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The map label for this gene is livH [H]

Identifier: 13488196

GI number: 13488196

Start: 35859

End: 36869

Strand: Direct

Name: livH [H]

Synonym: mlr9035

Alternate gene names: 13488196

Gene position: 35859-36869 (Clockwise)

Preceding gene: 13488195

Following gene: 13488197

Centisome position: 10.19

GC content: 58.95

Gene sequence:

>1011_bases
TTGCCAAATGGTGGAACGCGAACAAGGACGCGGCGCTCCCGGTCCTCGCACAGGGCGGTCAGGTTCCGGCCAACAAGTAG
AAACCCCAGCAAGCGAAGTGGTCGCGCTGATGCGACCACTTCTACGCCGCAGAGGTGGTCGACGCTCATGCAAATCGTCC
TGAATTGTCTCTCGCTCACGTCGTTCTACCTTTGCTTCGCCCTGGGCCTGGCATTGGTGTTCGGAGTGATGCGGATCATC
AACTTCGCTCACGGCGAGTTCTTCATGATCGGCGCCTACGCGACGTATTTGTGCGTCGCCACGCTTGCACCCCAAATCGG
AGGACCAAGCGCCTGGCTCGTCGGCGCAATCGTGGCAGCAGGGATAACCGGGCTGCTAGGTGCCGTGCTTTACAGGACGG
TGGTCGTTCCATTGGCTGACAAGCCGCTTGCGATTTTCATTGCGACGCTCGCGCTCTCGTACGTTCTGCAGACGATTGTC
GTCCAGATATTCGGTCCGGTTGGCCTCTCCATCTCGCCCCCACTGCGCGGCGTCGTGAGCGTGGGAGGGGCAATCCTCCC
AGCCTCGCGGGCAATGGTCATTGTAGCCGCGGCCGCCCTTTCAATAGGTTTATGGATCTACCTCATGAGAACTGAATCAG
GTCGTCGCATCCGCGCGGTCGCTCAGAATCCTCGAGGCGCATTGCTGCAGGGCATTAAGACGCGGAATGTTGGCAATCTG
ACGCTGATTATCGGATCGGGGATCGCAGGCATCTGCGGGGCAGCGATGGGACCGATAAGCCAGATATCGCCCTACATGGG
TGGTCCTGCTCTCTGGAAAGCGTTCATCATCATAATTGTGGGCGGGATCGGCAATGTCTGGGGAGCGGTGGCGGCGGCGG
CAATCTTTGGGGTGCTTGATACACTTATGTCGCAGTTCGGCGGCGGGCGCTTTCTTGCTCTGACGAGTGCGGCCATCATG
CTGTTCGTCCTTAGCGTAAAACCCTCCGGTCTATTCGGGGAAAAAGAATGA

Upstream 100 bases:

>100_bases
GGTGCAGAAATGTATGGTGCCAACAATTGGCTGCTCACGCCGCTACCAGTCTACGTGACTGACGACAAAGGTGGCGTGAA
AGTGGATGCGGTCGTCGACG

Downstream 100 bases:

>100_bases
TGGGCGCTCTGCATCGGGACATCGCAACCATCATCGTTGTTGGGCTTGCACTTGTCGTCGGCGGGCTCGTCGGCACCCCA
TACATTCTGGCAGTCTTGGT

Product: ABC transporter permease

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MPNGGTRTRTRRSRSSHRAVRFRPTSRNPSKRSGRADATTSTPQRWSTLMQIVLNCLSLTSFYLCFALGLALVFGVMRII
NFAHGEFFMIGAYATYLCVATLAPQIGGPSAWLVGAIVAAGITGLLGAVLYRTVVVPLADKPLAIFIATLALSYVLQTIV
VQIFGPVGLSISPPLRGVVSVGGAILPASRAMVIVAAAALSIGLWIYLMRTESGRRIRAVAQNPRGALLQGIKTRNVGNL
TLIIGSGIAGICGAAMGPISQISPYMGGPALWKAFIIIIVGGIGNVWGAVAAAAIFGVLDTLMSQFGGGRFLALTSAAIM
LFVLSVKPSGLFGEKE

