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The map label for this gene is proC [H]

Identifier: 13475432

GI number: 13475432

Start: 5307567

End: 5308382

Strand: Reverse

Name: proC [H]

Synonym: mll6498

Alternate gene names: 13475432

Gene position: 5308382-5307567 (Counterclockwise)

Preceding gene: 13475433

Following gene: 13475427

Centisome position: 75.45

GC content: 65.32

Gene sequence:

>816_bases
ATGACGAACAGGCTTGTTCTCGCCGGCTGCGGCAATATGGGCTACGCCATGCTTTCGGGCTGGCTGAAATCCGGCAAGCT
CGCGCCCTCGGCGGTTTTCGTTATCGAGCCCAATGCGGAGCTGCGCCAGCGCGCTGCAACGCTTGGCTGCGCCACATCAG
CGGACGCCGGTGAGATTCCAGCCGATGCGGTGCCCGATCTCGTCGTCATCGCGGTAAAACCCCAGGTGATCCGCGACGTC
ACCGCCGCCTACAAGCGTTTCGGCGATGGCCGCACCACCTTCGTCAGCATCGCCGCCGGCACGCCGGTCGCCACCTTCGA
AGACATCCTCGGCAACCGCGCGCCTGTTGTGCGCTGCATGCCCAACACGCCCGCCTCCATCGGCAAAGGCATGATGGTGG
TGTTTTCCAACCCGCTGGTCTCGGATGATACCAAGCGCTTTGTCGCCGACCTGCTGTCGGCCAGCGGCGAAGTGGCCACC
ATTGACGACGAAGGCCTGATGGATGCGGTGACCGCCGTGTCGGGATCCGGGCCGGCCTATATCTTCCACTTCATCGAAGC
GCTGACCGTGGCCGCCGAGAAGGCGGGGCTGCCTAGCGCAACCGCCAGGCTGCTCGCGATGCAGACCGTCTATGGCGCTG
CCTCGCTCGCTGCCGAAAGCCAGGAGGAACCCGGCGTGCTGCGCCAGCAGGTGACCAGCCCCAACGGCACGACGGCTGCG
GCGCTTGCCGTGCTGATGGGCGAAGACCGGTTGACCAATTTGCTGACGCAGGCAGTCGAGGCGGCTCGGCTGCGGTCGAT
CGAGTTGGGAAAGTAA

Upstream 100 bases:

>100_bases
GCTGCGGCCGATCGCGGTGCGTGGCTCGCGTCCCGCCTGACGGGGCTTCCCCCCTGAAGCGTGAGCGTCTATGTCAAAGC
CTTCCTTCGGAGGGCTTTCG

Downstream 100 bases:

>100_bases
AACTCAGTTCGCCCCGTACAGCATCTCGTCCTGCAGCCGGCGCAAGGCGAACAGTCTCGTCGTCTGGTCGGGCGCGGCAT
TGTCGGCGGTGAGCAATTCG

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MTNRLVLAGCGNMGYAMLSGWLKSGKLAPSAVFVIEPNAELRQRAATLGCATSADAGEIPADAVPDLVVIAVKPQVIRDV
TAAYKRFGDGRTTFVSIAAGTPVATFEDILGNRAPVVRCMPNTPASIGKGMMVVFSNPLVSDDTKRFVADLLSASGEVAT
IDDEGLMDAVTAVSGSGPAYIFHFIEALTVAAEKAGLPSATARLLAMQTVYGAASLAAESQEEPGVLRQQVTSPNGTTAA
ALAVLMGEDRLTNLLTQAVEAARLRSIELGK

Sequences:

