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The map label for this gene is ppsE [H]

Identifier: 13475628

GI number: 13475628

Start: 5538882

End: 5541635

Strand: Reverse

Name: ppsE [H]

Synonym: mll6746

Alternate gene names: 13475628

Gene position: 5541635-5538882 (Counterclockwise)

Preceding gene: 13475631

Following gene: 13475627

Centisome position: 78.76

GC content: 62.27

Gene sequence:

>2754_bases
ATGTCTTCAGCGTATTTGCAGTCTGAAGCGGTGGATCAAGATCTGTGGGTGGATTGTCGACCGACGACGACCCGCAGATG
GTCAGATATTCCCGAATATGCTCTTGACGAAGGGGGGCCTCTCTGGCGCCGCTATCAACAGATGGGCGCCGGCTTTGCGG
ACATTCCCGTCTTCGATCACCTTAGAAACGTCGCAAGGCAATATCCCGACAAGCTCGCGATCGGCGACGGCACCAATCGA
CTGACTTATTCCGAGCTTTCCCGGGCTGTCGAGACATTGTCGCACCGTGTCGCTGCCGTCGTTCCCGAAGGACAGGCGGT
CGGCATCCTTCAGGCTAATTCGGCCTGGTACGCCGTGGCGATACTGGCGAGCATGGCGGCCGGGCGACCTTCGGTTCCGC
TCAACATGAGAGATCCAGGTTCTCGGATCATCGAAATTGTGGACGCCGCACGGCTCGGCGCCATCATAGGCGCTGGAAAT
GTTCGCCCCATCGATTTGGCACAGGAAGTCCTATGGATCGATATTGCCGCCGGCATCGCGCCAAACGGTCAACAGGCATC
ACAGCAGCCGCAGCTCCCTTCCGTTTCCGTCGATGCACCCGCAATGGTGCTTTACACATCAGGTAGCACCGGACGTCCCA
AGGGCATCGTCAACAGCCAGCGCAGCCTGCTGTGGCGGGTCCGGCAATATGTGGACGCGTGCCATATCAACGCGGATGAT
GTTTTCCTGCCGCTGACCGGGCCCGCCACGATTGCCGGTTGCCGCGAGATTTTTACCGCACTGCTGACGGGCGCCACGTT
GCATCTTCTCGAGGTGGAGGCGGTCGGCCTGCGCGCAGTCCGCGCTCGGGTTCAAGCCGAAGGTGTGACGATCGCCTATC
TTGTGCCGGCACTGCTTCGGGCACTGTTGACCGAGGCCCCCACTGACGCCTACCAGTCGCTCAGAGTAGCCCGGATCGGT
GGTGAGAAGGTGTCCTGGACGGACATCGCCTTGCTGCGCAAAGCCGTTTCGGACCAGTGCCTGATCCAGATCGGCTACTC
GTCAACCGAGACCACCGGCTCGCAATGGTTCCTGCCGCAGGATTGGCCGGAGCAAGACGCTTCGATCCCCGTTGGCAGGC
TGCTTCCCGGGATGGCATTCGCCATTGTCGACGAAGCAGGACGCAATGTCGGGACAGGCGAGAGTGGAGAGCTTCTGATC
AGAAGCCCGTATGTTCTGCTTGGTCATTGGGAGAACGGTGTCGTCGTTCCCGCGCGGCCGGATCCGGACGATCCCGGTGT
TCGGGTTTTTGCGACGGGCGACCTCGTTCGGCTGGACGATGATGGCCTGTTGCGCATCGTCGGCCGCAAAGGTCGCCAGA
TCAAGATCAATGGTCGACGCATCGAGCCCGCCGAGCTCGAACGGGTCCTGCGTTGCGCGCCTTCGGTTGCGGATGCCGTG
GCAATCGTGACGCCCGCCGAGGAACTCATCGCATTCGCGGTTCCCCAGCGCTTTGCGGGGGCTGCTTTTGCGGAGGAACT
TCGTCAGCTCGTCAGAACGACGTTGCCGGCGCCGCTGCGTCCCTTGCGATTGCACACCATCACCGAGATCCCACGCCTGC
CGGGAGGGAAGATCGACCTGGCAACGCTCACCGAAATGGATCGTTCGGAGAGAAAGGCGCCAGCCGTCCAGCCGCCCACT
ACGCGACCGCTCCCCGCGGGAGGCGACCTGAATACAAGGCAAACGGTTCAGCACGCGTGGATGCAGGTTCTCAACACGGG
CACTGCGGCGGGAAACTGGGATGAGGCGGGGGGAGATTCGCTGCAGCTGCTGCATTGCGTCATGGCAATCGAGAGCGCCA
TCGGGCAAGAGCTCGGCCTCGAGGCCTTCACCGTCGGTATGAGCTTCGACGAGATGGTTGAGGCTGTCGTATCCGCCCAG
GCGGGCGAACGACACGCGAAGAAGCAACACCCTCCGGTTCTTTTCCTGTTCCCCGGGTCCGTCGGCTATGGCCCGAGCCT
GGCTGCGTTCGCAGCCGCCATGGGCAAAGTCGCCCGGGTGAACCCCATCCGGTATCCTGGCCTCGCCGCGATACTGGATG
GACACAACAGTCTTTCCGCCATGGCCGCCGCCGCACTCGAGCAGATAGGCCGCGCCCAACCTACCGGCCCCGTGCGACTT
CTCGGCCATTCGCTTGGCGGCGCGGTTGCGTTCGAGGTTGCCGCGCGGCTACTGACCGCCGGCCGATCGGTAAGGTTCTT
GGGTATCCTCGACACGAGCCTTCTGGACGAGCCGAGCAACCATTGGGAGACCCTTACCCGCACATTCCATCGCATTCGCA
CGAATCGGATATCCGCCCACCGGATGGCTTGCCGAGCCCTTGCGAAGATCACCGTCGCCATGGGCTGCGAGGCGTATCTC
GCCAGGACTCTCGATCGCTTTGCCAAGGGAGAGTTCAGCCCGACAAGTTTCAGAACCAAGCTGGAACTTCAGGAAGTCTT
GCGGGCGCGGTCTTTCTTCCAGTGGCTGGAGGCACCCAAACCGGCTCTGCCCATCTCCGGCACCTTGTTCCGGTGTCGCC
GGGAGGGAATGCCTCGGGCCTTGGGCTGGGACAGCGCTCTGGCACATCTGGACGTGGTTCCGATCATGGGCAACCACATC
GACCTTGTCATAGAGCCCAATCTTGCCACCAACCGCCCGCTCATCGAGACGGCCGTCGTGCAGACCTATTCCCCGGCCGA
GTCTCGCAAAAGGGAGGATCTGTCATCGACGTGA

Upstream 100 bases:

>100_bases
GGAAAGCGCTGTCTGATCAAGATCGAGGCATCATCCGAATGATTGATGAAAAGATTTCGGTGGCGAGTGATGGTCGACGT
TCAGCTTGGTGGGGCCCTGA

Downstream 100 bases:

>100_bases
TCTCACATTTCAGCAAGGACATGCTGGCGCTCGATGCTCGTGCGGAGGTCGATCGCATCGTTGACACCTTGCGCAAGCAG
GTTCTTGGCACGCTCCGCCG

Product: pristinamycin I synthase 3

Products: pyrophosphate; AMP; enterobactin; pyrophosphate; L-Seryl-AMP [C]

Alternate protein names: Peptide synthase 5; ATP-dependent isoleucine adenylase; IsoA; Isoleucine activase [H]

Number of amino acids: Translated: 917; Mature: 916

Protein sequence:

>917_residues
MSSAYLQSEAVDQDLWVDCRPTTTRRWSDIPEYALDEGGPLWRRYQQMGAGFADIPVFDHLRNVARQYPDKLAIGDGTNR
LTYSELSRAVETLSHRVAAVVPEGQAVGILQANSAWYAVAILASMAAGRPSVPLNMRDPGSRIIEIVDAARLGAIIGAGN
VRPIDLAQEVLWIDIAAGIAPNGQQASQQPQLPSVSVDAPAMVLYTSGSTGRPKGIVNSQRSLLWRVRQYVDACHINADD
VFLPLTGPATIAGCREIFTALLTGATLHLLEVEAVGLRAVRARVQAEGVTIAYLVPALLRALLTEAPTDAYQSLRVARIG
GEKVSWTDIALLRKAVSDQCLIQIGYSSTETTGSQWFLPQDWPEQDASIPVGRLLPGMAFAIVDEAGRNVGTGESGELLI
RSPYVLLGHWENGVVVPARPDPDDPGVRVFATGDLVRLDDDGLLRIVGRKGRQIKINGRRIEPAELERVLRCAPSVADAV
AIVTPAEELIAFAVPQRFAGAAFAEELRQLVRTTLPAPLRPLRLHTITEIPRLPGGKIDLATLTEMDRSERKAPAVQPPT
TRPLPAGGDLNTRQTVQHAWMQVLNTGTAAGNWDEAGGDSLQLLHCVMAIESAIGQELGLEAFTVGMSFDEMVEAVVSAQ
AGERHAKKQHPPVLFLFPGSVGYGPSLAAFAAAMGKVARVNPIRYPGLAAILDGHNSLSAMAAAALEQIGRAQPTGPVRL
LGHSLGGAVAFEVAARLLTAGRSVRFLGILDTSLLDEPSNHWETLTRTFHRIRTNRISAHRMACRALAKITVAMGCEAYL
ARTLDRFAKGEFSPTSFRTKLELQEVLRARSFFQWLEAPKPALPISGTLFRCRREGMPRALGWDSALAHLDVVPIMGNHI
DLVIEPNLATNRPLIETAVVQTYSPAESRKREDLSST

Sequences:

>Translated_917_residues
MSSAYLQSEAVDQDLWVDCRPTTTRRWSDIPEYALDEGGPLWRRYQQMGAGFADIPVFDHLRNVARQYPDKLAIGDGTNR
LTYSELSRAVETLSHRVAAVVPEGQAVGILQANSAWYAVAILASMAAGRPSVPLNMRDPGSRIIEIVDAARLGAIIGAGN
VRPIDLAQEVLWIDIAAGIAPNGQQASQQPQLPSVSVDAPAMVLYTSGSTGRPKGIVNSQRSLLWRVRQYVDACHINADD
VFLPLTGPATIAGCREIFTALLTGATLHLLEVEAVGLRAVRARVQAEGVTIAYLVPALLRALLTEAPTDAYQSLRVARIG
GEKVSWTDIALLRKAVSDQCLIQIGYSSTETTGSQWFLPQDWPEQDASIPVGRLLPGMAFAIVDEAGRNVGTGESGELLI
RSPYVLLGHWENGVVVPARPDPDDPGVRVFATGDLVRLDDDGLLRIVGRKGRQIKINGRRIEPAELERVLRCAPSVADAV
AIVTPAEELIAFAVPQRFAGAAFAEELRQLVRTTLPAPLRPLRLHTITEIPRLPGGKIDLATLTEMDRSERKAPAVQPPT
TRPLPAGGDLNTRQTVQHAWMQVLNTGTAAGNWDEAGGDSLQLLHCVMAIESAIGQELGLEAFTVGMSFDEMVEAVVSAQ
AGERHAKKQHPPVLFLFPGSVGYGPSLAAFAAAMGKVARVNPIRYPGLAAILDGHNSLSAMAAAALEQIGRAQPTGPVRL
LGHSLGGAVAFEVAARLLTAGRSVRFLGILDTSLLDEPSNHWETLTRTFHRIRTNRISAHRMACRALAKITVAMGCEAYL
ARTLDRFAKGEFSPTSFRTKLELQEVLRARSFFQWLEAPKPALPISGTLFRCRREGMPRALGWDSALAHLDVVPIMGNHI
DLVIEPNLATNRPLIETAVVQTYSPAESRKREDLSST
>Mature_916_residues
SSAYLQSEAVDQDLWVDCRPTTTRRWSDIPEYALDEGGPLWRRYQQMGAGFADIPVFDHLRNVARQYPDKLAIGDGTNRL
TYSELSRAVETLSHRVAAVVPEGQAVGILQANSAWYAVAILASMAAGRPSVPLNMRDPGSRIIEIVDAARLGAIIGAGNV
RPIDLAQEVLWIDIAAGIAPNGQQASQQPQLPSVSVDAPAMVLYTSGSTGRPKGIVNSQRSLLWRVRQYVDACHINADDV
FLPLTGPATIAGCREIFTALLTGATLHLLEVEAVGLRAVRARVQAEGVTIAYLVPALLRALLTEAPTDAYQSLRVARIGG
EKVSWTDIALLRKAVSDQCLIQIGYSSTETTGSQWFLPQDWPEQDASIPVGRLLPGMAFAIVDEAGRNVGTGESGELLIR
SPYVLLGHWENGVVVPARPDPDDPGVRVFATGDLVRLDDDGLLRIVGRKGRQIKINGRRIEPAELERVLRCAPSVADAVA
IVTPAEELIAFAVPQRFAGAAFAEELRQLVRTTLPAPLRPLRLHTITEIPRLPGGKIDLATLTEMDRSERKAPAVQPPTT
RPLPAGGDLNTRQTVQHAWMQVLNTGTAAGNWDEAGGDSLQLLHCVMAIESAIGQELGLEAFTVGMSFDEMVEAVVSAQA
GERHAKKQHPPVLFLFPGSVGYGPSLAAFAAAMGKVARVNPIRYPGLAAILDGHNSLSAMAAAALEQIGRAQPTGPVRLL
GHSLGGAVAFEVAARLLTAGRSVRFLGILDTSLLDEPSNHWETLTRTFHRIRTNRISAHRMACRALAKITVAMGCEAYLA
RTLDRFAKGEFSPTSFRTKLELQEVLRARSFFQWLEAPKPALPISGTLFRCRREGMPRALGWDSALAHLDVVPIMGNHID
LVIEPNLATNRPLIETAVVQTYSPAESRKREDLSST

