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The map label for this gene is bioA [H]

Identifier: 13474853

GI number: 13474853

Start: 4700814

End: 4702082

Strand: Reverse

Name: bioA [H]

Synonym: mll5828

Alternate gene names: 13474853

Gene position: 4702082-4700814 (Counterclockwise)

Preceding gene: 13474854

Following gene: 13474852

Centisome position: 66.83

GC content: 64.22

Gene sequence:

>1269_bases
ATGATGCCGCAGTCCCGTGTGTGGCATCCCTTCACCCAGCACGCGCTCGAGCCCGCCATCCCTGAAATCGCCCGGACGGA
AGGCGCCTACCTCTACAAGGCCGACGGCACGCGCATCCTGGATGCCATTTCCTCCTGGTGGGTCGTCACGCACGGCCACC
GCCATCCCCGCATCATCAAGGCTATCGAGACGACCGCGTCTAGCCTCGTCCAGATCATCTTCGCTGGCTTCACCCACGAG
CCGGCAGAGCGCCTGGCCAAGGCACTTGTCGGCCTCGCTCCCGCCGGACTCGACTGGGTGTTCTATTCCGACAGCGGCTC
GACCTCCGTCGAGGTCGCGCTGAAGATGGCGCTCGGCTATTTCCGCAACATCGACGCGCCGCGCTCGCGCATCGTCGTCA
TGGAGCACAGCTATCATGGCGACACCATCGGGACGATGAGCGTCGGTGCCCGTGGCGCGTTTAACGCCGCCTACGAACCT
TTGCTGTTCGAGGTCGACACCATCCCCTTCCCGGCCGCGGGACGCGAACAAGAGACGCTGGATCGGTTCGAGGCAGTTGC
CCGCGACCGGCGCACGGCCGCGCTGATCGTCGAACCGCTCGTGCTAGGCGCCGGCGGCATGCTGATGTATCCGGCCTGGG
TTCTGGCCGAATTGAAGAAGATCGCAGAAACCTCCGGCACGTTGCTGATCGCCGATGAAGTAATGACCGGCTGGGGGCGG
ACCGGAACCATGTTCGCCTGCGAGCAGGCGTCCATTTCTCCGGACATCCTATGCACGTCGAAGGGCTTGACCGGTGGCGC
GATCCCTTTGGCGGCCACGCTCGCCACCGATGCCATCTTCCAGGCCCATTATTCCGAAGACCGTAAGAAAACCTTCTTTC
ATTCGAGCTCATACACCGCCAATCCGATTGCCTGCGCGGCAGCACTCGCCAATGTCGAGATCTGGCGCGACGAGCCGGTG
GCCGAGCGGGTCGCGGCTTTGAGCGCGAAGCAGGCCGCCGGGCTGCAACGCTTCCGGGACAACCCATATTTCACCGACTG
CCGAGCCACTGGCACGATCGCTGCCCTCGACCTGCGCACCGGTTCCGCCGGCTATCTCGCCGAGATTGGTCCGAAACTGC
GCGCGTTCTTCCTCGAGCGCGGCCTGCTTGTTCGTCCGCTCGGCAATGTCCTCTATCTTCTCCCGCCCTATTGCATCACC
GGCGGCGAGTTGGACGCACTCTACGACGCGATCGAGGAGGCCGCCGAACGCTTCGGGTCTAGGCCATGA

Upstream 100 bases:

>100_bases
GCCAGCTTGGCAGGCTGCCACACATCGATCCGCTGACGAGTGAGACGCTGCGGGATGCGATGGTTGCCGGCTTCGACCTC
ACAGCGATCGCAGGAGGCGA

Downstream 100 bases:

