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The map label for this gene is hemN [H]

Identifier: 13475361

GI number: 13475361

Start: 5230462

End: 5231811

Strand: Reverse

Name: hemN [H]

Synonym: mll6408

Alternate gene names: 13475361

Gene position: 5231811-5230462 (Counterclockwise)

Preceding gene: 13475363

Following gene: 13475350

Centisome position: 74.36

GC content: 59.48

Gene sequence:

>1350_bases
ATGAGACCGGAATTAGCTGCCAAGCTTGGCGAGAACGTCCCGCGTTATACCAGTTACCCGACCGCGCCGCATTTCCATCC
TGGCGTCGACGCTGATGTCTATCGAAGCTGGTTGAAGGCGCTCGAAAGCGGTGACGAGGTCTCGCTCTACCTGCACATCC
CTTATTGCGACCGGCTGTGCTGGTTCTGTGCGTGCCATACAAAGCAGACCCGCCGCTACGAGCCGGTGGCTTCGTATCTC
CGCTCGCTTCACGCGGAGATCGCGACTGTCGCCGGTCTTGTCGGCGGCAAGGCCCATGTCCGCGCCGTGCATTTCGGCGG
CGGCTCGCCGACCATGCTGAAGCCCGAGGATATGGTAGCCTTGGGAACTGTCCTGCGGGATAGCTTCGATTTTCTTGCCG
ATGCGAAGATCAGCGTCGAAATCGAACCCAACGACATGGACGAAGCCCGCCTTGATACACTTGCCGAGATCGGCATGGCG
CGGGCGAGCCTCGGCGTTCAGGATTTCGATCCGAAGGTGCAGAAGGCGATCAATCGCGAGCAGAGCTTTTTGCAGACCAA
GGCGGTTGTAGACGGCATTCGCTCTCGCGGCGTAGGGTCCGTGAACCTCGATTTGCTTTACGGCCTGCCGCATCAGACCA
GGGAGAGCGTCTGTTCCACCGTGGCGCAGGCGCTGACTCTGGAGCCGGACCGGATGGCGCTGTTCGGCTACGCGCATGTG
CCCTGGTTCAAGAAGCATCAGACTATGATCGACGAGTCATGGTTGCCGGGTCCGGCCGAACGGTTCGCTCAGTGGCAAAT
TGCCGCCCGTCTGATCATGGGCGCCGGATACGAGGCGATTGGAATAGACCATTTCGCCAAGCCGGATGATGCGCTTGCAG
TCTCGGCTCGCGCGGGAACAATCCGCCGCAATTTCCAGGGCTACACCGAGGATCGCTGCGAAACACTGATCGGGCTCGGG
CCGTCATCGATCAGCCGGTTTCGACAGGGCTATTCGCAGAACATGCCGTCGACAGCCGAATATGGACGCATGGTCGAGGG
GGGACATCTGGCCACGGTCCGCGGCATCGCGTTTTCCGAAGATGACCGTGTTCGCGGCTGGATCATCGAGCGCTTGATGT
GCGATTTCGGCTTTTCAGCAGCCGATCTGGTGGAACGCTTCGGGGAAGCCGGACAAAAGCTTCTTTTCCAAGCAAGCTCC
ATCGCCATTGGCGACCCTGCTCGACCGCTTGAACTCCAAGGTGACAGTTACGTCGTATCGGCGGAAAGTCGTCCCTTTGT
AAGGAGCATTGCAGCGAAGTTCGACAAATATTTCGAAAGTGGAACGGCCAGGCACTCAGTGGCAGTCTGA

Upstream 100 bases:

>100_bases
CCTTGCGGCAGTTTGTCCGTGCTGGAGGCTGACCGAAATCAGGGCATTGGCTCTTCGACGCGTCCAGACTTCCGGCGAGG
CAAAAACGGCGGACCACCAA

Downstream 100 bases:

>100_bases
GTGCCACAGACGAACGTCACCGTCTTCAGTCGATCGCGAACCTCCTCAAAATCGCCGAAACCAGCAGCTAACAATTCGAT
AGTGCATATGACGCCACTTT

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MRPELAAKLGENVPRYTSYPTAPHFHPGVDADVYRSWLKALESGDEVSLYLHIPYCDRLCWFCACHTKQTRRYEPVASYL
RSLHAEIATVAGLVGGKAHVRAVHFGGGSPTMLKPEDMVALGTVLRDSFDFLADAKISVEIEPNDMDEARLDTLAEIGMA
RASLGVQDFDPKVQKAINREQSFLQTKAVVDGIRSRGVGSVNLDLLYGLPHQTRESVCSTVAQALTLEPDRMALFGYAHV
PWFKKHQTMIDESWLPGPAERFAQWQIAARLIMGAGYEAIGIDHFAKPDDALAVSARAGTIRRNFQGYTEDRCETLIGLG
PSSISRFRQGYSQNMPSTAEYGRMVEGGHLATVRGIAFSEDDRVRGWIIERLMCDFGFSAADLVERFGEAGQKLLFQASS
IAIGDPARPLELQGDSYVVSAESRPFVRSIAAKFDKYFESGTARHSVAV

Sequences:

