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The map label for this gene is hisC1

Identifier: 13475919

GI number: 13475919

Start: 5862865

End: 5863968

Strand: Reverse

Name: hisC1

Synonym: mll7105

Alternate gene names: 13475919

Gene position: 5863968-5862865 (Counterclockwise)

Preceding gene: 13475928

Following gene: 13475918

Centisome position: 83.34

GC content: 63.22

Gene sequence:

>1104_bases
GTGTCGAAAGCTTCAGACATGGTCCGAACCGAAGTCACGCGCCCGTCGCCTTACAATTCCGGGCTGACCATCACCGAGGT
CATGCAACGATATGCTCCGGCCAGGATCGCCAAGCTGGGCTCGAATGAAAACCCGCTCGGCCCGAGCCCGACGCTGGCCA
CGATGCTGCAGGCCGGCGCCGAGATGTTCCGGCTCTATCCGGATCCGGCCGGGCGCGAACTGCGCCAGGCGATCGCCGCC
AAATATGGATTCGGTGAGGACCAAATCATCCTCGGCAATGGCTCGGAGGACCTTCTCTCCGTCATCAGCCGTGCCGTGTT
AAGGCCCGGCGATTCCGTCGTCACGCTCTATCCATCATTCCCGCTGCACGAGGACTACGCGACGCTGATGGGCGCGAGCG
TCAAACGAGTGACCGTCAACGACGACCTCACCATCAATGCCGACGCCCTGATCGACGCGGTGCGCGAGCGGCCCCGCATG
CTGCTGTTCTCCAACCCGATGAACCCGGTCGGCAGCTGGCTGTCCGCCGGCGACCTGTCGAAGGTTCTGGATGCGGTCAG
CGACGAGACGCTGATCGTCGTCGACGAAGCCTATGCCGAATATGCGGAAGGCGACGACTATGCCTCGTCGCTGCCTGACC
TCTGCGAACGCGACCAGCCCTGGATTGTGCTGCGGACATTTTCCAAAGCGTTCGGGCTTGCCGGGTTGCGGATCGGCTTC
GGCATTGTCGGCGACCCGGAATTGCGCGCCCTGCTCGACAGGGTGCGCACACCGTTCAACGCCAATGGCATGGCGCAGGC
GGCCGCACTGGCGGCACTCGCGGATGAGGAACACCTCGCGAAGGTCGTCGCGCTGGCCAAGGCGGAAAGAACGCAGGTCG
AGAGTCTCCTCAGGAACATGGGCTTCGACGTCGCCCCTTCCCGCGGCAATTTCCTGTTTTTCAACTGCCGGCAAAATGCC
TCCGCCTTCGCCGAGGGCCTGCTGCGCGAAGGCGTCATCGTCAAACCCTGGAAGCAGGAAGGTTTTGACAGCTATGTGCG
TGTCAGCATCGGCTCGCCAGCGGAGAACGACCACTTCATGGCCGCGCTGTCGCAGCTGTTGTGA

Upstream 100 bases:

>100_bases
CTGTCAATGACCTGACTCACCCCGGGAACGATGCAGCGAAACCCAGTGATTGAGAACCCGTCGACGGGAGTCCGTCGGCC
GACCGCAGAGGAGCCCGCTC

Downstream 100 bases:

>100_bases
TTTCCCGAAAGCCATGCTGAATTGCCTGAAGCGCACCGGGCACGATATTGGACGGTCTGCCGTTCCCAATATGGAGTTTT
CGCAGGTGGCGCATCCCCTT

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 1

Number of amino acids: Translated: 367; Mature: 366

Protein sequence:

>367_residues
MSKASDMVRTEVTRPSPYNSGLTITEVMQRYAPARIAKLGSNENPLGPSPTLATMLQAGAEMFRLYPDPAGRELRQAIAA
KYGFGEDQIILGNGSEDLLSVISRAVLRPGDSVVTLYPSFPLHEDYATLMGASVKRVTVNDDLTINADALIDAVRERPRM
LLFSNPMNPVGSWLSAGDLSKVLDAVSDETLIVVDEAYAEYAEGDDYASSLPDLCERDQPWIVLRTFSKAFGLAGLRIGF
GIVGDPELRALLDRVRTPFNANGMAQAAALAALADEEHLAKVVALAKAERTQVESLLRNMGFDVAPSRGNFLFFNCRQNA
SAFAEGLLREGVIVKPWKQEGFDSYVRVSIGSPAENDHFMAALSQLL

Sequences:

>Translated_367_residues
MSKASDMVRTEVTRPSPYNSGLTITEVMQRYAPARIAKLGSNENPLGPSPTLATMLQAGAEMFRLYPDPAGRELRQAIAA
KYGFGEDQIILGNGSEDLLSVISRAVLRPGDSVVTLYPSFPLHEDYATLMGASVKRVTVNDDLTINADALIDAVRERPRM
LLFSNPMNPVGSWLSAGDLSKVLDAVSDETLIVVDEAYAEYAEGDDYASSLPDLCERDQPWIVLRTFSKAFGLAGLRIGF
GIVGDPELRALLDRVRTPFNANGMAQAAALAALADEEHLAKVVALAKAERTQVESLLRNMGFDVAPSRGNFLFFNCRQNA
SAFAEGLLREGVIVKPWKQEGFDSYVRVSIGSPAENDHFMAALSQLL
>Mature_366_residues
SKASDMVRTEVTRPSPYNSGLTITEVMQRYAPARIAKLGSNENPLGPSPTLATMLQAGAEMFRLYPDPAGRELRQAIAAK
YGFGEDQIILGNGSEDLLSVISRAVLRPGDSVVTLYPSFPLHEDYATLMGASVKRVTVNDDLTINADALIDAVRERPRML
LFSNPMNPVGSWLSAGDLSKVLDAVSDETLIVVDEAYAEYAEGDDYASSLPDLCERDQPWIVLRTFSKAFGLAGLRIGFG
IVGDPELRALLDRVRTPFNANGMAQAAALAALADEEHLAKVVALAKAERTQVESLLRNMGFDVAPSRGNFLFFNCRQNAS
AFAEGLLREGVIVKPWKQEGFDSYVRVSIGSPAENDHFMAALSQLL

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=366, Percent_Identity=24.0437158469945, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788722, Length=214, Percent_Identity=28.9719626168224, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1786816, Length=279, Percent_Identity=23.6559139784946, Blast_Score=71, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322075, Length=397, Percent_Identity=25.9445843828715, Blast_Score=107, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS81_RHILO (Q987C8)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_107489.1
- ProteinModelPortal:   Q987C8
- GeneID:   1230144
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mll7105
- NMPDR:   fig|266835.1.peg.5590
- HOGENOM:   HBG646350
- OMA:   VIVKPWK
- ProtClustDB:   PRK05166
- BRENDA:   2.6.1.9
- HAMAP:   MF_01023
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 39890; Mature: 39759

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKASDMVRTEVTRPSPYNSGLTITEVMQRYAPARIAKLGSNENPLGPSPTLATMLQAGA
CCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHCHHHHHHCCCCCCCCCCCHHHHHHHHHHH
EMFRLYPDPAGRELRQAIAAKYGFGEDQIILGNGSEDLLSVISRAVLRPGDSVVTLYPSF
HHEEECCCCCCHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEECCCC
PLHEDYATLMGASVKRVTVNDDLTINADALIDAVRERPRMLLFSNPMNPVGSWLSAGDLS
CCCHHHHHHHCCCEEEEEECCCCEECHHHHHHHHHHCCCEEEEECCCCHHHHHHHHCHHH
KVLDAVSDETLIVVDEAYAEYAEGDDYASSLPDLCERDQPWIVLRTFSKAFGLAGLRIGF
HHHHHHCCCEEEEEEHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEEHHHHHCCCHHHHCC
GIVGDPELRALLDRVRTPFNANGMAQAAALAALADEEHLAKVVALAKAERTQVESLLRNM
CCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHC
GFDVAPSRGNFLFFNCRQNASAFAEGLLREGVIVKPWKQEGFDSYVRVSIGSPAENDHFM
CCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCEECCHHHCCCCCEEEEEECCCCCCHHHH
AALSQLL
HHHHHHC
>Mature Secondary Structure 
SKASDMVRTEVTRPSPYNSGLTITEVMQRYAPARIAKLGSNENPLGPSPTLATMLQAGA
CCHHHHHHHHCCCCCCCCCCCCHHHHHHHHCHHHHHHCCCCCCCCCCCHHHHHHHHHHH
EMFRLYPDPAGRELRQAIAAKYGFGEDQIILGNGSEDLLSVISRAVLRPGDSVVTLYPSF
HHEEECCCCCCHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEECCCC
PLHEDYATLMGASVKRVTVNDDLTINADALIDAVRERPRMLLFSNPMNPVGSWLSAGDLS
CCCHHHHHHHCCCEEEEEECCCCEECHHHHHHHHHHCCCEEEEECCCCHHHHHHHHCHHH
KVLDAVSDETLIVVDEAYAEYAEGDDYASSLPDLCERDQPWIVLRTFSKAFGLAGLRIGF
HHHHHHCCCEEEEEEHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEEHHHHHCCCHHHHCC
GIVGDPELRALLDRVRTPFNANGMAQAAALAALADEEHLAKVVALAKAERTQVESLLRNM
CCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHC
GFDVAPSRGNFLFFNCRQNASAFAEGLLREGVIVKPWKQEGFDSYVRVSIGSPAENDHFM
CCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCEECCHHHCCCCCEEEEEECCCCCCHHHH
AALSQLL
HHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968