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The map label for this gene is uxuA

Identifier: 13475722

GI number: 13475722

Start: 5649067

End: 5650251

Strand: Direct

Name: uxuA

Synonym: mlr6866

Alternate gene names: 13475722

Gene position: 5649067-5650251 (Clockwise)

Preceding gene: 13475719

Following gene: 13475726

Centisome position: 80.29

GC content: 63.46

Gene sequence:

>1185_bases
ATGGAACAGTGCTGGCGCTGGTATGGTCCGGATGATCCGGTGACACTCGATCATGTCAGGCAGGCCGGCGCCACCGGCGT
TGTTTCGGCGCTTCACCACATCTATGATGGCAGGGCCTGGCCTGAGGCCGATGTGCTCGAGCGCAAACGGATCATCGAGG
CCGCCGGCCTGACATGGTCGGTAGTCGAGAGCATCCCGGTCCACAATTCCTTCAAGATCGGCGCGCCGGAACGCGAGCGC
TACGCCGGCTACTATCGCGACAGCATCCGCACGCTTGCCACGGCCGGCATCAAAACAATCTGCTACAATTTCATGCCGGT
GGTGGACTGGACGCGCACCGACCTCATGTATCGCCTGCCGACGACCGGCTATGCCTTGCGTTTCGACGCCGTCGATTTTG
CCGCCTATGATCTTTTCGTGCTGCAGCGCAAGGATGGCGCGGCCAGCTATACGCCGGCGCGGATCGCCGAAGCCGAGAAG
CGGCTGAAGGCGTTGACGTCGGAGCAGGTCGATCAGATCGAGCGCAACCTCATCGCCGGCCTGCCGGCAACCGAGCGCAA
ATATGACCGCGACAGTTTCCGCGAGGCGTTGGCGGAGTATGACGGAATCGGGCCGAAGGAGCTGCGCGACAACCTCGCCT
GGTTCCTGCGCGAGATCATTCCGGTCGCAGAAGAGGAGGGGGTGCGCATGTGCATCCATCCCGACGATCCGCCCTTTTCG
CTCTATGGCCTGCCCCGCGTCGTTTCGACCGCGCAGGATGCGCGCTTCATCCTCAACGCCGTCGACAGCCCGGCCAATGG
GCTGACCTTCTGCACCGGCTCCTACGGCACGCGCGCCGACAACGACATCGTCGCCATGGTCAAGGAATTCGCCGACCGCA
TCCATTTCGTCCACCTGCGCAACATCACCATCGAGGAGGACGGCTCGTTCTATGAAGCCGAGCATCTCGAGGGCGGCACC
GACATGGCGCATGTCATCCTGGCTCTGATGCAGGAGGAGGCACGCCGCCGCAAGGAGGGCCGCGCCGACTGGCGCATTCC
GATGCGGCCGGACCATGGCCATCTGCTCGCCGATGACATCGGCAAGAAGAAGATCAATCCCGGCTACTCGTTGATCGGCC
GGCTGAAAGGCCTCGCCGAACTGCGTGGCATCATGCGCGCCGTGGAGAAGTTCGGGCTGGCCTGA

Upstream 100 bases:

>100_bases
CAATTGGTGGGTCGTAAAAGGCCAGAATGCAGCCGATCTTAGCTTATTGACAGGCTCTTGGTCCAACAATATGGTCGCCG
CCTAACATTGAGGAGGCTTC

Downstream 100 bases:

>100_bases
TTAAATCTGTTGCCCAAGGTGTGTTGAGATTCAGGTCAGGCCGAGCCGAAAATGGTTGCTTTCGAGAACCGGAGCGGAGC
GGACATTCGGGTCCGTGAGC

Product: mannonate dehydratase

Products: NA

Alternate protein names: D-mannonate hydrolase

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MEQCWRWYGPDDPVTLDHVRQAGATGVVSALHHIYDGRAWPEADVLERKRIIEAAGLTWSVVESIPVHNSFKIGAPERER
YAGYYRDSIRTLATAGIKTICYNFMPVVDWTRTDLMYRLPTTGYALRFDAVDFAAYDLFVLQRKDGAASYTPARIAEAEK
RLKALTSEQVDQIERNLIAGLPATERKYDRDSFREALAEYDGIGPKELRDNLAWFLREIIPVAEEEGVRMCIHPDDPPFS
LYGLPRVVSTAQDARFILNAVDSPANGLTFCTGSYGTRADNDIVAMVKEFADRIHFVHLRNITIEEDGSFYEAEHLEGGT
DMAHVILALMQEEARRRKEGRADWRIPMRPDHGHLLADDIGKKKINPGYSLIGRLKGLAELRGIMRAVEKFGLA

Sequences:

>Translated_394_residues
MEQCWRWYGPDDPVTLDHVRQAGATGVVSALHHIYDGRAWPEADVLERKRIIEAAGLTWSVVESIPVHNSFKIGAPERER
YAGYYRDSIRTLATAGIKTICYNFMPVVDWTRTDLMYRLPTTGYALRFDAVDFAAYDLFVLQRKDGAASYTPARIAEAEK
RLKALTSEQVDQIERNLIAGLPATERKYDRDSFREALAEYDGIGPKELRDNLAWFLREIIPVAEEEGVRMCIHPDDPPFS
LYGLPRVVSTAQDARFILNAVDSPANGLTFCTGSYGTRADNDIVAMVKEFADRIHFVHLRNITIEEDGSFYEAEHLEGGT
DMAHVILALMQEEARRRKEGRADWRIPMRPDHGHLLADDIGKKKINPGYSLIGRLKGLAELRGIMRAVEKFGLA
>Mature_394_residues
MEQCWRWYGPDDPVTLDHVRQAGATGVVSALHHIYDGRAWPEADVLERKRIIEAAGLTWSVVESIPVHNSFKIGAPERER
YAGYYRDSIRTLATAGIKTICYNFMPVVDWTRTDLMYRLPTTGYALRFDAVDFAAYDLFVLQRKDGAASYTPARIAEAEK
RLKALTSEQVDQIERNLIAGLPATERKYDRDSFREALAEYDGIGPKELRDNLAWFLREIIPVAEEEGVRMCIHPDDPPFS
LYGLPRVVSTAQDARFILNAVDSPANGLTFCTGSYGTRADNDIVAMVKEFADRIHFVHLRNITIEEDGSFYEAEHLEGGT
DMAHVILALMQEEARRRKEGRADWRIPMRPDHGHLLADDIGKKKINPGYSLIGRLKGLAELRGIMRAVEKFGLA

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG1312

COG function: function code G; D-mannonate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannonate dehydratase family

Homologues:

Organism=Escherichia coli, GI1790778, Length=392, Percent_Identity=54.8469387755102, Blast_Score=446, Evalue=1e-126,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UXUA_RHILO (Q987X5)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_107289.1
- ProteinModelPortal:   Q987X5
- SMR:   Q987X5
- GeneID:   1229944
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mlr6866
- NMPDR:   fig|266835.1.peg.5390
- HOGENOM:   HBG585927
- OMA:   RPDHGHL
- ProtClustDB:   PRK03906
- BRENDA:   4.2.1.8
- HAMAP:   MF_00106
- InterPro:   IPR004628
- InterPro:   IPR013022
- Gene3D:   G3DSA:3.20.20.150
- PIRSF:   PIRSF016049
- TIGRFAMs:   TIGR00695

Pfam domain/function: PF03786 UxuA; SSF51658 Xyl_isomerase-like_TIM-brl

EC number: =4.2.1.8

Molecular weight: Translated: 44543; Mature: 44543

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQCWRWYGPDDPVTLDHVRQAGATGVVSALHHIYDGRAWPEADVLERKRIIEAAGLTWS
CCCCCCCCCCCCCEEHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHH
VVESIPVHNSFKIGAPERERYAGYYRDSIRTLATAGIKTICYNFMPVVDWTRTDLMYRLP
HHHHCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCEEEECC
TTGYALRFDAVDFAAYDLFVLQRKDGAASYTPARIAEAEKRLKALTSEQVDQIERNLIAG
CCCEEEEECCHHHHHHEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LPATERKYDRDSFREALAEYDGIGPKELRDNLAWFLREIIPVAEEEGVRMCIHPDDPPFS
CCCHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCEE
LYGLPRVVSTAQDARFILNAVDSPANGLTFCTGSYGTRADNDIVAMVKEFADRIHFVHLR
CCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHEEEEEE
NITIEEDGSFYEAEHLEGGTDMAHVILALMQEEARRRKEGRADWRIPMRPDHGHLLADDI
EEEEECCCCEEEHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEHHHH
GKKKINPGYSLIGRLKGLAELRGIMRAVEKFGLA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEQCWRWYGPDDPVTLDHVRQAGATGVVSALHHIYDGRAWPEADVLERKRIIEAAGLTWS
CCCCCCCCCCCCCEEHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHH
VVESIPVHNSFKIGAPERERYAGYYRDSIRTLATAGIKTICYNFMPVVDWTRTDLMYRLP
HHHHCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCEEEECC
TTGYALRFDAVDFAAYDLFVLQRKDGAASYTPARIAEAEKRLKALTSEQVDQIERNLIAG
CCCEEEEECCHHHHHHEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LPATERKYDRDSFREALAEYDGIGPKELRDNLAWFLREIIPVAEEEGVRMCIHPDDPPFS
CCCHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCEE
LYGLPRVVSTAQDARFILNAVDSPANGLTFCTGSYGTRADNDIVAMVKEFADRIHFVHLR
CCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHEEEEEE
NITIEEDGSFYEAEHLEGGTDMAHVILALMQEEARRRKEGRADWRIPMRPDHGHLLADDI
EEEEECCCCEEEHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEHHHH
GKKKINPGYSLIGRLKGLAELRGIMRAVEKFGLA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968