>Translated_449_residues
MRPELAAKLGENVPRYTSYPTAPHFHPGVDADVYRSWLKALESGDEVSLYLHIPYCDRLCWFCACHTKQTRRYEPVASYL
RSLHAEIATVAGLVGGKAHVRAVHFGGGSPTMLKPEDMVALGTVLRDSFDFLADAKISVEIEPNDMDEARLDTLAEIGMA
RASLGVQDFDPKVQKAINREQSFLQTKAVVDGIRSRGVGSVNLDLLYGLPHQTRESVCSTVAQALTLEPDRMALFGYAHV
PWFKKHQTMIDESWLPGPAERFAQWQIAARLIMGAGYEAIGIDHFAKPDDALAVSARAGTIRRNFQGYTEDRCETLIGLG
PSSISRFRQGYSQNMPSTAEYGRMVEGGHLATVRGIAFSEDDRVRGWIIERLMCDFGFSAADLVERFGEAGQKLLFQASS
IAIGDPARPLELQGDSYVVSAESRPFVRSIAAKFDKYFESGTARHSVAV
>Mature_449_residues
MRPELAAKLGENVPRYTSYPTAPHFHPGVDADVYRSWLKALESGDEVSLYLHIPYCDRLCWFCACHTKQTRRYEPVASYL
RSLHAEIATVAGLVGGKAHVRAVHFGGGSPTMLKPEDMVALGTVLRDSFDFLADAKISVEIEPNDMDEARLDTLAEIGMA
RASLGVQDFDPKVQKAINREQSFLQTKAVVDGIRSRGVGSVNLDLLYGLPHQTRESVCSTVAQALTLEPDRMALFGYAHV
PWFKKHQTMIDESWLPGPAERFAQWQIAARLIMGAGYEAIGIDHFAKPDDALAVSARAGTIRRNFQGYTEDRCETLIGLG
PSSISRFRQGYSQNMPSTAEYGRMVEGGHLATVRGIAFSEDDRVRGWIIERLMCDFGFSAADLVERFGEAGQKLLFQASS
IAIGDPARPLELQGDSYVVSAESRPFVRSIAAKFDKYFESGTARHSVAV

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=340, Percent_Identity=24.1176470588235, Blast_Score=91, Evalue=3e-18,
Organism=Escherichia coli, GI87082341, Length=439, Percent_Identity=37.129840546697, Blast_Score=288, Evalue=6e-79,
Organism=Escherichia coli, GI1789325, Length=250, Percent_Identity=28, Blast_Score=99, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 49573; Mature: 49573

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPELAAKLGENVPRYTSYPTAPHFHPGVDADVYRSWLKALESGDEVSLYLHIPYCDRLC
CCCHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCHHHHHH
WFCACHTKQTRRYEPVASYLRSLHAEIATVAGLVGGKAHVRAVHFGGGSPTMLKPEDMVA
HHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCHHHHH
LGTVLRDSFDFLADAKISVEIEPNDMDEARLDTLAEIGMARASLGVQDFDPKVQKAINRE
HHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
QSFLQTKAVVDGIRSRGVGSVNLDLLYGLPHQTRESVCSTVAQALTLEPDRMALFGYAHV
HHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCC
PWFKKHQTMIDESWLPGPAERFAQWQIAARLIMGAGYEAIGIDHFAKPDDALAVSARAGT
CHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCEEEECCCCH
IRRNFQGYTEDRCETLIGLGPSSISRFRQGYSQNMPSTAEYGRMVEGGHLATVRGIAFSE
HHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHCCCCCCCCEEEEECEEECC
DDRVRGWIIERLMCDFGFSAADLVERFGEAGQKLLFQASSIAIGDPARPLELQGDSYVVS
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCEEECCCCCCEEECCCEEEEE
AESRPFVRSIAAKFDKYFESGTARHSVAV
CCCCHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MRPELAAKLGENVPRYTSYPTAPHFHPGVDADVYRSWLKALESGDEVSLYLHIPYCDRLC
CCCHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCHHHHHH
WFCACHTKQTRRYEPVASYLRSLHAEIATVAGLVGGKAHVRAVHFGGGSPTMLKPEDMVA
HHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCHHHHH
LGTVLRDSFDFLADAKISVEIEPNDMDEARLDTLAEIGMARASLGVQDFDPKVQKAINRE
HHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
QSFLQTKAVVDGIRSRGVGSVNLDLLYGLPHQTRESVCSTVAQALTLEPDRMALFGYAHV
HHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCC
PWFKKHQTMIDESWLPGPAERFAQWQIAARLIMGAGYEAIGIDHFAKPDDALAVSARAGT
CHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCEEEECCCCH
IRRNFQGYTEDRCETLIGLGPSSISRFRQGYSQNMPSTAEYGRMVEGGHLATVRGIAFSE
HHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHCCCCCCCCEEEEECEEECC
DDRVRGWIIERLMCDFGFSAADLVERFGEAGQKLLFQASSIAIGDPARPLELQGDSYVVS
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCEEECCCCCCEEECCCEEEEE
AESRPFVRSIAAKFDKYFESGTARHSVAV
CCCCHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11157943; 12597275 [H]