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The map label for this gene is fabF [H]

Identifier: 13476516

GI number: 13476516

Start: 6498255

End: 6499517

Strand: Direct

Name: fabF [H]

Synonym: mlr7852

Alternate gene names: 13476516

Gene position: 6498255-6499517 (Clockwise)

Preceding gene: 13476515

Following gene: 13476517

Centisome position: 92.36

GC content: 64.21

Gene sequence:

>1263_bases
ATGAGGCGTGTCGTCGTCACGGGCCTTGGGTTGTTGTCGCCATTCGGCATGGGCTTCGAGCACAGCTGGAAGGAACTTCT
GACCGGCCGCAGCGCGGCCAAGCGCATCACCGAGTTCGAGGTGGAGGATCTTGCCTGCAAGATCGCCCACGTCGTTCCGC
GTGGTGACGGCAGCAATGCCACCTTCAATCCTGAATCCGTGCTCGAGCCGAAGGAATTGCGCAAGATCGGTGACTTCATC
CTGTACGGGATTGCCGCCGCCGACGAAGCGCTGAAGGATTCCGGCTGGGAGCCCAAGACCCACGAGGAGCAATGCGCCAC
CGGCGTGCTCATCGGTTCCGGCATTGGCGGCATCGAGGGCATCGCCGAGAACGCGATGATCCTCAAGGAACGCGGTCCGC
GCCGCATCAGCCCCTTCTTCATCCCGGGCCAGATCATCAATCTCGTCTCCGGCCAGGTTTCGATCCGGCACGGGCTGAAA
GGTCCGAACCATGCCGTCGTCACGGCCTGCTCGACCGGCGCGCATGCCATTGGCGATGCGGCCCGGCTGATCATGTGGGG
CGATGCCGACGTCATGGTCGCCGGTGGCGCGGAGGCGCCGGTGACCAGACTTTCGATCGCCGGCTTCGCCGCCTGCCGGG
CGCTGTCGACCGAGCGCAATGACACGCCGCAGACGGCGTCGCGTCCCTATGACCGTGACCGCGACGGCTTCGTCATGGGC
GAGGGCGCCGGTGTTGTGGTGCTGGAAGAACTCGAGCACGCCAAGGCGCGCGGCGCCAAGATTTATGCCGAGGTGACCGG
CTACGGCCTCACCGGCGATGCCTATCACATCACCGCACCGGCCGAAGACGGCGATGGCGCTTTCCGTTGCATGACCGCGG
CGTTGAACCGGGCCAAGCTTACGCCCGCCGATGTCGACTACATCAACGCGCATGGCACCTCGACCATGGCCGACACGATC
GAACTCGGCGCTGTCGAGCGGCTTGTCGGCAACGCCGCGTCGAAGATTTCGATGTCGTCGACCAAGTCGTCGATCGGCCA
TCTCCTTGGTGCAGCGGGAGCCGCCGAAGCGATCTTTTCGATCCTTGCGATCAGGGACAATGTCGCGCCGGCGACCATCA
ACCTCGACAATCCAGAGCGCGAAACCGCGATCGACCTGGTGCCGAACAAGCCTCGCTCCCGCCAGATCGACGTTGCGCTC
TCCAATTCCTTCGGCTTCGGCGGCACAAACGCATCGCTTGTGTTCCAGCGCTACAATGGCTGA

Upstream 100 bases:

>100_bases
GACGCGGCCGAGACCATCCTGACCGTCGGCGACGCGGTGAAGTACATCGACAAGGCTTCGGCCTGACGCTTTCCGCAGTC
ATCACTGGGGAGGACCTGCG

Downstream 100 bases:

