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The map label for this gene is gyaR [H]

Identifier: 13474643

GI number: 13474643

Start: 4472424

End: 4473425

Strand: Direct

Name: gyaR [H]

Synonym: mlr5574

Alternate gene names: 13474643

Gene position: 4472424-4473425 (Clockwise)

Preceding gene: 13474641

Following gene: 13474653

Centisome position: 63.56

GC content: 65.07

Gene sequence:

>1002_bases
ATGGTAGGCAAAAAGAAGCCTCTCGTGGTCATCACGCGAAAGCTGCCCGACCCGGTCGAGACCCGCATGCGCGAGCTGTT
CGACGCCAGGCTGAATGTCGAGGACAGACCGATGACGCAGCCGGAACTGGTCGCCGCGGTCAAGGAAGCCGACGTGCTGG
TGCCGACGGTGACCGACCAGATCGACGCGGCGCTGATCGCCCAGGCCGGCGACAACCTCAAGCTGATCGCCAATTTCGGC
AACGGCGTCGACAAGATCGACGTGGCGGCGGCCGCCAAGAAGGGCATCACCGTCACCAACACGCCCAACGTGCTGACCGA
AGATACCGCTGACATGACCATGGCGCTGATGCTGGCGGTGCCGCGCCGCCTCGCGGAGGGCGCCAATGTGCTCACCGGCG
ACAAGAAATGGGCCGGCTGGTCGCCGACCTGGATGCTTGGCCGGCGCATCTGGGGCAAGCGGCTCGGCATTGTCGGCATG
GGTCGCATCGGTACGGCCGTCGCGCGGCGGGCCAAGGCTTTCGGCCTTTCCATCCACTATCACAACCGCCATCGCGTTTT
GCCGGCGGTCGAGGATGGGCTGGAGGCGACCTATTGGGAGAGCCTCGACCAGATGCTGGCCCGCATGGACATCATCTCGG
TCAATTGTCCGTCGACGCCCGCGACCTTCCATCTTCTGTCGGCGCGGCGGCTGGCGCTGCTGCAGCCGACGGCCTATGTC
GTCAACACCGCGCGTGGCGACATCATCGACGAGGAAGCGCTGGTCAAACTGATCCAGGACGGCAAGATCGCCGGCGCCGG
CCTTGACGTCTACGAGCACGAGCCGGCGCTCAATGCCAAGCTGCTCAAGCTCGCCGCCAGGCACAAGGTCGTGCTTTTGC
CGCATATGGGCTCGGCCACGCTTGAGGGCCGCATCGACATGGGCGAGAAGGTCATCATCAACATCCGTGCCTTCGTTGAC
GGTCACCGTCCGCCGGATCGCGTGCTGCCGCTCAGAACCTGA

Upstream 100 bases:

>100_bases
TTGTCTTCGGCGGCACCGCTTGTTACATGGGTAAATCGGCTACCGCGACCGGCTTTCAGTTTCGCCGGTCTTGGTTAAAG
AGGTCTCAACGAGGGAAACA

Downstream 100 bases:

>100_bases
CGGTATCGCGGCGGCGCGCCCCTCTTGGTTCTTCAAATGCAAGCCAAGGCTTACGAAAGAGCCTTGCGCATGGTGATCGA
AGTCGGCCTAGCGTAGCCCT

Product: 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MVGKKKPLVVITRKLPDPVETRMRELFDARLNVEDRPMTQPELVAAVKEADVLVPTVTDQIDAALIAQAGDNLKLIANFG
NGVDKIDVAAAAKKGITVTNTPNVLTEDTADMTMALMLAVPRRLAEGANVLTGDKKWAGWSPTWMLGRRIWGKRLGIVGM
GRIGTAVARRAKAFGLSIHYHNRHRVLPAVEDGLEATYWESLDQMLARMDIISVNCPSTPATFHLLSARRLALLQPTAYV
VNTARGDIIDEEALVKLIQDGKIAGAGLDVYEHEPALNAKLLKLAARHKVVLLPHMGSATLEGRIDMGEKVIINIRAFVD
GHRPPDRVLPLRT

Sequences:

>Translated_333_residues
MVGKKKPLVVITRKLPDPVETRMRELFDARLNVEDRPMTQPELVAAVKEADVLVPTVTDQIDAALIAQAGDNLKLIANFG
NGVDKIDVAAAAKKGITVTNTPNVLTEDTADMTMALMLAVPRRLAEGANVLTGDKKWAGWSPTWMLGRRIWGKRLGIVGM
GRIGTAVARRAKAFGLSIHYHNRHRVLPAVEDGLEATYWESLDQMLARMDIISVNCPSTPATFHLLSARRLALLQPTAYV
VNTARGDIIDEEALVKLIQDGKIAGAGLDVYEHEPALNAKLLKLAARHKVVLLPHMGSATLEGRIDMGEKVIINIRAFVD
GHRPPDRVLPLRT
>Mature_333_residues
MVGKKKPLVVITRKLPDPVETRMRELFDARLNVEDRPMTQPELVAAVKEADVLVPTVTDQIDAALIAQAGDNLKLIANFG
NGVDKIDVAAAAKKGITVTNTPNVLTEDTADMTMALMLAVPRRLAEGANVLTGDKKWAGWSPTWMLGRRIWGKRLGIVGM
GRIGTAVARRAKAFGLSIHYHNRHRVLPAVEDGLEATYWESLDQMLARMDIISVNCPSTPATFHLLSARRLALLQPTAYV
VNTARGDIIDEEALVKLIQDGKIAGAGLDVYEHEPALNAKLLKLAARHKVVLLPHMGSATLEGRIDMGEKVIINIRAFVD
GHRPPDRVLPLRT

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=325, Percent_Identity=34.1538461538462, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI23308577, Length=318, Percent_Identity=31.7610062893082, Blast_Score=151, Evalue=8e-37,
Organism=Homo sapiens, GI61743967, Length=268, Percent_Identity=33.5820895522388, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI4557497, Length=268, Percent_Identity=33.5820895522388, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI145580578, Length=264, Percent_Identity=33.3333333333333, Blast_Score=134, Evalue=8e-32,
Organism=Homo sapiens, GI4557499, Length=264, Percent_Identity=33.3333333333333, Blast_Score=134, Evalue=8e-32,
Organism=Homo sapiens, GI145580575, Length=264, Percent_Identity=33.3333333333333, Blast_Score=132, Evalue=4e-31,
Organism=Escherichia coli, GI87082289, Length=327, Percent_Identity=35.474006116208, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI1789279, Length=257, Percent_Identity=29.5719844357977, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1787645, Length=268, Percent_Identity=27.9850746268657, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1788660, Length=314, Percent_Identity=26.1146496815287, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI87081824, Length=256, Percent_Identity=26.171875, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=287, Percent_Identity=31.0104529616725, Blast_Score=137, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI25147481, Length=263, Percent_Identity=31.1787072243346, Blast_Score=117, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6324055, Length=264, Percent_Identity=35.2272727272727, Blast_Score=158, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6322116, Length=269, Percent_Identity=31.5985130111524, Blast_Score=139, Evalue=7e-34,
Organism=Saccharomyces cerevisiae, GI6320925, Length=269, Percent_Identity=30.8550185873606, Blast_Score=137, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6324964, Length=283, Percent_Identity=30.0353356890459, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6321253, Length=261, Percent_Identity=28.735632183908, Blast_Score=79, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6325144, Length=175, Percent_Identity=30.8571428571429, Blast_Score=76, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6324980, Length=153, Percent_Identity=30.718954248366, Blast_Score=69, Evalue=7e-13,
Organism=Drosophila melanogaster, GI28571528, Length=291, Percent_Identity=37.1134020618557, Blast_Score=164, Evalue=7e-41,
Organism=Drosophila melanogaster, GI28574286, Length=303, Percent_Identity=32.013201320132, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI45552429, Length=280, Percent_Identity=32.5, Blast_Score=144, Evalue=6e-35,
Organism=Drosophila melanogaster, GI24585514, Length=279, Percent_Identity=32.6164874551971, Blast_Score=144, Evalue=7e-35,
Organism=Drosophila melanogaster, GI28574282, Length=279, Percent_Identity=32.6164874551971, Blast_Score=144, Evalue=7e-35,
Organism=Drosophila melanogaster, GI28574284, Length=279, Percent_Identity=32.6164874551971, Blast_Score=144, Evalue=7e-35,
Organism=Drosophila melanogaster, GI45551003, Length=279, Percent_Identity=32.6164874551971, Blast_Score=144, Evalue=7e-35,
Organism=Drosophila melanogaster, GI24646446, Length=256, Percent_Identity=34.765625, Blast_Score=141, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24646448, Length=256, Percent_Identity=34.765625, Blast_Score=141, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24646452, Length=256, Percent_Identity=34.765625, Blast_Score=141, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24646450, Length=256, Percent_Identity=34.765625, Blast_Score=141, Evalue=6e-34,
Organism=Drosophila melanogaster, GI62472511, Length=256, Percent_Identity=34.765625, Blast_Score=140, Evalue=9e-34,
Organism=Drosophila melanogaster, GI19921140, Length=271, Percent_Identity=33.9483394833948, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24585516, Length=310, Percent_Identity=27.741935483871, Blast_Score=129, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 36419; Mature: 36419