>Translated_271_residues
MTNRLVLAGCGNMGYAMLSGWLKSGKLAPSAVFVIEPNAELRQRAATLGCATSADAGEIPADAVPDLVVIAVKPQVIRDV
TAAYKRFGDGRTTFVSIAAGTPVATFEDILGNRAPVVRCMPNTPASIGKGMMVVFSNPLVSDDTKRFVADLLSASGEVAT
IDDEGLMDAVTAVSGSGPAYIFHFIEALTVAAEKAGLPSATARLLAMQTVYGAASLAAESQEEPGVLRQQVTSPNGTTAA
ALAVLMGEDRLTNLLTQAVEAARLRSIELGK
>Mature_270_residues
TNRLVLAGCGNMGYAMLSGWLKSGKLAPSAVFVIEPNAELRQRAATLGCATSADAGEIPADAVPDLVVIAVKPQVIRDVT
AAYKRFGDGRTTFVSIAAGTPVATFEDILGNRAPVVRCMPNTPASIGKGMMVVFSNPLVSDDTKRFVADLLSASGEVATI
DDEGLMDAVTAVSGSGPAYIFHFIEALTVAAEKAGLPSATARLLAMQTVYGAASLAAESQEEPGVLRQQVTSPNGTTAAA
LAVLMGEDRLTNLLTQAVEAARLRSIELGK

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797097, Length=266, Percent_Identity=33.4586466165414, Blast_Score=120, Evalue=9e-28,
Organism=Homo sapiens, GI24797095, Length=266, Percent_Identity=33.4586466165414, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI198041662, Length=269, Percent_Identity=31.2267657992565, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI21361454, Length=266, Percent_Identity=32.3308270676692, Blast_Score=109, Evalue=2e-24,
Organism=Escherichia coli, GI1786585, Length=247, Percent_Identity=36.0323886639676, Blast_Score=138, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17569021, Length=263, Percent_Identity=32.6996197718631, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17540664, Length=286, Percent_Identity=29.020979020979, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320861, Length=289, Percent_Identity=30.1038062283737, Blast_Score=107, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24648116, Length=280, Percent_Identity=35, Blast_Score=131, Evalue=6e-31,
Organism=Drosophila melanogaster, GI21358587, Length=266, Percent_Identity=36.4661654135338, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24647700, Length=173, Percent_Identity=39.8843930635838, Blast_Score=99, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 28054; Mature: 27922

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNRLVLAGCGNMGYAMLSGWLKSGKLAPSAVFVIEPNAELRQRAATLGCATSADAGEIP
CCCCEEEEECCCCCHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCC
ADAVPDLVVIAVKPQVIRDVTAAYKRFGDGRTTFVSIAAGTPVATFEDILGNRAPVVRCM
CCCCCCEEEEEECHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHCCCCCEEEEC
PNTPASIGKGMMVVFSNPLVSDDTKRFVADLLSASGEVATIDDEGLMDAVTAVSGSGPAY
CCCCHHHCCCEEEEECCCCCCCHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHCCCCHHH
IFHFIEALTVAAEKAGLPSATARLLAMQTVYGAASLAAESQEEPGVLRQQVTSPNGTTAA
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCHHHH
ALAVLMGEDRLTNLLTQAVEAARLRSIELGK
HHHHHHCCHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TNRLVLAGCGNMGYAMLSGWLKSGKLAPSAVFVIEPNAELRQRAATLGCATSADAGEIP
CCCEEEEECCCCCHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCC
ADAVPDLVVIAVKPQVIRDVTAAYKRFGDGRTTFVSIAAGTPVATFEDILGNRAPVVRCM
CCCCCCEEEEEECHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHCCCCCEEEEC
PNTPASIGKGMMVVFSNPLVSDDTKRFVADLLSASGEVATIDDEGLMDAVTAVSGSGPAY
CCCCHHHCCCEEEEECCCCCCCHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHCCCCHHH
IFHFIEALTVAAEKAGLPSATARLLAMQTVYGAASLAAESQEEPGVLRQQVTSPNGTTAA
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCHHHH
ALAVLMGEDRLTNLLTQAVEAARLRSIELGK
HHHHHHCCHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2107123; 10984043; 1676385 [H]