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The map label for this gene is hbd [H]

Identifier: 13475669

GI number: 13475669

Start: 5592558

End: 5593487

Strand: Direct

Name: hbd [H]

Synonym: mlr6793

Alternate gene names: 13475669

Gene position: 5592558-5593487 (Clockwise)

Preceding gene: 13475668

Following gene: 13475670

Centisome position: 79.48

GC content: 63.01

Gene sequence:

>930_bases
ATGATCCGAAATATCGCCATCATCGGCCTGGGTACGATGGGGCCGGGCATGGCCGCCCGGCTCGCCAGAGGCGGCCTGCA
GGTGGTCGCCTACGATGTTGCCCCGGCAGCGATAGAGCGCGCGCGATCCATGCTGAGCGTGGCCGAGACCGTTCTGGACG
CCTTGGGCATCGCGCTGCCGTCAGCTGGCGTCGGGACGGTTCGCTTCACCGACGATATCGGCGATGCGGTATCCGGTGCC
GACCTCGTCATCGAGAACGTTCCTGAAAACATCTCGATCAAGGCCGATGTCTATCGCACCATCGACGGCCTGATAGGCCA
GGATACGATCGTCGCGTCCGACACGTCGGGTATCCCGATCACCAAGTTGCAGGCGCATATCTCGTATCCCGAGCGGATGG
TGGGCATGCACTGGTCGAACCCGCCGCACATCATCCCGATGATCGAGGTGATCGCCGGCGAGAAGACCGCGCCGCAAACC
GTGGCGACGATCCGCGATCTCATCCGCTCGATCGGCCTGTTGCCGGTGGTGGTGAAGAAGGACGTCCCCGGTTTCGTCGA
AAACCGCGTGCTCTATGCGCTGCTGCGCGAGGCGGTCGACCTCGTCGAGCGCGGCGTCATCGATCCGGAAGATCTCGACA
CCTGCGTGTCCTGGGGCATCGGCTACAAGATCGCCGTGATCGGGCCGATGGCTCTGCTCGATATGGCGGGCCTGGATATC
TACAAGTCCGTCTCCTCCTTCCTCAACGCCGATCTTTCCAATCGCGACGATGTCGCGCCCATGGTGCTGGAAAAGACCAG
CGCGTCGAAGTTCGGCATCAAGTCAGGCGAGGGCATGTTTTGCTACACGCCCGAGCAGACCAAGGCGCTGCAAGCCGAAA
GGGCGCGCAAACTCGTCGCGGTACGACGCATCCTGGAAGGCCGGGAGTAG

Upstream 100 bases:

>100_bases
TGCCCGACCTGGTCTGCGGAAACATCAACGCGGCAGTGATCATGATTGCCGAAAAGGCCGCCGACCTCATCGCGAGCTCA
AAAGAAGGCAGGGCAGTGCA

Downstream 100 bases:

>100_bases
CCAATGGTTTATCGAGCTCACAAAGCCGGCTGGGTTGGGGAGGTCGTAACGGCCGCCGCGGATGCCAAGGGCGCCTTCGC
GGACCGGACGGTGCGGTTGA

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MIRNIAIIGLGTMGPGMAARLARGGLQVVAYDVAPAAIERARSMLSVAETVLDALGIALPSAGVGTVRFTDDIGDAVSGA
DLVIENVPENISIKADVYRTIDGLIGQDTIVASDTSGIPITKLQAHISYPERMVGMHWSNPPHIIPMIEVIAGEKTAPQT
VATIRDLIRSIGLLPVVVKKDVPGFVENRVLYALLREAVDLVERGVIDPEDLDTCVSWGIGYKIAVIGPMALLDMAGLDI
YKSVSSFLNADLSNRDDVAPMVLEKTSASKFGIKSGEGMFCYTPEQTKALQAERARKLVAVRRILEGRE

Sequences:

>Translated_309_residues
MIRNIAIIGLGTMGPGMAARLARGGLQVVAYDVAPAAIERARSMLSVAETVLDALGIALPSAGVGTVRFTDDIGDAVSGA
DLVIENVPENISIKADVYRTIDGLIGQDTIVASDTSGIPITKLQAHISYPERMVGMHWSNPPHIIPMIEVIAGEKTAPQT
VATIRDLIRSIGLLPVVVKKDVPGFVENRVLYALLREAVDLVERGVIDPEDLDTCVSWGIGYKIAVIGPMALLDMAGLDI
YKSVSSFLNADLSNRDDVAPMVLEKTSASKFGIKSGEGMFCYTPEQTKALQAERARKLVAVRRILEGRE
>Mature_309_residues
MIRNIAIIGLGTMGPGMAARLARGGLQVVAYDVAPAAIERARSMLSVAETVLDALGIALPSAGVGTVRFTDDIGDAVSGA
DLVIENVPENISIKADVYRTIDGLIGQDTIVASDTSGIPITKLQAHISYPERMVGMHWSNPPHIIPMIEVIAGEKTAPQT
VATIRDLIRSIGLLPVVVKKDVPGFVENRVLYALLREAVDLVERGVIDPEDLDTCVSWGIGYKIAVIGPMALLDMAGLDI
YKSVSSFLNADLSNRDDVAPMVLEKTSASKFGIKSGEGMFCYTPEQTKALQAERARKLVAVRRILEGRE

