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The map label for this gene is kbl [C]

Identifier: 13488120

GI number: 13488120

Start: 182727

End: 183911

Strand: Reverse

Name: kbl [C]

Synonym: mll9204

Alternate gene names: 13488120

Gene position: 183911-182727 (Counterclockwise)

Preceding gene: 13488121

Following gene: 13488331

Centisome position: 52.26

GC content: 61.43

Gene sequence:

>1185_bases
ATGACCGACGCTTTCATTTCTCATCTCTCGAACGAGCTTGCCGGCCTGAAATCGGCCGGGCTCTACAAATCCGAACGGGT
CATATCCTCGATGCAGTCGGCCGAGATCGAGGTCGGCGGCGAAAAGGTGCTCAATTTCTGCGCCAACAACTATCTCGGCC
TCGCCGACAGCGCCGACCTGCGAAAAGCGGCTACCCAGGCGCTCGACCGTTATGGCTACGGCATGGCGTCGGTGCGCTTC
ATCTGCGGCACGCAGGAGGAACACAAACAGCTCGAGGCGACGATTTCATCCTTCCTCGGCCTGGAAGACACCATCCTCTA
TGGCTCCTGCTTCGACGCCAATGGCGGCCTGTTCGAAACGCTGCTTGGTGAGGAAGATGCGATCATCTCGGATGCGCTGA
ACCACGCCTCGATCATCGATGGTGTCAGGCTGTCGAAGGCCAAGCGCTTCCGTTACGCCAACAACGATATGGCTGATCTG
GAAGCGCGGCTGAAGGAAGCGAAGGATTGCCGCTTCCGGTTGATCGCCACCGACGGCGTGTTCTCGATGGACGGCATCAT
CGCCAATCTCAAGGGAGTCTGCGATCTCGCAGACAAATACGACGCCATGGTCATGGTCGACGACAGCCATGCGGTCGGGT
TCGTCGGCAAGAACGGCCGTGGCTCGGCCGAGCATTGCGGCGTCGAGGGCAGGGTGGACATCATCACCGGAACGCTCGGC
AAGGCGCTCGGCGGTGCATCCGGCGGTTACACATCGGGCAAAAGCCAAGTGGTCGACTGGCTGCGCCAGCGCTCGCGGCC
CTATCTGTTTTCCAACACGCTGATGCCGGCGATCGCCGGCGCCTCGATCAAGGTGTTCGAGCTGATCCGCAATGGCGACG
CCTTGCGCGAACGCCTCTATGCGAATGCGGCACGGTTCAGGTCGCAGATGGGCAAGCTCGGCTTCACGCTGGCCGGCGCC
GACCACCCGATCATTCCGGTCATGCTGGGCGATGCCACGCTGGCGCGGGAAATGGCGGCCCGCATGCTGAAGCGCGGCAT
CTATGTGATCGGCTTTTCGTTTCCGGTGGTACCCAAGGGGCAGGCACGGATCCGCACGCAGATGTCGGCGGCGCATTCCA
CTGCCGACATTGACCGTGCGGTTGAGGCGTTTGCGGAGGTTGCAAGGGAGCTTTCGATCATATGA

Upstream 100 bases:

>100_bases
TCCCGCATGGTCGACAGCGGTAAATTACGCATAGTACCGCAACATACTGCCGAGAGGTCCTCCCCAGTGCGGGGAGGGCT
GTGCTGCCGTGAGTCTGCCG

Downstream 100 bases:

>100_bases
CCGGCGGTCGCTAGCTACCTCGTCGCCAAACAGAGCTTCGGTGAAAGAAAGGAACCCCATCAGCGTATCTGGGCTAGCTG
CTTCGGCGCCCGAAGGGTGA

Product: 2-amino-3-ketobutyrate coenzyme A ligase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MTDAFISHLSNELAGLKSAGLYKSERVISSMQSAEIEVGGEKVLNFCANNYLGLADSADLRKAATQALDRYGYGMASVRF
ICGTQEEHKQLEATISSFLGLEDTILYGSCFDANGGLFETLLGEEDAIISDALNHASIIDGVRLSKAKRFRYANNDMADL
EARLKEAKDCRFRLIATDGVFSMDGIIANLKGVCDLADKYDAMVMVDDSHAVGFVGKNGRGSAEHCGVEGRVDIITGTLG
KALGGASGGYTSGKSQVVDWLRQRSRPYLFSNTLMPAIAGASIKVFELIRNGDALRERLYANAARFRSQMGKLGFTLAGA
DHPIIPVMLGDATLAREMAARMLKRGIYVIGFSFPVVPKGQARIRTQMSAAHSTADIDRAVEAFAEVARELSII

