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The map label for this gene is hemA [H]

Identifier: 13474740

GI number: 13474740

Start: 4582393

End: 4583670

Strand: Reverse

Name: hemA [H]

Synonym: mll5695

Alternate gene names: 13474740

Gene position: 4583670-4582393 (Counterclockwise)

Preceding gene: 13474744

Following gene: 13474737

Centisome position: 65.15

GC content: 65.88

Gene sequence:

>1278_bases
ATGAACTACCAGCGGTTCTTCGAAGAAGCGATCGACCAGCTCCACGCGGAGCGTCGCTATCGTGTCTTCGCCGACCTCGA
GCGCATCGCGGGCAAGTTTCCGCGCGCCATCTGGCGCTCCAACGGCCGCGCCGAGGAAATCACCGTCTGGTGCTCCAACG
ACTATCTCGGCATGGGCCAGCACCCCGATGTCATCGCCGCGTTCCAGAACGCAGCCGGCAAGATGGGCTCGGGCGCCGGC
GGCACTCGCAACATTTCCGGCACGTCCAACCCGCTGGTCGAGCTCGAACATGAGCTTGCCGACCTGCACGGCAAGGACGC
GGCCCTGGTCTTCACCTCTGGCTTTGTCTCCAACGAAGCCTCGATCTCGACCATCGCCCGGCTGTTGCCCAATTGCCTGA
TCATCTCGGACGAACTGAACCACGCCTCGATGATCGAAGGCGTGCGCCGCTCGGGCGCCGAGAAGAAGATCTTCCGGCAC
AATGACGTCGCGCATCTGGAAAGCCTGCTGCAGGCGGCCGGGCGCGAACGCGCCAAGCTGATCGTCTTCGAAAGCGTCTA
TTCGATGGACGGCGATATCGCGCCGATCCGGGAGATCGTCGAACTCGCCGAGCGCTACAACGCCATGACCTATATCGACG
AGGTCCATGCGGTCGGCATGTACGGACCGCGCGGCGGCGGCATCACCGAGCGCGAGGGCCTGGCCGACCGCATCGACATC
ATTGAGGGCACGCTGGCCAAGGCATTCGGCACGCTGGGCGGCTACATCACCGGCACCAGCGCGGTGATCGACGCGGTGCG
CTCCTATGCGCCGGGCTTCATCTTCACCACGGCGCTGCCGCCGGCGATTGCCGCCGCGGCGACCACCTCGATCCGCCATC
TCAAGCGCTCGCAGGCCGAGCGCGATGCCCAGCAGCAGCAGGCAGCGCGGACCAAGCAGATCCTGTCGGCGGCCGGCCTG
CCGGTGATGGAGTCGCCAACCCATATCGTGCCGGTGCTGGTGGGTGACCCGGAGCTTTGCAAGATGGCCAGCGACCGCCT
GCTTGGCGTGCACGGCATCTACATCCAGCCGATCAACTACCCGACCGTGCCGCGCGGCACCGAGCGTCTGCGCATCACGC
CGACGCCGTTCCATTCCGATGCGCTGATCGCGGGACTACAGGATGCGCTGGTCGAGACATGGGACGCCCTCGGCATCCCC
TATGGCGCGGCAGGACGGCCCGCAGTGGCCAAGAGCGATCGGATCGTTCCATTGCTGGTGCCCAAGTCAGGCGGCTGA

Upstream 100 bases:

>100_bases
CGTTAGGAACAGGTGCGGGGCGTGGCATTTTGACCAAAACGGCCCGGTGGACGACCAATAGGCCAATGATTATGATCCCG
CGCAAAATTGGGAAGCCGAC

Downstream 100 bases:

>100_bases
AGCCCGTTTGAAACTCTACTCCAGCGGCCATCTGACGCGAGTATCTGCGCTTCTACAGCGCCGCGCGTCCATCGGACGCG
CAAAGGACGCTGTAGCAATT

Product: 5-aminolevulinate synthase

Products: NA

Alternate protein names: 5-aminolevulinic acid synthase; Delta-ALA synthase; Delta-aminolevulinate synthase [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MNYQRFFEEAIDQLHAERRYRVFADLERIAGKFPRAIWRSNGRAEEITVWCSNDYLGMGQHPDVIAAFQNAAGKMGSGAG
GTRNISGTSNPLVELEHELADLHGKDAALVFTSGFVSNEASISTIARLLPNCLIISDELNHASMIEGVRRSGAEKKIFRH
NDVAHLESLLQAAGRERAKLIVFESVYSMDGDIAPIREIVELAERYNAMTYIDEVHAVGMYGPRGGGITEREGLADRIDI
IEGTLAKAFGTLGGYITGTSAVIDAVRSYAPGFIFTTALPPAIAAAATTSIRHLKRSQAERDAQQQQAARTKQILSAAGL
PVMESPTHIVPVLVGDPELCKMASDRLLGVHGIYIQPINYPTVPRGTERLRITPTPFHSDALIAGLQDALVETWDALGIP
YGAAGRPAVAKSDRIVPLLVPKSGG

Sequences:

>Translated_425_residues
MNYQRFFEEAIDQLHAERRYRVFADLERIAGKFPRAIWRSNGRAEEITVWCSNDYLGMGQHPDVIAAFQNAAGKMGSGAG
GTRNISGTSNPLVELEHELADLHGKDAALVFTSGFVSNEASISTIARLLPNCLIISDELNHASMIEGVRRSGAEKKIFRH
NDVAHLESLLQAAGRERAKLIVFESVYSMDGDIAPIREIVELAERYNAMTYIDEVHAVGMYGPRGGGITEREGLADRIDI
IEGTLAKAFGTLGGYITGTSAVIDAVRSYAPGFIFTTALPPAIAAAATTSIRHLKRSQAERDAQQQQAARTKQILSAAGL
PVMESPTHIVPVLVGDPELCKMASDRLLGVHGIYIQPINYPTVPRGTERLRITPTPFHSDALIAGLQDALVETWDALGIP
YGAAGRPAVAKSDRIVPLLVPKSGG
>Mature_425_residues
MNYQRFFEEAIDQLHAERRYRVFADLERIAGKFPRAIWRSNGRAEEITVWCSNDYLGMGQHPDVIAAFQNAAGKMGSGAG
GTRNISGTSNPLVELEHELADLHGKDAALVFTSGFVSNEASISTIARLLPNCLIISDELNHASMIEGVRRSGAEKKIFRH
NDVAHLESLLQAAGRERAKLIVFESVYSMDGDIAPIREIVELAERYNAMTYIDEVHAVGMYGPRGGGITEREGLADRIDI
IEGTLAKAFGTLGGYITGTSAVIDAVRSYAPGFIFTTALPPAIAAAATTSIRHLKRSQAERDAQQQQAARTKQILSAAGL
PVMESPTHIVPVLVGDPELCKMASDRLLGVHGIYIQPINYPTVPRGTERLRITPTPFHSDALIAGLQDALVETWDALGIP
YGAAGRPAVAKSDRIVPLLVPKSGG

