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The map label for this gene is moaE

Identifier: 13476558

GI number: 13476558

Start: 6538527

End: 6539006

Strand: Direct

Name: moaE

Synonym: mlr7915

Alternate gene names: 13476558

Gene position: 6538527-6539006 (Clockwise)

Preceding gene: 13476557

Following gene: 13476559

Centisome position: 92.93

GC content: 65.62

Gene sequence:

>480_bases
ATGTCGGCCGTCCTGGCGCCGACCGTGCGCATCCAGCGCCAGGATTTCGACGTCGCCGCCGAGATCGCTGCGCTGACCCA
AGGCCGCGCGGACGTTGGCGCGGTGGTTTCTTTCTCCGGCCTCTGCCGCGATGAGCAGGGCGCGCTCTCGGCACTGGAGC
TCGAACATTATCCCGGCATGGCGGAGGCCGAGATCGGCCGTATCGCCGCCGAGGCGGTTGAGCGCTGGCCGCTGCAAGGC
CTCACCGTCATCCACCGCCATGGCAAGATTCGTCCGGGCGAAAACATCGTGCTGGTGGTGGCCGCCTCGGCCCATCGCCA
AGCCGCGTTCGAGGCGGCGAACTTTCTCATGGATTACCTCAAATCGCGCGCGCCCTTCTGGAAGAAGGAGCATCGCACCG
ATGGTTCCGAAGGTGGCTGGGTCGAGGCCAAGGAAACCGACACCCAGGCGGCAAAGCGCTGGAAGTCATCGTCCGAATAA

Upstream 100 bases:

>100_bases
TCCGCGTTGCCATCAACCAAGAACATGTCGACCACCGCGAAAAGATAGCGGGCGCGCGCGAGATCGCGCTGTTCCCGCCG
ATGACCGGAGGCTGACACCC

Downstream 100 bases:

>100_bases
ATCCCGTCGCAGCCATGTATTGACCGCAATCCTTTGGCCAATTGCGTGAGGTTGATCAGCCCAGGGCATCGGCGGCCAGG
GCACTGGCAGCCCGGGCACT

Product: molybdopterin converting factor, subunit 2

Products: NA

Alternate protein names: MPT synthase subunit 2; Molybdenum cofactor biosynthesis protein E; Molybdopterin-converting factor large subunit; Molybdopterin-converting factor subunit 2

Number of amino acids: Translated: 159; Mature: 158

Protein sequence:

>159_residues
MSAVLAPTVRIQRQDFDVAAEIAALTQGRADVGAVVSFSGLCRDEQGALSALELEHYPGMAEAEIGRIAAEAVERWPLQG
LTVIHRHGKIRPGENIVLVVAASAHRQAAFEAANFLMDYLKSRAPFWKKEHRTDGSEGGWVEAKETDTQAAKRWKSSSE

Sequences:

>Translated_159_residues
MSAVLAPTVRIQRQDFDVAAEIAALTQGRADVGAVVSFSGLCRDEQGALSALELEHYPGMAEAEIGRIAAEAVERWPLQG
LTVIHRHGKIRPGENIVLVVAASAHRQAAFEAANFLMDYLKSRAPFWKKEHRTDGSEGGWVEAKETDTQAAKRWKSSSE
>Mature_158_residues
SAVLAPTVRIQRQDFDVAAEIAALTQGRADVGAVVSFSGLCRDEQGALSALELEHYPGMAEAEIGRIAAEAVERWPLQGL
TVIHRHGKIRPGENIVLVVAASAHRQAAFEAANFLMDYLKSRAPFWKKEHRTDGSEGGWVEAKETDTQAAKRWKSSSE

Specific function: Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by moaD

COG id: COG0314

COG function: function code H; Molybdopterin converting factor, large subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaE family

Homologues:

Organism=Homo sapiens, GI4758732, Length=107, Percent_Identity=35.5140186915888, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1787003, Length=143, Percent_Identity=52.4475524475524, Blast_Score=143, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI17509279, Length=113, Percent_Identity=32.7433628318584, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21356259, Length=131, Percent_Identity=35.8778625954198, Blast_Score=75, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MOAE_RHILO (Q984P0)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_108128.1
- ProteinModelPortal:   Q984P0
- SMR:   Q984P0
- GeneID:   1230780
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mlr7915
- NMPDR:   fig|266835.1.peg.6227
- HOGENOM:   HBG460564
- OMA:   RERWPLN
- ProtClustDB:   CLSK506897
- InterPro:   IPR003448
- Gene3D:   G3DSA:3.90.1170.40
- PANTHER:   PTHR23404:SF2

Pfam domain/function: PF02391 MoaE; SSF54690 Mb_biosynth_MoaE

EC number: NA

Molecular weight: Translated: 17369; Mature: 17238

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: BINDING 121-121

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAVLAPTVRIQRQDFDVAAEIAALTQGRADVGAVVSFSGLCRDEQGALSALELEHYPGM
CCCCCCCCEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCHHHHHHHCCCCC
AEAEIGRIAAEAVERWPLQGLTVIHRHGKIRPGENIVLVVAASAHRQAAFEAANFLMDYL
CHHHHHHHHHHHHHHCCCCCHHEECCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHH
KSRAPFWKKEHRTDGSEGGWVEAKETDTQAAKRWKSSSE
HHCCCCCHHHHCCCCCCCCEEECCCCHHHHHHHHCCCCC
>Mature Secondary Structure 
SAVLAPTVRIQRQDFDVAAEIAALTQGRADVGAVVSFSGLCRDEQGALSALELEHYPGM
CCCCCCCEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCHHHHHHHCCCCC
AEAEIGRIAAEAVERWPLQGLTVIHRHGKIRPGENIVLVVAASAHRQAAFEAANFLMDYL
CHHHHHHHHHHHHHHCCCCCHHEECCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHH
KSRAPFWKKEHRTDGSEGGWVEAKETDTQAAKRWKSSSE
HHCCCCCHHHHCCCCCCCCEEECCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968