Sequences:

>Translated_394_residues
MTDAFISHLSNELAGLKSAGLYKSERVISSMQSAEIEVGGEKVLNFCANNYLGLADSADLRKAATQALDRYGYGMASVRF
ICGTQEEHKQLEATISSFLGLEDTILYGSCFDANGGLFETLLGEEDAIISDALNHASIIDGVRLSKAKRFRYANNDMADL
EARLKEAKDCRFRLIATDGVFSMDGIIANLKGVCDLADKYDAMVMVDDSHAVGFVGKNGRGSAEHCGVEGRVDIITGTLG
KALGGASGGYTSGKSQVVDWLRQRSRPYLFSNTLMPAIAGASIKVFELIRNGDALRERLYANAARFRSQMGKLGFTLAGA
DHPIIPVMLGDATLAREMAARMLKRGIYVIGFSFPVVPKGQARIRTQMSAAHSTADIDRAVEAFAEVARELSII
>Mature_393_residues
TDAFISHLSNELAGLKSAGLYKSERVISSMQSAEIEVGGEKVLNFCANNYLGLADSADLRKAATQALDRYGYGMASVRFI
CGTQEEHKQLEATISSFLGLEDTILYGSCFDANGGLFETLLGEEDAIISDALNHASIIDGVRLSKAKRFRYANNDMADLE
ARLKEAKDCRFRLIATDGVFSMDGIIANLKGVCDLADKYDAMVMVDDSHAVGFVGKNGRGSAEHCGVEGRVDIITGTLGK
ALGGASGGYTSGKSQVVDWLRQRSRPYLFSNTLMPAIAGASIKVFELIRNGDALRERLYANAARFRSQMGKLGFTLAGAD
HPIIPVMLGDATLAREMAARMLKRGIYVIGFSFPVVPKGQARIRTQMSAAHSTADIDRAVEAFAEVARELSII

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=383, Percent_Identity=59.2689295039164, Blast_Score=460, Evalue=1e-129,
Organism=Homo sapiens, GI284448556, Length=409, Percent_Identity=55.5012224938875, Blast_Score=451, Evalue=1e-127,
Organism=Homo sapiens, GI4758668, Length=369, Percent_Identity=33.8753387533875, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI83977442, Length=356, Percent_Identity=33.7078651685393, Blast_Score=201, Evalue=8e-52,
Organism=Homo sapiens, GI83977440, Length=356, Percent_Identity=33.7078651685393, Blast_Score=201, Evalue=9e-52,
Organism=Homo sapiens, GI83977444, Length=356, Percent_Identity=33.7078651685393, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI119220554, Length=369, Percent_Identity=33.0623306233062, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI4502025, Length=350, Percent_Identity=30.2857142857143, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI40316939, Length=350, Percent_Identity=30.2857142857143, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI5454084, Length=389, Percent_Identity=26.7352185089974, Blast_Score=122, Evalue=5e-28,
Organism=Escherichia coli, GI1790046, Length=397, Percent_Identity=69.5214105793451, Blast_Score=571, Evalue=1e-164,
Organism=Escherichia coli, GI1786993, Length=346, Percent_Identity=34.6820809248555, Blast_Score=199, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI71994529, Length=397, Percent_Identity=59.1939546599496, Blast_Score=483, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI32566772, Length=368, Percent_Identity=33.4239130434783, Blast_Score=194, Evalue=7e-50,
Organism=Caenorhabditis elegans, GI17560912, Length=359, Percent_Identity=33.1476323119777, Blast_Score=186, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17560914, Length=359, Percent_Identity=33.1476323119777, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI71982617, Length=269, Percent_Identity=28.2527881040892, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71982625, Length=269, Percent_Identity=28.2527881040892, Blast_Score=110, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6320438, Length=379, Percent_Identity=31.9261213720317, Blast_Score=209, Evalue=8e-55,
Organism=Saccharomyces cerevisiae, GI6320267, Length=368, Percent_Identity=30.9782608695652, Blast_Score=182, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6323954, Length=269, Percent_Identity=29.7397769516729, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24662918, Length=388, Percent_Identity=59.2783505154639, Blast_Score=480, Evalue=1e-136,
Organism=Drosophila melanogaster, GI17137420, Length=333, Percent_Identity=31.5315315315315, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI17136286, Length=371, Percent_Identity=31.8059299191375, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24653280, Length=392, Percent_Identity=25.765306122449, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24653276, Length=392, Percent_Identity=25.765306122449, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24653278, Length=392, Percent_Identity=25.765306122449, Blast_Score=120, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011282
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 42493; Mature: 42362

