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The map label for this gene is pleC [H]

Identifier: 13476392

GI number: 13476392

Start: 6374464

End: 6375534

Strand: Reverse

Name: pleC [H]

Synonym: mll7700

Alternate gene names: 13476392

Gene position: 6375534-6374464 (Counterclockwise)

Preceding gene: 13476393

Following gene: 13476379

Centisome position: 90.61

GC content: 63.12

Gene sequence:

>1071_bases
ATGCCGGGTGTGACACGCGCTTCGCTGGAGGGGCGGATGCTGGCCTTTGCGTCCGAACGCCGGCTTGCCAACACCAATGG
TCCGCAAGGCGGCGCCACTTTCGAGCGGCAGCTGTCCGACGGCCGCTGGCTGCAGGTCAATGAACTCAAGACAAGGGACG
GCGGCATCGTCTCGGTCGGCTCCGACATCACCCAGATCAAGCTGCATCAGGAAAAGCTGGTCGACAGCGAGCGGCGACTG
ATGGCGACGATCCATGATCTCAGCCTCGCGCGGCGGGCCGAAGAGGAACGGTCGCGCGAACTGGTCGATCTCAACCGCAA
ATATATGAAGGAAACCGAGCGCGCCGAGGCGGCGAACCGGGCCAAGTCTGAATTCCTGGCCAACATGTCGCATGAATTGC
GCACGCCGCTGAACGCCATCATCGGCTTCTCCGAGCTGATGGAACAGGGGCTGTTTGGTCCACTGGGATCGGCGCGCTAC
GAGGAGTACGCCACCGACATCAACAGCAGCGGCAAATACCTGCTCGGCGTCATCAACGATATTCTCGACATGTCCAAGAT
CGAGGCCGGCCAGTTCTCACTGGACCAGGAGCAGATCGACCTCGGTCCGCTGATCAGCGAGACGGTGCGCGTCGTCTCGC
TGCAGGCCGCGCAAAAAGCGATCACCGTGGAAACGCGCATCGCCGACGCGCTGAGTTTGTTCGCCGATCGCCGCGCCATC
AAGCAGATCGTCATCAACCTCCTGTCCAACGCGGTGAAGTTCACCGGCCAGGGCGGCCATATATCGGTCAGGGCCCGCAA
CACATCGGGTGCGCTGGTGCTGACCATCGAGGACAATGGCTGCGGCATTCCAAAGGAGGCGCTCGGCAAGCTCGGGCGGC
CCTTCGAACAGGTGCAGAACCAGTTCTCCAAGAACCATGCCGGATCGGGCCTCGGCCTTGCCATCTCGCGCTCGCTGGCT
GAGCTTCAGGGCGGCGCGCTGAAGATCCGTTCGACCGAAGGTGTCGGCACGATCGTGTCGGTGCGCATTCCGGTGAAGAA
GGCGCCGCCGGCCGTCAAGGCCGCCGCTTGA

Upstream 100 bases:

>100_bases
GAACATCAACGAATCCTTCGTGCTGTGGGATTCGGCGCAGCGGCTGATCATGTGCAACTCCAAATACCAGCAGGATAACG
GGCTGTCGGATCGCGACGTG

Downstream 100 bases:

>100_bases
GCAGCAGGCTCCGAGCGGTGTCGCCGGGGCCTGGATCAAACAATCTTATTGGACGCTGCCATCATCCGATTGGCGATGAT
GGCCAAAGCGGTGGCCCTTC

Product: two-component, sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 356; Mature: 355

Protein sequence:

>356_residues
MPGVTRASLEGRMLAFASERRLANTNGPQGGATFERQLSDGRWLQVNELKTRDGGIVSVGSDITQIKLHQEKLVDSERRL
MATIHDLSLARRAEEERSRELVDLNRKYMKETERAEAANRAKSEFLANMSHELRTPLNAIIGFSELMEQGLFGPLGSARY
EEYATDINSSGKYLLGVINDILDMSKIEAGQFSLDQEQIDLGPLISETVRVVSLQAAQKAITVETRIADALSLFADRRAI
KQIVINLLSNAVKFTGQGGHISVRARNTSGALVLTIEDNGCGIPKEALGKLGRPFEQVQNQFSKNHAGSGLGLAISRSLA
ELQGGALKIRSTEGVGTIVSVRIPVKKAPPAVKAAA

Sequences:

>Translated_356_residues
MPGVTRASLEGRMLAFASERRLANTNGPQGGATFERQLSDGRWLQVNELKTRDGGIVSVGSDITQIKLHQEKLVDSERRL
MATIHDLSLARRAEEERSRELVDLNRKYMKETERAEAANRAKSEFLANMSHELRTPLNAIIGFSELMEQGLFGPLGSARY
EEYATDINSSGKYLLGVINDILDMSKIEAGQFSLDQEQIDLGPLISETVRVVSLQAAQKAITVETRIADALSLFADRRAI
KQIVINLLSNAVKFTGQGGHISVRARNTSGALVLTIEDNGCGIPKEALGKLGRPFEQVQNQFSKNHAGSGLGLAISRSLA
ELQGGALKIRSTEGVGTIVSVRIPVKKAPPAVKAAA
>Mature_355_residues
PGVTRASLEGRMLAFASERRLANTNGPQGGATFERQLSDGRWLQVNELKTRDGGIVSVGSDITQIKLHQEKLVDSERRLM
ATIHDLSLARRAEEERSRELVDLNRKYMKETERAEAANRAKSEFLANMSHELRTPLNAIIGFSELMEQGLFGPLGSARYE
EYATDINSSGKYLLGVINDILDMSKIEAGQFSLDQEQIDLGPLISETVRVVSLQAAQKAITVETRIADALSLFADRRAIK
QIVINLLSNAVKFTGQGGHISVRARNTSGALVLTIEDNGCGIPKEALGKLGRPFEQVQNQFSKNHAGSGLGLAISRSLAE
LQGGALKIRSTEGVGTIVSVRIPVKKAPPAVKAAA

Specific function: Member of the two-component regulatory system involved in the regulation of polar organelle development. PleC functions as a membrane-associated protein kinase that transfers phosphate to the response regulator pleD, leading to its activation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI87081816, Length=260, Percent_Identity=38.8461538461538, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI48994928, Length=242, Percent_Identity=35.5371900826446, Blast_Score=141, Evalue=5e-35,
Organism=Escherichia coli, GI1789149, Length=243, Percent_Identity=35.3909465020576, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1788713, Length=250, Percent_Identity=35.6, Blast_Score=131, Evalue=6e-32,
Organism=Escherichia coli, GI145693157, Length=258, Percent_Identity=35.2713178294574, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1786600, Length=224, Percent_Identity=33.9285714285714, Blast_Score=118, Evalue=7e-28,
Organism=Escherichia coli, GI1788549, Length=242, Percent_Identity=30.1652892561983, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1788393, Length=279, Percent_Identity=24.7311827956989, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI87082128, Length=248, Percent_Identity=27.0161290322581, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI1790436, Length=267, Percent_Identity=27.7153558052434, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1786912, Length=237, Percent_Identity=29.535864978903, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1790861, Length=250, Percent_Identity=26, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1786783, Length=250, Percent_Identity=24.8, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1787894, Length=235, Percent_Identity=24.2553191489362, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1790346, Length=230, Percent_Identity=25.6521739130435, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1790300, Length=255, Percent_Identity=24.3137254901961, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 38628; Mature: 38496

Theoretical pI: Translated: 9.62; Mature: 9.62

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGVTRASLEGRMLAFASERRLANTNGPQGGATFERQLSDGRWLQVNELKTRDGGIVSVG
CCCCCCCCCCCCEEEEHHHHHHCCCCCCCCCCHHHHHCCCCCEEEEECCCCCCCCEEEEC
SDITQIKLHQEKLVDSERRLMATIHDLSLARRAEEERSRELVDLNRKYMKETERAEAANR
CCCHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKSEFLANMSHELRTPLNAIIGFSELMEQGLFGPLGSARYEEYATDINSSGKYLLGVIND
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHH
ILDMSKIEAGQFSLDQEQIDLGPLISETVRVVSLQAAQKAITVETRIADALSLFADRRAI
HHHHHHCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KQIVINLLSNAVKFTGQGGHISVRARNTSGALVLTIEDNGCGIPKEALGKLGRPFEQVQN
HHHHHHHHHHHHEECCCCCEEEEEEECCCCEEEEEECCCCCCCCHHHHHHCCCCHHHHHH
QFSKNHAGSGLGLAISRSLAELQGGALKIRSTEGVGTIVSVRIPVKKAPPAVKAAA
HHHHCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCEEEEEEECCCCCCCCCCCCC
>Mature Secondary Structure 
PGVTRASLEGRMLAFASERRLANTNGPQGGATFERQLSDGRWLQVNELKTRDGGIVSVG
CCCCCCCCCCCEEEEHHHHHHCCCCCCCCCCHHHHHCCCCCEEEEECCCCCCCCEEEEC
SDITQIKLHQEKLVDSERRLMATIHDLSLARRAEEERSRELVDLNRKYMKETERAEAANR
CCCHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKSEFLANMSHELRTPLNAIIGFSELMEQGLFGPLGSARYEEYATDINSSGKYLLGVIND
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHH
ILDMSKIEAGQFSLDQEQIDLGPLISETVRVVSLQAAQKAITVETRIADALSLFADRRAI
HHHHHHCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KQIVINLLSNAVKFTGQGGHISVRARNTSGALVLTIEDNGCGIPKEALGKLGRPFEQVQN
HHHHHHHHHHHHEECCCCCEEEEEEECCCCEEEEEECCCCCCCCHHHHHHCCCCHHHHHH
QFSKNHAGSGLGLAISRSLAELQGGALKIRSTEGVGTIVSVRIPVKKAPPAVKAAA
HHHHCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCEEEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8421698; 11259647 [H]