Click here to switch to the map view.

The map label for this gene is alkK [H]

Identifier: 13476260

GI number: 13476260

Start: 6220683

End: 6222311

Strand: Direct

Name: alkK [H]

Synonym: mlr7537

Alternate gene names: 13476260

Gene position: 6220683-6222311 (Clockwise)

Preceding gene: 13476257

Following gene: 13476261

Centisome position: 88.41

GC content: 62.55

Gene sequence:

>1629_bases
ATGCTGGGGCTGATGCAGGAATGGCCGCTGCTGTGCCACAAGCTTATCGACAACGCCGAACGGCAGCATGGGGTGCGCGA
GATCGTGTCGCGCTCGATCGAGGGGCCGATCGTGCGGACCACCTATGCCGACATCCATCGTCGTTCTCTCAAGGTCGCCC
AGCGGCTGGAGCGGGACGGCTATGGGTTGGGCGACCGCATCGCCACGCTGGCCTGGAACACGGCGCGCCACCTCGAGGCC
TGGTACGGCATCATGGGCGTCGGCGCCATCTATCACACGCTCAATCCGCGCCTGTTTCCCGAGCAGATCGTCTGGATCAT
GAACCATGCCGAGGACAAGGCGGTCTTCGTCGACCTCACGTTCATTCCGCTGCTGGAGAAGATCGCCGGTGCCGTCAAAT
CGCTGAAAAAGGTGATCGTGCTGACCGACAAGGCGCACATGCCGCAGACGACCTTGCCCAATGCCGTCGCCTATGAGGAG
TGGCTTGACGAGGTCGATGGCGACTTCGCCTGGAAGACTTTCGACGAAGGCACCGCAGCCGGCATGTGCTATACATCGGG
CACCACGGGCGATCCCAAGGGCGTCGTCTACAGCCACCGCTCGAACGTGCTGCACGCCATGATCGCCGCCATGCCCGACG
CGATGGGCCTGTCGTCGCGCGACACGGTCCTGCCGGTTGTGCCGATGTTCCATGCCAATGCCTGGGGCCTCGGCCAGAGC
GGTCCGATGGTCGGCGCCAACCTGGTCATGCCCGGCTGCAAGATGGACGGCGCCTCGATCTATGAATTGCTCGACACCGA
GAAGGTAACCTTCAGCGCCGCCGTGCCGACCGTCTGGATGATGCTGCTGCAATATCTGGAGGAGACCGGCAAGAAGCTTC
CCTATCTCAACAAGGTCGTCATCGGCGGCTCGTCCTGCCCGCGCGCGATCATGACGAAATTCCAGGACAATTACGACGTC
CAGGTCATCCATGCCTGGGGCATGACCGAAATGTCGCCGCTCGGCACGTTGTGCACCCTGAAGCCGGAATATGCCGGTCT
CCAGGGCGAGGCCCGGCTCGATGTCAAGCAGAAGCAGGGCTACCCGCCCTTCGGCGTTGAAATGAAGGTGACCGATGACG
AGAACAATGCGCAACCCTGGGATGGCAAGACCTTTGGCCGCCTGAAAGTGCGTGGTCCGGCCGTCGCACGCGCTTATTAC
GGCGGCGCCGGGGCGGAGCAATTCGATGCGGACGGCTGGTTCGATACCGGCGATGTCGCTCACATCGACGCCGGCGGCTA
CATGCAGATCACAGATCGGGCCAAGGACGTCATCAAGTCCGGCGGCGAATGGATTTCGACCATCGACCTCGAGAATCTGG
CCGTCGGCCACCCGGACGTGGCGGAAGCGGCGGCCATCGGCGTCCATCATTCGAAATGGGGCGAGCGGCCCTTGCTGGTT
GTCGTTGCCAAGCCAGGTAAGGAGCCGACCAAGGCGGATATTCTCGGTTTCATGGATGGCAAGGTGGCCAAGTGGTGGAT
GCCCGACGATGTCGCTTTCGTCGGCGAAATACCGCACACCGCCACCGGCAAGATCCAGAAGACAACCTTGCGCCAGCAGT
TCAGGGACTACCGCTTGCCGACGGATTGA

Upstream 100 bases:

>100_bases
GAAATTCGCATCCCGCGCGAGCGGGCGACTGGACAATCCGCCGGTTCGCTTCACAATGCGCCAAAGCTACGACGCAAAAT
GCGCGAGGGAGGAGGAACCG

Downstream 100 bases:

