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The map label for this gene is livH [H]

Identifier: 13475975

GI number: 13475975

Start: 5924973

End: 5925881

Strand: Reverse

Name: livH [H]

Synonym: mll7173

Alternate gene names: 13475975

Gene position: 5925881-5924973 (Counterclockwise)

Preceding gene: 13475976

Following gene: 13475974

Centisome position: 84.22

GC content: 65.9

Gene sequence:

>909_bases
ATGAGCCTGCAATTTGTCGTCGATGGATTGCTGACGGGTTCGATGATCGGCCTTGGCGCCATTGGCGTGACGCTGACCTA
TTCGATCCTGCGCTTCTCGAATTTTGCCCATGGCGACTTCATGGCCTGGGGCACCTATGCGACGCTCGCCGTCGTCAGCG
CCATTGGTGCCACCTTCGGCAAGGTAGCACCCATCGCGCCGCTGTCCTTCGGCTGGCCGCTCCTGGTTGCGCTGGTCGTC
GGCATGGCCTTCACCGCCTTGCTGGCCCTGCTGCTCGACAGAGTGCTGTTCTCGCGGCTGCGCTCCCAGGGCCAGGCGAT
TATCGTGGTGATGGCGAGCTTCGGTGCCTCGATGGCGTTGAGGAGCCTGCTCGAATTCACCTTCAGCTCGCGGCCGACCT
ATTTCAGCCGGGCGATCCAGATTGCCATGCCGGTCGGCTTCGGCATCCGCGTCACCCCCGACCAGATCGCGCTTCTGCTG
CTGACCACGGTGCTGGTGCTCGGCGTGCATCTGTTGATGACGCGCACGCAGACCGGCCGCGCCATGCAGGCGCTCAGCCA
GAACGCGGCGCTGGCCCGCATCGTCGGCATCGACGTCGCCAGCGTCGTGCGCGTCACCTGGATCATCGGCGGCGCGCTCG
CCTGCGTCGCCGGCGTGATGATCGGCATCCTGGTGCAGATCCGTCCGTTCATGGGCTTCGACATGCTGCTGCCGATGTTC
GCCGCCGCCATCCTCGGCGGCATCGGCAGCATTCCGGGTGCGGTGCTCGGCGGGCTGATCATCGGGCTCGCCGAGGCCGG
CGCGGTGCAGCTGATCGGCGCCGAATGGCGCGCCGCCGTCTCCTTCATCATCCTGATGGCGGTGCTGTTCGTGCGGCCGA
TCGGCCTTTTCGGAGTTCGGGAAAGATGA

Upstream 100 bases:

>100_bases
ACCGGCACGAGGGCGTCGCTTCCGAACTGTGGAACGATCCTGTGGTCGCCGAACTCTATCTCGGCCAACGCCCTTCCCGC
GCCAGCAAGGGAGGCGCGGC

Downstream 100 bases:

>100_bases
TCGATCTCATCGGCTACGGCGCCTTCTTCCTGACCACCGCGCTGATCTTTTCGCTGGTCACGCTGGGGCTCAATCTGCAG
TGGGGGCTGACCGGCCTGTT

Product: ABC transporter, permease protein

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MSLQFVVDGLLTGSMIGLGAIGVTLTYSILRFSNFAHGDFMAWGTYATLAVVSAIGATFGKVAPIAPLSFGWPLLVALVV
GMAFTALLALLLDRVLFSRLRSQGQAIIVVMASFGASMALRSLLEFTFSSRPTYFSRAIQIAMPVGFGIRVTPDQIALLL
LTTVLVLGVHLLMTRTQTGRAMQALSQNAALARIVGIDVASVVRVTWIIGGALACVAGVMIGILVQIRPFMGFDMLLPMF
AAAILGGIGSIPGAVLGGLIIGLAEAGAVQLIGAEWRAAVSFIILMAVLFVRPIGLFGVRER

Sequences:

>Translated_302_residues
MSLQFVVDGLLTGSMIGLGAIGVTLTYSILRFSNFAHGDFMAWGTYATLAVVSAIGATFGKVAPIAPLSFGWPLLVALVV
GMAFTALLALLLDRVLFSRLRSQGQAIIVVMASFGASMALRSLLEFTFSSRPTYFSRAIQIAMPVGFGIRVTPDQIALLL
LTTVLVLGVHLLMTRTQTGRAMQALSQNAALARIVGIDVASVVRVTWIIGGALACVAGVMIGILVQIRPFMGFDMLLPMF
AAAILGGIGSIPGAVLGGLIIGLAEAGAVQLIGAEWRAAVSFIILMAVLFVRPIGLFGVRER
>Mature_301_residues
SLQFVVDGLLTGSMIGLGAIGVTLTYSILRFSNFAHGDFMAWGTYATLAVVSAIGATFGKVAPIAPLSFGWPLLVALVVG
MAFTALLALLLDRVLFSRLRSQGQAIIVVMASFGASMALRSLLEFTFSSRPTYFSRAIQIAMPVGFGIRVTPDQIALLLL
TTVLVLGVHLLMTRTQTGRAMQALSQNAALARIVGIDVASVVRVTWIIGGALACVAGVMIGILVQIRPFMGFDMLLPMFA
AAILGGIGSIPGAVLGGLIIGLAEAGAVQLIGAEWRAAVSFIILMAVLFVRPIGLFGVRER

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=305, Percent_Identity=32.1311475409836, Blast_Score=127, Evalue=7e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 31697; Mature: 31566

Theoretical pI: Translated: 11.67; Mature: 11.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLQFVVDGLLTGSMIGLGAIGVTLTYSILRFSNFAHGDFMAWGTYATLAVVSAIGATFG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
KVAPIAPLSFGWPLLVALVVGMAFTALLALLLDRVLFSRLRSQGQAIIVVMASFGASMAL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHCHHHHH
RSLLEFTFSSRPTYFSRAIQIAMPVGFGIRVTPDQIALLLLTTVLVLGVHLLMTRTQTGR
HHHHHHHHCCCCHHHHHHHHHHCCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHCCCCHH
AMQALSQNAALARIVGIDVASVVRVTWIIGGALACVAGVMIGILVQIRPFMGFDMLLPMF
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
AAAILGGIGSIPGAVLGGLIIGLAEAGAVQLIGAEWRAAVSFIILMAVLFVRPIGLFGVR
HHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHCCHHCCCCC
ER
CC
>Mature Secondary Structure 
SLQFVVDGLLTGSMIGLGAIGVTLTYSILRFSNFAHGDFMAWGTYATLAVVSAIGATFG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
KVAPIAPLSFGWPLLVALVVGMAFTALLALLLDRVLFSRLRSQGQAIIVVMASFGASMAL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHCHHHHH
RSLLEFTFSSRPTYFSRAIQIAMPVGFGIRVTPDQIALLLLTTVLVLGVHLLMTRTQTGR
HHHHHHHHCCCCHHHHHHHHHHCCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHCCCCHH
AMQALSQNAALARIVGIDVASVVRVTWIIGGALACVAGVMIGILVQIRPFMGFDMLLPMF
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
AAAILGGIGSIPGAVLGGLIIGLAEAGAVQLIGAEWRAAVSFIILMAVLFVRPIGLFGVR
HHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHCCHHCCCCC
ER
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]