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The map label for this gene is serA [H]

Identifier: 13476055

GI number: 13476055

Start: 6006880

End: 6007872

Strand: Direct

Name: serA [H]

Synonym: mlr7269

Alternate gene names: 13476055

Gene position: 6006880-6007872 (Clockwise)

Preceding gene: 13476054

Following gene: 13476056

Centisome position: 85.37

GC content: 66.67

Gene sequence:

>993_bases
GTGTTTCGCGCCAAAATCGAGAAGGTCGCTACTGGTGACCTCGATATCAGGACATTGCAGACGGCGTGGCCCGACGAGCC
GATGGAGTTCGGCAATCCGGCGCTCGGCCTCGACAAGGTCAAGGAATATTTCGGCCACCCCGACGAGGTCGTCGATTTCA
TCGGCGATGCCGAGATCCTCGTCACCCAGCTGGCGCCCCTGTCGGAGGCCATGATGCGGCGCTTGCCGGCGCTCAAGCTG
GTTGCCGTTTCGCGCGGCGGCCCGATCAACATCGACATGGCGGCCGCCAGGGCGCACGGCATCACCGTGGTCAACGTGCC
GGGCCGCAACGCGACGGCCGTGGCCGAGTTCACCCTCGGCGCCATCCTGGCCGAGACGCGGCTGATCCGGGTCGGCCACG
AGGCCTTGCGCAAGGGAGAATGGCGCGGCGATCTCTACCGCGCCGACCGCACCGGCCGCGAACTCAGCGAAATGACCGTC
GGCGTCATCGGCTATGGCAATATCGGCACCAAGGTCGTGCGCCTGCTGCGCGCCTTCGGCTGCCACGTCCTGGTCAGTGA
CCCCTATGTGCAGTTGAGCGCCGAAGACCGCAATGCCGGTGTCGAACTCGTCGCGCTGGACAATCTGCTCGCCCGCTCCG
ACGTGGTCACGCTGCATCCCCGGGTGACCGAGGAGACGCGCGGCCTCATCGGCAAAGACGCCATCGCGCTGATGAAACCG
GGCGTGATTCTCATCAACACCGCGCGCGGGCCGCTGGTCGACTATGACGCGCTCTACGAGGCGCTGGTTTCAGGGCAGAT
AGCCAGCGCCATGCTGGAGACCTTCGCGGTCGAGCCGGTGCCGTCGGACTGGCCCTTGCTGCAACTGCCCAACGTGACGC
TGACGCCGCATATCGCCGGCGCCTCGGTGCGCACCGTCACCTATGCCGCCGAACAGGCCGCCGAAGAGGTGCGCCGCTAC
CTAACCGGCCTGCCTCCGGTCAATCCGTGCTGA

Upstream 100 bases:

>100_bases
CGGCCGGTCTGGCGCGCGATGGCTTCAGTGCAGGCAAATTGAGAAGTCGAGTATGCGTAAGAGAATAGCGATCATTGGCG
ACAACTTCATGCTTCCGCAG

Downstream 100 bases:

>100_bases
GGCAGTGGCCATGACTTTTCAAACCGGCATCGAGGCCATGGCGACATGAACGGCGGTCCTGAAATCGTCGACCTCTTCGT
CATCGGTGGCGGCGTCAATG

Product: phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MFRAKIEKVATGDLDIRTLQTAWPDEPMEFGNPALGLDKVKEYFGHPDEVVDFIGDAEILVTQLAPLSEAMMRRLPALKL
VAVSRGGPINIDMAAARAHGITVVNVPGRNATAVAEFTLGAILAETRLIRVGHEALRKGEWRGDLYRADRTGRELSEMTV
GVIGYGNIGTKVVRLLRAFGCHVLVSDPYVQLSAEDRNAGVELVALDNLLARSDVVTLHPRVTEETRGLIGKDAIALMKP
GVILINTARGPLVDYDALYEALVSGQIASAMLETFAVEPVPSDWPLLQLPNVTLTPHIAGASVRTVTYAAEQAAEEVRRY
LTGLPPVNPC

Sequences:

>Translated_330_residues
MFRAKIEKVATGDLDIRTLQTAWPDEPMEFGNPALGLDKVKEYFGHPDEVVDFIGDAEILVTQLAPLSEAMMRRLPALKL
VAVSRGGPINIDMAAARAHGITVVNVPGRNATAVAEFTLGAILAETRLIRVGHEALRKGEWRGDLYRADRTGRELSEMTV
GVIGYGNIGTKVVRLLRAFGCHVLVSDPYVQLSAEDRNAGVELVALDNLLARSDVVTLHPRVTEETRGLIGKDAIALMKP
GVILINTARGPLVDYDALYEALVSGQIASAMLETFAVEPVPSDWPLLQLPNVTLTPHIAGASVRTVTYAAEQAAEEVRRY
LTGLPPVNPC
>Mature_330_residues
MFRAKIEKVATGDLDIRTLQTAWPDEPMEFGNPALGLDKVKEYFGHPDEVVDFIGDAEILVTQLAPLSEAMMRRLPALKL
VAVSRGGPINIDMAAARAHGITVVNVPGRNATAVAEFTLGAILAETRLIRVGHEALRKGEWRGDLYRADRTGRELSEMTV
GVIGYGNIGTKVVRLLRAFGCHVLVSDPYVQLSAEDRNAGVELVALDNLLARSDVVTLHPRVTEETRGLIGKDAIALMKP
GVILINTARGPLVDYDALYEALVSGQIASAMLETFAVEPVPSDWPLLQLPNVTLTPHIAGASVRTVTYAAEQAAEEVRRY
LTGLPPVNPC

Specific function: Serine biosynthesis; first step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI61743967, Length=265, Percent_Identity=36.2264150943396, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI4557497, Length=265, Percent_Identity=36.2264150943396, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI23308577, Length=291, Percent_Identity=30.5841924398625, Blast_Score=128, Evalue=6e-30,
Organism=Homo sapiens, GI145580578, Length=265, Percent_Identity=34.7169811320755, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI4557499, Length=265, Percent_Identity=34.7169811320755, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI145580575, Length=262, Percent_Identity=34.7328244274809, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI6912396, Length=250, Percent_Identity=31.6, Blast_Score=114, Evalue=2e-25,
Organism=Escherichia coli, GI1789279, Length=232, Percent_Identity=35.3448275862069, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI87082289, Length=253, Percent_Identity=32.0158102766798, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1787645, Length=254, Percent_Identity=32.6771653543307, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1788660, Length=302, Percent_Identity=27.8145695364238, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI87081824, Length=175, Percent_Identity=35.4285714285714, Blast_Score=73, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=247, Percent_Identity=34.412955465587, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI25147481, Length=268, Percent_Identity=32.4626865671642, Blast_Score=116, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6322116, Length=326, Percent_Identity=28.8343558282209, Blast_Score=124, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6324964, Length=299, Percent_Identity=30.1003344481605, Blast_Score=117, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6320925, Length=326, Percent_Identity=27.9141104294479, Blast_Score=116, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6324055, Length=272, Percent_Identity=31.9852941176471, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6324980, Length=188, Percent_Identity=28.7234042553192, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28574286, Length=256, Percent_Identity=32.421875, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI19921140, Length=271, Percent_Identity=31.7343173431734, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646446, Length=275, Percent_Identity=34.1818181818182, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24646448, Length=275, Percent_Identity=34.1818181818182, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24646452, Length=275, Percent_Identity=34.1818181818182, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24646450, Length=275, Percent_Identity=34.1818181818182, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI62472511, Length=275, Percent_Identity=34.1818181818182, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24585514, Length=264, Percent_Identity=30.3030303030303, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI28574282, Length=264, Percent_Identity=30.3030303030303, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI28574284, Length=264, Percent_Identity=30.3030303030303, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI45552429, Length=264, Percent_Identity=30.3030303030303, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI45551003, Length=264, Percent_Identity=30.3030303030303, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24585516, Length=252, Percent_Identity=26.5873015873016, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI28571528, Length=248, Percent_Identity=33.0645161290323, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 35688; Mature: 35688

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRAKIEKVATGDLDIRTLQTAWPDEPMEFGNPALGLDKVKEYFGHPDEVVDFIGDAEIL
CCCHHHHHHHCCCCEEEEEECCCCCCCHHCCCCCCCHHHHHHHHCCHHHHHHHHCCHHHH
VTQLAPLSEAMMRRLPALKLVAVSRGGPINIDMAAARAHGITVVNVPGRNATAVAEFTLG
HHHHCCHHHHHHHHCCCEEEEEECCCCCEEEEEEHHHHCCEEEEEECCCCCHHHHHHHHH
AILAETRLIRVGHEALRKGEWRGDLYRADRTGRELSEMTVGVIGYGNIGTKVVRLLRAFG
HHHHHHHHHHHCHHHHHCCCCCCCHHHCCCCCCHHHHCEEEEEEECCHHHHHHHHHHHHC
CHVLVSDPYVQLSAEDRNAGVELVALDNLLARSDVVTLHPRVTEETRGLIGKDAIALMKP
CEEEECCCEEEEECCCCCCCEEEEEECHHHHHCCEEEECCCCCHHHCCCCCCCHHHHHCC
GVILINTARGPLVDYDALYEALVSGQIASAMLETFAVEPVPSDWPLLQLPNVTLTPHIAG
CEEEEECCCCCCCCHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCEEECCCEEECCCCCC
ASVRTVTYAAEQAAEEVRRYLTGLPPVNPC
CCEEHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MFRAKIEKVATGDLDIRTLQTAWPDEPMEFGNPALGLDKVKEYFGHPDEVVDFIGDAEIL
CCCHHHHHHHCCCCEEEEEECCCCCCCHHCCCCCCCHHHHHHHHCCHHHHHHHHCCHHHH
VTQLAPLSEAMMRRLPALKLVAVSRGGPINIDMAAARAHGITVVNVPGRNATAVAEFTLG
HHHHCCHHHHHHHHCCCEEEEEECCCCCEEEEEEHHHHCCEEEEEECCCCCHHHHHHHHH
AILAETRLIRVGHEALRKGEWRGDLYRADRTGRELSEMTVGVIGYGNIGTKVVRLLRAFG
HHHHHHHHHHHCHHHHHCCCCCCCHHHCCCCCCHHHHCEEEEEEECCHHHHHHHHHHHHC
CHVLVSDPYVQLSAEDRNAGVELVALDNLLARSDVVTLHPRVTEETRGLIGKDAIALMKP
CEEEECCCEEEEECCCCCCCEEEEEECHHHHHCCEEEECCCCCHHHCCCCCCCHHHHHCC
GVILINTARGPLVDYDALYEALVSGQIASAMLETFAVEPVPSDWPLLQLPNVTLTPHIAG
CEEEEECCCCCCCCHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCEEECCCEEECCCCCC
ASVRTVTYAAEQAAEEVRRYLTGLPPVNPC
CCEEHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]