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The map label for this gene is nhaA [H]

Identifier: 13476173

GI number: 13476173

Start: 6134761

End: 6135621

Strand: Reverse

Name: nhaA [H]

Synonym: mll7424

Alternate gene names: 13476173

Gene position: 6135621-6134761 (Counterclockwise)

Preceding gene: 13476174

Following gene: 13476172

Centisome position: 87.2

GC content: 64.34

Gene sequence:

>861_bases
GTGAAACGCCTTTTCAACCGCCTGCTGCCGAAATCCTGGCGCTCCACCGTCGTCACCATTCCGGTCATCCGGCTGCATGG
CACGATCATGGCCGGCGGCCAGTTCCGGCAGAATCTGTCGCTGGCCTCCACCGCCGGCCTTATCGAGAAGGCGTTTTCCT
TCGATGCGCCGGCGGTTGCCATCTCGATCAATTCGCCCGGCGGCTCGCCGGTGCAGTCGCGGCTGATCTTCAGGCGCATC
CGCGACCTGGCGGCCGAAAAGAACAAGAAGGTGCTGGTCTTCGTCGAGGATGTCGCGGCCTCGGGCGGCTACATGATCGC
GGTCGCCGGCGACGAGATTTTTGCCGACCCGTCGTCCATCGTCGGCTCCATCGGCGTGGTCTCGGCCTCGTTCGGCTTTC
CCGAACTGATGAAGAAGATCGGCGTCGAGCGCCGTGTCCACACCGCCGGCCAGAACAAGGCGGTGCTCGATCCGTTCAAG
CCCGAGAAGAAGGAGGACGTCGAGCGGCTGAAGGCGCTGCAGCTCGAGGTGCACGAAACCTTCATCGACCTGGTCAAGGA
GCGGCGCGGCACCAAGCTGAAGGACGATCCGGATCTGTTCACCGGCCTGTTCTGGACCGGCAAAAAGGGTCTGGAACTCG
GCCTCGTCGATGCGCTCGGCGACATGCGCACGGTGCTGAAGACCCGGTTTGGCGCCAAAACCCAGCTCAGGCTGATCACT
GCGCCGCGCGGTTTCCTCGGCCGTTTCGGCCTGTTCGGCTCAAGCAAGGGCTTTTCAGCGCCCGATATCGCCGCTGCTGC
CGCCAGCGGCGTCATCGATGCGGCGGAAGAGCGCGCTCTGTGGGCTCGCTTCGGGCTTTGA

Upstream 100 bases:

>100_bases
GCCTCGCTGTTTGGAGATTGAGCTATTCCTGGCCGCCGCATTGCCGTTGGCCGGGAAATCCCTACATGCCTGCAACCCAT
CGACCGGAGACCACGCCCTC

Downstream 100 bases:

>100_bases
AAACCGCGCAAAACCGTCTAGCATGAAGGCTTGAAGTCCTGTGCATGCCGCTTTCCAAAAACCGGACACAGTTTTGGGCG
ACATGCATCAACCGACCCGA

Product: proteinase

Products: NA

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MKRLFNRLLPKSWRSTVVTIPVIRLHGTIMAGGQFRQNLSLASTAGLIEKAFSFDAPAVAISINSPGGSPVQSRLIFRRI
RDLAAEKNKKVLVFVEDVAASGGYMIAVAGDEIFADPSSIVGSIGVVSASFGFPELMKKIGVERRVHTAGQNKAVLDPFK
PEKKEDVERLKALQLEVHETFIDLVKERRGTKLKDDPDLFTGLFWTGKKGLELGLVDALGDMRTVLKTRFGAKTQLRLIT
APRGFLGRFGLFGSSKGFSAPDIAAAAASGVIDAAEERALWARFGL

Sequences:

>Translated_286_residues
MKRLFNRLLPKSWRSTVVTIPVIRLHGTIMAGGQFRQNLSLASTAGLIEKAFSFDAPAVAISINSPGGSPVQSRLIFRRI
RDLAAEKNKKVLVFVEDVAASGGYMIAVAGDEIFADPSSIVGSIGVVSASFGFPELMKKIGVERRVHTAGQNKAVLDPFK
PEKKEDVERLKALQLEVHETFIDLVKERRGTKLKDDPDLFTGLFWTGKKGLELGLVDALGDMRTVLKTRFGAKTQLRLIT
APRGFLGRFGLFGSSKGFSAPDIAAAAASGVIDAAEERALWARFGL
>Mature_286_residues
MKRLFNRLLPKSWRSTVVTIPVIRLHGTIMAGGQFRQNLSLASTAGLIEKAFSFDAPAVAISINSPGGSPVQSRLIFRRI
RDLAAEKNKKVLVFVEDVAASGGYMIAVAGDEIFADPSSIVGSIGVVSASFGFPELMKKIGVERRVHTAGQNKAVLDPFK
PEKKEDVERLKALQLEVHETFIDLVKERRGTKLKDDPDLFTGLFWTGKKGLELGLVDALGDMRTVLKTRFGAKTQLRLIT
APRGFLGRFGLFGSSKGFSAPDIAAAAASGVIDAAEERALWARFGL

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1787527, Length=191, Percent_Identity=34.5549738219895, Blast_Score=91, Evalue=6e-20,
Organism=Escherichia coli, GI1788064, Length=207, Percent_Identity=31.4009661835749, Blast_Score=79, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670
- InterPro:   IPR002142 [H]

Pfam domain/function: PF06965 Na_H_antiport_1; PF01343 Peptidase_S49 [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 31012; Mature: 31012

Theoretical pI: Translated: 10.74; Mature: 10.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLFNRLLPKSWRSTVVTIPVIRLHGTIMAGGQFRQNLSLASTAGLIEKAFSFDAPAVA
CHHHHHHHCCHHHCCEEEEEEEEEECCEEEECCHHHHCCHHHHHHHHHHHHHCCCCCEEE
ISINSPGGSPVQSRLIFRRIRDLAAEKNKKVLVFVEDVAASGGYMIAVAGDEIFADPSSI
EEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEEEECCCHHCCHHHH
VGSIGVVSASFGFPELMKKIGVERRVHTAGQNKAVLDPFKPEKKEDVERLKALQLEVHET
HHHHHHEECCCCCHHHHHHHCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
FIDLVKERRGTKLKDDPDLFTGLFWTGKKGLELGLVDALGDMRTVLKTRFGAKTQLRLIT
HHHHHHHHCCCCCCCCCHHHHEEEECCCCCCEEHHHHHHHHHHHHHHHHCCCCEEEEEEE
APRGFLGRFGLFGSSKGFSAPDIAAAAASGVIDAAEERALWARFGL
CCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKRLFNRLLPKSWRSTVVTIPVIRLHGTIMAGGQFRQNLSLASTAGLIEKAFSFDAPAVA
CHHHHHHHCCHHHCCEEEEEEEEEECCEEEECCHHHHCCHHHHHHHHHHHHHCCCCCEEE
ISINSPGGSPVQSRLIFRRIRDLAAEKNKKVLVFVEDVAASGGYMIAVAGDEIFADPSSI
EEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEEEECCCHHCCHHHH
VGSIGVVSASFGFPELMKKIGVERRVHTAGQNKAVLDPFKPEKKEDVERLKALQLEVHET
HHHHHHEECCCCCHHHHHHHCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
FIDLVKERRGTKLKDDPDLFTGLFWTGKKGLELGLVDALGDMRTVLKTRFGAKTQLRLIT
HHHHHHHHCCCCCCCCCHHHHEEEECCCCCCEEHHHHHHHHHHHHHHHHCCCCEEEEEEE
APRGFLGRFGLFGSSKGFSAPDIAAAAASGVIDAAEERALWARFGL
CCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA