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The map label for this gene is glyA2

Identifier: 13475106

GI number: 13475106

Start: 4947567

End: 4948880

Strand: Direct

Name: glyA2

Synonym: mlr6114

Alternate gene names: 13475106

Gene position: 4947567-4948880 (Clockwise)

Preceding gene: 13475102

Following gene: 13475107

Centisome position: 70.32

GC content: 59.13

Gene sequence:

>1314_bases
ATGGCAGAGCCCGGCACATACGGACGGTCTTCCTTGGTCCAGGTCGATTGCCGCGTTCATGAACTGCTTCTACGACAGAG
GCGGCAAGAGCGGACGATGCTCAAACTTATCGCATCTGAGAACTTTGCCTCCTCAGCCGTACTGGAAGCGACCGGCTCTA
TCTTCGCGAACAAGTATGCCGAGGGCTACCCGGGTGCGCGCTACTACGCGGGAAATGAGATCGTCGATGAGCTTGAGACC
CTCGCGATCGAGCGCCTGAAAGCGCTATTTGGCAGTGAGCACGCCAACGTCCAGCCTTATTCGGGCTCACCAGCCAACCA
GGCTGTCTATCGCGCGCTTTTGAGCCCCCGTGACAAAGTCATGGGGCTGCCGTTGCCCGAAGGGGGCCATCTGACTCATG
GGTGGTCCGTCAACTTTTCCGGCACTGATTATCAACGCGTCCCCTATGGGCTGCACGATAAGACGCAGCAAATTGACTAT
GACCGCTTGCGCGAGACCGCCAGGCGGGAACGGCCGAAACTCATTTGGGTCGGCGGAACTTCCTACCCGCGTGTCTTTGA
CTACGCGGCAATGGCAGAAATCGCTCTGGAGGCGAACTCTTATCTCGTGGCCGACATCGCCCACATCAGCGGCCTGATTG
TCGCTGGAGCGCATCCGAATCCCGTGGTCCATTGCGACGTCGTCACCAGCACATCTCACAAGTCGATCCGCGGCCCCCGT
GGAGGCTTTATTTTGTCGAAGAATGAAGATCGTTATCAGGCGCTCTATCATTCCACGAGCAAACACAATCTCGCCAAACG
GATTGATCGCGCGGTGTTTCCTCAACTGCAAGGTGGGCCGCACATGAATACCATCGCCGCGCTCGCTGTTGCTTTGCAGG
AAGCCGCGACCCCCTCTTTCCGCACCTACGGTCACCAGATCGTCAAGAATGCCAAGGCGCTGGCCGAGGCGCTTCTGGGT
CGTGGTTATTATCTGGTCACCGGCGGGACTGACAATCACATGCTGATCCTTGATCTTCGGGACCGGCCGCTATCAGGCAA
AGCCTATGCCGAGCGCCTGGCAAGGGCAGGCATCATTACGAACTTTGATATGGTGCCGGGCGACCCGCGCGACCCGACGG
TCACAAGCGGAATCCGCTTGGGGTCGCCGGCAGTGACGTCCATGGGCATGCGTGAGGCGGAAATGGTGCAGATCGCCGCT
TTCATCGACTCCGTCTGCCGCCAGCCCGACGACCAGGAAGTTCATGCGAGCGTACGAAGAGACGTTGCCGACTTCTGCAC
TGCGTTCGACGTCCCCGGCATCAGCGACCGGTAA

Upstream 100 bases:

>100_bases
GGTGCAAGATGCGTGGTCGACGGGGACTGCTGCTTGATCGTGAAAAGATCTGCCTAAGTGGGAGTGCGAAACTACCATGA
AGAACTCCGCTGACGTAGCC

Downstream 100 bases:

>100_bases
GACCGCCCCAGTCCAGAAACTCCCATCCAACTCCAACACTTGAAGCGAGGACATTCCATGACCAGGCAGTTCGTGTTCTC
TTCCGAATCCGTCGGCGCGG

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT 2; Serine methylase 2

Number of amino acids: Translated: 437; Mature: 436

Protein sequence:

>437_residues
MAEPGTYGRSSLVQVDCRVHELLLRQRRQERTMLKLIASENFASSAVLEATGSIFANKYAEGYPGARYYAGNEIVDELET
LAIERLKALFGSEHANVQPYSGSPANQAVYRALLSPRDKVMGLPLPEGGHLTHGWSVNFSGTDYQRVPYGLHDKTQQIDY
DRLRETARRERPKLIWVGGTSYPRVFDYAAMAEIALEANSYLVADIAHISGLIVAGAHPNPVVHCDVVTSTSHKSIRGPR
GGFILSKNEDRYQALYHSTSKHNLAKRIDRAVFPQLQGGPHMNTIAALAVALQEAATPSFRTYGHQIVKNAKALAEALLG
RGYYLVTGGTDNHMLILDLRDRPLSGKAYAERLARAGIITNFDMVPGDPRDPTVTSGIRLGSPAVTSMGMREAEMVQIAA
FIDSVCRQPDDQEVHASVRRDVADFCTAFDVPGISDR

Sequences:

>Translated_437_residues
MAEPGTYGRSSLVQVDCRVHELLLRQRRQERTMLKLIASENFASSAVLEATGSIFANKYAEGYPGARYYAGNEIVDELET
LAIERLKALFGSEHANVQPYSGSPANQAVYRALLSPRDKVMGLPLPEGGHLTHGWSVNFSGTDYQRVPYGLHDKTQQIDY
DRLRETARRERPKLIWVGGTSYPRVFDYAAMAEIALEANSYLVADIAHISGLIVAGAHPNPVVHCDVVTSTSHKSIRGPR
GGFILSKNEDRYQALYHSTSKHNLAKRIDRAVFPQLQGGPHMNTIAALAVALQEAATPSFRTYGHQIVKNAKALAEALLG
RGYYLVTGGTDNHMLILDLRDRPLSGKAYAERLARAGIITNFDMVPGDPRDPTVTSGIRLGSPAVTSMGMREAEMVQIAA
FIDSVCRQPDDQEVHASVRRDVADFCTAFDVPGISDR
>Mature_436_residues
AEPGTYGRSSLVQVDCRVHELLLRQRRQERTMLKLIASENFASSAVLEATGSIFANKYAEGYPGARYYAGNEIVDELETL
AIERLKALFGSEHANVQPYSGSPANQAVYRALLSPRDKVMGLPLPEGGHLTHGWSVNFSGTDYQRVPYGLHDKTQQIDYD
RLRETARRERPKLIWVGGTSYPRVFDYAAMAEIALEANSYLVADIAHISGLIVAGAHPNPVVHCDVVTSTSHKSIRGPRG
GFILSKNEDRYQALYHSTSKHNLAKRIDRAVFPQLQGGPHMNTIAALAVALQEAATPSFRTYGHQIVKNAKALAEALLGR
GYYLVTGGTDNHMLILDLRDRPLSGKAYAERLARAGIITNFDMVPGDPRDPTVTSGIRLGSPAVTSMGMREAEMVQIAAF
IDSVCRQPDDQEVHASVRRDVADFCTAFDVPGISDR

Specific function: Interconversion of serine and glycine

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family

Homologues:

Organism=Homo sapiens, GI261862352, Length=469, Percent_Identity=44.7761194029851, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI261862350, Length=469, Percent_Identity=44.7761194029851, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI261862348, Length=469, Percent_Identity=44.7761194029851, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI19923315, Length=469, Percent_Identity=44.7761194029851, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI261862346, Length=469, Percent_Identity=43.7100213219616, Blast_Score=353, Evalue=2e-97,
Organism=Homo sapiens, GI22547186, Length=460, Percent_Identity=42.8260869565217, Blast_Score=337, Evalue=1e-92,
Organism=Homo sapiens, GI22547189, Length=457, Percent_Identity=39.3873085339169, Blast_Score=297, Evalue=1e-80,
Organism=Escherichia coli, GI1788902, Length=421, Percent_Identity=47.7434679334917, Blast_Score=381, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI25144732, Length=451, Percent_Identity=42.5720620842572, Blast_Score=349, Evalue=2e-96,
Organism=Caenorhabditis elegans, GI25144729, Length=451, Percent_Identity=42.5720620842572, Blast_Score=348, Evalue=2e-96,
Organism=Saccharomyces cerevisiae, GI6319739, Length=421, Percent_Identity=41.3301662707838, Blast_Score=331, Evalue=1e-91,
Organism=Saccharomyces cerevisiae, GI6323087, Length=436, Percent_Identity=41.5137614678899, Blast_Score=324, Evalue=2e-89,
Organism=Drosophila melanogaster, GI24640005, Length=458, Percent_Identity=40.8296943231441, Blast_Score=367, Evalue=1e-102,
Organism=Drosophila melanogaster, GI221329721, Length=458, Percent_Identity=40.8296943231441, Blast_Score=367, Evalue=1e-102,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): GLYA2_RHILO (Q98A81)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_106670.1
- ProteinModelPortal:   Q98A81
- SMR:   Q98A81
- GeneID:   1229325
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mlr6114
- NMPDR:   fig|266835.1.peg.4771
- HOGENOM:   HBG301263
- OMA:   CATTHKV
- BRENDA:   2.1.2.1
- GO:   GO:0005737
- HAMAP:   MF_00051_B
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11680
- PIRSF:   PIRSF000412

Pfam domain/function: PF00464 SHMT; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.1.2.1

Molecular weight: Translated: 47992; Mature: 47861

Theoretical pI: Translated: 7.74; Mature: 7.74

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEPGTYGRSSLVQVDCRVHELLLRQRRQERTMLKLIASENFASSAVLEATGSIFANKYA
CCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHC
EGYPGARYYAGNEIVDELETLAIERLKALFGSEHANVQPYSGSPANQAVYRALLSPRDKV
CCCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCHHE
MGLPLPEGGHLTHGWSVNFSGTDYQRVPYGLHDKTQQIDYDRLRETARRERPKLIWVGGT
EECCCCCCCCEECCEEEECCCCCCCCCCCCCCCCHHCCCHHHHHHHHHHCCCCEEEECCC
SYPRVFDYAAMAEIALEANSYLVADIAHISGLIVAGAHPNPVVHCDVVTSTSHKSIRGPR
CCCHHHHHHHHHHHHHCCCCEEEEEHHHHCCEEEECCCCCCEEEEEEEECCCCCCCCCCC
GGFILSKNEDRYQALYHSTSKHNLAKRIDRAVFPQLQGGPHMNTIAALAVALQEAATPSF
CCEEECCCCHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCH
RTYGHQIVKNAKALAEALLGRGYYLVTGGTDNHMLILDLRDRPLSGKAYAERLARAGIIT
HHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHCCCEE
NFDMVPGDPRDPTVTSGIRLGSPAVTSMGMREAEMVQIAAFIDSVCRQPDDQEVHASVRR
ECCCCCCCCCCCCCCCCEECCCCHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
DVADFCTAFDVPGISDR
HHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
AEPGTYGRSSLVQVDCRVHELLLRQRRQERTMLKLIASENFASSAVLEATGSIFANKYA
CCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHC
EGYPGARYYAGNEIVDELETLAIERLKALFGSEHANVQPYSGSPANQAVYRALLSPRDKV
CCCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCHHE
MGLPLPEGGHLTHGWSVNFSGTDYQRVPYGLHDKTQQIDYDRLRETARRERPKLIWVGGT
EECCCCCCCCEECCEEEECCCCCCCCCCCCCCCCHHCCCHHHHHHHHHHCCCCEEEECCC
SYPRVFDYAAMAEIALEANSYLVADIAHISGLIVAGAHPNPVVHCDVVTSTSHKSIRGPR
CCCHHHHHHHHHHHHHCCCCEEEEEHHHHCCEEEECCCCCCEEEEEEEECCCCCCCCCCC
GGFILSKNEDRYQALYHSTSKHNLAKRIDRAVFPQLQGGPHMNTIAALAVALQEAATPSF
CCEEECCCCHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCH
RTYGHQIVKNAKALAEALLGRGYYLVTGGTDNHMLILDLRDRPLSGKAYAERLARAGIIT
HHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHCCCEE
NFDMVPGDPRDPTVTSGIRLGSPAVTSMGMREAEMVQIAAFIDSVCRQPDDQEVHASVRR
ECCCCCCCCCCCCCCCCEECCCCHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
DVADFCTAFDVPGISDR
HHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968