Click here to switch to the map view.

The map label for this gene is scrR [H]

Identifier: 13476012

GI number: 13476012

Start: 5959133

End: 5960167

Strand: Direct

Name: scrR [H]

Synonym: mlr7217

Alternate gene names: 13476012

Gene position: 5959133-5960167 (Clockwise)

Preceding gene: 13476008

Following gene: 13476016

Centisome position: 84.69

GC content: 64.06

Gene sequence:

>1035_bases
ATGGCGGAGAAGACCCACCGCACGATGGATGATTTCGCCAGGGCGTCAGGCGTATCGCGACCGACCCTGTCGAAGTATTT
CGATGATCCGGCCAGTGTTAAGCCGGCGACGCGGGCGCGCATCGAGGCGGCGCTGCGATCCTCGGACTATCAGCCGAACG
TTTTCGCGCGCAATCTCAACCGCAAGCGCACCCGCAATGTCGGCATCGTCGTGCCGGCGCTCACCGATCCGTTCTATGCC
GAAATGGTCAGCCGCATCGAACTGCGCTGCCGCGACGAAGGTTTCTGGCCGATCGTCATCTCCTCGCACGGGTCGCCGAA
ACTGGAGGCGGAATCGGTCAGGACGTTGATGTCGCTGAAGGTCGCCGGCGCCATCGTCGCTCCGCTGGGGTTGGTCTCCG
AACCCGGCGTCTTCGAGCGAATGAGCGAGGACATTCCGATCGTCTATTTCGACACCTATATCGAAGGCGACACGCCTTTC
GTCGGCAACGACAATCACCAGAGCACGTCGACCATCGTCGACTATCTCTGCCGGTCCGGCGAGCCGCCGGTCTACGTCGA
CATTCCGCACGTCAACCACAATTCCGGCGAGCGCCTGCAGAGCTATATCGACACGATGCGGGCTACCGGTCTGGAACCCG
TCGTGCTCAAGGCGGCGGGCGACTACAGCTGGGATTTCGAGCGCATCGGCCATGAATGGATGGACAGGACGCTCGAGACG
GGCGGCCTGCCGGCGCGCACGCTGCTGTGTGCCAATGACCGTCTCGCCTTCGGCGTTATGGCGGCGGCCTTTTCGCGTGG
GCTGAAGATCGGCCGCCGGGCCGATTGCGATTTCCGGGTCGCTGCCCACGATGATCATCCGCTGAGCCGCTACACCTGTC
CGGCGCTGACCACCATGGCGCAGGATTTCGCCGCCATGGCCGGCCGCAGCGTCGAGATCCTGCTGGCCTTGCTGGATGAG
GCCGATCCACCCGGCCAGGGTCTGGTGCGCAACGTCAAGCTCGGCGCGACGCTGGTGATGCGTCAGTCTGCCTGA

Upstream 100 bases:

>100_bases
AAATTCGGTCAAGCAATGCTGCCTCGCGGCAACGGCCGCAAGACTGATTCTGGCCCGACCCGGAAGGTTGACGGGCGCGA
GCAAGGGGCTGGACATATCG

Downstream 100 bases:

>100_bases
ACACGCGTCTGCAATTGCAGCCAGGCCGCTGCCTCGCTCACCGCTTGCCGCGCCGCCAGTATATGGCGGCCCATCGAGAC
GAAGCCGTGGATTTGACCCG

Product: transcriptional regulator

Products: NA

Alternate protein names: Scr operon regulatory protein [H]

Number of amino acids: Translated: 344; Mature: 343

Protein sequence:

>344_residues
MAEKTHRTMDDFARASGVSRPTLSKYFDDPASVKPATRARIEAALRSSDYQPNVFARNLNRKRTRNVGIVVPALTDPFYA
EMVSRIELRCRDEGFWPIVISSHGSPKLEAESVRTLMSLKVAGAIVAPLGLVSEPGVFERMSEDIPIVYFDTYIEGDTPF
VGNDNHQSTSTIVDYLCRSGEPPVYVDIPHVNHNSGERLQSYIDTMRATGLEPVVLKAAGDYSWDFERIGHEWMDRTLET
GGLPARTLLCANDRLAFGVMAAAFSRGLKIGRRADCDFRVAAHDDHPLSRYTCPALTTMAQDFAAMAGRSVEILLALLDE
ADPPGQGLVRNVKLGATLVMRQSA

Sequences:

