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The map label for this gene is hisD

Identifier: 13475400

GI number: 13475400

Start: 5275692

End: 5276984

Strand: Reverse

Name: hisD

Synonym: mll6456

Alternate gene names: 13475400

Gene position: 5276984-5275692 (Counterclockwise)

Preceding gene: 13475402

Following gene: 13475399

Centisome position: 75.0

GC content: 65.66

Gene sequence:

>1293_bases
ATGGCCATCACGCTTCGCCAGTCCGATGCCGATTTCGAGCAGCGCTTCGCCGCTTTCCTGACGACCAAGAGGGAAGTGTC
CGAGGACGTCGACGCAGGGGTTCGCCAGATCATCGCACGCGTGCGCGCCGAAGGTGACGCGGCACTGATCGACTATACGC
AACGATTCGATCGGGCCGATTTGAAAAGCCTCGGCATTGCCGTGTCGAAGCAAGACATTGCGGCCGCTTACGAGACGGCC
GATCCAAAGGCGATCGAAGCGCTCGAATTCGCGCGCGATCGCATCCGCTCCCACCACGAGCGGCAGCGACCGAAGGACGA
TCGCTACACAGATGCCACCGGCGTCGAGCTCGGCTGGCGCTGGACAGCCATCGAGGCGGTCGGGCTCTATGTGCCGGGCG
GCACGGCGAGCTATCCAAGCTCGGTGCTGATGAACGCCGTGCCGGCCCGGGTGGCCGGCGTCGAGCGCGTCGTCATGGTT
GTGCCGGCCCCGGGTGGCATCATCAATCCGCTGGTGCTGGTGGCGGCCGACATATCAGGCGTGACCGAAATCTACCGCGT
CGGCGGCGCACACGCGATCGCTGCCCTTGCCTATGGCACAGAGACCATAAAGCCGGTTGCCAAGATTGTCGGGCCGGGCA
ACGCCTATGTCGCGGCGGCCAAACGCCAGGTGTTCGGCACGGTCGGCATCGACATGATCGCCGGCCCCTCGGAAGTGCTC
GTGGTGGCCGACGGCAGCAACAATGCGGACTGGATCGCCGCCGATCTGCTCGCCCAGGCCGAACACGATGTGTCGGCGCA
ATCGATCCTGATCACCGATGATCCGGCCTTTGGCAAGGCGGTCGAACAGGCTGTCGAACGGCAATTGCAGACCCTGCCAC
GCGGTGAAACGGCAGCGGCGAGCTGGCGCGATTTCGGCGCGGTGATCGAGGTCGCGACCATCGAGGCGGCGCTGCCGCTG
GTCGACCGCATCGCCGCCGAACATGTCGAACTGGCCATCGACGATGCCGAAGGTTTCCTGTCGCGGATGCGCAATGCGGG
CGCGGTCTTTCTCGGGCGCCACACGCCGGAAGCCATCGGCGACTATGTCGGCGGCTCCAACCATGTGCTGCCTACGGCAC
GCTCGGCGCGCTTCTCGTCAGGCCTGTCCGTGCTCGATTTCGTCAAGCGGACTTCGATCTTGAAGCTCGGGCCGGAGCAA
TTGCGCGTGCTGGCGCCGGCGGCGATCGCGCTCGCCAAGGCGGAAGGGCTCGACGCGCATGGCCGCTCCGTCGCTATCCG
GCTGAACATGTAG

Upstream 100 bases:

>100_bases
ACCATCATGCTCGATGTCGAATGCATCGAGGCCCGCCTTGCCGACATTGGCGGCGCGTGGGAAGCCACGTCGCGCCCCAT
TCACAAGGCTTGAGCGCCCC

Downstream 100 bases:

>100_bases
GCTGAGATGACGGGCTCCGATCAAACCCGCGCAAAGCTGATCGATATCGAACTCGATGAATCGATCGGCCGTTCGACGCC
CGATGTCGAGCATGAGCGAG

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH 1

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MAITLRQSDADFEQRFAAFLTTKREVSEDVDAGVRQIIARVRAEGDAALIDYTQRFDRADLKSLGIAVSKQDIAAAYETA
DPKAIEALEFARDRIRSHHERQRPKDDRYTDATGVELGWRWTAIEAVGLYVPGGTASYPSSVLMNAVPARVAGVERVVMV
VPAPGGIINPLVLVAADISGVTEIYRVGGAHAIAALAYGTETIKPVAKIVGPGNAYVAAAKRQVFGTVGIDMIAGPSEVL
VVADGSNNADWIAADLLAQAEHDVSAQSILITDDPAFGKAVEQAVERQLQTLPRGETAAASWRDFGAVIEVATIEAALPL
VDRIAAEHVELAIDDAEGFLSRMRNAGAVFLGRHTPEAIGDYVGGSNHVLPTARSARFSSGLSVLDFVKRTSILKLGPEQ
LRVLAPAAIALAKAEGLDAHGRSVAIRLNM

Sequences:

