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The map label for this gene is 13475812

Identifier: 13475812

GI number: 13475812

Start: 5742864

End: 5743844

Strand: Reverse

Name: 13475812

Synonym: mll6982

Alternate gene names: NA

Gene position: 5743844-5742864 (Counterclockwise)

Preceding gene: 13475813

Following gene: 13475810

Centisome position: 81.63

GC content: 68.91

Gene sequence:

>981_bases
ATGAAGATCACCATTTTCGGCGCCGGCGCGATCGGCGGCTATCTCGCCGCCAAGCTGGCGATCGCCGGCCGCACCGACCT
GTCGATCGTCGCGCGCGGCGCGCATCTGGAAGCGATCCAGGCAAACGGCCTGCGCCTGATCGAGGACGGCGAGGAATCGA
TGGCGCCCGTCCGGGCCGCCGCCAAGGCCGAGGAACTTGGCGCCCAGGATTATGTGGTGCTGGCGCTGAAGGCCCATTCG
CTGACCCCCGCACTTGACCAGATCGCGCCGCTGCTCGGGGACCACACATCCGTCGTCACCATGCAGAACGGCGTGCCGTG
GTGGTATTTCCATGGAGTGGGCGGGCCGCTCGAAGGCACAAGGCTGAACGCGGTCGATCCCGGTGGCGCGATCTGGCAGC
GGATCGGGCCGCAGCGCGTCATCGGCTCGGTGGTCTATCCCGCCGTCGAGGTCGACGCGCCCGGCCTCATCCGCCATGTC
GAGGGCAAGCGCTTCTCGCTCGGCGAGCCCTCGGGCGAGCGCAGCGAACGGGTCACGCTTCTGGCGGAGGAGATGGTCAA
GGCCGGCCTGCAGGCGCCGGTGCGCGATGACATCCGCAGCGAAATCTGGGTGAAGCTGTGGGGCAACCTTTCCTTCAACC
CGATCTCGGCGCTGACCGGCTCGACGCTGGCCGCCATCGTCGCCGACGAAGGCACCCGCGCGCTCGCCCGCACGATGATG
CTCGAGGCGCAAGCGATCGGCGAAAGCCTCGGCGTGCGCTTTCCGATCGGGGTCGACCGCCGCATCAAGGGCGCCGGCGA
TGTCGGCGAGCACAAGACCTCGATGCTGCAGGACCTGGAACGCGGCCGGCCGATGGAGATCGACGCGCTGGTGAGCGCGG
TGCAGGAGCTTGGCCGGCTGGTGGACAAGCCGACGCCGACCATAGATGCGGTGCTGGCGCTGGTGCGGCGGCTCGCGGTG
GAGCGAGGCTGCTATTCCTGA

Upstream 100 bases:

>100_bases
TCAAGGTGCCGCGCAAGATCCTGATCCTGGACGAGATCCCCAAGGGCGCGACCGGCAAGCTGCAGCGCATCGGGCTCGCC
GCCAAACTCGGGCTTTGACG

Downstream 100 bases:

>100_bases
GACGGCAAGCGTCATCTCAGCATAAAGGCAGCGATGAATTCAACGCTCCACCATCTCCGCTTTAATGACTGGTTTTTCGA
CAAGCGGCCGGCTACGGCTT

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MKITIFGAGAIGGYLAAKLAIAGRTDLSIVARGAHLEAIQANGLRLIEDGEESMAPVRAAAKAEELGAQDYVVLALKAHS
LTPALDQIAPLLGDHTSVVTMQNGVPWWYFHGVGGPLEGTRLNAVDPGGAIWQRIGPQRVIGSVVYPAVEVDAPGLIRHV
EGKRFSLGEPSGERSERVTLLAEEMVKAGLQAPVRDDIRSEIWVKLWGNLSFNPISALTGSTLAAIVADEGTRALARTMM
LEAQAIGESLGVRFPIGVDRRIKGAGDVGEHKTSMLQDLERGRPMEIDALVSAVQELGRLVDKPTPTIDAVLALVRRLAV
ERGCYS

Sequences:

>Translated_326_residues
MKITIFGAGAIGGYLAAKLAIAGRTDLSIVARGAHLEAIQANGLRLIEDGEESMAPVRAAAKAEELGAQDYVVLALKAHS
LTPALDQIAPLLGDHTSVVTMQNGVPWWYFHGVGGPLEGTRLNAVDPGGAIWQRIGPQRVIGSVVYPAVEVDAPGLIRHV
EGKRFSLGEPSGERSERVTLLAEEMVKAGLQAPVRDDIRSEIWVKLWGNLSFNPISALTGSTLAAIVADEGTRALARTMM
LEAQAIGESLGVRFPIGVDRRIKGAGDVGEHKTSMLQDLERGRPMEIDALVSAVQELGRLVDKPTPTIDAVLALVRRLAV
ERGCYS
>Mature_326_residues
MKITIFGAGAIGGYLAAKLAIAGRTDLSIVARGAHLEAIQANGLRLIEDGEESMAPVRAAAKAEELGAQDYVVLALKAHS
LTPALDQIAPLLGDHTSVVTMQNGVPWWYFHGVGGPLEGTRLNAVDPGGAIWQRIGPQRVIGSVVYPAVEVDAPGLIRHV
EGKRFSLGEPSGERSERVTLLAEEMVKAGLQAPVRDDIRSEIWVKLWGNLSFNPISALTGSTLAAIVADEGTRALARTMM
LEAQAIGESLGVRFPIGVDRRIKGAGDVGEHKTSMLQDLERGRPMEIDALVSAVQELGRLVDKPTPTIDAVLALVRRLAV
ERGCYS

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANE_RHILO (Q987N5)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_107382.1
- ProteinModelPortal:   Q987N5
- GeneID:   1230037
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mll6982
- NMPDR:   fig|266835.1.peg.5483
- HOGENOM:   HBG668370
- OMA:   VVQEMGR
- ProtClustDB:   PRK06522
- BRENDA:   1.1.1.169
- GO:   GO:0005737
- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21708:SF21
- TIGRFAMs:   TIGR00745

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C; SSF48179 6DGDH_C_like

EC number: =1.1.1.169

Molecular weight: Translated: 34712; Mature: 34712

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: NA

Important sites: ACT_SITE 205-205 BINDING 103-103 BINDING 103-103 BINDING 209-209 BINDING 213-213 BINDING 274-274 BINDING 286-286

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKITIFGAGAIGGYLAAKLAIAGRTDLSIVARGAHLEAIQANGLRLIEDGEESMAPVRAA
CEEEEEECCHHHHHHHHHHHHCCCCCCEEEECCCEEEEEECCCEEEEECCCHHHHHHHHH
AKAEELGAQDYVVLALKAHSLTPALDQIAPLLGDHTSVVTMQNGVPWWYFHGVGGPLEGT
HHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCEEEEECCCCCCCCC
RLNAVDPGGAIWQRIGPQRVIGSVVYPAVEVDAPGLIRHVEGKRFSLGEPSGERSERVTL
EECCCCCCHHHHHHCCHHHHHHHHHCCEEECCCCHHHEECCCCEEECCCCCCCCHHHHHH
LAEEMVKAGLQAPVRDDIRSEIWVKLWGNLSFNPISALTGSTLAAIVADEGTRALARTMM
HHHHHHHHCCCCCHHHHHHHHEEHHEECCCCCCHHHHHCCCCEEEEEECCCHHHHHHHHH
LEAQAIGESLGVRFPIGVDRRIKGAGDVGEHKTSMLQDLERGRPMEIDALVSAVQELGRL
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
VDKPTPTIDAVLALVRRLAVERGCYS
HCCCCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKITIFGAGAIGGYLAAKLAIAGRTDLSIVARGAHLEAIQANGLRLIEDGEESMAPVRAA
CEEEEEECCHHHHHHHHHHHHCCCCCCEEEECCCEEEEEECCCEEEEECCCHHHHHHHHH
AKAEELGAQDYVVLALKAHSLTPALDQIAPLLGDHTSVVTMQNGVPWWYFHGVGGPLEGT
HHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCEEEEECCCCCCCCC
RLNAVDPGGAIWQRIGPQRVIGSVVYPAVEVDAPGLIRHVEGKRFSLGEPSGERSERVTL
EECCCCCCHHHHHHCCHHHHHHHHHCCEEECCCCHHHEECCCCEEECCCCCCCCHHHHHH
LAEEMVKAGLQAPVRDDIRSEIWVKLWGNLSFNPISALTGSTLAAIVADEGTRALARTMM
HHHHHHHHCCCCCHHHHHHHHEEHHEECCCCCCHHHHHCCCCEEEEEECCCHHHHHHHHH
LEAQAIGESLGVRFPIGVDRRIKGAGDVGEHKTSMLQDLERGRPMEIDALVSAVQELGRL
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
VDKPTPTIDAVLALVRRLAVERGCYS
HCCCCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968