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The map label for this gene is qor [C]

Identifier: 13476432

GI number: 13476432

Start: 6419778

End: 6420869

Strand: Direct

Name: qor [C]

Synonym: mlr7750

Alternate gene names: 13476432

Gene position: 6419778-6420869 (Clockwise)

Preceding gene: 13476430

Following gene: 13476435

Centisome position: 91.24

GC content: 62.09

Gene sequence:

>1092_bases
ATGTGCATTCTTGCGCTTGACGCACATAATCCGCATCTCTGCCCCAGACAAAGCTCAACAGCAATCGCGGAGACCAGAAT
GCGCGCCGTCGGCTATCAAATCCCAGCCCCGATCACCGATGAAGCCTCCCTTGTCGATATCGACCTGCCCAAGCCGGAGC
CGAAAGGCCGTCAACTGCTGGTCGAGGTAAAGGCGATCTCGGTCAATCCCGTTGACACCAAGATAAGGCGAAGTGCCAAA
CCCGAAGCCGGAAGCTGGCGTGTGCTTGGCTGGGACGCTGCCGGCCGGGTCGTTGCAACGGGGCAGGATGCCAGCCTGTT
CAAGCCCGGAGACGACGTCTTCTATTCCGGTGCGCTCGCGCCGCAAGGCACCAATGCCGAGTTCCACCTTGTCGATGAGC
GCCTCGTCGGCCGCAAGCCCAGTTCGCTCGACTATGCGCAGGCTGCCGCGCTGCCGCTGACGGCGATCACCGCTTTTGAG
GCGCTGTTCGATCGCCTTGACGTGAAGAAGCCTGTCGTGGGTGCCGCGAATGCCATCCTGATCATCGGCGGCGCCGGCGG
CGTCGGCTCGATCGCGGTTCAGCTTGCACGCCAACTGACCGATCTGACGGTAATCGCCACCGCATCAAGGCCAGAGACAC
GCGACTGGGTGCTTGGGCTTGGCGCCCATCATGTCATCGATCATTCCAAGCCGCTGGCTGCCGAAGTCGCGGCACTCGGT
ATCGGCGCACCAGCCTTCGTGTTCTCGACAACCAACACCGACCGGCACCTGGCCGAGATTGCCGAATTGATCGCACCGCA
AGGCCGGTTCGGGGTGATCGACGATCCCCAGACGCTGGATATCAGTCCGTTCAAACGCAAGAGCGTTTCGGTCCATTGGG
AACTGATGTTCACCCGCTCGCTGTTCGAGACGCAGGACATGGCCGCGCAGGGCGGGCATCTGAACGAGTTGTCGCGCCTT
GTCGACGCAGGCACCGTCCGCACCACCTTGGGCGAAACCTTCGGTCGGATCAATGCCGCCAATCTGAAGCGCGCCCATGC
ACTGATCGAGACCGGCAAGGCCAAGGGCAAGATCGTGCTGGAGGGGTTCTGA

Upstream 100 bases:

>100_bases
TAGCGCAGCGTTCCCTCCACGGTGCAGCCGGGGCTGCAATCGAATCGTTCATGACGAATGCGCGGCATCACGGTATCCTT
TTCGACACTATGTGCTTTAT

Downstream 100 bases:

>100_bases
AAGGGCGTTATTTCCGCAGGAACGCCGCGATCTCGCTGAACACGTTGACGAACATTTCTTCCGTCAGGACACCGGTGTTG
GTGTTGTAGCGCGAGCAATG

Product: alginate lyase

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 363; Mature: 363

Protein sequence:

>363_residues
MCILALDAHNPHLCPRQSSTAIAETRMRAVGYQIPAPITDEASLVDIDLPKPEPKGRQLLVEVKAISVNPVDTKIRRSAK
PEAGSWRVLGWDAAGRVVATGQDASLFKPGDDVFYSGALAPQGTNAEFHLVDERLVGRKPSSLDYAQAAALPLTAITAFE
ALFDRLDVKKPVVGAANAILIIGGAGGVGSIAVQLARQLTDLTVIATASRPETRDWVLGLGAHHVIDHSKPLAAEVAALG
IGAPAFVFSTTNTDRHLAEIAELIAPQGRFGVIDDPQTLDISPFKRKSVSVHWELMFTRSLFETQDMAAQGGHLNELSRL
VDAGTVRTTLGETFGRINAANLKRAHALIETGKAKGKIVLEGF

Sequences:

