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The map label for this gene is atpB

Identifier: 13476163

GI number: 13476163

Start: 6126644

End: 6127402

Strand: Direct

Name: atpB

Synonym: mlr7411

Alternate gene names: 13476163

Gene position: 6126644-6127402 (Clockwise)

Preceding gene: 13476162

Following gene: 13476164

Centisome position: 87.07

GC content: 59.42

Gene sequence:

>759_bases
GTGGCAGCTGACAAGGTCGATCCGATCCACCAGTTCCATATCATCAAGCTGGTTCCGATTAACATCGGCGGCTACGACCT
GTCCTTTACGAATTCGGCATTGTTCATGGTCGCGACCGTGGTGGTCGCCGCCGCATTCCTGTTCCTCACGACGTCGAGCC
GAAGCCTGGTTCCCGGCCGGTTGCAGTCGATCTCCGAGATGGCCTACGAATTCGTCGCAAACATGTTGCGTGACGCCGCC
GGCACGCAGGGCATGAAGTTCTTCCCGCTTGTGTTCTCGCTGTTCATGTTCGTGCTGGTCGCCAATCTGCTCGGCCTATT
CCCCTATTTCTTCACCGTCACCAGCCACATCATCGTCACCTTCGGTCTGGCCATCCTGGTGATCGGCACCGTCATCGTCT
ACGGTTTCATGAAGCATGGGCTGGGCTTCCTGAAGCTGTTCGTGCCGAAGGGCGTGCCTCTCGTGATGATGGTGCTTGTC
GTTCCGATCGAGGTGATTTCCTTCGTCTCGCGCCCGATCAGCCTCTCGGTTCGTCTGTTCGCCAACATGTTGGCCGGCCA
CATCACACTGAAGGTGTTTTCGGGCTTCGTCGTCAGCCTCTCAGCGCTGGGCGCGGTCGGCGTCGCGGGCTCGATCCTGC
CGCTGGCCATGGCGGTAGCGCTGACAGCGCTGGAACTGCTCGTTGCCTTCCTGCAGGCCTACGTCTTTGCGGTGTTGACC
TGCATGTACCTCAACGACGCCCTACACCCCAGCCACTAA

Upstream 100 bases:

>100_bases
GGACGACAGCAAATGACCGCCCTTCAGGCGGCATTCGGAAATAGCCGCCCTCACGCGGCAATGGTAATTTGGCCGTACGC
GGCATTGACGGGGTTAGAAC

Downstream 100 bases:

>100_bases
ATTTCACCGGCGCATGACGCCAACTACAATCTGCAACGACAAACGGAACCACAAGGAGTTTGACATGGAAGTAAATGCAG
CAGCTGCAATCGGCGCCGGC

Product: F0F1 ATP synthase subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6

Number of amino acids: Translated: 252; Mature: 251

Protein sequence:

>252_residues
MAADKVDPIHQFHIIKLVPINIGGYDLSFTNSALFMVATVVVAAAFLFLTTSSRSLVPGRLQSISEMAYEFVANMLRDAA
GTQGMKFFPLVFSLFMFVLVANLLGLFPYFFTVTSHIIVTFGLAILVIGTVIVYGFMKHGLGFLKLFVPKGVPLVMMVLV
VPIEVISFVSRPISLSVRLFANMLAGHITLKVFSGFVVSLSALGAVGVAGSILPLAMAVALTALELLVAFLQAYVFAVLT
CMYLNDALHPSH

Sequences:

>Translated_252_residues
MAADKVDPIHQFHIIKLVPINIGGYDLSFTNSALFMVATVVVAAAFLFLTTSSRSLVPGRLQSISEMAYEFVANMLRDAA
GTQGMKFFPLVFSLFMFVLVANLLGLFPYFFTVTSHIIVTFGLAILVIGTVIVYGFMKHGLGFLKLFVPKGVPLVMMVLV
VPIEVISFVSRPISLSVRLFANMLAGHITLKVFSGFVVSLSALGAVGVAGSILPLAMAVALTALELLVAFLQAYVFAVLT
CMYLNDALHPSH
>Mature_251_residues
AADKVDPIHQFHIIKLVPINIGGYDLSFTNSALFMVATVVVAAAFLFLTTSSRSLVPGRLQSISEMAYEFVANMLRDAAG
TQGMKFFPLVFSLFMFVLVANLLGLFPYFFTVTSHIIVTFGLAILVIGTVIVYGFMKHGLGFLKLFVPKGVPLVMMVLVV
PIEVISFVSRPISLSVRLFANMLAGHITLKVFSGFVVSLSALGAVGVAGSILPLAMAVALTALELLVAFLQAYVFAVLTC
MYLNDALHPSH

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family

Homologues:

Organism=Homo sapiens, GI251831112, Length=195, Percent_Identity=29.7435897435897, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6226527, Length=247, Percent_Identity=33.1983805668016, Blast_Score=143, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ATP6_RHILO (Q986D4)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_107733.1
- ProteinModelPortal:   Q986D4
- SMR:   Q986D4
- GeneID:   1230388
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mlr7411
- NMPDR:   fig|266835.1.peg.5834
- HOGENOM:   HBG734175
- OMA:   RFANTVE
- ProtClustDB:   PRK05815
- HAMAP:   MF_01393
- InterPro:   IPR000568
- InterPro:   IPR023011
- Gene3D:   G3DSA:1.20.120.220
- PANTHER:   PTHR11410
- PRINTS:   PR00123
- TIGRFAMs:   TIGR01131

Pfam domain/function: PF00119 ATP-synt_A; SSF81336 ATPase_F0_A

EC number: 3.6.3.14

Molecular weight: Translated: 27169; Mature: 27038

Theoretical pI: Translated: 9.39; Mature: 9.39

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1749f1c0)-; HASH(0x10941d34)-; HASH(0x15e5c594)-; HASH(0x1204dfc4)-; HASH(0x1792bd9c)-; HASH(0x17984274)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAADKVDPIHQFHIIKLVPINIGGYDLSFTNSALFMVATVVVAAAFLFLTTSSRSLVPGR
CCCCCCCCHHHEEEEEEEEEECCCEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
LQSISEMAYEFVANMLRDAAGTQGMKFFPLVFSLFMFVLVANLLGLFPYFFTVTSHIIVT
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FGLAILVIGTVIVYGFMKHGLGFLKLFVPKGVPLVMMVLVVPIEVISFVSRPISLSVRLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
ANMLAGHITLKVFSGFVVSLSALGAVGVAGSILPLAMAVALTALELLVAFLQAYVFAVLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CMYLNDALHPSH
HHHHHHCCCCCH
>Mature Secondary Structure 
AADKVDPIHQFHIIKLVPINIGGYDLSFTNSALFMVATVVVAAAFLFLTTSSRSLVPGR
CCCCCCCHHHEEEEEEEEEECCCEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
LQSISEMAYEFVANMLRDAAGTQGMKFFPLVFSLFMFVLVANLLGLFPYFFTVTSHIIVT
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FGLAILVIGTVIVYGFMKHGLGFLKLFVPKGVPLVMMVLVVPIEVISFVSRPISLSVRLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
ANMLAGHITLKVFSGFVVSLSALGAVGVAGSILPLAMAVALTALELLVAFLQAYVFAVLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CMYLNDALHPSH
HHHHHHCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11214968