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The map label for this gene is betA [C]

Identifier: 13488051

GI number: 13488051

Start: 4625

End: 6148

Strand: Reverse

Name: betA [C]

Synonym: mll9006

Alternate gene names: 13488051

Gene position: 6148-4625 (Counterclockwise)

Preceding gene: 13488179

Following gene: 13488323

Centisome position: 1.75

GC content: 58.53

Gene sequence:

>1524_bases
ATGAAAGGCCGTTTTCAACCGGGCAACGCACTGCAACTGGAAGCAGATGCGGTGATTATCGGCTCTGGCGCGGGTGGTGC
CAGCGTAGCAGATGTGCTGACAGCTGCTGGCATTTCTGTAATCATGCTTGAAGAAGGTAAGCATATTCCGTCATCATCAG
CTTCTCCTATCGCAAGCGAGGCATTTTTAGCAGCCTGGCGCAGCGGAGGACTAACCGCCGCGATTGGGCGCCCCCCCATT
AACTATGCCGAAGGCCGCTGCGTCGGGGGAGGAACAGAAATCAACAGCGCTATTACCCAGCGAGCCGATAGCAATCTCAT
TGATCAATGGCGCGAGCTCTATAAGATCGAGAATTTTACGCCGGATGAATTGGCGCAATATTACGAGCGCGCGGAGACGG
CGGTAAATGCAAGCTTGACCCCCGGTCCGCTCGGACGTGCCACCGACATTCTGCGGAAGGGGGGCGAAGCGCTCGGCTGG
AAAGTGTCGGAACTGAAACGGGGGCAACGTGGCTGCAAGGGCGCCAACCGCTGTTCTTATGTTTGTCCGAACGGCGCCAA
GCAGTCCATGGCGATTACCCTTCTGCCAAAGGCAGTGGACCGCGGTATGCGTCTGCTGACGCAAACGCGGGTGGACAACA
TACGAATTGAAAAGGGCCGTGCCACAGAAGTCCTTGCCCGTTCACGCGATCCAGGCGGACATGCCATGGCAGTGCGCGTA
AAAGCCGGCATGGTGTTTGTGTGCGCAGGTGCAATTCACACCCCGGCGCTTTTGCGCCGATCCGGCCCGCGCAAATGCAT
TGGCAATACGCTGCGCGTTCACCCGACAATCAGGGCAACGGCGCTGTTTGATGAGCCGGTCGATGCGCATCAGTCGCGGC
TCCCTCTGACGGCGATTACCGAATTCATGCCGGAACAGCGGATCGGTGGATCAGTATTTACGCCCGCGATCTTTGGCCTC
TCGCTTGCGGAAGACTGGACCAATCGCGGCGATCTGATGCGGAACTGGCGTTTTTGCGGCTCATATTACGGCATGATACG
GCCTCGCGGAGTTGGCTCGGTGAGGCCGCTTCCCGGCATCAATGAGCCGCTTGTTGGTTTCAAACTCGCCCCTGACGACT
GGATCGCTTTGTGCCAAGTTCTCACCCGTCTTGGCCAAGTCATGTTTGAGGCCGGCGCCCGCAAGGTGTTCCCGGGCATA
TCCGGCCATGAAGGGTGGACGAGCCCTAATCAGGTGCATGAGTACTGGAACAAGCCTTTGCCCAAACAGGCAACCAACCT
GATGTCCATACACCTGTTTTCGAGCTGCCCGCCTGGCGAGCATCGGGATGCTTGCGCGGTCGACAGTTACGGACGGGTGC
GTGGCGTCGAAAACCTCTTTGTCGCTGATGGCAGCCTCATTCCGGAAGCGCCCGGCGTCAATCCTCAAATGACCATCATG
GCCCTGGCGTTCCGGGCCGCGGAAGCAGCACTCTGTCATTCCGCACAAGAACGCGCCCGGTCAGCCGCAAGAGACAGAAA
CTAA

Upstream 100 bases:

>100_bases
GCGCCTTTATCGATCGATGACGCTGCTCGCATTTTATGAGCAGATGCCCGTGGCGGCAAGACTGTTATACGTACGGCCTG
CAGGGAATTAAGGCCTTGAC

Downstream 100 bases:

>100_bases
AACCTGCGGTAACCGGGGCAGATTTCCGGGCAGTCAGGCTTGAGCGGCTTGCCTAACGAGATCCGGGAGCGGTGGAATCG
GCGGTTGTGCGTGTATGCCG

Product: oxidoreductase

Products: Betaine Aldehyde; Reduced Acceptor. [C]

Alternate protein names: NA

Number of amino acids: Translated: 507; Mature: 507

Protein sequence:

>507_residues
MKGRFQPGNALQLEADAVIIGSGAGGASVADVLTAAGISVIMLEEGKHIPSSSASPIASEAFLAAWRSGGLTAAIGRPPI
NYAEGRCVGGGTEINSAITQRADSNLIDQWRELYKIENFTPDELAQYYERAETAVNASLTPGPLGRATDILRKGGEALGW
KVSELKRGQRGCKGANRCSYVCPNGAKQSMAITLLPKAVDRGMRLLTQTRVDNIRIEKGRATEVLARSRDPGGHAMAVRV
KAGMVFVCAGAIHTPALLRRSGPRKCIGNTLRVHPTIRATALFDEPVDAHQSRLPLTAITEFMPEQRIGGSVFTPAIFGL
SLAEDWTNRGDLMRNWRFCGSYYGMIRPRGVGSVRPLPGINEPLVGFKLAPDDWIALCQVLTRLGQVMFEAGARKVFPGI
SGHEGWTSPNQVHEYWNKPLPKQATNLMSIHLFSSCPPGEHRDACAVDSYGRVRGVENLFVADGSLIPEAPGVNPQMTIM
ALAFRAAEAALCHSAQERARSAARDRN

Sequences:

>Translated_507_residues
MKGRFQPGNALQLEADAVIIGSGAGGASVADVLTAAGISVIMLEEGKHIPSSSASPIASEAFLAAWRSGGLTAAIGRPPI
NYAEGRCVGGGTEINSAITQRADSNLIDQWRELYKIENFTPDELAQYYERAETAVNASLTPGPLGRATDILRKGGEALGW
KVSELKRGQRGCKGANRCSYVCPNGAKQSMAITLLPKAVDRGMRLLTQTRVDNIRIEKGRATEVLARSRDPGGHAMAVRV
KAGMVFVCAGAIHTPALLRRSGPRKCIGNTLRVHPTIRATALFDEPVDAHQSRLPLTAITEFMPEQRIGGSVFTPAIFGL
SLAEDWTNRGDLMRNWRFCGSYYGMIRPRGVGSVRPLPGINEPLVGFKLAPDDWIALCQVLTRLGQVMFEAGARKVFPGI
SGHEGWTSPNQVHEYWNKPLPKQATNLMSIHLFSSCPPGEHRDACAVDSYGRVRGVENLFVADGSLIPEAPGVNPQMTIM
ALAFRAAEAALCHSAQERARSAARDRN
>Mature_507_residues
MKGRFQPGNALQLEADAVIIGSGAGGASVADVLTAAGISVIMLEEGKHIPSSSASPIASEAFLAAWRSGGLTAAIGRPPI
NYAEGRCVGGGTEINSAITQRADSNLIDQWRELYKIENFTPDELAQYYERAETAVNASLTPGPLGRATDILRKGGEALGW
KVSELKRGQRGCKGANRCSYVCPNGAKQSMAITLLPKAVDRGMRLLTQTRVDNIRIEKGRATEVLARSRDPGGHAMAVRV
KAGMVFVCAGAIHTPALLRRSGPRKCIGNTLRVHPTIRATALFDEPVDAHQSRLPLTAITEFMPEQRIGGSVFTPAIFGL
SLAEDWTNRGDLMRNWRFCGSYYGMIRPRGVGSVRPLPGINEPLVGFKLAPDDWIALCQVLTRLGQVMFEAGARKVFPGI
SGHEGWTSPNQVHEYWNKPLPKQATNLMSIHLFSSCPPGEHRDACAVDSYGRVRGVENLFVADGSLIPEAPGVNPQMTIM
ALAFRAAEAALCHSAQERARSAARDRN

Specific function: Can Catalyze The Oxidation Of Choline To Betaine Aldehyde And Betaine Aldehyde To Glycine Betaine At The Same Rate. [C]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: 1.1.99.1 [C]

Molecular weight: Translated: 54614; Mature: 54614

Theoretical pI: Translated: 9.29; Mature: 9.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGRFQPGNALQLEADAVIIGSGAGGASVADVLTAAGISVIMLEEGKHIPSSSASPIASE
CCCCCCCCCEEEEECCEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHH
AFLAAWRSGGLTAAIGRPPINYAEGRCVGGGTEINSAITQRADSNLIDQWRELYKIENFT
HHHHHHHCCCEEEECCCCCCCCCCCEEECCCCHHHHHHHHHHCHHHHHHHHHHHHHCCCC
PDELAQYYERAETAVNASLTPGPLGRATDILRKGGEALGWKVSELKRGQRGCKGANRCSY
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHCCCHHHHHHHHHCCCCCCCCCE
VCPNGAKQSMAITLLPKAVDRGMRLLTQTRVDNIRIEKGRATEVLARSRDPGGHAMAVRV
ECCCCCCCCEEEEECHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHCCCCCCCEEEEEE
KAGMVFVCAGAIHTPALLRRSGPRKCIGNTLRVHPTIRATALFDEPVDAHQSRLPLTAIT
ECCEEEEECCHHHHHHHHHCCCCHHHHCCCEEECCCEEEEEEECCCHHHHHHCCCHHHHH
EFMPEQRIGGSVFTPAIFGLSLAEDWTNRGDLMRNWRFCGSYYGMIRPRGVGSVRPLPGI
HHCCHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
NEPLVGFKLAPDDWIALCQVLTRLGQVMFEAGARKVFPGISGHEGWTSPNQVHEYWNKPL
CCCCCCCEECCHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCCCHHHHHHHHCCCC
PKQATNLMSIHLFSSCPPGEHRDACAVDSYGRVRGVENLFVADGSLIPEAPGVNPQMTIM
CHHHHHEEEEEEECCCCCCCCCCCCCCCCCHHHCCCCEEEEECCCCCCCCCCCCCHHHHH
ALAFRAAEAALCHSAQERARSAARDRN
HHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKGRFQPGNALQLEADAVIIGSGAGGASVADVLTAAGISVIMLEEGKHIPSSSASPIASE
CCCCCCCCCEEEEECCEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHH
AFLAAWRSGGLTAAIGRPPINYAEGRCVGGGTEINSAITQRADSNLIDQWRELYKIENFT
HHHHHHHCCCEEEECCCCCCCCCCCEEECCCCHHHHHHHHHHCHHHHHHHHHHHHHCCCC
PDELAQYYERAETAVNASLTPGPLGRATDILRKGGEALGWKVSELKRGQRGCKGANRCSY
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHCCCHHHHHHHHHCCCCCCCCCE
VCPNGAKQSMAITLLPKAVDRGMRLLTQTRVDNIRIEKGRATEVLARSRDPGGHAMAVRV
ECCCCCCCCEEEEECHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHCCCCCCCEEEEEE
KAGMVFVCAGAIHTPALLRRSGPRKCIGNTLRVHPTIRATALFDEPVDAHQSRLPLTAIT
ECCEEEEECCHHHHHHHHHCCCCHHHHCCCEEECCCEEEEEEECCCHHHHHHCCCHHHHH
EFMPEQRIGGSVFTPAIFGLSLAEDWTNRGDLMRNWRFCGSYYGMIRPRGVGSVRPLPGI
HHCCHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
NEPLVGFKLAPDDWIALCQVLTRLGQVMFEAGARKVFPGISGHEGWTSPNQVHEYWNKPL
CCCCCCCEECCHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCCCHHHHHHHHCCCC
PKQATNLMSIHLFSSCPPGEHRDACAVDSYGRVRGVENLFVADGSLIPEAPGVNPQMTIM
CHHHHHEEEEEEECCCCCCCCCCCCCCCCCHHHCCCCEEEEECCCCCCCCCCCCCHHHHH
ALAFRAAEAALCHSAQERARSAARDRN
HHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Coenzyme Q [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 7 {choline}} 1.1 {phenazine}} [C]

Substrates: Choline; Acceptor [C]

Specific reaction: Choline + Acceptor = Betaine Aldehyde + Reduced Acceptor. [C]

General reaction: Redox reaction [C]

Inhibitor: 2-Dimethylaminoethanol; Betaine aldehyde; Monoethanolamine; Semicarbazide [C]

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]