Sequences:

>Translated_336_residues
MPNGGTRTRTRRSRSSHRAVRFRPTSRNPSKRSGRADATTSTPQRWSTLMQIVLNCLSLTSFYLCFALGLALVFGVMRII
NFAHGEFFMIGAYATYLCVATLAPQIGGPSAWLVGAIVAAGITGLLGAVLYRTVVVPLADKPLAIFIATLALSYVLQTIV
VQIFGPVGLSISPPLRGVVSVGGAILPASRAMVIVAAAALSIGLWIYLMRTESGRRIRAVAQNPRGALLQGIKTRNVGNL
TLIIGSGIAGICGAAMGPISQISPYMGGPALWKAFIIIIVGGIGNVWGAVAAAAIFGVLDTLMSQFGGGRFLALTSAAIM
LFVLSVKPSGLFGEKE
>Mature_335_residues
PNGGTRTRTRRSRSSHRAVRFRPTSRNPSKRSGRADATTSTPQRWSTLMQIVLNCLSLTSFYLCFALGLALVFGVMRIIN
FAHGEFFMIGAYATYLCVATLAPQIGGPSAWLVGAIVAAGITGLLGAVLYRTVVVPLADKPLAIFIATLALSYVLQTIVV
QIFGPVGLSISPPLRGVVSVGGAILPASRAMVIVAAAALSIGLWIYLMRTESGRRIRAVAQNPRGALLQGIKTRNVGNLT
LIIGSGIAGICGAAMGPISQISPYMGGPALWKAFIIIIVGGIGNVWGAVAAAAIFGVLDTLMSQFGGGRFLALTSAAIML
FVLSVKPSGLFGEKE

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=307, Percent_Identity=31.2703583061889, Blast_Score=106, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 35175; Mature: 35044

Theoretical pI: Translated: 11.89; Mature: 11.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNGGTRTRTRRSRSSHRAVRFRPTSRNPSKRSGRADATTSTPQRWSTLMQIVLNCLSLT
CCCCCCCHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
SFYLCFALGLALVFGVMRIINFAHGEFFMIGAYATYLCVATLAPQIGGPSAWLVGAIVAA
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
GITGLLGAVLYRTVVVPLADKPLAIFIATLALSYVLQTIVVQIFGPVGLSISPPLRGVVS
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
VGGAILPASRAMVIVAAAALSIGLWIYLMRTESGRRIRAVAQNPRGALLQGIKTRNVGNL
HCCHHCCCCHHHHHHHHHHHHHHHHHEEEECCCCCEEEHHHCCCCHHHHHHHHCCCCCCE
TLIIGSGIAGICGAAMGPISQISPYMGGPALWKAFIIIIVGGIGNVWGAVAAAAIFGVLD
EEEECCCHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
TLMSQFGGGRFLALTSAAIMLFVLSVKPSGLFGEKE
HHHHHCCCCEEHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
PNGGTRTRTRRSRSSHRAVRFRPTSRNPSKRSGRADATTSTPQRWSTLMQIVLNCLSLT
CCCCCCHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
SFYLCFALGLALVFGVMRIINFAHGEFFMIGAYATYLCVATLAPQIGGPSAWLVGAIVAA
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
GITGLLGAVLYRTVVVPLADKPLAIFIATLALSYVLQTIVVQIFGPVGLSISPPLRGVVS
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
VGGAILPASRAMVIVAAAALSIGLWIYLMRTESGRRIRAVAQNPRGALLQGIKTRNVGNL
HCCHHCCCCHHHHHHHHHHHHHHHHHEEEECCCCCEEEHHHCCCCHHHHHHHHCCCCCCE
TLIIGSGIAGICGAAMGPISQISPYMGGPALWKAFIIIIVGGIGNVWGAVAAAAIFGVLD
EEEECCCHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
TLMSQFGGGRFLALTSAAIMLFVLSVKPSGLFGEKE
HHHHHCCCCEEHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]