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The map label for this gene is hdl IVa [H]

Identifier: 13476342

GI number: 13476342

Start: 6323515

End: 6324174

Strand: Reverse

Name: hdl IVa [H]

Synonym: mll7634

Alternate gene names: 13476342

Gene position: 6324174-6323515 (Counterclockwise)

Preceding gene: 13476347

Following gene: 13476341

Centisome position: 89.88

GC content: 63.94

Gene sequence:

>660_bases
ATGCAATACGCTGCCTATGTTTTCGATGCCTACGGCACGCTGTTCGACGTGCATGCCGCCGTGCGCCGGCATGCCGACCG
GATCGGACCTGACGGCCAGTTGCTGTCCGAAATCTGGCGCGCCAAGCAGCTCGAATATTCCTGGGTGCGCTCGCTGATGG
GCTCCTATGCCGATTTCTGGCAGCTGACCGAACAGGCGCTCGACTTCGCCTTGCGCAAGGTCCCCTCCGCCGATCCCGGC
CTCAGGACAAAACTGCTGGAAGCCTACTGGCGGTTGGACTGCTACCCGGAGGTACCGGCCGTGCTGAAGGCGCTCAAGGC
CTCTGGAGCCAGGCTGGCGCTCCTCTCCAACGGCTCGCCCGAAATGCTGGAAGCGGCGGTCAAATCCGCCGCGCTCGACC
AGGTTCTGGACGACATCTACTCGGTCGATACGGTGCGGCGCTTCAAGACCGATCCGGCGGTCTACGACATGGTGGCCACT
GGCTGGCGCCTCTATCCCGGCGCGGTGTCCTTCCAGTCCTCCAATCGCTGGGACATTGCCGGCGCCACCAAATTCGGCTT
CCGCACGGTGTGGATCAACCGTTCCAACCAGCCCGAGGAGTACCGGGACTTTCCGCCAGCCCTGATCCTGCCGACCCTCG
AATCGCTGGTCACCGCCTGA

Upstream 100 bases:

>100_bases
CGTTGCCGTCAACGGGCATGGGGCAGTTTTGTTGAGGCCAGCGGCGGCGCGATGCAATCAAGGCTTGCACCTTGCCCCGC
CTCGCCTCAAAACTGTCGCC

Downstream 100 bases:

>100_bases
GCTGTCGAGCTGTGGCCCTGGCGCCACAGTGGCGGCGCAGTCACAGCTTCGCCTTTGTTTGTCCACGTTCGGGCCAGAAT
CGGAACCGCCTATCGCCCCA

Product: 2-haloacid halidohydrolase IVA

Products: NA

Alternate protein names: 2-haloalkanoic acid dehalogenase IVA; Halocarboxylic acid halidohydrolase IVA; L-2-haloacid dehalogenase IVA [H]

Number of amino acids: Translated: 219; Mature: 219

Protein sequence:

>219_residues
MQYAAYVFDAYGTLFDVHAAVRRHADRIGPDGQLLSEIWRAKQLEYSWVRSLMGSYADFWQLTEQALDFALRKVPSADPG
LRTKLLEAYWRLDCYPEVPAVLKALKASGARLALLSNGSPEMLEAAVKSAALDQVLDDIYSVDTVRRFKTDPAVYDMVAT
GWRLYPGAVSFQSSNRWDIAGATKFGFRTVWINRSNQPEEYRDFPPALILPTLESLVTA

Sequences:

>Translated_219_residues
MQYAAYVFDAYGTLFDVHAAVRRHADRIGPDGQLLSEIWRAKQLEYSWVRSLMGSYADFWQLTEQALDFALRKVPSADPG
LRTKLLEAYWRLDCYPEVPAVLKALKASGARLALLSNGSPEMLEAAVKSAALDQVLDDIYSVDTVRRFKTDPAVYDMVAT
GWRLYPGAVSFQSSNRWDIAGATKFGFRTVWINRSNQPEEYRDFPPALILPTLESLVTA
>Mature_219_residues
MQYAAYVFDAYGTLFDVHAAVRRHADRIGPDGQLLSEIWRAKQLEYSWVRSLMGSYADFWQLTEQALDFALRKVPSADPG
LRTKLLEAYWRLDCYPEVPAVLKALKASGARLALLSNGSPEMLEAAVKSAALDQVLDDIYSVDTVRRFKTDPAVYDMVAT
GWRLYPGAVSFQSSNRWDIAGATKFGFRTVWINRSNQPEEYRDFPPALILPTLESLVTA

Specific function: Catalyzes the hydrolytic dehalogenation of small (S)-2- haloalkanoic acids to yield the corresponding (R)-2- hydroxyalkanoic acids. Acts on acids of short chain lengths, C(2) to C(4), with inversion of configuration at C-3 [H]

COG id: COG1011

COG function: function code R; Predicted hydrolase (HAD superfamily)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAD-like hydrolase superfamily. S-2- haloalkanoic acid dehalogenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR006439
- InterPro:   IPR006388
- InterPro:   IPR006402
- InterPro:   IPR006328
- InterPro:   IPR005833 [H]

Pfam domain/function: PF00702 Hydrolase [H]

EC number: =3.8.1.2 [H]

Molecular weight: Translated: 24676; Mature: 24676

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQYAAYVFDAYGTLFDVHAAVRRHADRIGPDGQLLSEIWRAKQLEYSWVRSLMGSYADFW
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
QLTEQALDFALRKVPSADPGLRTKLLEAYWRLDCYPEVPAVLKALKASGARLALLSNGSP
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEECCCCH
EMLEAAVKSAALDQVLDDIYSVDTVRRFKTDPAVYDMVATGWRLYPGAVSFQSSNRWDIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCEECCCEEEECCCCCEECC
GATKFGFRTVWINRSNQPEEYRDFPPALILPTLESLVTA
CCCCCCEEEEEECCCCCCHHHHCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MQYAAYVFDAYGTLFDVHAAVRRHADRIGPDGQLLSEIWRAKQLEYSWVRSLMGSYADFW
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
QLTEQALDFALRKVPSADPGLRTKLLEAYWRLDCYPEVPAVLKALKASGARLALLSNGSP
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEECCCCH
EMLEAAVKSAALDQVLDDIYSVDTVRRFKTDPAVYDMVATGWRLYPGAVSFQSSNRWDIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCEECCCEEEECCCCCEECC
GATKFGFRTVWINRSNQPEEYRDFPPALILPTLESLVTA
CCCCCCEEEEEECCCCCCHHHHCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1376111 [H]