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The map label for this gene is hemN [H]

Identifier: 13474841

GI number: 13474841

Start: 4691544

End: 4692863

Strand: Reverse

Name: hemN [H]

Synonym: mll5815

Alternate gene names: 13474841

Gene position: 4692863-4691544 (Counterclockwise)

Preceding gene: 13474842

Following gene: 13474840

Centisome position: 66.7

GC content: 60.38

Gene sequence:

>1320_bases
ATGCTACAGACAAAACATAGCGAGGCGTGCCTGCCTTGGTATTTCAATTATCCAACTGCACCGCAGTTCTCCGCAGCGAT
CGGCGCGGAGGCCTATGGGGAATGGCTCGGCGGCCTATCGGCTAACGATCCCGTATCGCTCTATATCCATATTCCGTTCT
GCCGGTCGATGTGCTGGTATTGCGGCTGCCCTACTACCATCACCCAGCGGGACCCGCCGAACCAAAATTACGTGGCGGCG
CTGCGCGGCGAGATCCATTTGGTCTCAGAGCTAACGCCGCAGGCGCTGCCCGTGAGCGACGTGCACTTTGGCGGCGGAAC
GCCCACGCTCCTTGAGCCAACGGAATTCCTCGCCTTGACGGAGCTTCTACGCCGCCGCTTCGCGTTCAGGCAAAAGACCG
CCATCGCCGTCGAGATCGATCCGCGCACGTTCACCGCGGAGATGGCCGAAGCCTTAAGTGCAGCCGGGGTGAACCGCGCG
AGCCTCGGCGTGCAAAGTTTCGACCCCAGTGTTCAAAAAGCGATCAATCGTATCCAGAGTGTAGAGCAGACGGCGACTGC
CGTCGAAAACCTGCGCCAGCAGGGAATAAACCGCATTAACATCGATCTCATCTACGGTCTTCCCAATCAGACGATGCAGT
CCTGCGTCCAGACCGCCACGGTGGCGGTGGCGATGCGCCCGCAGCGGATTGCCGTGTTCGGATACGCTCACACGCCGTCT
TCTAATAAACATCAGCGCCTCATCGAAAAGGCAGGACTACCGGACAGCGCTGCCCGCGCCGAACAAGCTGCGGCCGTCGC
CGAGACGCTGGTTGCTGCCGGCTACCGAGAGATTGGGGTCGACCACTTCGCCTTGCCGGACGACGAGCTCGCATTGGCTC
AGAAAACCGGTCGCCTGCGGCGCAACTCCCAAGGTTACTCTGCCGACACCTGCAAAACCCTGATCGCCTTTGGTGCGTCG
GCTATCGGGCGTGTTGGAGAGGGTTACGTCGAGAACGCAGGCGCGCTGGAGGCCTATAGTCAGCATATCGCAGCTGGTCG
CTTGGCAACGTCGAAGGGCTACCGTCTCATCGGCGAAGACCGCGTCCGAGGCGCAATCATCGAGCGACTGATGTGTGATC
TCGAGGCCGACGTACCGGCAATCTGTGCCGCCCACGGATTTGATTGGACCCATTTTCTCGATTCAGCTGAGCGCTTGGCG
ATGCTGGCCGACGACGGGATAGTGGACGTCGAGAATGGCTTCATCCGCGTGCGGCATGGCCATCGCATTTTGCTTCGCTC
TGTTGCTGCCGCGTTCGACGCTTATCTCGACCAATCGTAG

Upstream 100 bases:

>100_bases
ATTGGCACGACGGAAATACAAGTTGCGCCGCGACAGTTGAAGATCAGAGACATAGGAGAGCGCGGCAGGTATGGAGCTAA
CATCAAGATGAGAAACGGCT

Downstream 100 bases:

>100_bases
TGAGCCACAGCGAGTCACCATGAGCGGAGGCCTGAGAAGGTCGACTGTTGCAATCCGCTGTGGATCGGAAGTCCTTTGTG
TACCCGTTTTTGCAGCACCG

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MLQTKHSEACLPWYFNYPTAPQFSAAIGAEAYGEWLGGLSANDPVSLYIHIPFCRSMCWYCGCPTTITQRDPPNQNYVAA
LRGEIHLVSELTPQALPVSDVHFGGGTPTLLEPTEFLALTELLRRRFAFRQKTAIAVEIDPRTFTAEMAEALSAAGVNRA
SLGVQSFDPSVQKAINRIQSVEQTATAVENLRQQGINRINIDLIYGLPNQTMQSCVQTATVAVAMRPQRIAVFGYAHTPS
SNKHQRLIEKAGLPDSAARAEQAAAVAETLVAAGYREIGVDHFALPDDELALAQKTGRLRRNSQGYSADTCKTLIAFGAS
AIGRVGEGYVENAGALEAYSQHIAAGRLATSKGYRLIGEDRVRGAIIERLMCDLEADVPAICAAHGFDWTHFLDSAERLA
MLADDGIVDVENGFIRVRHGHRILLRSVAAAFDAYLDQS

Sequences:

>Translated_439_residues
MLQTKHSEACLPWYFNYPTAPQFSAAIGAEAYGEWLGGLSANDPVSLYIHIPFCRSMCWYCGCPTTITQRDPPNQNYVAA
LRGEIHLVSELTPQALPVSDVHFGGGTPTLLEPTEFLALTELLRRRFAFRQKTAIAVEIDPRTFTAEMAEALSAAGVNRA
SLGVQSFDPSVQKAINRIQSVEQTATAVENLRQQGINRINIDLIYGLPNQTMQSCVQTATVAVAMRPQRIAVFGYAHTPS
SNKHQRLIEKAGLPDSAARAEQAAAVAETLVAAGYREIGVDHFALPDDELALAQKTGRLRRNSQGYSADTCKTLIAFGAS
AIGRVGEGYVENAGALEAYSQHIAAGRLATSKGYRLIGEDRVRGAIIERLMCDLEADVPAICAAHGFDWTHFLDSAERLA
MLADDGIVDVENGFIRVRHGHRILLRSVAAAFDAYLDQS
>Mature_439_residues
MLQTKHSEACLPWYFNYPTAPQFSAAIGAEAYGEWLGGLSANDPVSLYIHIPFCRSMCWYCGCPTTITQRDPPNQNYVAA
LRGEIHLVSELTPQALPVSDVHFGGGTPTLLEPTEFLALTELLRRRFAFRQKTAIAVEIDPRTFTAEMAEALSAAGVNRA
SLGVQSFDPSVQKAINRIQSVEQTATAVENLRQQGINRINIDLIYGLPNQTMQSCVQTATVAVAMRPQRIAVFGYAHTPS
SNKHQRLIEKAGLPDSAARAEQAAAVAETLVAAGYREIGVDHFALPDDELALAQKTGRLRRNSQGYSADTCKTLIAFGAS
AIGRVGEGYVENAGALEAYSQHIAAGRLATSKGYRLIGEDRVRGAIIERLMCDLEADVPAICAAHGFDWTHFLDSAERLA
MLADDGIVDVENGFIRVRHGHRILLRSVAAAFDAYLDQS

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=180, Percent_Identity=28.3333333333333, Blast_Score=72, Evalue=8e-13,
Organism=Escherichia coli, GI87082341, Length=429, Percent_Identity=37.5291375291375, Blast_Score=294, Evalue=7e-81,
Organism=Escherichia coli, GI1789325, Length=248, Percent_Identity=29.4354838709677, Blast_Score=111, Evalue=8e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 47749; Mature: 47749

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQTKHSEACLPWYFNYPTAPQFSAAIGAEAYGEWLGGLSANDPVSLYIHIPFCRSMCWY
CCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECHHHHHHHHH
CGCPTTITQRDPPNQNYVAALRGEIHLVSELTPQALPVSDVHFGGGTPTLLEPTEFLALT
CCCCCCCCCCCCCCCCEEEEECCCEEEEECCCCCCCCCCCEECCCCCCCCCCHHHHHHHH
ELLRRRFAFRQKTAIAVEIDPRTFTAEMAEALSAAGVNRASLGVQSFDPSVQKAINRIQS
HHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHCCCCHHHCCCHHCCHHHHHHHHHHHH
VEQTATAVENLRQQGINRINIDLIYGLPNQTMQSCVQTATVAVAMRPQRIAVFGYAHTPS
HHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHEEECCCEEEEEEEECCCC
SNKHQRLIEKAGLPDSAARAEQAAAVAETLVAAGYREIGVDHFALPDDELALAQKTGRLR
CCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCHHHHHHHHHHHHH
RNSQGYSADTCKTLIAFGASAIGRVGEGYVENAGALEAYSQHIAAGRLATSKGYRLIGED
CCCCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCHHHHHHHHHHHHHHCCCCCCEEECHH
RVRGAIIERLMCDLEADVPAICAAHGFDWTHFLDSAERLAMLADDGIVDVENGFIRVRHG
HHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEECCCEEEEECC
HRILLRSVAAAFDAYLDQS
CHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLQTKHSEACLPWYFNYPTAPQFSAAIGAEAYGEWLGGLSANDPVSLYIHIPFCRSMCWY
CCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECHHHHHHHHH
CGCPTTITQRDPPNQNYVAALRGEIHLVSELTPQALPVSDVHFGGGTPTLLEPTEFLALT
CCCCCCCCCCCCCCCCEEEEECCCEEEEECCCCCCCCCCCEECCCCCCCCCCHHHHHHHH
ELLRRRFAFRQKTAIAVEIDPRTFTAEMAEALSAAGVNRASLGVQSFDPSVQKAINRIQS
HHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHCCCCHHHCCCHHCCHHHHHHHHHHHH
VEQTATAVENLRQQGINRINIDLIYGLPNQTMQSCVQTATVAVAMRPQRIAVFGYAHTPS
HHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHEEECCCEEEEEEEECCCC
SNKHQRLIEKAGLPDSAARAEQAAAVAETLVAAGYREIGVDHFALPDDELALAQKTGRLR
CCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCHHHHHHHHHHHHH
RNSQGYSADTCKTLIAFGASAIGRVGEGYVENAGALEAYSQHIAAGRLATSKGYRLIGED
CCCCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCHHHHHHHHHHHHHHCCCCCCEEECHH
RVRGAIIERLMCDLEADVPAICAAHGFDWTHFLDSAERLAMLADDGIVDVENGFIRVRHG
HHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEECCCEEEEECC
HRILLRSVAAAFDAYLDQS
CHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11157943; 12597275 [H]