>100_bases
GCAAGTCGTCGCGCATTCTCGGGTTCGGTCATCATACGCCTGGGCGCAAGGTGGCGAATGCCGAGATCGAGAACAATCTC
GGCCTCGAGCCGGGCTGGAT

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MMPQSRVWHPFTQHALEPAIPEIARTEGAYLYKADGTRILDAISSWWVVTHGHRHPRIIKAIETTASSLVQIIFAGFTHE
PAERLAKALVGLAPAGLDWVFYSDSGSTSVEVALKMALGYFRNIDAPRSRIVVMEHSYHGDTIGTMSVGARGAFNAAYEP
LLFEVDTIPFPAAGREQETLDRFEAVARDRRTAALIVEPLVLGAGGMLMYPAWVLAELKKIAETSGTLLIADEVMTGWGR
TGTMFACEQASISPDILCTSKGLTGGAIPLAATLATDAIFQAHYSEDRKKTFFHSSSYTANPIACAAALANVEIWRDEPV
AERVAALSAKQAAGLQRFRDNPYFTDCRATGTIAALDLRTGSAGYLAEIGPKLRAFFLERGLLVRPLGNVLYLLPPYCIT
GGELDALYDAIEEAAERFGSRP

Sequences:

>Translated_422_residues
MMPQSRVWHPFTQHALEPAIPEIARTEGAYLYKADGTRILDAISSWWVVTHGHRHPRIIKAIETTASSLVQIIFAGFTHE
PAERLAKALVGLAPAGLDWVFYSDSGSTSVEVALKMALGYFRNIDAPRSRIVVMEHSYHGDTIGTMSVGARGAFNAAYEP
LLFEVDTIPFPAAGREQETLDRFEAVARDRRTAALIVEPLVLGAGGMLMYPAWVLAELKKIAETSGTLLIADEVMTGWGR
TGTMFACEQASISPDILCTSKGLTGGAIPLAATLATDAIFQAHYSEDRKKTFFHSSSYTANPIACAAALANVEIWRDEPV
AERVAALSAKQAAGLQRFRDNPYFTDCRATGTIAALDLRTGSAGYLAEIGPKLRAFFLERGLLVRPLGNVLYLLPPYCIT
GGELDALYDAIEEAAERFGSRP
>Mature_422_residues
MMPQSRVWHPFTQHALEPAIPEIARTEGAYLYKADGTRILDAISSWWVVTHGHRHPRIIKAIETTASSLVQIIFAGFTHE
PAERLAKALVGLAPAGLDWVFYSDSGSTSVEVALKMALGYFRNIDAPRSRIVVMEHSYHGDTIGTMSVGARGAFNAAYEP
LLFEVDTIPFPAAGREQETLDRFEAVARDRRTAALIVEPLVLGAGGMLMYPAWVLAELKKIAETSGTLLIADEVMTGWGR
TGTMFACEQASISPDILCTSKGLTGGAIPLAATLATDAIFQAHYSEDRKKTFFHSSSYTANPIACAAALANVEIWRDEPV
AERVAALSAKQAAGLQRFRDNPYFTDCRATGTIAALDLRTGSAGYLAEIGPKLRAFFLERGLLVRPLGNVLYLLPPYCIT
GGELDALYDAIEEAAERFGSRP

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=417, Percent_Identity=25.4196642685851, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI13994255, Length=430, Percent_Identity=24.8837209302326, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI37574042, Length=436, Percent_Identity=26.1467889908257, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI24119277, Length=426, Percent_Identity=24.6478873239437, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI284507298, Length=319, Percent_Identity=26.3322884012539, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI226442705, Length=436, Percent_Identity=25.6880733944954, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI226442709, Length=406, Percent_Identity=26.1083743842365, Blast_Score=95, Evalue=1e-19,
Organism=Escherichia coli, GI1786991, Length=421, Percent_Identity=37.5296912114014, Blast_Score=266, Evalue=2e-72,
Organism=Escherichia coli, GI145693181, Length=340, Percent_Identity=31.1764705882353, Blast_Score=182, Evalue=2e-47,
Organism=Escherichia coli, GI1789759, Length=401, Percent_Identity=28.927680798005, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1788044, Length=415, Percent_Identity=30.1204819277108, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1787560, Length=402, Percent_Identity=27.363184079602, Blast_Score=128, Evalue=8e-31,
Organism=Escherichia coli, GI1789016, Length=399, Percent_Identity=27.8195488721804, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1786349, Length=323, Percent_Identity=27.2445820433437, Blast_Score=91, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI25144271, Length=418, Percent_Identity=24.6411483253589, Blast_Score=138, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI32564660, Length=459, Percent_Identity=26.797385620915, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI25144274, Length=292, Percent_Identity=26.3698630136986, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17541228, Length=436, Percent_Identity=23.1651376146789, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6324386, Length=465, Percent_Identity=28.8172043010753, Blast_Score=191, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6323470, Length=431, Percent_Identity=26.2180974477958, Blast_Score=134, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6324432, Length=314, Percent_Identity=28.6624203821656, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21357415, Length=412, Percent_Identity=25, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI21356575, Length=407, Percent_Identity=25.5528255528256, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI161085790, Length=433, Percent_Identity=27.2517321016166, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI28574759, Length=419, Percent_Identity=27.9236276849642, Blast_Score=105, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 45839; Mature: 45839

