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The map label for this gene is 13476210

Identifier: 13476210

GI number: 13476210

Start: 6170996

End: 6171922

Strand: Direct

Name: 13476210

Synonym: mlr7469

Alternate gene names: NA

Gene position: 6170996-6171922 (Clockwise)

Preceding gene: 13476208

Following gene: 13476211

Centisome position: 87.71

GC content: 67.1

Gene sequence:

>927_bases
ATGACAACCCGTCTCTACACGCATCCGATCTTCCTCGAACACATCACACCGCCCGGTCACCCCGAGCGGCCGGACCGCTT
GCGCGCCATCGAGCGCGTGCTCGACGACGAGGCCTTTGCCGCGCTCGATCGCGTCAAGGCGCCGGAGGGCGACGAGGCCA
CCATCCTCTACGCGCACCCCGCCGATTTCGTCGCCCGTGTGCGTGCCGCCATTCCCGAAGAGGGCATTGCCCGCATCGAT
GCCGACACCACCGCCAGCCCGAAGAGCTGGCAGGCGGTGATCGCCGCGATCGGCGCCGCCAACGCGGCCGTCGACGACGT
CTTCGCAGGCCGCGCCGACAATGTCTTCGTTGCCGCGCGGCCGCCTGGCCACCATGCCGAGAAGACGACGGCCATGGGCT
TCTGCTTCTTCAACACAGCGGCGATTGCCGCGCGCTATGCGCAGAACAAGCATGGCGCCGAGCGTGTCGCCGTCGTCGAC
TGGGATGTGCATCACGGCAACGGCACGCAGGATATTTTCTGGGACGATCCCTCGGTGCTCTATTGCTCGACGCACCAGAT
GCCGCTCTATCCGGGCACGGGCGCGAAGACCGAGACCGGCGCCGGCAACATCGTCAACGCGCCCTTGGCGCCGCAGACCG
GCAGCGAGGTGTTTCGCGATGCCTTCCTGTCGCGGGTGCTGCCGTCGCTCGACAATTTCGCGCCCGACCTGATCATCATC
TCGGCCGGGTTCGACGCGCATCACCGCGACCCGCTGGCCGAGATCAACCTGACCGAGGACGATTTCGACTGGGCGACCGG
CCAGCTGATGCAGCGCGCCGCGCGCCACAGCGGCAACCGGCTCGTCAGCCTGCTCGAGGGCGGCTACGATCTGCAGGGAC
TGGCATTTTCGGTCGCCGCTCATGTCGGGCGACTGATGAAAGGATGA

Upstream 100 bases:

>100_bases
CCAATCCCCGCAGCGACGCCAATGGACGCAGGCGCGATTTTCCCCAGTCATCAGGCTGCAATGCATGGCCATCGCGGCGC
CGGGGCACTAGATAGGGAGC

Downstream 100 bases:

>100_bases
ATGATGGCTGGTGAAACCAACGAAGACGTCAAGGCGATGAGCTTCGAACAGGCACTCGACGCGCTGGAGAAGATCGTCGA
TGATCTGGAGCGTGGCGACG

Product: histone deacetylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MTTRLYTHPIFLEHITPPGHPERPDRLRAIERVLDDEAFAALDRVKAPEGDEATILYAHPADFVARVRAAIPEEGIARID
ADTTASPKSWQAVIAAIGAANAAVDDVFAGRADNVFVAARPPGHHAEKTTAMGFCFFNTAAIAARYAQNKHGAERVAVVD
WDVHHGNGTQDIFWDDPSVLYCSTHQMPLYPGTGAKTETGAGNIVNAPLAPQTGSEVFRDAFLSRVLPSLDNFAPDLIII
SAGFDAHHRDPLAEINLTEDDFDWATGQLMQRAARHSGNRLVSLLEGGYDLQGLAFSVAAHVGRLMKG

Sequences:

>Translated_308_residues
MTTRLYTHPIFLEHITPPGHPERPDRLRAIERVLDDEAFAALDRVKAPEGDEATILYAHPADFVARVRAAIPEEGIARID
ADTTASPKSWQAVIAAIGAANAAVDDVFAGRADNVFVAARPPGHHAEKTTAMGFCFFNTAAIAARYAQNKHGAERVAVVD
WDVHHGNGTQDIFWDDPSVLYCSTHQMPLYPGTGAKTETGAGNIVNAPLAPQTGSEVFRDAFLSRVLPSLDNFAPDLIII
SAGFDAHHRDPLAEINLTEDDFDWATGQLMQRAARHSGNRLVSLLEGGYDLQGLAFSVAAHVGRLMKG
>Mature_307_residues
TTRLYTHPIFLEHITPPGHPERPDRLRAIERVLDDEAFAALDRVKAPEGDEATILYAHPADFVARVRAAIPEEGIARIDA
DTTASPKSWQAVIAAIGAANAAVDDVFAGRADNVFVAARPPGHHAEKTTAMGFCFFNTAAIAARYAQNKHGAERVAVVDW
DVHHGNGTQDIFWDDPSVLYCSTHQMPLYPGTGAKTETGAGNIVNAPLAPQTGSEVFRDAFLSRVLPSLDNFAPDLIIIS
AGFDAHHRDPLAEINLTEDDFDWATGQLMQRAARHSGNRLVSLLEGGYDLQGLAFSVAAHVGRLMKG

Specific function: Putative deacetylase [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI13128864, Length=298, Percent_Identity=37.5838926174497, Blast_Score=170, Evalue=1e-42,
Organism=Homo sapiens, GI153085395, Length=346, Percent_Identity=34.971098265896, Blast_Score=168, Evalue=6e-42,
Organism=Homo sapiens, GI169234807, Length=349, Percent_Identity=34.6704871060172, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI148539870, Length=349, Percent_Identity=34.6704871060172, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI62750347, Length=325, Percent_Identity=36.3076923076923, Blast_Score=162, Evalue=3e-40,
Organism=Homo sapiens, GI20070354, Length=301, Percent_Identity=36.8770764119601, Blast_Score=162, Evalue=3e-40,
Organism=Homo sapiens, GI62750349, Length=325, Percent_Identity=36.3076923076923, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI17158039, Length=340, Percent_Identity=33.8235294117647, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI30795204, Length=340, Percent_Identity=33.8235294117647, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI30795202, Length=340, Percent_Identity=33.8235294117647, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI226529806, Length=301, Percent_Identity=33.8870431893688, Blast_Score=131, Evalue=8e-31,
Organism=Homo sapiens, GI13128860, Length=256, Percent_Identity=25, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI8923769, Length=170, Percent_Identity=29.4117647058824, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI293336691, Length=140, Percent_Identity=31.4285714285714, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI13128862, Length=257, Percent_Identity=24.9027237354086, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI262073088, Length=141, Percent_Identity=29.0780141843972, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17540334, Length=306, Percent_Identity=35.2941176470588, Blast_Score=175, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI193206283, Length=306, Percent_Identity=35.2941176470588, Blast_Score=174, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI17540332, Length=306, Percent_Identity=35.2941176470588, Blast_Score=174, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI193209491, Length=242, Percent_Identity=41.3223140495868, Blast_Score=160, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI25154020, Length=277, Percent_Identity=29.6028880866426, Blast_Score=120, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI25154022, Length=277, Percent_Identity=29.2418772563177, Blast_Score=114, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI17537347, Length=298, Percent_Identity=32.2147651006711, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17534739, Length=303, Percent_Identity=26.4026402640264, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17508561, Length=256, Percent_Identity=25, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17561978, Length=140, Percent_Identity=32.1428571428571, Blast_Score=74, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6324307, Length=331, Percent_Identity=32.3262839879154, Blast_Score=140, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6325141, Length=284, Percent_Identity=28.8732394366197, Blast_Score=105, Evalue=9e-24,
Organism=Saccharomyces cerevisiae, GI6323999, Length=256, Percent_Identity=25, Blast_Score=80, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6321244, Length=257, Percent_Identity=25.2918287937743, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24642146, Length=310, Percent_Identity=34.5161290322581, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI281360899, Length=310, Percent_Identity=34.5161290322581, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24642142, Length=310, Percent_Identity=34.5161290322581, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24642144, Length=310, Percent_Identity=34.5161290322581, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24641720, Length=349, Percent_Identity=32.9512893982808, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI281360801, Length=349, Percent_Identity=32.9512893982808, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI281360799, Length=349, Percent_Identity=32.9512893982808, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24657891, Length=257, Percent_Identity=26.4591439688716, Blast_Score=81, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24644244, Length=266, Percent_Identity=24.812030075188, Blast_Score=72, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 33306; Mature: 33174

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTRLYTHPIFLEHITPPGHPERPDRLRAIERVLDDEAFAALDRVKAPEGDEATILYAHP
CCCEEEECCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECC
ADFVARVRAAIPEEGIARIDADTTASPKSWQAVIAAIGAANAAVDDVFAGRADNVFVAAR
HHHHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCEEEEEC
PPGHHAEKTTAMGFCFFNTAAIAARYAQNKHGAERVAVVDWDVHHGNGTQDIFWDDPSVL
CCCCCCCHHHHEEEHHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCCCEEECCCCEE
YCSTHQMPLYPGTGAKTETGAGNIVNAPLAPQTGSEVFRDAFLSRVLPSLDNFAPDLIII
EEECCCCCCCCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEE
SAGFDAHHRDPLAEINLTEDDFDWATGQLMQRAARHSGNRLVSLLEGGYDLQGLAFSVAA
ECCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHH
HVGRLMKG
HHHHHHCC
>Mature Secondary Structure 
TTRLYTHPIFLEHITPPGHPERPDRLRAIERVLDDEAFAALDRVKAPEGDEATILYAHP
CCEEEECCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECC
ADFVARVRAAIPEEGIARIDADTTASPKSWQAVIAAIGAANAAVDDVFAGRADNVFVAAR
HHHHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCEEEEEC
PPGHHAEKTTAMGFCFFNTAAIAARYAQNKHGAERVAVVDWDVHHGNGTQDIFWDDPSVL
CCCCCCCHHHHEEEHHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCCCEEECCCCEE
YCSTHQMPLYPGTGAKTETGAGNIVNAPLAPQTGSEVFRDAFLSRVLPSLDNFAPDLIII
EEECCCCCCCCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEE
SAGFDAHHRDPLAEINLTEDDFDWATGQLMQRAARHSGNRLVSLLEGGYDLQGLAFSVAA
ECCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHH
HVGRLMKG
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]