>Translated_363_residues
MCILALDAHNPHLCPRQSSTAIAETRMRAVGYQIPAPITDEASLVDIDLPKPEPKGRQLLVEVKAISVNPVDTKIRRSAK
PEAGSWRVLGWDAAGRVVATGQDASLFKPGDDVFYSGALAPQGTNAEFHLVDERLVGRKPSSLDYAQAAALPLTAITAFE
ALFDRLDVKKPVVGAANAILIIGGAGGVGSIAVQLARQLTDLTVIATASRPETRDWVLGLGAHHVIDHSKPLAAEVAALG
IGAPAFVFSTTNTDRHLAEIAELIAPQGRFGVIDDPQTLDISPFKRKSVSVHWELMFTRSLFETQDMAAQGGHLNELSRL
VDAGTVRTTLGETFGRINAANLKRAHALIETGKAKGKIVLEGF
>Mature_363_residues
MCILALDAHNPHLCPRQSSTAIAETRMRAVGYQIPAPITDEASLVDIDLPKPEPKGRQLLVEVKAISVNPVDTKIRRSAK
PEAGSWRVLGWDAAGRVVATGQDASLFKPGDDVFYSGALAPQGTNAEFHLVDERLVGRKPSSLDYAQAAALPLTAITAFE
ALFDRLDVKKPVVGAANAILIIGGAGGVGSIAVQLARQLTDLTVIATASRPETRDWVLGLGAHHVIDHSKPLAAEVAALG
IGAPAFVFSTTNTDRHLAEIAELIAPQGRFGVIDDPQTLDISPFKRKSVSVHWELMFTRSLFETQDMAAQGGHLNELSRL
VDAGTVRTTLGETFGRINAANLKRAHALIETGKAKGKIVLEGF

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI194239674, Length=272, Percent_Identity=33.4558823529412, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI13236495, Length=272, Percent_Identity=33.4558823529412, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI47519420, Length=337, Percent_Identity=28.486646884273, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI194239676, Length=184, Percent_Identity=39.1304347826087, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI24308257, Length=299, Percent_Identity=23.7458193979933, Blast_Score=68, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71987554, Length=183, Percent_Identity=33.3333333333333, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17507255, Length=269, Percent_Identity=31.5985130111524, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 38702; Mature: 38702

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCILALDAHNPHLCPRQSSTAIAETRMRAVGYQIPAPITDEASLVDIDLPKPEPKGRQLL
CEEEEEECCCCCCCCCCCCHHHHHHHHHHHCEECCCCCCCCCEEEEEECCCCCCCCCEEE
VEVKAISVNPVDTKIRRSAKPEAGSWRVLGWDAAGRVVATGQDASLFKPGDDVFYSGALA
EEEEEEECCCCHHHHHHCCCCCCCCEEEEEECCCCCEEEECCCCCCCCCCCCEEECCCCC
PQGTNAEFHLVDERLVGRKPSSLDYAQAAALPLTAITAFEALFDRLDVKKPVVGAANAIL
CCCCCCEEEEECHHHHCCCCCCCCHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCEEE
IIGGAGGVGSIAVQLARQLTDLTVIATASRPETRDWVLGLGAHHVIDHSKPLAAEVAALG
EEECCCCHHHHHHHHHHHHHCEEEEEECCCCCCCCEEEECCCHHHHCCCCCHHHHHHHHC
IGAPAFVFSTTNTDRHLAEIAELIAPQGRFGVIDDPQTLDISPFKRKSVSVHWELMFTRS
CCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEHH
LFETQDMAAQGGHLNELSRLVDAGTVRTTLGETFGRINAANLKRAHALIETGKAKGKIVL
HHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEE
EGF
ECC
>Mature Secondary Structure
MCILALDAHNPHLCPRQSSTAIAETRMRAVGYQIPAPITDEASLVDIDLPKPEPKGRQLL
CEEEEEECCCCCCCCCCCCHHHHHHHHHHHCEECCCCCCCCCEEEEEECCCCCCCCCEEE
VEVKAISVNPVDTKIRRSAKPEAGSWRVLGWDAAGRVVATGQDASLFKPGDDVFYSGALA
EEEEEEECCCCHHHHHHCCCCCCCCEEEEEECCCCCEEEECCCCCCCCCCCCEEECCCCC
PQGTNAEFHLVDERLVGRKPSSLDYAQAAALPLTAITAFEALFDRLDVKKPVVGAANAIL
CCCCCCEEEEECHHHHCCCCCCCCHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCEEE
IIGGAGGVGSIAVQLARQLTDLTVIATASRPETRDWVLGLGAHHVIDHSKPLAAEVAALG
EEECCCCHHHHHHHHHHHHHCEEEEEECCCCCCCCEEEECCCHHHHCCCCCHHHHHHHHC
IGAPAFVFSTTNTDRHLAEIAELIAPQGRFGVIDDPQTLDISPFKRKSVSVHWELMFTRS
CCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEHH
LFETQDMAAQGGHLNELSRLVDAGTVRTTLGETFGRINAANLKRAHALIETGKAKGKIVL
HHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEE
EGF
ECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]