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDAFISHLSNELAGLKSAGLYKSERVISSMQSAEIEVGGEKVLNFCANNYLGLADSADL
CCHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHHEECCHHHHHHHHHCCCCCCCCCHHH
RKAATQALDRYGYGMASVRFICGTQEEHKQLEATISSFLGLEDTILYGSCFDANGGLFET
HHHHHHHHHHHCCCHHHEEEEECCCHHHHHHHHHHHHHCCCCHHEEEEEEECCCCCHHHH
LLGEEDAIISDALNHASIIDGVRLSKAKRFRYANNDMADLEARLKEAKDCRFRLIATDGV
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEEEECCC
FSMDGIIANLKGVCDLADKYDAMVMVDDSHAVGFVGKNGRGSAEHCGVEGRVDIITGTLG
EEHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEECCCCCCHHHCCCCCEEEEEECHHH
KALGGASGGYTSGKSQVVDWLRQRSRPYLFSNTLMPAIAGASIKVFELIRNGDALRERLY
HHHCCCCCCCCCCHHHHHHHHHHCCCCEEEECCHHHHHCCCCHHHHHHHHCCHHHHHHHH
ANAARFRSQMGKLGFTLAGADHPIIPVMLGDATLAREMAARMLKRGIYVIGFSFPVVPKG
HHHHHHHHHHCCCCEEEECCCCCEEEEEECCHHHHHHHHHHHHHCCEEEEEEECCCCCCC
QARIRTQMSAAHSTADIDRAVEAFAEVARELSII
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TDAFISHLSNELAGLKSAGLYKSERVISSMQSAEIEVGGEKVLNFCANNYLGLADSADL
CHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHHEECCHHHHHHHHHCCCCCCCCCHHH
RKAATQALDRYGYGMASVRFICGTQEEHKQLEATISSFLGLEDTILYGSCFDANGGLFET
HHHHHHHHHHHCCCHHHEEEEECCCHHHHHHHHHHHHHCCCCHHEEEEEEECCCCCHHHH
LLGEEDAIISDALNHASIIDGVRLSKAKRFRYANNDMADLEARLKEAKDCRFRLIATDGV
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEEEECCC
FSMDGIIANLKGVCDLADKYDAMVMVDDSHAVGFVGKNGRGSAEHCGVEGRVDIITGTLG
EEHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEECCCCCCHHHCCCCCEEEEEECHHH
KALGGASGGYTSGKSQVVDWLRQRSRPYLFSNTLMPAIAGASIKVFELIRNGDALRERLY
HHHCCCCCCCCCCHHHHHHHHHHCCCCEEEECCHHHHHCCCCHHHHHHHHCCHHHHHHHH
ANAARFRSQMGKLGFTLAGADHPIIPVMLGDATLAREMAARMLKRGIYVIGFSFPVVPKG
HHHHHHHHHHCCCCEEEECCCCCEEEEEECCHHHHHHHHHHHHHCCEEEEEEECCCCCCC
QARIRTQMSAAHSTADIDRAVEAFAEVARELSII
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]