>100_bases
GGGGATGTTGCGTGTTTCGGCTTCAAGCCGCCGCGAAAAGGCACTAAACCTCCGTCCGGGTTGGGGCAACGCAGAGAACC
ATGGTTAGCATTCCCGAACG

Product: putative acyl-CoA synthetase

Products: NA

Alternate protein names: Medium-chain acyl-CoA synthetase [H]

Number of amino acids: Translated: 542; Mature: 542

Protein sequence:

>542_residues
MLGLMQEWPLLCHKLIDNAERQHGVREIVSRSIEGPIVRTTYADIHRRSLKVAQRLERDGYGLGDRIATLAWNTARHLEA
WYGIMGVGAIYHTLNPRLFPEQIVWIMNHAEDKAVFVDLTFIPLLEKIAGAVKSLKKVIVLTDKAHMPQTTLPNAVAYEE
WLDEVDGDFAWKTFDEGTAAGMCYTSGTTGDPKGVVYSHRSNVLHAMIAAMPDAMGLSSRDTVLPVVPMFHANAWGLGQS
GPMVGANLVMPGCKMDGASIYELLDTEKVTFSAAVPTVWMMLLQYLEETGKKLPYLNKVVIGGSSCPRAIMTKFQDNYDV
QVIHAWGMTEMSPLGTLCTLKPEYAGLQGEARLDVKQKQGYPPFGVEMKVTDDENNAQPWDGKTFGRLKVRGPAVARAYY
GGAGAEQFDADGWFDTGDVAHIDAGGYMQITDRAKDVIKSGGEWISTIDLENLAVGHPDVAEAAAIGVHHSKWGERPLLV
VVAKPGKEPTKADILGFMDGKVAKWWMPDDVAFVGEIPHTATGKIQKTTLRQQFRDYRLPTD

Sequences:

>Translated_542_residues
MLGLMQEWPLLCHKLIDNAERQHGVREIVSRSIEGPIVRTTYADIHRRSLKVAQRLERDGYGLGDRIATLAWNTARHLEA
WYGIMGVGAIYHTLNPRLFPEQIVWIMNHAEDKAVFVDLTFIPLLEKIAGAVKSLKKVIVLTDKAHMPQTTLPNAVAYEE
WLDEVDGDFAWKTFDEGTAAGMCYTSGTTGDPKGVVYSHRSNVLHAMIAAMPDAMGLSSRDTVLPVVPMFHANAWGLGQS
GPMVGANLVMPGCKMDGASIYELLDTEKVTFSAAVPTVWMMLLQYLEETGKKLPYLNKVVIGGSSCPRAIMTKFQDNYDV
QVIHAWGMTEMSPLGTLCTLKPEYAGLQGEARLDVKQKQGYPPFGVEMKVTDDENNAQPWDGKTFGRLKVRGPAVARAYY
GGAGAEQFDADGWFDTGDVAHIDAGGYMQITDRAKDVIKSGGEWISTIDLENLAVGHPDVAEAAAIGVHHSKWGERPLLV
VVAKPGKEPTKADILGFMDGKVAKWWMPDDVAFVGEIPHTATGKIQKTTLRQQFRDYRLPTD
>Mature_542_residues
MLGLMQEWPLLCHKLIDNAERQHGVREIVSRSIEGPIVRTTYADIHRRSLKVAQRLERDGYGLGDRIATLAWNTARHLEA
WYGIMGVGAIYHTLNPRLFPEQIVWIMNHAEDKAVFVDLTFIPLLEKIAGAVKSLKKVIVLTDKAHMPQTTLPNAVAYEE
WLDEVDGDFAWKTFDEGTAAGMCYTSGTTGDPKGVVYSHRSNVLHAMIAAMPDAMGLSSRDTVLPVVPMFHANAWGLGQS
GPMVGANLVMPGCKMDGASIYELLDTEKVTFSAAVPTVWMMLLQYLEETGKKLPYLNKVVIGGSSCPRAIMTKFQDNYDV
QVIHAWGMTEMSPLGTLCTLKPEYAGLQGEARLDVKQKQGYPPFGVEMKVTDDENNAQPWDGKTFGRLKVRGPAVARAYY
GGAGAEQFDADGWFDTGDVAHIDAGGYMQITDRAKDVIKSGGEWISTIDLENLAVGHPDVAEAAAIGVHHSKWGERPLLV
VVAKPGKEPTKADILGFMDGKVAKWWMPDDVAFVGEIPHTATGKIQKTTLRQQFRDYRLPTD

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=535, Percent_Identity=26.5420560747664, Blast_Score=143, Evalue=5e-34,
Organism=Homo sapiens, GI187761345, Length=528, Percent_Identity=24.2424242424242, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI187761343, Length=528, Percent_Identity=24.2424242424242, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI28416953, Length=552, Percent_Identity=25.5434782608696, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI38505220, Length=516, Percent_Identity=23.4496124031008, Blast_Score=104, Evalue=3e-22,
Organism=Homo sapiens, GI157311624, Length=500, Percent_Identity=23.6, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI157311622, Length=500, Percent_Identity=23.6, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI58082049, Length=501, Percent_Identity=23.3532934131737, Blast_Score=90, Evalue=7e-18,
Organism=Homo sapiens, GI115511026, Length=527, Percent_Identity=23.5294117647059, Blast_Score=89, Evalue=2e-17,
Organism=Homo sapiens, GI122937307, Length=527, Percent_Identity=23.1499051233397, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI13375727, Length=562, Percent_Identity=21.5302491103203, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI253970489, Length=418, Percent_Identity=24.4019138755981, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI8923896, Length=418, Percent_Identity=24.4019138755981, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI145693145, Length=519, Percent_Identity=27.1676300578035, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI221142682, Length=525, Percent_Identity=22.4761904761905, Blast_Score=142, Evalue=8e-35,
Organism=Escherichia coli, GI1788107, Length=522, Percent_Identity=25.095785440613, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1786810, Length=361, Percent_Identity=29.0858725761773, Blast_Score=125, Evalue=9e-30,
Organism=Escherichia coli, GI1790505, Length=540, Percent_Identity=23.5185185185185, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1788595, Length=505, Percent_Identity=21.980198019802, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17531443, Length=512, Percent_Identity=24.0234375, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17558820, Length=511, Percent_Identity=25.8317025440313, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI71994703, Length=538, Percent_Identity=24.907063197026, Blast_Score=124, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI71994690, Length=538, Percent_Identity=24.907063197026, Blast_Score=124, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI71994694, Length=538, Percent_Identity=24.907063197026, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17557194, Length=546, Percent_Identity=23.8095238095238, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI32563687, Length=510, Percent_Identity=24.1176470588235, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17538037, Length=511, Percent_Identity=23.679060665362, Blast_Score=118, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI71985884, Length=368, Percent_Identity=27.445652173913, Blast_Score=108, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17559526, Length=370, Percent_Identity=26.2162162162162, Blast_Score=106, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17560308, Length=535, Percent_Identity=23.7383177570093, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI71996755, Length=542, Percent_Identity=23.6162361623616, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17560140, Length=354, Percent_Identity=23.4463276836158, Blast_Score=87, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319699, Length=364, Percent_Identity=29.1208791208791, Blast_Score=133, Evalue=8e-32,
Organism=Saccharomyces cerevisiae, GI6319264, Length=390, Percent_Identity=23.8461538461538, Blast_Score=63, Evalue=1e-10,
Organism=Drosophila melanogaster, GI18859661, Length=516, Percent_Identity=27.1317829457364, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24581924, Length=531, Percent_Identity=24.4821092278719, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI21355181, Length=529, Percent_Identity=24.5746691871456, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24648260, Length=511, Percent_Identity=25.8317025440313, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21355225, Length=575, Percent_Identity=23.304347826087, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24648257, Length=521, Percent_Identity=22.4568138195777, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI281365686, Length=516, Percent_Identity=21.1240310077519, Blast_Score=96, Evalue=8e-20,
Organism=Drosophila melanogaster, GI21358303, Length=509, Percent_Identity=21.0216110019646, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI19922652, Length=507, Percent_Identity=22.2879684418146, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24667955, Length=594, Percent_Identity=23.2323232323232, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24648255, Length=529, Percent_Identity=20.0378071833648, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21356947, Length=506, Percent_Identity=22.1343873517787, Blast_Score=87, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24648253, Length=529, Percent_Identity=19.8487712665406, Blast_Score=86, Evalue=8e-17,
Organism=Drosophila melanogaster, GI62472339, Length=559, Percent_Identity=23.0769230769231, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24667959, Length=414, Percent_Identity=24.3961352657005, Blast_Score=83, Evalue=6e-16,
Organism=Drosophila melanogaster, GI21356441, Length=503, Percent_Identity=21.8687872763419, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24653035, Length=502, Percent_Identity=19.9203187250996, Blast_Score=79, Evalue=9e-15,
Organism=Drosophila melanogaster, GI161076582, Length=505, Percent_Identity=20.5940594059406, Blast_Score=70, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: NA

Molecular weight: Translated: 59756; Mature: 59756

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGLMQEWPLLCHKLIDNAERQHGVREIVSRSIEGPIVRTTYADIHRRSLKVAQRLERDG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHCC
YGLGDRIATLAWNTARHLEAWYGIMGVGAIYHTLNPRLFPEQIVWIMNHAEDKAVFVDLT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCEEEEEEH
FIPLLEKIAGAVKSLKKVIVLTDKAHMPQTTLPNAVAYEEWLDEVDGDFAWKTFDEGTAA
HHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCC
GMCYTSGTTGDPKGVVYSHRSNVLHAMIAAMPDAMGLSSRDTVLPVVPMFHANAWGLGQS
EEEEECCCCCCCCCEEECCHHHHHHHHHHHCCHHCCCCCCCCEEEEEHHHCCCCCCCCCC
GPMVGANLVMPGCKMDGASIYELLDTEKVTFSAAVPTVWMMLLQYLEETGKKLPYLNKVV
CCCCCCEEECCCCCCCCHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
IGGSSCPRAIMTKFQDNYDVQVIHAWGMTEMSPLGTLCTLKPEYAGLQGEARLDVKQKQG
ECCCCCCHHHHHHHCCCCCEEEEEECCCCCCCCCCCEEEECHHHCCCCCCEEECCHHHCC
YPPFGVEMKVTDDENNAQPWDGKTFGRLKVRGPAVARAYYGGAGAEQFDADGWFDTGDVA
CCCCCEEEEEECCCCCCCCCCCCCCCEEEECCCHHHHHHCCCCCCCCCCCCCCCCCCCEE
HIDAGGYMQITDRAKDVIKSGGEWISTIDLENLAVGHPDVAEAAAIGVHHSKWGERPLLV
EECCCCEEEEHHHHHHHHHCCCCEEEEEEHHHCCCCCCCHHHHHHHCCCHHCCCCCCEEE
VVAKPGKEPTKADILGFMDGKVAKWWMPDDVAFVGEIPHTATGKIQKTTLRQQFRDYRLP
EEECCCCCCCHHHHHECCCCCEEEEECCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCCC
TD
CC
>Mature Secondary Structure
MLGLMQEWPLLCHKLIDNAERQHGVREIVSRSIEGPIVRTTYADIHRRSLKVAQRLERDG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHCC
YGLGDRIATLAWNTARHLEAWYGIMGVGAIYHTLNPRLFPEQIVWIMNHAEDKAVFVDLT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCEEEEEEH
FIPLLEKIAGAVKSLKKVIVLTDKAHMPQTTLPNAVAYEEWLDEVDGDFAWKTFDEGTAA
HHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCC
GMCYTSGTTGDPKGVVYSHRSNVLHAMIAAMPDAMGLSSRDTVLPVVPMFHANAWGLGQS
EEEEECCCCCCCCCEEECCHHHHHHHHHHHCCHHCCCCCCCCEEEEEHHHCCCCCCCCCC
GPMVGANLVMPGCKMDGASIYELLDTEKVTFSAAVPTVWMMLLQYLEETGKKLPYLNKVV
CCCCCCEEECCCCCCCCHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
IGGSSCPRAIMTKFQDNYDVQVIHAWGMTEMSPLGTLCTLKPEYAGLQGEARLDVKQKQG
ECCCCCCHHHHHHHCCCCCEEEEEECCCCCCCCCCCEEEECHHHCCCCCCEEECCHHHCC
YPPFGVEMKVTDDENNAQPWDGKTFGRLKVRGPAVARAYYGGAGAEQFDADGWFDTGDVA
CCCCCEEEEEECCCCCCCCCCCCCCCEEEECCCHHHHHHCCCCCCCCCCCCCCCCCCCEE
HIDAGGYMQITDRAKDVIKSGGEWISTIDLENLAVGHPDVAEAAAIGVHHSKWGERPLLV
EECCCCEEEEHHHHHHHHHCCCCEEEEEEHHHCCCCCCCHHHHHHHCCCHHCCCCCCEEE
VVAKPGKEPTKADILGFMDGKVAKWWMPDDVAFVGEIPHTATGKIQKTTLRQQFRDYRLP
EEECCCCCCCHHHHHECCCCCEEEEECCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCCC
TD
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1453953 [H]