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The map label for this gene is bioA [H]

Identifier: 13475016

GI number: 13475016

Start: 4854120

End: 4854827

Strand: Reverse

Name: bioA [H]

Synonym: mll6003

Alternate gene names: 13475016

Gene position: 4854827-4854120 (Counterclockwise)

Preceding gene: 13475017

Following gene: 13475015

Centisome position: 69.0

GC content: 64.27

Gene sequence:

>708_bases
ATGATGACGCAGTCTCGAGTCTGGCATCCGTTCACCCAGCACGCGCTTGAGCCCGCGATCCCTGAAATCGTGCTGACGGA
AGGCGCCTATCTCCACAAGACCGACGGCTCCCGCATCCTGGACGCCATTTCCTCCTGGTGGGTCGTCACCCATGGCCACC
GTCATCCCCGCATCATGAAGGCTATCGAGACAACCGCATCGAGACTCGACCAGATCATTTTCGCCGGCTTCACCCACGAG
CCCGCCCAACGACTGGCCGAGGCGCTCGTCGACCTCGCTCCGCCCGGACTCGACTGGGTGTTCTATTCCGACAGCGGCTC
GACTTCCGTCGAAGTCGCGCTGAAGATGGCGCTCGGCTATTTCCGCAACATCGGCGCGCCGCGCTCGCGCATCGTCGTCA
TGGAGCACAGCTACCATGGCGACACAATCGGCACGATGAGCGTCGGCGCCCGCGGCGTGTTCAACGCCGCCTACGAGCCT
TTGCTGTTCGAGGTCGACACCGTCCCCTTCGCGGCCGCCGGGCGCGAGCAGGAGACGCTGGATCGGTTCGAAGCCATCAG
CCTCGACCGACGCGCCGCCGCCCTGATCGTCGAGCCGCTCGTGCTAGGCGCCGGCGGCATGCTGATGTATCCGGCCTGGG
TTCTGAGCGAATTGAAGAAGATCGCCGAAGCCTCCGGCACGCTCTTGATCGCCGATGATTCGGATTGA

Upstream 100 bases:

>100_bases
CGCAGCTTGGCAGGCTGCCGCACCTCGATCCGCTGATGGGTGGAACGCTGAGAGATGCAATGATTGCCGGATTCGACCTT
GCCCTTACTGCCGGAGGCGA

Downstream 100 bases:

>100_bases
TCGCTGCCACAGGTACATCGAAGGTCAGATCATTGCTCGAGCGTATCGCGACTGATGAAACGCTGCCTGAACTGGCACGT
GAACTGTTTGGGCTGCACGG

Product: adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MMTQSRVWHPFTQHALEPAIPEIVLTEGAYLHKTDGSRILDAISSWWVVTHGHRHPRIMKAIETTASRLDQIIFAGFTHE
PAQRLAEALVDLAPPGLDWVFYSDSGSTSVEVALKMALGYFRNIGAPRSRIVVMEHSYHGDTIGTMSVGARGVFNAAYEP
LLFEVDTVPFAAAGREQETLDRFEAISLDRRAAALIVEPLVLGAGGMLMYPAWVLSELKKIAEASGTLLIADDSD

Sequences:

>Translated_235_residues
MMTQSRVWHPFTQHALEPAIPEIVLTEGAYLHKTDGSRILDAISSWWVVTHGHRHPRIMKAIETTASRLDQIIFAGFTHE
PAQRLAEALVDLAPPGLDWVFYSDSGSTSVEVALKMALGYFRNIGAPRSRIVVMEHSYHGDTIGTMSVGARGVFNAAYEP
LLFEVDTVPFAAAGREQETLDRFEAISLDRRAAALIVEPLVLGAGGMLMYPAWVLSELKKIAEASGTLLIADDSD
>Mature_235_residues
MMTQSRVWHPFTQHALEPAIPEIVLTEGAYLHKTDGSRILDAISSWWVVTHGHRHPRIMKAIETTASRLDQIIFAGFTHE
PAQRLAEALVDLAPPGLDWVFYSDSGSTSVEVALKMALGYFRNIGAPRSRIVVMEHSYHGDTIGTMSVGARGVFNAAYEP
LLFEVDTVPFAAAGREQETLDRFEAISLDRRAAALIVEPLVLGAGGMLMYPAWVLSELKKIAEASGTLLIADDSD

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786991, Length=239, Percent_Identity=38.0753138075314, Blast_Score=160, Evalue=8e-41,
Organism=Escherichia coli, GI145693181, Length=206, Percent_Identity=29.126213592233, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1788044, Length=221, Percent_Identity=29.4117647058824, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1789759, Length=211, Percent_Identity=26.5402843601896, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1787560, Length=216, Percent_Identity=25.9259259259259, Blast_Score=70, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324386, Length=253, Percent_Identity=30.8300395256917, Blast_Score=118, Evalue=7e-28,
Organism=Saccharomyces cerevisiae, GI6323470, Length=219, Percent_Identity=26.4840182648402, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 25786; Mature: 25786

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMTQSRVWHPFTQHALEPAIPEIVLTEGAYLHKTDGSRILDAISSWWVVTHGHRHPRIMK
CCCCCCCCCCHHHHHCCCCCCEEEEECCCEEEECCCHHHHHHHHHCEEEECCCCCHHHHH
AIETTASRLDQIIFAGFTHEPAQRLAEALVDLAPPGLDWVFYSDSGSTSVEVALKMALGY
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHH
FRNIGAPRSRIVVMEHSYHGDTIGTMSVGARGVFNAAYEPLLFEVDTVPFAAAGREQETL
HHHCCCCCCEEEEEEECCCCCCCEEHHCCCCHHHHHHCCCEEEEECCCCCCCCCCCHHHH
DRFEAISLDRRAAALIVEPLVLGAGGMLMYPAWVLSELKKIAEASGTLLIADDSD
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCC
>Mature Secondary Structure
MMTQSRVWHPFTQHALEPAIPEIVLTEGAYLHKTDGSRILDAISSWWVVTHGHRHPRIMK
CCCCCCCCCCHHHHHCCCCCCEEEEECCCEEEECCCHHHHHHHHHCEEEECCCCCHHHHH
AIETTASRLDQIIFAGFTHEPAQRLAEALVDLAPPGLDWVFYSDSGSTSVEVALKMALGY
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHH
FRNIGAPRSRIVVMEHSYHGDTIGTMSVGARGVFNAAYEPLLFEVDTVPFAAAGREQETL
HHHCCCCCCEEEEEEECCCCCCCEEHHCCCCHHHHHHCCCEEEEECCCCCCCCCCCHHHH
DRFEAISLDRRAAALIVEPLVLGAGGMLMYPAWVLSELKKIAEASGTLLIADDSD
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]