>Translated_430_residues
MAITLRQSDADFEQRFAAFLTTKREVSEDVDAGVRQIIARVRAEGDAALIDYTQRFDRADLKSLGIAVSKQDIAAAYETA
DPKAIEALEFARDRIRSHHERQRPKDDRYTDATGVELGWRWTAIEAVGLYVPGGTASYPSSVLMNAVPARVAGVERVVMV
VPAPGGIINPLVLVAADISGVTEIYRVGGAHAIAALAYGTETIKPVAKIVGPGNAYVAAAKRQVFGTVGIDMIAGPSEVL
VVADGSNNADWIAADLLAQAEHDVSAQSILITDDPAFGKAVEQAVERQLQTLPRGETAAASWRDFGAVIEVATIEAALPL
VDRIAAEHVELAIDDAEGFLSRMRNAGAVFLGRHTPEAIGDYVGGSNHVLPTARSARFSSGLSVLDFVKRTSILKLGPEQ
LRVLAPAAIALAKAEGLDAHGRSVAIRLNM
>Mature_429_residues
AITLRQSDADFEQRFAAFLTTKREVSEDVDAGVRQIIARVRAEGDAALIDYTQRFDRADLKSLGIAVSKQDIAAAYETAD
PKAIEALEFARDRIRSHHERQRPKDDRYTDATGVELGWRWTAIEAVGLYVPGGTASYPSSVLMNAVPARVAGVERVVMVV
PAPGGIINPLVLVAADISGVTEIYRVGGAHAIAALAYGTETIKPVAKIVGPGNAYVAAAKRQVFGTVGIDMIAGPSEVLV
VADGSNNADWIAADLLAQAEHDVSAQSILITDDPAFGKAVEQAVERQLQTLPRGETAAASWRDFGAVIEVATIEAALPLV
DRIAAEHVELAIDDAEGFLSRMRNAGAVFLGRHTPEAIGDYVGGSNHVLPTARSARFSSGLSVLDFVKRTSILKLGPEQL
RVLAPAAIALAKAEGLDAHGRSVAIRLNM

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=421, Percent_Identity=39.9049881235154, Blast_Score=270, Evalue=1e-73,
Organism=Saccharomyces cerevisiae, GI6319819, Length=410, Percent_Identity=38.2926829268293, Blast_Score=251, Evalue=2e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX1_RHILO (Q989E7)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_106964.1
- ProteinModelPortal:   Q989E7
- SMR:   Q989E7
- GeneID:   1229619
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mll6456
- NMPDR:   fig|266835.1.peg.5065
- HOGENOM:   HBG329596
- OMA:   LDAHKNA
- ProtClustDB:   PRK00877
- BRENDA:   1.1.1.23
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PIRSF:   PIRSF000099
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 45685; Mature: 45554

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00611 HISOL_DEHYDROGENASE; PS00435 PEROXIDASE_1

Important sites: ACT_SITE 327-327 ACT_SITE 328-328 BINDING 237-237 BINDING 259-259 BINDING 262-262 BINDING 328-328 BINDING 361-361 BINDING 415-415 BINDING 420-420

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAITLRQSDADFEQRFAAFLTTKREVSEDVDAGVRQIIARVRAEGDAALIDYTQRFDRAD
CEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHCCHHH
LKSLGIAVSKQDIAAAYETADPKAIEALEFARDRIRSHHERQRPKDDRYTDATGVELGWR
HHHHCCEECHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECEE
WTAIEAVGLYVPGGTASYPSSVLMNAVPARVAGVERVVMVVPAPGGIINPLVLVAADISG
EEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCEEEEEEEECCCCHHHHHHHHHHCHHH
VTEIYRVGGAHAIAALAYGTETIKPVAKIVGPGNAYVAAAKRQVFGTVGIDMIAGPSEVL
HHHHHHCCCHHHHHHHHHCCHHHHHHHHHCCCCCCEEHHHHHHHHHHCCCCEECCCCEEE
VVADGSNNADWIAADLLAQAEHDVSAQSILITDDPAFGKAVEQAVERQLQTLPRGETAAA
EEEECCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCHH
SWRDFGAVIEVATIEAALPLVDRIAAEHVELAIDDAEGFLSRMRNAGAVFLGRHTPEAIG
HHHHHHHHEEHHHHHHHHHHHHHHHHHHHEEEEECHHHHHHHHCCCCEEEEECCCHHHHH
DYVGGSNHVLPTARSARFSSGLSVLDFVKRTSILKLGPEQLRVLAPAAIALAKAEGLDAH
HHCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCC
GRSVAIRLNM
CCEEEEEECC
>Mature Secondary Structure 
AITLRQSDADFEQRFAAFLTTKREVSEDVDAGVRQIIARVRAEGDAALIDYTQRFDRAD
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHCCHHH
LKSLGIAVSKQDIAAAYETADPKAIEALEFARDRIRSHHERQRPKDDRYTDATGVELGWR
HHHHCCEECHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECEE
WTAIEAVGLYVPGGTASYPSSVLMNAVPARVAGVERVVMVVPAPGGIINPLVLVAADISG
EEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCEEEEEEEECCCCHHHHHHHHHHCHHH
VTEIYRVGGAHAIAALAYGTETIKPVAKIVGPGNAYVAAAKRQVFGTVGIDMIAGPSEVL
HHHHHHCCCHHHHHHHHHCCHHHHHHHHHCCCCCCEEHHHHHHHHHHCCCCEECCCCEEE
VVADGSNNADWIAADLLAQAEHDVSAQSILITDDPAFGKAVEQAVERQLQTLPRGETAAA
EEEECCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCHH
SWRDFGAVIEVATIEAALPLVDRIAAEHVELAIDDAEGFLSRMRNAGAVFLGRHTPEAIG
HHHHHHHHEEHHHHHHHHHHHHHHHHHHHEEEEECHHHHHHHHCCCCEEEEECCCHHHHH
DYVGGSNHVLPTARSARFSSGLSVLDFVKRTSILKLGPEQLRVLAPAAIALAKAEGLDAH
HHCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCC
GRSVAIRLNM
CCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968