>Translated_344_residues
MAEKTHRTMDDFARASGVSRPTLSKYFDDPASVKPATRARIEAALRSSDYQPNVFARNLNRKRTRNVGIVVPALTDPFYA
EMVSRIELRCRDEGFWPIVISSHGSPKLEAESVRTLMSLKVAGAIVAPLGLVSEPGVFERMSEDIPIVYFDTYIEGDTPF
VGNDNHQSTSTIVDYLCRSGEPPVYVDIPHVNHNSGERLQSYIDTMRATGLEPVVLKAAGDYSWDFERIGHEWMDRTLET
GGLPARTLLCANDRLAFGVMAAAFSRGLKIGRRADCDFRVAAHDDHPLSRYTCPALTTMAQDFAAMAGRSVEILLALLDE
ADPPGQGLVRNVKLGATLVMRQSA
>Mature_343_residues
AEKTHRTMDDFARASGVSRPTLSKYFDDPASVKPATRARIEAALRSSDYQPNVFARNLNRKRTRNVGIVVPALTDPFYAE
MVSRIELRCRDEGFWPIVISSHGSPKLEAESVRTLMSLKVAGAIVAPLGLVSEPGVFERMSEDIPIVYFDTYIEGDTPFV
GNDNHQSTSTIVDYLCRSGEPPVYVDIPHVNHNSGERLQSYIDTMRATGLEPVVLKAAGDYSWDFERIGHEWMDRTLETG
GLPARTLLCANDRLAFGVMAAAFSRGLKIGRRADCDFRVAAHDDHPLSRYTCPALTTMAQDFAAMAGRSVEILLALLDEA
DPPGQGLVRNVKLGATLVMRQSA

Specific function: Negative regulator of scrB expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=326, Percent_Identity=26.6871165644172, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1790194, Length=311, Percent_Identity=25.4019292604502, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1786268, Length=331, Percent_Identity=28.0966767371601, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1786540, Length=340, Percent_Identity=26.7647058823529, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1789202, Length=306, Percent_Identity=25.1633986928105, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1789068, Length=325, Percent_Identity=24.6153846153846, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1787948, Length=321, Percent_Identity=25.5451713395639, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI48994940, Length=321, Percent_Identity=23.6760124610592, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788474, Length=315, Percent_Identity=23.1746031746032, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790689, Length=324, Percent_Identity=23.4567901234568, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1790715, Length=325, Percent_Identity=23.0769230769231, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1787580, Length=217, Percent_Identity=25.8064516129032, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1787906, Length=218, Percent_Identity=26.605504587156, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 37936; Mature: 37804

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEKTHRTMDDFARASGVSRPTLSKYFDDPASVKPATRARIEAALRSSDYQPNVFARNLN
CCCHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHCCC
RKRTRNVGIVVPALTDPFYAEMVSRIELRCRDEGFWPIVISSHGSPKLEAESVRTLMSLK
HHHCCCCCEEEECCCCHHHHHHHHHHHHEECCCCCEEEEEECCCCCCCCHHHHHHHHHHH
VAGAIVAPLGLVSEPGVFERMSEDIPIVYFDTYIEGDTPFVGNDNHQSTSTIVDYLCRSG
HHHHHHHHHCCCCCCCHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCC
EPPVYVDIPHVNHNSGERLQSYIDTMRATGLEPVVLKAAGDYSWDFERIGHEWMDRTLET
CCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHC
GGLPARTLLCANDRLAFGVMAAAFSRGLKIGRRADCDFRVAAHDDHPLSRYTCPALTTMA
CCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCHHCCHHHHHHH
QDFAAMAGRSVEILLALLDEADPPGQGLVRNVKLGATLVMRQSA
HHHHHHCCCHHHHHHHHHHCCCCCCCCCEEEEECCEEEEEECCC
>Mature Secondary Structure 
AEKTHRTMDDFARASGVSRPTLSKYFDDPASVKPATRARIEAALRSSDYQPNVFARNLN
CCHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHCCC
RKRTRNVGIVVPALTDPFYAEMVSRIELRCRDEGFWPIVISSHGSPKLEAESVRTLMSLK
HHHCCCCCEEEECCCCHHHHHHHHHHHHEECCCCCEEEEEECCCCCCCCHHHHHHHHHHH
VAGAIVAPLGLVSEPGVFERMSEDIPIVYFDTYIEGDTPFVGNDNHQSTSTIVDYLCRSG
HHHHHHHHHCCCCCCCHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCC
EPPVYVDIPHVNHNSGERLQSYIDTMRATGLEPVVLKAAGDYSWDFERIGHEWMDRTLET
CCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHC
GGLPARTLLCANDRLAFGVMAAAFSRGLKIGRRADCDFRVAAHDDHPLSRYTCPALTTMA
CCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCHHCCHHHHHHH
QDFAAMAGRSVEILLALLDEADPPGQGLVRNVKLGATLVMRQSA
HHHHHHCCCHHHHHHHHHHCCCCCCCCCEEEEECCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA