVNAVNQK*KMTPQDIAITQFRVSSELLGQTENGLF*NTKSGGSQH
DLYVCPLKNPPSDLEELQIIVDECTTHAQFVTMRAASTFFVDVQLGWY*RGYYYTPQLSG*SYQMKTPDGQIFYDLKTSK
IFFVQDNQNVFFLHNKLNKQTGYSWD*VEWLKHDMNEDKDENFKWYFSRDDLTIPSVEGLNFRHIRCYADNQQLKVIISG
SRWGGWYSTYDKVESNVEDKILVKDGFDRF

Specific function: Acts as an ADP-ribosylating toxin, which may transfer the ADP-ribosyl group from NAD(+) to specific amino acids in target proteins. Elicits cytopathic effects in mammalian cells, such as disorganization and disruption of respiratory epithelial integrity i

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Extracellular side. Note=Surface-associated protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial exotoxin subunit A family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003898 [H]

Pfam domain/function: PF02917 Pertussis_S1 [H]

EC number: NA

Molecular weight: Translated: 66424; Mature: 66293

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNPVRFVYRVDLRSPEEIFEHGFSTLGDVRNFFEHILSTNFGRSYFISTSETPTAAIRF
CCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHH
FGSWLREYVPEHPRRAYLYEIRADQHFYNARATGENLLDLMRQRQVVFDSGDREMAQMGI
HHHHHHHHCCCCCCEEEEEEEECCCEEECCCCCHHHHHHHHHHCHHEECCCCHHHHHHHH
RALRTSFAYQREWFTDGPIAAANVRSALVDAVPVEPGHAHHPAGRVVETTRINEPEMHNP
HHHHHHHHHHHCCCCCCCEEHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCC
HYQELQTQANDQPLPTPGIATPVHLSIPQAASVADVSEGTSASLSFACPDSPPSSNGENP
HHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCH
LDKCIAEKIDNYNLQSLPQYASSVKELEDTPVYLRGIKTQKTFMLQADPQNNNVFLVEVN
HHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEECCCCCCEEEEEEC
PKQKSSFPQTIFFWDVYQRICLKDLTGAQISLSLTAFTTQYAGQLKVHLSVSAVNAVNQK
CCCCCCCCCEEEHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCEEEEEEEEEEHHHHHHC
KMTPQDIAITQFRVSSELLGQTENGLFNTKSGGSQHDLYVCPLKNPPSDLEELQIIVDEC
CCCCCCEEEEEEEHHHHHHCCCCCCEEECCCCCCCCCEEEEECCCCCCCHHHHHHHHHHH
TTHAQFVTMRAASTFFVDVQLGWYRGYYYTPQLSGSYQMKTPDGQIFYDLKTSKIFFVQD
CCCCEEEEEEECEEEEEEEEEEEEECEEECCCCCCCEEEECCCCCEEEEEECCEEEEEEC
NQNVFFLHNKLNKQTGYSWDVEWLKHDMNEDKDENFKWYFSRDDLTIPSVEGLNFRHIRC
CCCEEEEEECCCCCCCCCCCHHHHHHHCCCCCCCCEEEEEECCCEECCCCCCCCEEEEEE
YADNQQLKVIISGSRWGGWYSTYDKVESNVEDKILVKDGFDRF
EECCCEEEEEEECCCCCCCHHHHHHHHCCCCCEEEEECCCCCC
>Mature Secondary Structure 
PNPVRFVYRVDLRSPEEIFEHGFSTLGDVRNFFEHILSTNFGRSYFISTSETPTAAIRF
CCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHH
FGSWLREYVPEHPRRAYLYEIRADQHFYNARATGENLLDLMRQRQVVFDSGDREMAQMGI
HHHHHHHHCCCCCCEEEEEEEECCCEEECCCCCHHHHHHHHHHCHHEECCCCHHHHHHHH
RALRTSFAYQREWFTDGPIAAANVRSALVDAVPVEPGHAHHPAGRVVETTRINEPEMHNP
HHHHHHHHHHHCCCCCCCEEHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCC
HYQELQTQANDQPLPTPGIATPVHLSIPQAASVADVSEGTSASLSFACPDSPPSSNGENP
HHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCH
LDKCIAEKIDNYNLQSLPQYASSVKELEDTPVYLRGIKTQKTFMLQADPQNNNVFLVEVN
HHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEECCCCCCEEEEEEC
PKQKSSFPQTIFFWDVYQRICLKDLTGAQISLSLTAFTTQYAGQLKVHLSVSAVNAVNQK
CCCCCCCCCEEEHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCEEEEEEEEEEHHHHHHC
KMTPQDIAITQFRVSSELLGQTENGLFNTKSGGSQHDLYVCPLKNPPSDLEELQIIVDEC
CCCCCCEEEEEEEHHHHHHCCCCCCEEECCCCCCCCCEEEEECCCCCCCHHHHHHHHHHH
TTHAQFVTMRAASTFFVDVQLGWYRGYYYTPQLSGSYQMKTPDGQIFYDLKTSKIFFVQD
CCCCEEEEEEECEEEEEEEEEEEEECEEECCCCCCCEEEECCCCCEEEEEECCEEEEEEC
NQNVFFLHNKLNKQTGYSWDVEWLKHDMNEDKDENFKWYFSRDDLTIPSVEGLNFRHIRC
CCCEEEEEECCCCCCCCCCCHHHHHHHCCCCCCCCEEEEEECCCEECCCCCCCCEEEEEE
YADNQQLKVIISGSRWGGWYSTYDKVESNVEDKILVKDGFDRF
EECCCEEEEEEECCCCCCCHHHHHHHHCCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8948633 [H]