Click here to switch to the map view.

The map label for this gene is gabT [C]

Identifier: 13475861

GI number: 13475861

Start: 5802792

End: 5804165

Strand: Reverse

Name: gabT [C]

Synonym: mll7037

Alternate gene names: 13475861

Gene position: 5804165-5802792 (Counterclockwise)

Preceding gene: 13475862

Following gene: 13475860

Centisome position: 82.49

GC content: 65.72

Gene sequence:

>1374_bases
ATGCTCGCCAATTCCCTGATCGAACTCGACCGCGCCCATCTCATTCATCCGGTCTCCTCATATCGCGGCCATGAGGCGCT
CGGCGTGCGTGTGCTGAAATCGGCCAAGGGCGCGACCGTGACCGAAGCGTCCGGCCGGCAACTCGTCGACGGCTTCGCGG
GACTGTGGTGCGTCAACGCCGGTTACGGCCACGACAGCATCGTCGAGGCGGCCGCCCGGCAGATGCGCGAGCTTCCCTAC
GCCACCGCCTATTTCGACCTCGGCGCGGAGCCGGCCATCCGGCTCGCTTCGGAGCTGGCCGAGCGCGCGCCCGGGGATCT
CAATCATGTCTTTTTCACGCTTGGCGGATCCGACGCGGTCGACAGCACGGTCCGTTTCGTTCGCTACTACTGGAATGCCA
GGGGCGCGCCGAAACGCGACCAGTTCATTTCCATCGAACAGGGCTATCATGGGTCGTCGGTGGTCGGCGCGGGCCTGACT
GCCCTGCCCGCCTTTCACGCCGGTTTCGGCATTCCTTTCGAATGGCAGCACAAGATCCCGTCCCCCTACCCCTATCGCAA
CCCGGTCGGCGAGGACGCCAACGCGATCATTGCCGCATCGCTCGCCGCGCTGAAGGCCAAGATCGAAGAGCTCGGACCGG
AGCGGGTCGCCGCCTTCTATGCCGAGCCGATCCAGGGCTCGGGCGGCGTCATCGTCCCGCCGAAAGGCTGGATCAAGGCC
ATGCGCGAACTCTGCCGGGAGTACGGCATCCTGTTCATCGCCGACGAGGTGATCACTGGCTTCGGTCGCACGGGGCCGCT
GTTCGCCTGCACGGACGAGGAGATCGTTCCCGATTTCATGACGACCGCGAAAGGGCTGACCTCGGGCTATGTTCCCATGG
GCGCCGTGTTCATGGCCGATCATGTCTACGACGTCATTGCCGATGGCGCGGGCGCTTCGTCCGTCGGCCACGGCTACACC
TATTCCGCGCACCCCGTCAGCGCTGCCGTCGCGCTCGAGGTGTTGAAGCTCTACGAAGACGGCCTGTTGGAGAATGGCAT
CAAGGCCGGCGCCCGCCTGATGGCAGGGTTGTCCGGCCTGAGCGATCATCCGCTGGTCGGGGACGTGCGCGGCCGCGGCA
TGCTAGCCGCCATCGAGCTCGTGGTCGACAAGGAGAAGAAGACGCCGCTTCCGGCGTCGGCGATGCCGGCACGGCGCATC
TTCGACCGGGCGTGGGACAACGGCCTGATCATCCGCGCTTTTGCCAATGGGGTTCTTGGTTATGCTCCCCCGCTCTGCTG
CACCGACGCCGACATCGATGCGATCATCGAGCGCACACGCCGGACGCTCGACCAGACGCTGGCGGATCCCGATGTCCGCC
AGGCTCTGGCATGA

Upstream 100 bases:

>100_bases
GCGTGACCATGGACCGTCCGCCCGGGAAGAGCGCGGAACAGGCCAGGCCGAAAGTTTACGCACTCGCCAACCAGGCGCTC
GGCTAGTCCGGAGGATAACA

Downstream 100 bases:

>100_bases
CGGCGGCGAAATATGTCGTGTCTCGAAATATCGCCGGGGCGGACGATTTCGCAATTTTGTGCCGCCTCCTCACGCCTTTT
CGGCGAATCCAGCGCGGGGG

Product: hypothetical protein

Products: L-Glutamate; Succinic semialdehyde [C]

Alternate protein names: NA

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MLANSLIELDRAHLIHPVSSYRGHEALGVRVLKSAKGATVTEASGRQLVDGFAGLWCVNAGYGHDSIVEAAARQMRELPY
ATAYFDLGAEPAIRLASELAERAPGDLNHVFFTLGGSDAVDSTVRFVRYYWNARGAPKRDQFISIEQGYHGSSVVGAGLT
ALPAFHAGFGIPFEWQHKIPSPYPYRNPVGEDANAIIAASLAALKAKIEELGPERVAAFYAEPIQGSGGVIVPPKGWIKA
MRELCREYGILFIADEVITGFGRTGPLFACTDEEIVPDFMTTAKGLTSGYVPMGAVFMADHVYDVIADGAGASSVGHGYT
YSAHPVSAAVALEVLKLYEDGLLENGIKAGARLMAGLSGLSDHPLVGDVRGRGMLAAIELVVDKEKKTPLPASAMPARRI
FDRAWDNGLIIRAFANGVLGYAPPLCCTDADIDAIIERTRRTLDQTLADPDVRQALA

Sequences:

>Translated_457_residues
MLANSLIELDRAHLIHPVSSYRGHEALGVRVLKSAKGATVTEASGRQLVDGFAGLWCVNAGYGHDSIVEAAARQMRELPY
ATAYFDLGAEPAIRLASELAERAPGDLNHVFFTLGGSDAVDSTVRFVRYYWNARGAPKRDQFISIEQGYHGSSVVGAGLT
ALPAFHAGFGIPFEWQHKIPSPYPYRNPVGEDANAIIAASLAALKAKIEELGPERVAAFYAEPIQGSGGVIVPPKGWIKA
MRELCREYGILFIADEVITGFGRTGPLFACTDEEIVPDFMTTAKGLTSGYVPMGAVFMADHVYDVIADGAGASSVGHGYT
YSAHPVSAAVALEVLKLYEDGLLENGIKAGARLMAGLSGLSDHPLVGDVRGRGMLAAIELVVDKEKKTPLPASAMPARRI
FDRAWDNGLIIRAFANGVLGYAPPLCCTDADIDAIIERTRRTLDQTLADPDVRQALA
>Mature_457_residues
MLANSLIELDRAHLIHPVSSYRGHEALGVRVLKSAKGATVTEASGRQLVDGFAGLWCVNAGYGHDSIVEAAARQMRELPY
ATAYFDLGAEPAIRLASELAERAPGDLNHVFFTLGGSDAVDSTVRFVRYYWNARGAPKRDQFISIEQGYHGSSVVGAGLT
ALPAFHAGFGIPFEWQHKIPSPYPYRNPVGEDANAIIAASLAALKAKIEELGPERVAAFYAEPIQGSGGVIVPPKGWIKA
MRELCREYGILFIADEVITGFGRTGPLFACTDEEIVPDFMTTAKGLTSGYVPMGAVFMADHVYDVIADGAGASSVGHGYT
YSAHPVSAAVALEVLKLYEDGLLENGIKAGARLMAGLSGLSDHPLVGDVRGRGMLAAIELVVDKEKKTPLPASAMPARRI
FDRAWDNGLIIRAFANGVLGYAPPLCCTDADIDAIIERTRRTLDQTLADPDVRQALA

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI37574042, Length=409, Percent_Identity=31.7848410757946, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI226442709, Length=394, Percent_Identity=31.9796954314721, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI13994255, Length=468, Percent_Identity=28.2051282051282, Blast_Score=155, Evalue=9e-38,
Organism=Homo sapiens, GI226442705, Length=405, Percent_Identity=31.8518518518519, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI24119277, Length=431, Percent_Identity=27.8422273781903, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI4557809, Length=418, Percent_Identity=29.9043062200957, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI284507298, Length=331, Percent_Identity=31.7220543806647, Blast_Score=127, Evalue=3e-29,
Organism=Escherichia coli, GI1789016, Length=437, Percent_Identity=32.0366132723112, Blast_Score=182, Evalue=3e-47,
Organism=Escherichia coli, GI145693181, Length=411, Percent_Identity=30.6569343065693, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI1786991, Length=427, Percent_Identity=30.4449648711944, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1787560, Length=426, Percent_Identity=32.6291079812207, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1789759, Length=405, Percent_Identity=27.4074074074074, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1788044, Length=406, Percent_Identity=27.5862068965517, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1786349, Length=432, Percent_Identity=25.6944444444444, Blast_Score=82, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI32564660, Length=436, Percent_Identity=31.4220183486239, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI25144271, Length=408, Percent_Identity=27.9411764705882, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI71992977, Length=433, Percent_Identity=28.8683602771363, Blast_Score=142, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI25144274, Length=299, Percent_Identity=31.438127090301, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17541228, Length=472, Percent_Identity=26.271186440678, Blast_Score=89, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6323470, Length=424, Percent_Identity=25.9433962264151, Blast_Score=130, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6324386, Length=470, Percent_Identity=26.1702127659574, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6324432, Length=430, Percent_Identity=22.5581395348837, Blast_Score=103, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6321456, Length=371, Percent_Identity=23.989218328841, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28574759, Length=442, Percent_Identity=31.447963800905, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI161085790, Length=425, Percent_Identity=32.2352941176471, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI21357415, Length=417, Percent_Identity=29.2565947242206, Blast_Score=145, Evalue=8e-35,
Organism=Drosophila melanogaster, GI21356575, Length=429, Percent_Identity=27.7389277389277, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI281366494, Length=383, Percent_Identity=25.3263707571802, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24667139, Length=383, Percent_Identity=25.3263707571802, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24667143, Length=383, Percent_Identity=25.3263707571802, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: 2.6.1.19 [C]

Molecular weight: Translated: 48867; Mature: 48867

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLANSLIELDRAHLIHPVSSYRGHEALGVRVLKSAKGATVTEASGRQLVDGFAGLWCVNA
CCCHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHEEEEC
GYGHDSIVEAAARQMRELPYATAYFDLGAEPAIRLASELAERAPGDLNHVFFTLGGSDAV
CCCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCHHH
DSTVRFVRYYWNARGAPKRDQFISIEQGYHGSSVVGAGLTALPAFHAGFGIPFEWQHKIP
HHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCHHHHCCHHHHHHHHHCCCCCCCCCCCCC
SPYPYRNPVGEDANAIIAASLAALKAKIEELGPERVAAFYAEPIQGSGGVIVPPKGWIKA
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCEEECCHHHHHH
MRELCREYGILFIADEVITGFGRTGPLFACTDEEIVPDFMTTAKGLTSGYVPMGAVFMAD
HHHHHHHCCEEEEEHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHH
HVYDVIADGAGASSVGHGYTYSAHPVSAAVALEVLKLYEDGLLENGIKAGARLMAGLSGL
HHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SDHPLVGDVRGRGMLAAIELVVDKEKKTPLPASAMPARRIFDRAWDNGLIIRAFANGVLG
CCCCCEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEHHCCHHH
YAPPLCCTDADIDAIIERTRRTLDQTLADPDVRQALA
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHCC
>Mature Secondary Structure
MLANSLIELDRAHLIHPVSSYRGHEALGVRVLKSAKGATVTEASGRQLVDGFAGLWCVNA
CCCHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHEEEEC
GYGHDSIVEAAARQMRELPYATAYFDLGAEPAIRLASELAERAPGDLNHVFFTLGGSDAV
CCCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCHHH
DSTVRFVRYYWNARGAPKRDQFISIEQGYHGSSVVGAGLTALPAFHAGFGIPFEWQHKIP
HHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCHHHHCCHHHHHHHHHCCCCCCCCCCCCC
SPYPYRNPVGEDANAIIAASLAALKAKIEELGPERVAAFYAEPIQGSGGVIVPPKGWIKA
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCEEECCHHHHHH
MRELCREYGILFIADEVITGFGRTGPLFACTDEEIVPDFMTTAKGLTSGYVPMGAVFMAD
HHHHHHHCCEEEEEHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHH
HVYDVIADGAGASSVGHGYTYSAHPVSAAVALEVLKLYEDGLLENGIKAGARLMAGLSGL
HHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SDHPLVGDVRGRGMLAAIELVVDKEKKTPLPASAMPARRIFDRAWDNGLIIRAFANGVLG
CCCCCEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEHHCCHHH
YAPPLCCTDADIDAIIERTRRTLDQTLADPDVRQALA
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Pyridoxal 5'-phosphate lysine-residue [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 3.3 {4-aminobutanoate}} 1.1 {4-aminobutanoate}} 1.3 {2-oxoglutarate}} 0.7 {2-oxoglutarate}} [C]

Substrates: 4-Aminobutanoate; 2-Oxoglutarate [C]

Specific reaction: 4-Aminobutanoate + 2-Oxoglutarate --> L-Glutamate + Succinic semialdehyde [C]

General reaction: Amino group transfer [C]

Inhibitor: 2-Oxoglutarate; Lysyl reagents; SH-group reagents [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8796346; 9163424 [H]