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMPQSRVWHPFTQHALEPAIPEIARTEGAYLYKADGTRILDAISSWWVVTHGHRHPRIIK
CCCCCCCCCCHHHHHHCCCCHHHHHCCCCEEEECCCHHHHHHHHCCEEEECCCCCCHHHH
AIETTASSLVQIIFAGFTHEPAERLAKALVGLAPAGLDWVFYSDSGSTSVEVALKMALGY
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHH
FRNIDAPRSRIVVMEHSYHGDTIGTMSVGARGAFNAAYEPLLFEVDTIPFPAAGREQETL
HHCCCCCCCEEEEEEECCCCCCCEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHH
DRFEAVARDRRTAALIVEPLVLGAGGMLMYPAWVLAELKKIAETSGTLLIADEVMTGWGR
HHHHHHHHCCCHHHHEEHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHCCCC
TGTMFACEQASISPDILCTSKGLTGGAIPLAATLATDAIFQAHYSEDRKKTFFHSSSYTA
CCCEEEECCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHEEECCCCCC
NPIACAAALANVEIWRDEPVAERVAALSAKQAAGLQRFRDNPYFTDCRATGTIAALDLRT
CHHHHHHHHHHCEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCEEEEEECC
GSAGYLAEIGPKLRAFFLERGLLVRPLGNVLYLLPPYCITGGELDALYDAIEEAAERFGS
CCCCHHHHHCHHHHHHHHHCCCEEECHHCCCEECCCEEECCCCHHHHHHHHHHHHHHHCC
RP
CC
>Mature Secondary Structure
MMPQSRVWHPFTQHALEPAIPEIARTEGAYLYKADGTRILDAISSWWVVTHGHRHPRIIK
CCCCCCCCCCHHHHHHCCCCHHHHHCCCCEEEECCCHHHHHHHHCCEEEECCCCCCHHHH
AIETTASSLVQIIFAGFTHEPAERLAKALVGLAPAGLDWVFYSDSGSTSVEVALKMALGY
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHH
FRNIDAPRSRIVVMEHSYHGDTIGTMSVGARGAFNAAYEPLLFEVDTIPFPAAGREQETL
HHCCCCCCCEEEEEEECCCCCCCEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHH
DRFEAVARDRRTAALIVEPLVLGAGGMLMYPAWVLAELKKIAETSGTLLIADEVMTGWGR
HHHHHHHHCCCHHHHEEHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHCCCC
TGTMFACEQASISPDILCTSKGLTGGAIPLAATLATDAIFQAHYSEDRKKTFFHSSSYTA
CCCEEEECCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHEEECCCCCC
NPIACAAALANVEIWRDEPVAERVAALSAKQAAGLQRFRDNPYFTDCRATGTIAALDLRT
CHHHHHHHHHHCEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCEEEEEECC
GSAGYLAEIGPKLRAFFLERGLLVRPLGNVLYLLPPYCITGGELDALYDAIEEAAERFGS
CCCCHHHHHCHHHHHHHHHCCCEEECHHCCCEECCCEEECCCCHHHHHHHHHHHHHHHCC
RP
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]