>100_bases
TCGCCCGGCTGCCGGGCGATGCTTCGGCATGTCGTCAATTTTGCCATATTCGCCCCTACTCTGCCGCAGGGGATTCGTTG
AGAGATCAAACGGTAGGGCG

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MRRVVVTGLGLLSPFGMGFEHSWKELLTGRSAAKRITEFEVEDLACKIAHVVPRGDGSNATFNPESVLEPKELRKIGDFI
LYGIAAADEALKDSGWEPKTHEEQCATGVLIGSGIGGIEGIAENAMILKERGPRRISPFFIPGQIINLVSGQVSIRHGLK
GPNHAVVTACSTGAHAIGDAARLIMWGDADVMVAGGAEAPVTRLSIAGFAACRALSTERNDTPQTASRPYDRDRDGFVMG
EGAGVVVLEELEHAKARGAKIYAEVTGYGLTGDAYHITAPAEDGDGAFRCMTAALNRAKLTPADVDYINAHGTSTMADTI
ELGAVERLVGNAASKISMSSTKSSIGHLLGAAGAAEAIFSILAIRDNVAPATINLDNPERETAIDLVPNKPRSRQIDVAL
SNSFGFGGTNASLVFQRYNG

Sequences:

>Translated_420_residues
MRRVVVTGLGLLSPFGMGFEHSWKELLTGRSAAKRITEFEVEDLACKIAHVVPRGDGSNATFNPESVLEPKELRKIGDFI
LYGIAAADEALKDSGWEPKTHEEQCATGVLIGSGIGGIEGIAENAMILKERGPRRISPFFIPGQIINLVSGQVSIRHGLK
GPNHAVVTACSTGAHAIGDAARLIMWGDADVMVAGGAEAPVTRLSIAGFAACRALSTERNDTPQTASRPYDRDRDGFVMG
EGAGVVVLEELEHAKARGAKIYAEVTGYGLTGDAYHITAPAEDGDGAFRCMTAALNRAKLTPADVDYINAHGTSTMADTI
ELGAVERLVGNAASKISMSSTKSSIGHLLGAAGAAEAIFSILAIRDNVAPATINLDNPERETAIDLVPNKPRSRQIDVAL
SNSFGFGGTNASLVFQRYNG
>Mature_420_residues
MRRVVVTGLGLLSPFGMGFEHSWKELLTGRSAAKRITEFEVEDLACKIAHVVPRGDGSNATFNPESVLEPKELRKIGDFI
LYGIAAADEALKDSGWEPKTHEEQCATGVLIGSGIGGIEGIAENAMILKERGPRRISPFFIPGQIINLVSGQVSIRHGLK
GPNHAVVTACSTGAHAIGDAARLIMWGDADVMVAGGAEAPVTRLSIAGFAACRALSTERNDTPQTASRPYDRDRDGFVMG
EGAGVVVLEELEHAKARGAKIYAEVTGYGLTGDAYHITAPAEDGDGAFRCMTAALNRAKLTPADVDYINAHGTSTMADTI
ELGAVERLVGNAASKISMSSTKSSIGHLLGAAGAAEAIFSILAIRDNVAPATINLDNPERETAIDLVPNKPRSRQIDVAL
SNSFGFGGTNASLVFQRYNG

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=417, Percent_Identity=48.9208633093525, Blast_Score=396, Evalue=1e-110,
Organism=Homo sapiens, GI223972627, Length=193, Percent_Identity=42.4870466321244, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI41872631, Length=367, Percent_Identity=24.5231607629428, Blast_Score=82, Evalue=9e-16,
Organism=Escherichia coli, GI1787337, Length=418, Percent_Identity=53.5885167464115, Blast_Score=394, Evalue=1e-111,
Organism=Escherichia coli, GI1788663, Length=423, Percent_Identity=36.8794326241135, Blast_Score=249, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI71983541, Length=424, Percent_Identity=38.6792452830189, Blast_Score=269, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI71983535, Length=266, Percent_Identity=42.4812030075188, Blast_Score=206, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17550940, Length=365, Percent_Identity=25.2054794520548, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI212642053, Length=358, Percent_Identity=24.3016759776536, Blast_Score=92, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6320904, Length=447, Percent_Identity=38.7024608501119, Blast_Score=291, Evalue=1e-79,
Organism=Drosophila melanogaster, GI24644341, Length=427, Percent_Identity=46.135831381733, Blast_Score=349, Evalue=3e-96,
Organism=Drosophila melanogaster, GI221330659, Length=297, Percent_Identity=24.9158249158249, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI19920632, Length=297, Percent_Identity=24.9158249158249, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24581345, Length=342, Percent_Identity=23.0994152046784, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 44253; Mature: 44253