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=294, Percent_Identity=31.9727891156463, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI115430219, Length=235, Percent_Identity=33.6170212765957, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI296179427, Length=311, Percent_Identity=30.2250803858521, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI20127408, Length=292, Percent_Identity=29.4520547945205, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI68989263, Length=304, Percent_Identity=27.6315789473684, Blast_Score=111, Evalue=7e-25,
Organism=Homo sapiens, GI261878539, Length=304, Percent_Identity=27.6315789473684, Blast_Score=111, Evalue=7e-25,
Organism=Escherichia coli, GI1787661, Length=300, Percent_Identity=31.6666666666667, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1790281, Length=204, Percent_Identity=33.8235294117647, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1788682, Length=211, Percent_Identity=31.7535545023697, Blast_Score=102, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17553560, Length=290, Percent_Identity=30.3448275862069, Blast_Score=131, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI25144276, Length=320, Percent_Identity=31.5625, Blast_Score=130, Evalue=9e-31,
Organism=Caenorhabditis elegans, GI17549919, Length=293, Percent_Identity=31.3993174061433, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17508951, Length=290, Percent_Identity=32.4137931034483, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17508953, Length=290, Percent_Identity=32.4137931034483, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17563036, Length=291, Percent_Identity=28.5223367697594, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI71985923, Length=291, Percent_Identity=27.8350515463918, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17558304, Length=298, Percent_Identity=30.5369127516779, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI71985930, Length=282, Percent_Identity=24.822695035461, Blast_Score=109, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI193203623, Length=189, Percent_Identity=31.7460317460317, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI115533614, Length=241, Percent_Identity=29.4605809128631, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI45549573, Length=243, Percent_Identity=31.2757201646091, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI20129993, Length=237, Percent_Identity=29.535864978903, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI19921000, Length=296, Percent_Identity=31.0810810810811, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24583077, Length=288, Percent_Identity=30.5555555555556, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24583079, Length=288, Percent_Identity=30.5555555555556, Blast_Score=110, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 33062; Mature: 33062

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00895 3_HYDROXYISOBUT_DH ; PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRNIAIIGLGTMGPGMAARLARGGLQVVAYDVAPAAIERARSMLSVAETVLDALGIALP
CCCEEEEEEECCCCCHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCC
SAGVGTVRFTDDIGDAVSGADLVIENVPENISIKADVYRTIDGLIGQDTIVASDTSGIPI
CCCCCEEEEECCCCCCCCCCHHEEECCCCCCEEHHHHHHHHHHHCCCCEEEECCCCCCCH
TKLQAHISYPERMVGMHWSNPPHIIPMIEVIAGEKTAPQTVATIRDLIRSIGLLPVVVKK
HHHHHHHCCHHHHHCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEECC
DVPGFVENRVLYALLREAVDLVERGVIDPEDLDTCVSWGIGYKIAVIGPMALLDMAGLDI
CCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHH
YKSVSSFLNADLSNRDDVAPMVLEKTSASKFGIKSGEGMFCYTPEQTKALQAERARKLVA
HHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHH
VRRILEGRE
HHHHHCCCC
>Mature Secondary Structure
MIRNIAIIGLGTMGPGMAARLARGGLQVVAYDVAPAAIERARSMLSVAETVLDALGIALP
CCCEEEEEEECCCCCHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCC
SAGVGTVRFTDDIGDAVSGADLVIENVPENISIKADVYRTIDGLIGQDTIVASDTSGIPI
CCCCCEEEEECCCCCCCCCCHHEEECCCCCCEEHHHHHHHHHHHCCCCEEEECCCCCCCH
TKLQAHISYPERMVGMHWSNPPHIIPMIEVIAGEKTAPQTVATIRDLIRSIGLLPVVVKK
HHHHHHHCCHHHHHCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEECC
DVPGFVENRVLYALLREAVDLVERGVIDPEDLDTCVSWGIGYKIAVIGPMALLDMAGLDI
CCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHH
YKSVSSFLNADLSNRDDVAPMVLEKTSASKFGIKSGEGMFCYTPEQTKALQAERARKLVA
HHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHH
VRRILEGRE
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10567266 [H]