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The map label for this gene is groEL [H]

Identifier: 13488302

GI number: 13488302

Start: 301127

End: 302776

Strand: Direct

Name: groEL [H]

Synonym: mlr9342

Alternate gene names: 13488302

Gene position: 301127-302776 (Clockwise)

Preceding gene: 13488366

Following gene: 13488303

Centisome position: 85.57

GC content: 64.18

Gene sequence:

>1650_bases
ATGGCTGCCAAAGACGTAAAATTCTCCCGCGACGCCCGTGAGCGCATGCTGCGCGGCGTGAACATCCTCGCCGACGCGGT
GAAGGTGACCCTCGGCCCCAAGGGCCGCAACGTCGTCATCGACAAGTCGTTCGGCGCCCCGCGCATCACCAAGGACGGCG
TCACCGTCGCCAAGGAAATCGAGCTTGAGGACAAGTTCGAGAACATGGGCGCGCAGATGGTCCGCGAAGTTGCTTCGAAG
ACCAACGACATCGCCGGCGACGGCACCACGACCGCAACCGTTCTGGCACAGTCGATCGTCCAGGAAGGCCACAAGGCGGT
TGCCGCCGGCATGAACCCGATGGACCTGAAGCGCGGCATCGACCTCGCGGTTGCCGACGTCGTCGCGACGCTGATCAAGA
ACGCCAAGAAGATCAAGACCTCGGAAGAGGTTGCCCAGGTCGGCACCATCGCCGGCAACGGCGACTCCTCGGTCGGTTCG
ATGATCGCGGAAGCGATGCAGAAGGTCGGCAATGAGGGCGTCATCACGGTCGAGGAAGCCAAGACCGCCGAGACCGAACT
CGAAGTCGTCGAAGGCATGCAGTTCGACCGCGGCTACCTCTCGCCCTACTTCGTCACCAACGCCGACAAGATGGTTGCGG
ATCTGGAAGACGCCTACATCCTTCTCCACGAGAAGAAGCTCTCCAACCTGCAGGCCATGCTGCCGATCCTCGAGGCTGTC
GTACAGACCTCGAAGCCGCTGGTCATCATCTCGGAAGACGTCGAAGGCGAGGCTCTGGCCACGCTGGTCGTCAACAAGCT
GCGTGGCGGCCTGAAGATCGCCGCCGTCAAGGCGCCGGGCTTCGGTGATCGCCGCAAGGCCATGCTGGAAGACATCGCCA
TCCTCACCGGTGGCCAGGTCATTTCCGAAGACCTCGGCATCAAGCTCGAGAACGTCGGCCTCAACATGCTCGGCCGCGCC
AAGAAGGTGTCGATCTCCAAGGAGAACACCACCATCGTCGACGGCGCCGGCAAGAAGGCCGAGATCCAGGGCCGCGTTGC
CCAGATCAAGCAGCAGATCGAGGAGACCACCTCGGACTACGACAAGGAGAAGCTGCAGGAGCGTCTCGCCAAGCTCGCGG
GCGGCGTTGCGGTGATCCGCGTCGGCGGCGCGACGGAAGTCGAAGTCAAGGAAAAGAAGGACCGCGTTGACGATGCGCTG
AACGCGACACGCGCAGCCGTCGAAGAAGGCATCGTTCCCGGCGGCGGCGTTGCCCTGCTGCGCGCTTCGCTGAGCATCAA
CGCTGTCGGCGCAAACTCCGACCAGACCGCTGGCATCAGCATCGTGCGTCGTGCGCTGCAGGCTCCGGCCCGCCAGATCG
CGGCCAACGCCGGTGCGGAAGCCTCGATCGTTGCCGGCAAGATCCTTGAGAACAAGGGCGCGACCTACGGCTACAACGCC
CAGACCGGCGAATATGGCGACATGATCGCCATGGGCATCGTCGATCCGGTCAAGGTCGTGCGCACGGCTCTCCAGGACGC
GGCCTCGGTCGCCGGCCTGCTGGTCACCGCCGAAGCCATGATCGCGGAGGCTCCGAAGAAGGAGTCGGCTGGCGGCGGCA
TGCCGGGTGGTATGCCCGGCGGCGGCATGGGCGGTATGGGTGGTTTCTAA

Upstream 100 bases:

>100_bases
CATGAAGGAATCCGACATTATGGGCATCATCGGCTGATTATCGGCCTCACCGTCAACTGAATTTCGGGCTTGATCGCAAG
CCCATGCCAGGAGCTAAAAC

Downstream 100 bases:

>100_bases
GGCCCACGCATCTCAACATCTTCAAGGGCGGCAGCATTGCCGCCCTTTTCTTTAGCGCAAATCCGGTCGGAAAAGTTCGG
CGCTCGCGAAATTTCTCGCC

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 3; Protein Cpn60 3 [H]

Number of amino acids: Translated: 549; Mature: 548

Protein sequence:

>549_residues
MAAKDVKFSRDARERMLRGVNILADAVKVTLGPKGRNVVIDKSFGAPRITKDGVTVAKEIELEDKFENMGAQMVREVASK
TNDIAGDGTTTATVLAQSIVQEGHKAVAAGMNPMDLKRGIDLAVADVVATLIKNAKKIKTSEEVAQVGTIAGNGDSSVGS
MIAEAMQKVGNEGVITVEEAKTAETELEVVEGMQFDRGYLSPYFVTNADKMVADLEDAYILLHEKKLSNLQAMLPILEAV
VQTSKPLVIISEDVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAMLEDIAILTGGQVISEDLGIKLENVGLNMLGRA
KKVSISKENTTIVDGAGKKAEIQGRVAQIKQQIEETTSDYDKEKLQERLAKLAGGVAVIRVGGATEVEVKEKKDRVDDAL
NATRAAVEEGIVPGGGVALLRASLSINAVGANSDQTAGISIVRRALQAPARQIAANAGAEASIVAGKILENKGATYGYNA
QTGEYGDMIAMGIVDPVKVVRTALQDAASVAGLLVTAEAMIAEAPKKESAGGGMPGGMPGGGMGGMGGF

Sequences:

>Translated_549_residues
MAAKDVKFSRDARERMLRGVNILADAVKVTLGPKGRNVVIDKSFGAPRITKDGVTVAKEIELEDKFENMGAQMVREVASK
TNDIAGDGTTTATVLAQSIVQEGHKAVAAGMNPMDLKRGIDLAVADVVATLIKNAKKIKTSEEVAQVGTIAGNGDSSVGS
MIAEAMQKVGNEGVITVEEAKTAETELEVVEGMQFDRGYLSPYFVTNADKMVADLEDAYILLHEKKLSNLQAMLPILEAV
VQTSKPLVIISEDVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAMLEDIAILTGGQVISEDLGIKLENVGLNMLGRA
KKVSISKENTTIVDGAGKKAEIQGRVAQIKQQIEETTSDYDKEKLQERLAKLAGGVAVIRVGGATEVEVKEKKDRVDDAL
NATRAAVEEGIVPGGGVALLRASLSINAVGANSDQTAGISIVRRALQAPARQIAANAGAEASIVAGKILENKGATYGYNA
QTGEYGDMIAMGIVDPVKVVRTALQDAASVAGLLVTAEAMIAEAPKKESAGGGMPGGMPGGGMGGMGGF
>Mature_548_residues
AAKDVKFSRDARERMLRGVNILADAVKVTLGPKGRNVVIDKSFGAPRITKDGVTVAKEIELEDKFENMGAQMVREVASKT
NDIAGDGTTTATVLAQSIVQEGHKAVAAGMNPMDLKRGIDLAVADVVATLIKNAKKIKTSEEVAQVGTIAGNGDSSVGSM
IAEAMQKVGNEGVITVEEAKTAETELEVVEGMQFDRGYLSPYFVTNADKMVADLEDAYILLHEKKLSNLQAMLPILEAVV
QTSKPLVIISEDVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAMLEDIAILTGGQVISEDLGIKLENVGLNMLGRAK
KVSISKENTTIVDGAGKKAEIQGRVAQIKQQIEETTSDYDKEKLQERLAKLAGGVAVIRVGGATEVEVKEKKDRVDDALN
ATRAAVEEGIVPGGGVALLRASLSINAVGANSDQTAGISIVRRALQAPARQIAANAGAEASIVAGKILENKGATYGYNAQ
TGEYGDMIAMGIVDPVKVVRTALQDAASVAGLLVTAEAMIAEAPKKESAGGGMPGGMPGGGMGGMGGF

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=528, Percent_Identity=55.1136363636364, Blast_Score=579, Evalue=1e-165,
Organism=Homo sapiens, GI31542947, Length=528, Percent_Identity=55.1136363636364, Blast_Score=579, Evalue=1e-165,
Organism=Homo sapiens, GI5453607, Length=535, Percent_Identity=22.2429906542056, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1790586, Length=531, Percent_Identity=67.7966101694915, Blast_Score=697, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=54.4423440453686, Blast_Score=571, Evalue=1e-163,
Organism=Caenorhabditis elegans, GI193210679, Length=211, Percent_Identity=54.9763033175355, Blast_Score=227, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI17564182, Length=562, Percent_Identity=22.7758007117438, Blast_Score=75, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=57.0342205323194, Blast_Score=589, Evalue=1e-169,
Organism=Drosophila melanogaster, GI24641193, Length=528, Percent_Identity=56.8181818181818, Blast_Score=596, Evalue=1e-170,
Organism=Drosophila melanogaster, GI24641191, Length=528, Percent_Identity=56.8181818181818, Blast_Score=596, Evalue=1e-170,
Organism=Drosophila melanogaster, GI45550936, Length=528, Percent_Identity=54.3560606060606, Blast_Score=571, Evalue=1e-163,
Organism=Drosophila melanogaster, GI45550132, Length=528, Percent_Identity=54.3560606060606, Blast_Score=571, Evalue=1e-163,
Organism=Drosophila melanogaster, GI45550935, Length=528, Percent_Identity=54.3560606060606, Blast_Score=571, Evalue=1e-163,
Organism=Drosophila melanogaster, GI17864606, Length=555, Percent_Identity=44.3243243243243, Blast_Score=461, Evalue=1e-130,
Organism=Drosophila melanogaster, GI24584129, Length=532, Percent_Identity=37.0300751879699, Blast_Score=339, Evalue=3e-93,
Organism=Drosophila melanogaster, GI19921262, Length=532, Percent_Identity=37.0300751879699, Blast_Score=339, Evalue=3e-93,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57245; Mature: 57113

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKDVKFSRDARERMLRGVNILADAVKVTLGPKGRNVVIDKSFGAPRITKDGVTVAKEI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEECCCCCCCCCCCCCCEEHHC
ELEDKFENMGAQMVREVASKTNDIAGDGTTTATVLAQSIVQEGHKAVAAGMNPMDLKRGI
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCC
DLAVADVVATLIKNAKKIKTSEEVAQVGTIAGNGDSSVGSMIAEAMQKVGNEGVITVEEA
HHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECC
KTAETELEVVEGMQFDRGYLSPYFVTNADKMVADLEDAYILLHEKKLSNLQAMLPILEAV
CCHHHHHHHHHCCCCCCCCCCCEEEECHHHHHHHHCHHEEEEEHHHHHHHHHHHHHHHHH
VQTSKPLVIISEDVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAMLEDIAILTGGQV
HHCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHH
ISEDLGIKLENVGLNMLGRAKKVSISKENTTIVDGAGKKAEIQGRVAQIKQQIEETTSDY
HHHHHCEEEECCCCHHHCCCCEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHC
DKEKLQERLAKLAGGVAVIRVGGATEVEVKEKKDRVDDALNATRAAVEEGIVPGGGVALL
CHHHHHHHHHHHHCCEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHE
RASLSINAVGANSDQTAGISIVRRALQAPARQIAANAGAEASIVAGKILENKGATYGYNA
EECCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCC
QTGEYGDMIAMGIVDPVKVVRTALQDAASVAGLLVTAEAMIAEAPKKESAGGGMPGGMPG
CCCCCCCEEEHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
GGMGGMGGF
CCCCCCCCC
>Mature Secondary Structure 
AAKDVKFSRDARERMLRGVNILADAVKVTLGPKGRNVVIDKSFGAPRITKDGVTVAKEI
CCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEECCCCCCCCCCCCCCEEHHC
ELEDKFENMGAQMVREVASKTNDIAGDGTTTATVLAQSIVQEGHKAVAAGMNPMDLKRGI
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCC
DLAVADVVATLIKNAKKIKTSEEVAQVGTIAGNGDSSVGSMIAEAMQKVGNEGVITVEEA
HHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECC
KTAETELEVVEGMQFDRGYLSPYFVTNADKMVADLEDAYILLHEKKLSNLQAMLPILEAV
CCHHHHHHHHHCCCCCCCCCCCEEEECHHHHHHHHCHHEEEEEHHHHHHHHHHHHHHHHH
VQTSKPLVIISEDVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAMLEDIAILTGGQV
HHCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHH
ISEDLGIKLENVGLNMLGRAKKVSISKENTTIVDGAGKKAEIQGRVAQIKQQIEETTSDY
HHHHHCEEEECCCCHHHCCCCEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHC
DKEKLQERLAKLAGGVAVIRVGGATEVEVKEKKDRVDDALNATRAAVEEGIVPGGGVALL
CHHHHHHHHHHHHCCEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHE
RASLSINAVGANSDQTAGISIVRRALQAPARQIAANAGAEASIVAGKILENKGATYGYNA
EECCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCC
QTGEYGDMIAMGIVDPVKVVRTALQDAASVAGLLVTAEAMIAEAPKKESAGGGMPGGMPG
CCCCCCCEEEHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
GGMGGMGGF
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]