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVVVTGLGLLSPFGMGFEHSWKELLTGRSAAKRITEFEVEDLACKIAHVVPRGDGSNA
CCEEEEECCHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHEEEHHEEECCCCCCC
TFNPESVLEPKELRKIGDFILYGIAAADEALKDSGWEPKTHEEQCATGVLIGSGIGGIEG
CCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCEEEEECCCCCHHH
IAENAMILKERGPRRISPFFIPGQIINLVSGQVSIRHGLKGPNHAVVTACSTGAHAIGDA
HHCCEEEEECCCCCCCCCEECCHHHHHHHCCCEEEECCCCCCCCEEEEEECCCCHHHCCC
ARLIMWGDADVMVAGGAEAPVTRLSIAGFAACRALSTERNDTPQTASRPYDRDRDGFVMG
EEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEE
EGAGVVVLEELEHAKARGAKIYAEVTGYGLTGDAYHITAPAEDGDGAFRCMTAALNRAKL
CCCCEEEEEHHHHHHHCCCEEEEEEECCCCCCCCEEEECCCCCCCCHHHHHHHHHHHCCC
TPADVDYINAHGTSTMADTIELGAVERLVGNAASKISMSSTKSSIGHLLGAAGAAEAIFS
CCCCCCEEECCCCCHHHHHHHHHHHHHHHCCHHHHEEHHHHHHHHHHHHHCCHHHHHHHH
ILAIRDNVAPATINLDNPERETAIDLVPNKPRSRQIDVALSNSFGFGGTNASLVFQRYNG
HHHHHCCCCCEEEECCCCCCCCEEEECCCCCCCCEEEEEEECCCCCCCCCCEEEEEECCC
>Mature Secondary Structure
MRRVVVTGLGLLSPFGMGFEHSWKELLTGRSAAKRITEFEVEDLACKIAHVVPRGDGSNA
CCEEEEECCHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHEEEHHEEECCCCCCC
TFNPESVLEPKELRKIGDFILYGIAAADEALKDSGWEPKTHEEQCATGVLIGSGIGGIEG
CCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCEEEEECCCCCHHH
IAENAMILKERGPRRISPFFIPGQIINLVSGQVSIRHGLKGPNHAVVTACSTGAHAIGDA
HHCCEEEEECCCCCCCCCEECCHHHHHHHCCCEEEECCCCCCCCEEEEEECCCCHHHCCC
ARLIMWGDADVMVAGGAEAPVTRLSIAGFAACRALSTERNDTPQTASRPYDRDRDGFVMG
EEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEE
EGAGVVVLEELEHAKARGAKIYAEVTGYGLTGDAYHITAPAEDGDGAFRCMTAALNRAKL
CCCCEEEEEHHHHHHHCCCEEEEEEECCCCCCCCEEEECCCCCCCCHHHHHHHHHHHCCC
TPADVDYINAHGTSTMADTIELGAVERLVGNAASKISMSSTKSSIGHLLGAAGAAEAIFS
CCCCCCEEECCCCCHHHHHHHHHHHHHHHCCHHHHEEHHHHHHHHHHHHHCCHHHHHHHH
ILAIRDNVAPATINLDNPERETAIDLVPNKPRSRQIDVALSNSFGFGGTNASLVFQRYNG
HHHHHCCCCCEEEECCCCCCCCEEEECCCCCCCCEEEEEEECCCCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10784042; 11481430 [H]