Specific function: Unknown

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI83977442, Length=404, Percent_Identity=49.7524752475247, Blast_Score=421, Evalue=1e-118,
Organism=Homo sapiens, GI83977440, Length=404, Percent_Identity=49.7524752475247, Blast_Score=420, Evalue=1e-117,
Organism=Homo sapiens, GI83977444, Length=404, Percent_Identity=49.7524752475247, Blast_Score=420, Evalue=1e-117,
Organism=Homo sapiens, GI4502025, Length=411, Percent_Identity=49.8783454987835, Blast_Score=404, Evalue=1e-112,
Organism=Homo sapiens, GI40316939, Length=411, Percent_Identity=49.8783454987835, Blast_Score=404, Evalue=1e-112,
Organism=Homo sapiens, GI7657118, Length=356, Percent_Identity=36.2359550561798, Blast_Score=234, Evalue=9e-62,
Organism=Homo sapiens, GI284448556, Length=348, Percent_Identity=36.4942528735632, Blast_Score=232, Evalue=5e-61,
Organism=Homo sapiens, GI119220554, Length=407, Percent_Identity=30.2211302211302, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI4758668, Length=391, Percent_Identity=31.2020460358056, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI5454084, Length=253, Percent_Identity=30.8300395256917, Blast_Score=124, Evalue=2e-28,
Organism=Escherichia coli, GI1790046, Length=399, Percent_Identity=33.8345864661654, Blast_Score=205, Evalue=4e-54,
Organism=Escherichia coli, GI1786993, Length=329, Percent_Identity=34.6504559270517, Blast_Score=166, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI71994529, Length=375, Percent_Identity=36, Blast_Score=234, Evalue=6e-62,
Organism=Caenorhabditis elegans, GI17560914, Length=368, Percent_Identity=30.9782608695652, Blast_Score=154, Evalue=9e-38,
Organism=Caenorhabditis elegans, GI17560912, Length=368, Percent_Identity=30.9782608695652, Blast_Score=154, Evalue=9e-38,
Organism=Caenorhabditis elegans, GI32566772, Length=383, Percent_Identity=29.242819843342, Blast_Score=152, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI71982617, Length=229, Percent_Identity=30.1310043668122, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI71982625, Length=229, Percent_Identity=30.1310043668122, Blast_Score=115, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6320438, Length=422, Percent_Identity=45.0236966824645, Blast_Score=391, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6320267, Length=376, Percent_Identity=30.0531914893617, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6323954, Length=292, Percent_Identity=24.6575342465753, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI17137420, Length=401, Percent_Identity=48.3790523690773, Blast_Score=400, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24662918, Length=360, Percent_Identity=35.2777777777778, Blast_Score=237, Evalue=1e-62,
Organism=Drosophila melanogaster, GI17136286, Length=380, Percent_Identity=31.3157894736842, Blast_Score=148, Evalue=6e-36,
Organism=Drosophila melanogaster, GI24653280, Length=275, Percent_Identity=28.3636363636364, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24653276, Length=275, Percent_Identity=28.3636363636364, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24653278, Length=275, Percent_Identity=28.3636363636364, Blast_Score=115, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010961
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.37 [H]

Molecular weight: Translated: 45961; Mature: 45961

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00599 AA_TRANSFER_CLASS_2 ; PS00678 WD_REPEATS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYQRFFEEAIDQLHAERRYRVFADLERIAGKFPRAIWRSNGRAEEITVWCSNDYLGMGQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCC
HPDVIAAFQNAAGKMGSGAGGTRNISGTSNPLVELEHELADLHGKDAALVFTSGFVSNEA
CCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCH
SISTIARLLPNCLIISDELNHASMIEGVRRSGAEKKIFRHNDVAHLESLLQAAGRERAKL
HHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHCCCCCEEE
IVFESVYSMDGDIAPIREIVELAERYNAMTYIDEVHAVGMYGPRGGGITEREGLADRIDI
EEEEHHHHCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHH
IEGTLAKAFGTLGGYITGTSAVIDAVRSYAPGFIFTTALPPAIAAAATTSIRHLKRSQAE
HHHHHHHHHHHHCCHHCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHH
RDAQQQQAARTKQILSAAGLPVMESPTHIVPVLVGDPELCKMASDRLLGVHGIYIQPINY
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHCCEEEEEEEEEEECCC
PTVPRGTERLRITPTPFHSDALIAGLQDALVETWDALGIPYGAAGRPAVAKSDRIVPLLV
CCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEE
PKSGG
CCCCC
>Mature Secondary Structure
MNYQRFFEEAIDQLHAERRYRVFADLERIAGKFPRAIWRSNGRAEEITVWCSNDYLGMGQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCC
HPDVIAAFQNAAGKMGSGAGGTRNISGTSNPLVELEHELADLHGKDAALVFTSGFVSNEA
CCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCH
SISTIARLLPNCLIISDELNHASMIEGVRRSGAEKKIFRHNDVAHLESLLQAAGRERAKL
HHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHCCCCCEEE
IVFESVYSMDGDIAPIREIVELAERYNAMTYIDEVHAVGMYGPRGGGITEREGLADRIDI
EEEEHHHHCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHH
IEGTLAKAFGTLGGYITGTSAVIDAVRSYAPGFIFTTALPPAIAAAATTSIRHLKRSQAE
HHHHHHHHHHHHCCHHCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHH
RDAQQQQAARTKQILSAAGLPVMESPTHIVPVLVGDPELCKMASDRLLGVHGIYIQPINY
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHCCEEEEEEEEEEECCC
PTVPRGTERLRITPTPFHSDALIAGLQDALVETWDALGIPYGAAGRPAVAKSDRIVPLLV
CCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEE
PKSGG
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3609750; 12597275 [H]