Theoretical pI: Translated: 9.95; Mature: 9.95

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVGKKKPLVVITRKLPDPVETRMRELFDARLNVEDRPMTQPELVAAVKEADVLVPTVTDQ
CCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCEEEECHHHH
IDAALIAQAGDNLKLIANFGNGVDKIDVAAAAKKGITVTNTPNVLTEDTADMTMALMLAV
HHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCEEEECCCCCCCCCHHHHHHHHHHHH
PRRLAEGANVLTGDKKWAGWSPTWMLGRRIWGKRLGIVGMGRIGTAVARRAKAFGLSIHY
HHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHHHEEEEEE
HNRHRVLPAVEDGLEATYWESLDQMLARMDIISVNCPSTPATFHLLSARRLALLQPTAYV
CCCCEECCHHHCCCCHHHHHHHHHHHHHHHEEEECCCCCCHHEEHHHHHHHHEECCHHHE
VNTARGDIIDEEALVKLIQDGKIAGAGLDVYEHEPALNAKLLKLAARHKVVLLPHMGSAT
EECCCCCCCCHHHHHHHHHCCCEECCCCCCCCCCCCCCHHHHHHHHCCEEEEEECCCCCE
LEGRIDMGEKVIINIRAFVDGHRPPDRVLPLRT
ECCCCCCCCEEEEEEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MVGKKKPLVVITRKLPDPVETRMRELFDARLNVEDRPMTQPELVAAVKEADVLVPTVTDQ
CCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCEEEECHHHH
IDAALIAQAGDNLKLIANFGNGVDKIDVAAAAKKGITVTNTPNVLTEDTADMTMALMLAV
HHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCEEEECCCCCCCCCHHHHHHHHHHHH
PRRLAEGANVLTGDKKWAGWSPTWMLGRRIWGKRLGIVGMGRIGTAVARRAKAFGLSIHY
HHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHHHEEEEEE
HNRHRVLPAVEDGLEATYWESLDQMLARMDIISVNCPSTPATFHLLSARRLALLQPTAYV
CCCCEECCHHHCCCCHHHHHHHHHHHHHHHEEEECCCCCCHHEEHHHHHHHHEECCHHHE
VNTARGDIIDEEALVKLIQDGKIAGAGLDVYEHEPALNAKLLKLAARHKVVLLPHMGSAT
EECCCCCCCCHHHHHHHHHCCCEECCCCCCCCCCCCCCHHHHHHHHCCEEEEEECCCCCE
LEGRIDMGEKVIINIRAFVDGHRPPDRVLPLRT
ECCCCCCCCEEEEEEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA