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The map label for this gene is aphA [H]

Identifier: 13475797

GI number: 13475797

Start: 5727449

End: 5728489

Strand: Direct

Name: aphA [H]

Synonym: mlr6968

Alternate gene names: 13475797

Gene position: 5727449-5728489 (Clockwise)

Preceding gene: 13475796

Following gene: 13475798

Centisome position: 81.4

GC content: 57.93

Gene sequence:

>1041_bases
ATGAAAACGATTTTCTCGCCGATACAGCTGAAACACCAGGGTCAATTTGAATTTTACAATGGCGCTGTTGTCGAGGGTTA
CGAGAACACATCGCGCGCAACGTTCATAACAAGCCGGATCGAGGAGGTGCGTCTCGGACCCGTTCTTAACCCACGGCCGC
AGTCCCTGGATACCGCCAAACGGATTCACTCACCTACCTATCTCGACTTCATAGCGTCAGCGTGGAGGCTTTGGCGGGAC
GCTGGACGGACGGGTACGGCTCTTCCCTACGCTTGGCCGGCGAGAGGCCGATACAAGGATGTAGCGCCAGACTCTATCGA
TGCCCAGCTGGGACAATATTCCATCGATGCCAGCACAGGGTTTGTTGAAGGCACCTGGGAAGCCGTCAAGGCTTCGCACG
ACAGCGCCCTGACCGCGGCAGATTTGATCATCGAGGGCGAACAGGCTTGTTTTGCCCTTTGCCGTCCGCCCGGCCATCAT
GCCGGAACCGATTTCAATGGCGGATACTGTTTCGTCAACAATGCTGCCGTCGCCGCGCAACGGCTGCTGGACGGTGGCGC
TTCGCGCGTGACCATTCTGGACATCGACTATCACCATGGCAACGGCACACAAGAGATATTCTACGCCCGCGGTGACGTTC
AGGTTGTCAGCCTGCACGCCGATCCCCGCAATGATTATCCGTTTTTTGCCGGCTATGCGGATGAACGAGGCTCCGGCAGC
GGAGAGGGGTTCAACATCAACATACCGCTTCCGCATGGCACCGATTGGGCGCAATGGGAGGGCGCACTTGACTTCGCGCT
TGGCAGCGTCCGGCAGTTTGGCCCTGACGTAGTCGTCATCTCCCATGGCGTTGACACCTTCGAGGGCGATCCGATTAGTC
GCTTCCGACTTTCCCACGACCATTTTCCGCTTATCGGCGCCCGCCTGGCAGGCCTTCAGACGAAAACCCTGTTCGTTCTG
GAAGGCGGCTATGCCGTCGAAGACGTCGGCATCAATGTTGTCGGGGTTCTTTCTGGCTATGAAGATGCCATCCGCCGCTG
A

Upstream 100 bases:

>100_bases
CTTGTCATTTGCATCTACGTCGTCAACCAGCGAACGAAGATCAATTGAGTTCTCACTTTCTCACATCCTGTCTTGTTACC
TGCAACGTGGGCAATGCTTT

Downstream 100 bases:

>100_bases
GCCAATGGCAAGAACGAACAACAATCTTACTGGAGCAAGCATGCAGTCCGACAACGCGTCGAAATTCTATATCGATGGAC
AATGGGTCATGCCAGGCGGT

Product: acetylpolyamine aminohydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MKTIFSPIQLKHQGQFEFYNGAVVEGYENTSRATFITSRIEEVRLGPVLNPRPQSLDTAKRIHSPTYLDFIASAWRLWRD
AGRTGTALPYAWPARGRYKDVAPDSIDAQLGQYSIDASTGFVEGTWEAVKASHDSALTAADLIIEGEQACFALCRPPGHH
AGTDFNGGYCFVNNAAVAAQRLLDGGASRVTILDIDYHHGNGTQEIFYARGDVQVVSLHADPRNDYPFFAGYADERGSGS
GEGFNINIPLPHGTDWAQWEGALDFALGSVRQFGPDVVVISHGVDTFEGDPISRFRLSHDHFPLIGARLAGLQTKTLFVL
EGGYAVEDVGINVVGVLSGYEDAIRR

Sequences:

>Translated_346_residues
MKTIFSPIQLKHQGQFEFYNGAVVEGYENTSRATFITSRIEEVRLGPVLNPRPQSLDTAKRIHSPTYLDFIASAWRLWRD
AGRTGTALPYAWPARGRYKDVAPDSIDAQLGQYSIDASTGFVEGTWEAVKASHDSALTAADLIIEGEQACFALCRPPGHH
AGTDFNGGYCFVNNAAVAAQRLLDGGASRVTILDIDYHHGNGTQEIFYARGDVQVVSLHADPRNDYPFFAGYADERGSGS
GEGFNINIPLPHGTDWAQWEGALDFALGSVRQFGPDVVVISHGVDTFEGDPISRFRLSHDHFPLIGARLAGLQTKTLFVL
EGGYAVEDVGINVVGVLSGYEDAIRR
>Mature_346_residues
MKTIFSPIQLKHQGQFEFYNGAVVEGYENTSRATFITSRIEEVRLGPVLNPRPQSLDTAKRIHSPTYLDFIASAWRLWRD
AGRTGTALPYAWPARGRYKDVAPDSIDAQLGQYSIDASTGFVEGTWEAVKASHDSALTAADLIIEGEQACFALCRPPGHH
AGTDFNGGYCFVNNAAVAAQRLLDGGASRVTILDIDYHHGNGTQEIFYARGDVQVVSLHADPRNDYPFFAGYADERGSGS
GEGFNINIPLPHGTDWAQWEGALDFALGSVRQFGPDVVVISHGVDTFEGDPISRFRLSHDHFPLIGARLAGLQTKTLFVL
EGGYAVEDVGINVVGVLSGYEDAIRR

Specific function: Acts on many types of acetylpolyamines has high affinity towards acetylputrescine, acetylcadaverine, acetylspermidine, and acetylspermine [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI30795204, Length=213, Percent_Identity=36.150234741784, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI30795202, Length=213, Percent_Identity=36.150234741784, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI17158039, Length=213, Percent_Identity=36.150234741784, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI148539870, Length=193, Percent_Identity=38.860103626943, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI169234807, Length=193, Percent_Identity=38.860103626943, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI153085395, Length=207, Percent_Identity=38.6473429951691, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI13128864, Length=191, Percent_Identity=35.6020942408377, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI8923769, Length=302, Percent_Identity=27.8145695364238, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI62750347, Length=235, Percent_Identity=32.3404255319149, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI62750349, Length=235, Percent_Identity=32.3404255319149, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI20070354, Length=238, Percent_Identity=31.0924369747899, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI13128860, Length=239, Percent_Identity=27.1966527196653, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI293336691, Length=207, Percent_Identity=27.536231884058, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI262073088, Length=173, Percent_Identity=29.4797687861272, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI13128862, Length=175, Percent_Identity=32, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI226529806, Length=236, Percent_Identity=29.2372881355932, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI262073092, Length=230, Percent_Identity=27.8260869565217, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17540334, Length=226, Percent_Identity=36.283185840708, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI193206283, Length=226, Percent_Identity=36.283185840708, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17540332, Length=226, Percent_Identity=36.283185840708, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI193209491, Length=335, Percent_Identity=27.4626865671642, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17508561, Length=288, Percent_Identity=26.0416666666667, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17537347, Length=218, Percent_Identity=29.3577981651376, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17561978, Length=259, Percent_Identity=26.6409266409266, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI25154020, Length=231, Percent_Identity=26.8398268398268, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI25154022, Length=231, Percent_Identity=26.8398268398268, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17534739, Length=173, Percent_Identity=28.9017341040462, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324307, Length=234, Percent_Identity=35.8974358974359, Blast_Score=119, Evalue=7e-28,
Organism=Saccharomyces cerevisiae, GI6323999, Length=237, Percent_Identity=25.7383966244726, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6321244, Length=143, Percent_Identity=31.4685314685315, Blast_Score=70, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6325325, Length=141, Percent_Identity=27.6595744680851, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24642144, Length=210, Percent_Identity=36.6666666666667, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24642146, Length=210, Percent_Identity=36.6666666666667, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24642142, Length=210, Percent_Identity=36.6666666666667, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI281360899, Length=222, Percent_Identity=35.1351351351351, Blast_Score=111, Evalue=6e-25,
Organism=Drosophila melanogaster, GI281360799, Length=197, Percent_Identity=37.5634517766497, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24641720, Length=197, Percent_Identity=37.5634517766497, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI281360801, Length=197, Percent_Identity=37.5634517766497, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24657891, Length=295, Percent_Identity=25.0847457627119, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24644244, Length=175, Percent_Identity=32.5714285714286, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 37748; Mature: 37748

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.3 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTIFSPIQLKHQGQFEFYNGAVVEGYENTSRATFITSRIEEVRLGPVLNPRPQSLDTAK
CCCCCCCEEEEECCCEEEECCEEEECCCCCCCEEEEHHHHHHHHCCCCCCCCCCCHHHHH
RIHSPTYLDFIASAWRLWRDAGRTGTALPYAWPARGRYKDVAPDSIDAQLGQYSIDASTG
HHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCEEECCCCC
FVEGTWEAVKASHDSALTAADLIIEGEQACFALCRPPGHHAGTDFNGGYCFVNNAAVAAQ
EECCCHHHHHCCCCCHHEEEEEEEECCHHEEEEECCCCCCCCCCCCCCEEEECCHHHHHH
RLLDGGASRVTILDIDYHHGNGTQEIFYARGDVQVVSLHADPRNDYPFFAGYADERGSGS
HHHCCCCCEEEEEEEEEECCCCCCEEEEEECCEEEEEEECCCCCCCCEEEECCCCCCCCC
GEGFNINIPLPHGTDWAQWEGALDFALGSVRQFGPDVVVISHGVDTFEGDPISRFRLSHD
CCCEEEEEECCCCCCHHHHCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHEEECCC
HFPLIGARLAGLQTKTLFVLEGGYAVEDVGINVVGVLSGYEDAIRR
CCCCHHHHHCCCEEEEEEEEECCEEEEECCEEEEEEECCCHHHHCC
>Mature Secondary Structure
MKTIFSPIQLKHQGQFEFYNGAVVEGYENTSRATFITSRIEEVRLGPVLNPRPQSLDTAK
CCCCCCCEEEEECCCEEEECCEEEECCCCCCCEEEEHHHHHHHHCCCCCCCCCCCHHHHH
RIHSPTYLDFIASAWRLWRDAGRTGTALPYAWPARGRYKDVAPDSIDAQLGQYSIDASTG
HHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCEEECCCCC
FVEGTWEAVKASHDSALTAADLIIEGEQACFALCRPPGHHAGTDFNGGYCFVNNAAVAAQ
EECCCHHHHHCCCCCHHEEEEEEEECCHHEEEEECCCCCCCCCCCCCCEEEECCHHHHHH
RLLDGGASRVTILDIDYHHGNGTQEIFYARGDVQVVSLHADPRNDYPFFAGYADERGSGS
HHHCCCCCEEEEEEEEEECCCCCCEEEEEECCEEEEEEECCCCCCCCEEEECCCCCCCCC
GEGFNINIPLPHGTDWAQWEGALDFALGSVRQFGPDVVVISHGVDTFEGDPISRFRLSHD
CCCEEEEEECCCCCCHHHHCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHEEECCC
HFPLIGARLAGLQTKTLFVLEGGYAVEDVGINVVGVLSGYEDAIRR
CCCCHHHHHCCCEEEEEEEEECCEEEEECCEEEEEEECCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8824626; 3207420 [H]