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The map label for this gene is gcvT [H]

Identifier: 13476096

GI number: 13476096

Start: 6055233

End: 6056366

Strand: Direct

Name: gcvT [H]

Synonym: mlr7320

Alternate gene names: 13476096

Gene position: 6055233-6056366 (Clockwise)

Preceding gene: 13476079

Following gene: 13476097

Centisome position: 86.06

GC content: 60.32

Gene sequence:

>1134_bases
ATGACGGCATCCTGGAGATTTTCGACCCTGGCGGATCGCCATCGCGCGCTGGGTTCGAAGCTCGAAGACTGGAGCGGCAT
GGGCACCGCCTGGACCTACGACAAGGATGCCGACGAAGAATACATCGCCATCCGCACCAAGGCCGGGCTAATGGATGTGT
CGGGCCTAAAGAAGGTTCACATTACAGGGCCGCACGCCTCGCATCTCATCGACCTCGCCACGACGCGCGATGTCGAAAAG
ATCTACCCCGGCAAATCGGCCTATGCCTGCATGCTGAACGAGGCGGGAAAATTCACCGACGACTGCATCCTCTACCGCAC
CGGCCCGAACAGCTGGATGGTCGTGCATGGCTCCGGCACCGGCCATGAGGAATTGCAGCGGGCCGCGATCGGCCGCGATG
TCTCGCTACGCTTCGATGACAATCTGCACGATCTGTCGCTGCAGGGACCAACCGCGGTCGACTATCTGGCCAAACATGTG
CCGGGGATTCGCGATCTCAACTATTTCCATCACATGCAGACGCAGCTCTTCGGTTTCCCGGTCATGATCTCGCGCACCGG
CTACACCGGCGAGCGCGGCTACGAAATCTTCTGCCGCGGCCAGGATACCGGCACGATCTGGGACAGGATCCTCGACGAGG
GCAAGAGCGCCGGCATCATTCCCTGCCGCTTCACCACACTCGATATGCTGCGTGTCGAAAGCTACCTGCTGTTCTACCCC
TACGACAATTCGCAAAAATATCCCTTCGAGAACGAAGGCCCCGGCGACACGTTGTGGGAACTCGGCCTCGACTTCACCGT
CAGCCCCGGCAAGACCGGCTTCCGTGGCGCGGAGGAGCACTATCGCCTGAAGGGCAAGGAGCGCTTCAAGATTTTTGGCG
TTCTGCTCGACGGCAAGGAGCCGGCCGATGAGGGCGCGCCGGTCTATCGCGACGGCAAAAAGGTCGGCGTGGTGACCTGC
GCCATGTATTCGCAGCTGGTCAAGAAATCGATGGGCATCGCCCGTCTCGATGTCGACTGTGCGGTCAAGGACACCAAGCT
CGAAATCCGCAACAAGAGCGGTTCGATCAAGGCGACGGCGCAGCCACTACCGTTCGATGATCCGAAAAAGACCAAGCGCA
CCGCCAAGGGTTAA

Upstream 100 bases:

>100_bases
ATTGCGGCCCTCTCGCGTTTGCGGTCAATATTCGCCTCAAAGCTCCGGCCACCGCGTCAAGGAGCAGGGAACAGTGGATT
TTTGAACGGAGGACGAGCGG

Downstream 100 bases:

>100_bases
GGCATCATCAGCAGCGAGGGATTTAAGGCACAGAGAGAGAATGGCAGCCAAGACGATCATCAGCCGGCCTATTTATGGAG
CCCTGTCTCCGCAGCCCGGC

Product: aminomethyltransferase

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 377; Mature: 376

Protein sequence:

>377_residues
MTASWRFSTLADRHRALGSKLEDWSGMGTAWTYDKDADEEYIAIRTKAGLMDVSGLKKVHITGPHASHLIDLATTRDVEK
IYPGKSAYACMLNEAGKFTDDCILYRTGPNSWMVVHGSGTGHEELQRAAIGRDVSLRFDDNLHDLSLQGPTAVDYLAKHV
PGIRDLNYFHHMQTQLFGFPVMISRTGYTGERGYEIFCRGQDTGTIWDRILDEGKSAGIIPCRFTTLDMLRVESYLLFYP
YDNSQKYPFENEGPGDTLWELGLDFTVSPGKTGFRGAEEHYRLKGKERFKIFGVLLDGKEPADEGAPVYRDGKKVGVVTC
AMYSQLVKKSMGIARLDVDCAVKDTKLEIRNKSGSIKATAQPLPFDDPKKTKRTAKG

Sequences:

>Translated_377_residues
MTASWRFSTLADRHRALGSKLEDWSGMGTAWTYDKDADEEYIAIRTKAGLMDVSGLKKVHITGPHASHLIDLATTRDVEK
IYPGKSAYACMLNEAGKFTDDCILYRTGPNSWMVVHGSGTGHEELQRAAIGRDVSLRFDDNLHDLSLQGPTAVDYLAKHV
PGIRDLNYFHHMQTQLFGFPVMISRTGYTGERGYEIFCRGQDTGTIWDRILDEGKSAGIIPCRFTTLDMLRVESYLLFYP
YDNSQKYPFENEGPGDTLWELGLDFTVSPGKTGFRGAEEHYRLKGKERFKIFGVLLDGKEPADEGAPVYRDGKKVGVVTC
AMYSQLVKKSMGIARLDVDCAVKDTKLEIRNKSGSIKATAQPLPFDDPKKTKRTAKG
>Mature_376_residues
TASWRFSTLADRHRALGSKLEDWSGMGTAWTYDKDADEEYIAIRTKAGLMDVSGLKKVHITGPHASHLIDLATTRDVEKI
YPGKSAYACMLNEAGKFTDDCILYRTGPNSWMVVHGSGTGHEELQRAAIGRDVSLRFDDNLHDLSLQGPTAVDYLAKHVP
GIRDLNYFHHMQTQLFGFPVMISRTGYTGERGYEIFCRGQDTGTIWDRILDEGKSAGIIPCRFTTLDMLRVESYLLFYPY
DNSQKYPFENEGPGDTLWELGLDFTVSPGKTGFRGAEEHYRLKGKERFKIFGVLLDGKEPADEGAPVYRDGKKVGVVTCA
MYSQLVKKSMGIARLDVDCAVKDTKLEIRNKSGSIKATAQPLPFDDPKKTKRTAKG

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=375, Percent_Identity=27.2, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI257796258, Length=364, Percent_Identity=27.7472527472527, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI24797151, Length=354, Percent_Identity=24.0112994350282, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI257796256, Length=323, Percent_Identity=27.2445820433437, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1789272, Length=374, Percent_Identity=27.5401069518717, Blast_Score=99, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17560118, Length=356, Percent_Identity=27.247191011236, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320222, Length=398, Percent_Identity=25.1256281407035, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI20129441, Length=394, Percent_Identity=25.8883248730964, Blast_Score=88, Evalue=8e-18,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 42131; Mature: 42000

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASWRFSTLADRHRALGSKLEDWSGMGTAWTYDKDADEEYIAIRTKAGLMDVSGLKKVH
CCCCCCHHHHHHHHHHHHCCCHHHCCCCCEEECCCCCCCCEEEEEECCCEEECCCCEEEE
ITGPHASHLIDLATTRDVEKIYPGKSAYACMLNEAGKFTDDCILYRTGPNSWMVVHGSGT
EECCCHHHEEEHHHHCCHHHHCCCCCEEEEEECCCCCCCCCEEEEEECCCCEEEEECCCC
GHEELQRAAIGRDVSLRFDDNLHDLSLQGPTAVDYLAKHVPGIRDLNYFHHMQTQLFGFP
CHHHHHHHHCCCCEEEEECCCCEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCE
VMISRTGYTGERGYEIFCRGQDTGTIWDRILDEGKSAGIIPCRFTTLDMLRVESYLLFYP
EEEEECCCCCCCCCEEEEECCCCCHHHHHHHHCCCCCCEEEEEHHHHHHEEECEEEEEEE
YDNSQKYPFENEGPGDTLWELGLDFTVSPGKTGFRGAEEHYRLKGKERFKIFGVLLDGKE
ECCCCCCCCCCCCCCCHHHHCCCCEEECCCCCCCCCCHHHHCCCCCCEEEEEEEEECCCC
PADEGAPVYRDGKKVGVVTCAMYSQLVKKSMGIARLDVDCAVKDTKLEIRNKSGSIKATA
CCCCCCCCEECCCEEEEEHHHHHHHHHHHHCCEEEEEEEEEEECCEEEEECCCCCEEEEC
QPLPFDDPKKTKRTAKG
CCCCCCCCHHHHHCCCC
>Mature Secondary Structure 
TASWRFSTLADRHRALGSKLEDWSGMGTAWTYDKDADEEYIAIRTKAGLMDVSGLKKVH
CCCCCHHHHHHHHHHHHCCCHHHCCCCCEEECCCCCCCCEEEEEECCCEEECCCCEEEE
ITGPHASHLIDLATTRDVEKIYPGKSAYACMLNEAGKFTDDCILYRTGPNSWMVVHGSGT
EECCCHHHEEEHHHHCCHHHHCCCCCEEEEEECCCCCCCCCEEEEEECCCCEEEEECCCC
GHEELQRAAIGRDVSLRFDDNLHDLSLQGPTAVDYLAKHVPGIRDLNYFHHMQTQLFGFP
CHHHHHHHHCCCCEEEEECCCCEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCE
VMISRTGYTGERGYEIFCRGQDTGTIWDRILDEGKSAGIIPCRFTTLDMLRVESYLLFYP
EEEEECCCCCCCCCEEEEECCCCCHHHHHHHHCCCCCCEEEEEHHHHHHEEECEEEEEEE
YDNSQKYPFENEGPGDTLWELGLDFTVSPGKTGFRGAEEHYRLKGKERFKIFGVLLDGKE
ECCCCCCCCCCCCCCCHHHHCCCCEEECCCCCCCCCCHHHHCCCCCCEEEEEEEEECCCC
PADEGAPVYRDGKKVGVVTCAMYSQLVKKSMGIARLDVDCAVKDTKLEIRNKSGSIKATA
CCCCCCCCEECCCEEEEEHHHHHHHHHHHHCCEEEEEEEEEEECCEEEEECCCCCEEEEC
QPLPFDDPKKTKRTAKG
CCCCCCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA