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The map label for this gene is fruA [H]

Identifier: 13507817

GI number: 13507817

Start: 93191

End: 95275

Strand: Direct

Name: fruA [H]

Synonym: MPN078

Alternate gene names: 13507817

Gene position: 93191-95275 (Clockwise)

Preceding gene: 13507814

Following gene: 13507818

Centisome position: 11.41

GC content: 42.35

Gene sequence:

>2085_bases
ATGTTCAAGCCATTGTTAAGCGCTGAGCTGTTTTTTAACTGAACAGCTAAAGATTTTAAAGATAAAACAAGCTTTTTAAA
ACAAGCGTGTCGTGTTTTACAGGACAAAAACTGCATTAAAGAAGAACAAATAGCACTCACTGCTTTAAAAGAAAGGGAGG
CACAAATCACCACCGGAATTATGTCAAAACTGGCATTGCCCCACATGCAAAGTGCTACCGTGTTAAAACCGTTTGTGGCG
GTGTTTAAGGTCAACAATGTGGACTGGCAATCCTTAGACAACCAACCGGTTAAACTAATCTTTTTAATTGGCGTACCCAA
AGATCAAGGCAACCTCCACTTGGAATTTATTTCGCAGTTTTCCAAGTTAATGTTGCAGGACGAGTTTGCCAACAAAGTGC
CCAACATTCGCAGCTTTAACGGGTTGATCAATTTAATTGACAGTTTTCAACAAACTGCAGTTGCAAGTCAACCTGTTGTT
AACGAAGCAGCAGCTCAGACTGAAGAGCCAAAGGACACAAACACTCAGTATGACTTTGTGGCGGTAACGGCGTGTCCCAC
CGGGATTGCTCACACCTTTATGGCCAAGGAAGCGCTGGAAAAGTTTGCCCGCGATCACAACCTCAAAGTTAAGGTCGAAA
CTCAAGGAACTGATGGGATTCAGAACCAGTTAACCGAGTCTGATTTAAACAATACCAAAGGCATTATTTTGGCCTGTGAC
CGCTTAATTGATTTAACGCGTTTTTACGGTCACGCAAATGTGGTGGAAGTGTCCACAACCAAAGCAATTAAAACACCACA
AACAGTTTATGACCAAGTGGTAAAGAAGGAAGGCAAACTACTCGGTAATAAGTCCAGTGATAGTGCTAGTCAAACGGAAC
TCAAAGAAACCACTGAACAGCTCTCGTTTAAAGACTTTCACAAACGGATTTACCGCGCCATTTTAAGTGGGGTTTCTTAC
ATGCTGCCATTTGTCGTGTTTGGTGGCATCTTAATTGCAATTGCCTTTTTAATTGACATTAATAATGCTGGCAATGCTGG
TAAACAATTTGGCTCTAAAGATCCCATAGCTAACTGGTTTAAAACACTCGGTGGGTTGTCGTTTGGTTTAATTGTTCCCA
TTTTAAGTGCTTACATTGCCTTTGCTCTAGTCGGCCGGCAAGGGTTACTGCCCGGCTTTATTGTGGGGTTAATTTCAGCT
GGTAAGTTTTTACTCAACATTGACATTGTTACTGGAAAAATTGATTGAGCGACTGAATCAAAAGTATCGAGTGGTTTCTT
TGGTGCCATTTTTGGAGGCTTGTTGGCAGCAGTGTTAATTATTGTGCAGCAACGTTACATCTATAGAAAATTACCGCAAG
CATTACAAGGCATTAAGAACATTCTCTTTATTCCGTTACTAGGAACGCTAGTCACAGCAGCCTTGTTCTGAGTCATTAAC
ATTCCCCTAATTTACTTGAACTATGGTCTGTCCAAGTTCTTGCAAATTATGGACAAACCATATTTGGCTCCCTTACTTGG
TTTAGTGATTGGACTCATGATGTGCTTTGACTTGGGTGGACCGGTCAACAAAGCGGCCTATGTGTTTGGGGTAGTTTCGC
TAGAGAGCCAAAACAGTGGTACGGTTGCAATGGCTAGTGCTATCTTATCGGGGATGGTGCCACCATTGGGTATTGCCATT
GCTGCGACCATTCGCAAGCAGTGCTTTGACAAGGAAGAATTACCAGCAGCGTATGCTTGTTATGTGATGGGATTAAGTTT
TATTAGTGAAGGGGCGATTCCTTTTGTTGCTAAACGGCCTAAGATTATGTTAGCTGCTAACCTAATTGGTGGTGCTGTGT
GTGGTGTTTTAACGGGAGCATTTGCGCTAACGATTCGTGCCCCTCATGGTGGCGTGTTTGTCTTTGCCTTATTGAAAACT
AACTTAGAGGGCATTGCCGGCAACACACTCCAAATCGGCGCTGGGGTTGGCTTAGCACTTCTAGCGCTAATAGTATCCAG
CTTCATTAGTGCTGGCATTATTATTGGTCATAACCTGCTTGTAGTGCGTAAAAAAACAAAACAACTAGTAAATACCAATG
CTTAA

Upstream 100 bases:

>100_bases
CGATCTAACACCTTAGCAGGGTGTCCTCTTAACCACTTGAGTACGCTCCCAGGAACTGGAATCTAAATTTATTATAAATA
TTGGATTTTCTGACTTTAGG

Downstream 100 bases:

>100_bases
CCACAACAGTAAAGTTTGAATAGTTAACTATGCTTGTGCGATTGACTATTACTTAGATAAACACAAACAACAACGCGGTG
TGTTAACACCCGGTGGTAAG

Product: fructose-permease IIBC component

Products: NA

Alternate protein names: EIIABC-Fru; Fructose-specific phosphotransferase enzyme IIA component; EII-Fru; PTS system fructose-specific EIIA component; Fructose-specific phosphotransferase enzyme IIB component; EIII-Fru; PTS system fructose-specific EIIB component; Fructose permease IIC component; PTS system fructose-specific EIIC component [H]

Number of amino acids: Translated: 694; Mature: 694

Protein sequence:

>694_residues
MFKPLLSAELFFNWTAKDFKDKTSFLKQACRVLQDKNCIKEEQIALTALKEREAQITTGIMSKLALPHMQSATVLKPFVA
VFKVNNVDWQSLDNQPVKLIFLIGVPKDQGNLHLEFISQFSKLMLQDEFANKVPNIRSFNGLINLIDSFQQTAVASQPVV
NEAAAQTEEPKDTNTQYDFVAVTACPTGIAHTFMAKEALEKFARDHNLKVKVETQGTDGIQNQLTESDLNNTKGIILACD
RLIDLTRFYGHANVVEVSTTKAIKTPQTVYDQVVKKEGKLLGNKSSDSASQTELKETTEQLSFKDFHKRIYRAILSGVSY
MLPFVVFGGILIAIAFLIDINNAGNAGKQFGSKDPIANWFKTLGGLSFGLIVPILSAYIAFALVGRQGLLPGFIVGLISA
GKFLLNIDIVTGKIDWATESKVSSGFFGAIFGGLLAAVLIIVQQRYIYRKLPQALQGIKNILFIPLLGTLVTAALFWVIN
IPLIYLNYGLSKFLQIMDKPYLAPLLGLVIGLMMCFDLGGPVNKAAYVFGVVSLESQNSGTVAMASAILSGMVPPLGIAI
AATIRKQCFDKEELPAAYACYVMGLSFISEGAIPFVAKRPKIMLAANLIGGAVCGVLTGAFALTIRAPHGGVFVFALLKT
NLEGIAGNTLQIGAGVGLALLALIVSSFISAGIIIGHNLLVVRKKTKQLVNTNA

Sequences:

>Translated_694_residues
MFKPLLSAELFFN*TAKDFKDKTSFLKQACRVLQDKNCIKEEQIALTALKEREAQITTGIMSKLALPHMQSATVLKPFVA
VFKVNNVDWQSLDNQPVKLIFLIGVPKDQGNLHLEFISQFSKLMLQDEFANKVPNIRSFNGLINLIDSFQQTAVASQPVV
NEAAAQTEEPKDTNTQYDFVAVTACPTGIAHTFMAKEALEKFARDHNLKVKVETQGTDGIQNQLTESDLNNTKGIILACD
RLIDLTRFYGHANVVEVSTTKAIKTPQTVYDQVVKKEGKLLGNKSSDSASQTELKETTEQLSFKDFHKRIYRAILSGVSY
MLPFVVFGGILIAIAFLIDINNAGNAGKQFGSKDPIANWFKTLGGLSFGLIVPILSAYIAFALVGRQGLLPGFIVGLISA
GKFLLNIDIVTGKID*ATESKVSSGFFGAIFGGLLAAVLIIVQQRYIYRKLPQALQGIKNILFIPLLGTLVTAALF*VIN
IPLIYLNYGLSKFLQIMDKPYLAPLLGLVIGLMMCFDLGGPVNKAAYVFGVVSLESQNSGTVAMASAILSGMVPPLGIAI
AATIRKQCFDKEELPAAYACYVMGLSFISEGAIPFVAKRPKIMLAANLIGGAVCGVLTGAFALTIRAPHGGVFVFALLKT
NLEGIAGNTLQIGAGVGLALLALIVSSFISAGIIIGHNLLVVRKKTKQLVNTNA
>Mature_694_residues
MFKPLLSAELFFN*TAKDFKDKTSFLKQACRVLQDKNCIKEEQIALTALKEREAQITTGIMSKLALPHMQSATVLKPFVA
VFKVNNVDWQSLDNQPVKLIFLIGVPKDQGNLHLEFISQFSKLMLQDEFANKVPNIRSFNGLINLIDSFQQTAVASQPVV
NEAAAQTEEPKDTNTQYDFVAVTACPTGIAHTFMAKEALEKFARDHNLKVKVETQGTDGIQNQLTESDLNNTKGIILACD
RLIDLTRFYGHANVVEVSTTKAIKTPQTVYDQVVKKEGKLLGNKSSDSASQTELKETTEQLSFKDFHKRIYRAILSGVSY
MLPFVVFGGILIAIAFLIDINNAGNAGKQFGSKDPIANWFKTLGGLSFGLIVPILSAYIAFALVGRQGLLPGFIVGLISA
GKFLLNIDIVTGKID*ATESKVSSGFFGAIFGGLLAAVLIIVQQRYIYRKLPQALQGIKNILFIPLLGTLVTAALF*VIN
IPLIYLNYGLSKFLQIMDKPYLAPLLGLVIGLMMCFDLGGPVNKAAYVFGVVSLESQNSGTVAMASAILSGMVPPLGIAI
AATIRKQCFDKEELPAAYACYVMGLSFISEGAIPFVAKRPKIMLAANLIGGAVCGVLTGAFALTIRAPHGGVFVFALLKT
NLEGIAGNTLQIGAGVGLALLALIVSSFISAGIIIGHNLLVVRKKTKQLVNTNA

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG1299

COG function: function code G; Phosphotransferase system, fructose-specific IIC component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1788492, Length=534, Percent_Identity=35.9550561797753, Blast_Score=277, Evalue=2e-75,
Organism=Escherichia coli, GI1786951, Length=636, Percent_Identity=29.0880503144654, Blast_Score=226, Evalue=4e-60,
Organism=Escherichia coli, GI87082348, Length=467, Percent_Identity=30.8351177730193, Blast_Score=183, Evalue=3e-47,
Organism=Escherichia coli, GI1790386, Length=338, Percent_Identity=30.7692307692308, Blast_Score=139, Evalue=6e-34,
Organism=Escherichia coli, GI1788729, Length=443, Percent_Identity=27.5395033860045, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI1790387, Length=94, Percent_Identity=39.3617021276596, Blast_Score=76, Evalue=7e-15,
Organism=Escherichia coli, GI1788730, Length=95, Percent_Identity=37.8947368421053, Blast_Score=70, Evalue=6e-13,
Organism=Escherichia coli, GI1790390, Length=97, Percent_Identity=36.0824742268041, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016152
- InterPro:   IPR002178
- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR004715
- InterPro:   IPR003353
- InterPro:   IPR006327 [H]

Pfam domain/function: PF00359 PTS_EIIA_2; PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 74553; Mature: 74553

Theoretical pI: Translated: 9.55; Mature: 9.55

Prosite motif: PS51094 PTS_EIIA_TYPE_2 ; PS51099 PTS_EIIB_TYPE_2 ; PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKPLLSAELFFNTAKDFKDKTSFLKQACRVLQDKNCIKEEQIALTALKEREAQITTGIM
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
SKLALPHMQSATVLKPFVAVFKVNNVDWQSLDNQPVKLIFLIGVPKDQGNLHLEFISQFS
HHHCCCCCCCHHHHHHHHHHHEECCCCHHCCCCCCEEEEEEEECCCCCCCCHHHHHHHHH
KLMLQDEFANKVPNIRSFNGLINLIDSFQQTAVASQPVVNEAAAQTEEPKDTNTQYDFVA
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCEEEEE
VTACPTGIAHTFMAKEALEKFARDHNLKVKVETQGTDGIQNQLTESDLNNTKGIILACDR
EEECCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCEEEHHH
LIDLTRFYGHANVVEVSTTKAIKTPQTVYDQVVKKEGKLLGNKSSDSASQTELKETTEQL
HHHHHHHHCCCCEEEEECCHHHCCCHHHHHHHHHHHCHHCCCCCCCCHHHHHHHHHHHHH
SFKDFHKRIYRAILSGVSYMLPFVVFGGILIAIAFLIDINNAGNAGKQFGSKDPIANWFK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCHHHHHHH
TLGGLSFGLIVPILSAYIAFALVGRQGLLPGFIVGLISAGKFLLNIDIVTGKIDATESKV
HHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEEEEEECCCCCCHHHH
SSGFFGAIFGGLLAAVLIIVQQRYIYRKLPQALQGIKNILFIPLLGTLVTAALFVINIPL
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IYLNYGLSKFLQIMDKPYLAPLLGLVIGLMMCFDLGGPVNKAAYVFGVVSLESQNSGTVA
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHEEEEEEECCCCCCHHH
MASAILSGMVPPLGIAIAATIRKQCFDKEELPAAYACYVMGLSFISEGAIPFVAKRPKIM
HHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCEE
LAANLIGGAVCGVLTGAFALTIRAPHGGVFVFALLKTNLEGIAGNTLQIGAGVGLALLAL
EEHHHHHHHHHHHHHHHHEEEEECCCCCEEEHHHHHHCCCCCCCCCEEECCCHHHHHHHH
IVSSFISAGIIIGHNLLVVRKKTKQLVNTNA
HHHHHHHCCHHCCCCEEEEEHHHHHHHCCCC
>Mature Secondary Structure
MFKPLLSAELFFNTAKDFKDKTSFLKQACRVLQDKNCIKEEQIALTALKEREAQITTGIM
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
SKLALPHMQSATVLKPFVAVFKVNNVDWQSLDNQPVKLIFLIGVPKDQGNLHLEFISQFS
HHHCCCCCCCHHHHHHHHHHHEECCCCHHCCCCCCEEEEEEEECCCCCCCCHHHHHHHHH
KLMLQDEFANKVPNIRSFNGLINLIDSFQQTAVASQPVVNEAAAQTEEPKDTNTQYDFVA
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCEEEEE
VTACPTGIAHTFMAKEALEKFARDHNLKVKVETQGTDGIQNQLTESDLNNTKGIILACDR
EEECCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCEEEHHH
LIDLTRFYGHANVVEVSTTKAIKTPQTVYDQVVKKEGKLLGNKSSDSASQTELKETTEQL
HHHHHHHHCCCCEEEEECCHHHCCCHHHHHHHHHHHCHHCCCCCCCCHHHHHHHHHHHHH
SFKDFHKRIYRAILSGVSYMLPFVVFGGILIAIAFLIDINNAGNAGKQFGSKDPIANWFK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCHHHHHHH
TLGGLSFGLIVPILSAYIAFALVGRQGLLPGFIVGLISAGKFLLNIDIVTGKIDATESKV
HHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEEEEEECCCCCCHHHH
SSGFFGAIFGGLLAAVLIIVQQRYIYRKLPQALQGIKNILFIPLLGTLVTAALFVINIPL
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IYLNYGLSKFLQIMDKPYLAPLLGLVIGLMMCFDLGGPVNKAAYVFGVVSLESQNSGTVA
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHEEEEEEECCCCCCHHH
MASAILSGMVPPLGIAIAATIRKQCFDKEELPAAYACYVMGLSFISEGAIPFVAKRPKIM
HHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCEE
LAANLIGGAVCGVLTGAFALTIRAPHGGVFVFALLKTNLEGIAGNTLQIGAGVGLALLAL
EEHHHHHHHHHHHHHHHHEEEEECCCCCEEEHHHHHHCCCCCCCCCEEECCCHHHHHHHH
IVSSFISAGIIIGHNLLVVRKKTKQLVNTNA
HHHHHHHCCHHCCCCEEEEEHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8948633 [H]