Specific function: This protein is a multifunctional enzyme, able to activate and polymerize the amino acid Ile as part of the biosynthesis of the lipopeptide antibiotic plipastatin. The activation sites for this amino acid consist of individual domains [H]

COG id: COG1020

COG function: function code Q; Non-ribosomal peptide synthetase modules and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 acyl carrier domain [H]

Homologues:

Organism=Homo sapiens, GI38505220, Length=464, Percent_Identity=23.4913793103448, Blast_Score=89, Evalue=2e-17,
Organism=Homo sapiens, GI156151445, Length=374, Percent_Identity=25.9358288770053, Blast_Score=83, Evalue=1e-15,
Organism=Homo sapiens, GI28416953, Length=392, Percent_Identity=27.2959183673469, Blast_Score=76, Evalue=2e-13,
Organism=Escherichia coli, GI1786801, Length=871, Percent_Identity=24.4546498277842, Blast_Score=150, Evalue=4e-37,
Organism=Escherichia coli, GI1789201, Length=506, Percent_Identity=26.6798418972332, Blast_Score=94, Evalue=5e-20,
Organism=Escherichia coli, GI145693145, Length=543, Percent_Identity=25.5985267034991, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI221142682, Length=523, Percent_Identity=23.5181644359465, Blast_Score=91, Evalue=4e-19,
Organism=Escherichia coli, GI1788107, Length=361, Percent_Identity=27.7008310249307, Blast_Score=84, Evalue=6e-17,
Organism=Escherichia coli, GI1790505, Length=475, Percent_Identity=25.0526315789474, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1786810, Length=551, Percent_Identity=23.2304900181488, Blast_Score=79, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI71985884, Length=402, Percent_Identity=26.6169154228856, Blast_Score=87, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI71994703, Length=482, Percent_Identity=22.6141078838174, Blast_Score=85, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71994694, Length=482, Percent_Identity=22.6141078838174, Blast_Score=85, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71994690, Length=482, Percent_Identity=22.6141078838174, Blast_Score=85, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17531443, Length=349, Percent_Identity=24.6418338108883, Blast_Score=82, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17560308, Length=504, Percent_Identity=25.1984126984127, Blast_Score=81, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17558820, Length=346, Percent_Identity=24.2774566473988, Blast_Score=70, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6319591, Length=680, Percent_Identity=21.0294117647059, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21355181, Length=558, Percent_Identity=25.2688172043011, Blast_Score=100, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24648260, Length=308, Percent_Identity=26.9480519480519, Blast_Score=92, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21356441, Length=507, Percent_Identity=24.65483234714, Blast_Score=84, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24653035, Length=350, Percent_Identity=27.1428571428571, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI161076582, Length=389, Percent_Identity=24.9357326478149, Blast_Score=74, Evalue=4e-13,
Organism=Drosophila melanogaster, GI20130357, Length=304, Percent_Identity=25.3289473684211, Blast_Score=72, Evalue=3e-12,
Organism=Drosophila melanogaster, GI19922652, Length=470, Percent_Identity=22.7659574468085, Blast_Score=71, Evalue=3e-12,
Organism=Drosophila melanogaster, GI18859661, Length=365, Percent_Identity=26.3013698630137, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010071
- InterPro:   IPR009081
- InterPro:   IPR020459
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR001242
- InterPro:   IPR006163
- InterPro:   IPR006162
- InterPro:   IPR001031 [H]

Pfam domain/function: PF00501 AMP-binding; PF00668 Condensation; PF00550 PP-binding; PF00975 Thioesterase [H]

EC number: 2.7.7.- [C]

Molecular weight: Translated: 99202; Mature: 99071

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: PS00120 LIPASE_SER ; PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSAYLQSEAVDQDLWVDCRPTTTRRWSDIPEYALDEGGPLWRRYQQMGAGFADIPVFDH
CCCCHHHHHCCCCCCEEECCCCCCCCCCCCCHHHHCCCCHHHHHHHHHCCCCCCCHHHHH
LRNVARQYPDKLAIGDGTNRLTYSELSRAVETLSHRVAAVVPEGQAVGILQANSAWYAVA
HHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHEEEECCCCEEEEEECCCCHHHHH
ILASMAAGRPSVPLNMRDPGSRIIEIVDAARLGAIIGAGNVRPIDLAQEVLWIDIAAGIA
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHEEECCCC
PNGQQASQQPQLPSVSVDAPAMVLYTSGSTGRPKGIVNSQRSLLWRVRQYVDACHINADD
CCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
VFLPLTGPATIAGCREIFTALLTGATLHLLEVEAVGLRAVRARVQAEGVTIAYLVPALLR
EEEECCCCHHHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
ALLTEAPTDAYQSLRVARIGGEKVSWTDIALLRKAVSDQCLIQIGYSSTETTGSQWFLPQ
HHHHCCCCHHHHHEEEEECCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEECCC
DWPEQDASIPVGRLLPGMAFAIVDEAGRNVGTGESGELLIRSPYVLLGHWENGVVVPARP
CCCCCCCCCCHHHHHCCHHHHHHHHHCCCCCCCCCCCEEEECCEEEEEECCCCEEECCCC
DPDDPGVRVFATGDLVRLDDDGLLRIVGRKGRQIKINGRRIEPAELERVLRCAPSVADAV
CCCCCCEEEEEECCEEEECCCCEEEEECCCCCEEEECCCCCCHHHHHHHHHHCCCHHHHE
AIVTPAEELIAFAVPQRFAGAAFAEELRQLVRTTLPAPLRPLRLHTITEIPRLPGGKIDL
EEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCEEH
ATLTEMDRSERKAPAVQPPTTRPLPAGGDLNTRQTVQHAWMQVLNTGTAAGNWDEAGGDS
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCH
LQLLHCVMAIESAIGQELGLEAFTVGMSFDEMVEAVVSAQAGERHAKKQHPPVLFLFPGS
HHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHCCHHHHHHCCCCEEEEECCC
VGYGPSLAAFAAAMGKVARVNPIRYPGLAAILDGHNSLSAMAAAALEQIGRAQPTGPVRL
CCCCHHHHHHHHHHCCHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCHHHH
LGHSLGGAVAFEVAARLLTAGRSVRFLGILDTSLLDEPSNHWETLTRTFHRIRTNRISAH
HHHHHCHHHHHHHHHHHHHCCCCEEEEEEECHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
RMACRALAKITVAMGCEAYLARTLDRFAKGEFSPTSFRTKLELQEVLRARSFFQWLEAPK
HHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
PALPISGTLFRCRREGMPRALGWDSALAHLDVVPIMGNHIDLVIEPNLATNRPLIETAVV
CCCCCCHHHHHHHHCCCCCCCCCHHHHHHHEEEEECCCCEEEEECCCCCCCCCHHHHHHH
QTYSPAESRKREDLSST
HCCCCHHHHHHHCCCCC
>Mature Secondary Structure 
SSAYLQSEAVDQDLWVDCRPTTTRRWSDIPEYALDEGGPLWRRYQQMGAGFADIPVFDH
CCCHHHHHCCCCCCEEECCCCCCCCCCCCCHHHHCCCCHHHHHHHHHCCCCCCCHHHHH
LRNVARQYPDKLAIGDGTNRLTYSELSRAVETLSHRVAAVVPEGQAVGILQANSAWYAVA
HHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHEEEECCCCEEEEEECCCCHHHHH
ILASMAAGRPSVPLNMRDPGSRIIEIVDAARLGAIIGAGNVRPIDLAQEVLWIDIAAGIA
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHEEECCCC
PNGQQASQQPQLPSVSVDAPAMVLYTSGSTGRPKGIVNSQRSLLWRVRQYVDACHINADD
CCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
VFLPLTGPATIAGCREIFTALLTGATLHLLEVEAVGLRAVRARVQAEGVTIAYLVPALLR
EEEECCCCHHHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
ALLTEAPTDAYQSLRVARIGGEKVSWTDIALLRKAVSDQCLIQIGYSSTETTGSQWFLPQ
HHHHCCCCHHHHHEEEEECCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEECCC
DWPEQDASIPVGRLLPGMAFAIVDEAGRNVGTGESGELLIRSPYVLLGHWENGVVVPARP
CCCCCCCCCCHHHHHCCHHHHHHHHHCCCCCCCCCCCEEEECCEEEEEECCCCEEECCCC
DPDDPGVRVFATGDLVRLDDDGLLRIVGRKGRQIKINGRRIEPAELERVLRCAPSVADAV
CCCCCCEEEEEECCEEEECCCCEEEEECCCCCEEEECCCCCCHHHHHHHHHHCCCHHHHE
AIVTPAEELIAFAVPQRFAGAAFAEELRQLVRTTLPAPLRPLRLHTITEIPRLPGGKIDL
EEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCEEH
ATLTEMDRSERKAPAVQPPTTRPLPAGGDLNTRQTVQHAWMQVLNTGTAAGNWDEAGGDS
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCH
LQLLHCVMAIESAIGQELGLEAFTVGMSFDEMVEAVVSAQAGERHAKKQHPPVLFLFPGS
HHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHCCHHHHHHCCCCEEEEECCC
VGYGPSLAAFAAAMGKVARVNPIRYPGLAAILDGHNSLSAMAAAALEQIGRAQPTGPVRL
CCCCHHHHHHHHHHCCHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCHHHH
LGHSLGGAVAFEVAARLLTAGRSVRFLGILDTSLLDEPSNHWETLTRTFHRIRTNRISAH
HHHHHCHHHHHHHHHHHHHCCCCEEEEEEECHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
RMACRALAKITVAMGCEAYLARTLDRFAKGEFSPTSFRTKLELQEVLRARSFFQWLEAPK
HHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
PALPISGTLFRCRREGMPRALGWDSALAHLDVVPIMGNHIDLVIEPNLATNRPLIETAVV
CCCCCCHHHHHHHHCCCCCCCCCHHHHHHHEEEEECCCCEEEEECCCCCCCCCHHHHHHH
QTYSPAESRKREDLSST
HCCCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Phosphopantetheine. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 6 ATP; L-serine; 2,3-dihydroxybenzoate [C]

Specific reaction: 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Seryl-AMP 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Ser

General reaction: Transferases; Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377; 10471562 [H]