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The map label for this gene is kdsB

Identifier: 13474584

GI number: 13474584

Start: 4410608

End: 4411336

Strand: Direct

Name: kdsB

Synonym: mlr5497

Alternate gene names: 13474584

Gene position: 4410608-4411336 (Clockwise)

Preceding gene: 13474576

Following gene: 13474585

Centisome position: 62.69

GC content: 67.63

Gene sequence:

>729_bases
ATGTCCACCTTGATCTTGATACCGGCCCGCATGGCCTCCACCCGCCTGCCGGGCAAGCCGCTGGCCGACATATCCGGCGC
GCCGATGATCGTCCATGTCGCCCGCCGCGCGGCCGAAGCCGGCCTCGGGCGGGTGGTGGTGGCGACCGACACGCAAAGCG
TCGCCGAAGCGGTGCGCGCGCATGGTTTCGAGGCGGTGATGACGCGCATCGACCACGAATCCGGCTCCGACCGCATCCAC
GAGGCGCTGGCCGCGCTTGATCCCGGGCGCAAGGTCGAAACCATCGTCAATGTGCAGGGCGACCTGCCGACCATCGATCC
CGGCATCATCGCCGCCTCGCTCAGGCCGTTCGAGGACGCGGCGGTGGATATCGCCACGCTCGGCGTCGAGATCGTCCGCG
AAGAGGAAAAGACCAACCCGAACGTCGTCAAGATCGTCGGTTCGCCGCTGTCAGCCACGCGGCTGAGGGCGCTCTATTTC
ACCCGCGCCACAGCACCTTGGGGCGAGGGGCCGCTCTATCACCATGTCGGTCTCTACGCCTATCGCCGCTCGGCACTCGA
ACGCTTCGTCGCGCTGAAACCGTCGCCGCTCGAGCGCCGCGAGCGGCTGGAGCAGTTGCGGGCGCTGGAAGCCGGCATGC
GCATCGATGCCGAGATCGTCCGGTCGCTGCCGCTTGGCGTCGACACGCCGCAAGACCTTGAGCGCGCCCGAACCATTCTT
TCCAACTGA

Upstream 100 bases:

>100_bases
ACTAGGTCTTTTGCTCCGGCGTTGCAACACCTATAAGGGCGCTGCCAGTGAGACCTTTTGCCACTTTTCCCCTCCTCTTT
TCGAACGCCTTGCCACAGCG

Downstream 100 bases:

>100_bases
GAAATCCCTTCGACACCGTGACGTGAATCGAGACCTGGCCCATGCCTGAAAAGACCAACAGAATATCCTTCCAGGGCGAG
CCGGGCGCCAATTCCGACAC

Product: 3-deoxy-manno-octulosonate cytidylyltransferase

Products: NA

Alternate protein names: CMP-2-keto-3-deoxyoctulosonic acid synthase; CKS; CMP-KDO synthase

Number of amino acids: Translated: 242; Mature: 241

Protein sequence:

>242_residues
MSTLILIPARMASTRLPGKPLADISGAPMIVHVARRAAEAGLGRVVVATDTQSVAEAVRAHGFEAVMTRIDHESGSDRIH
EALAALDPGRKVETIVNVQGDLPTIDPGIIAASLRPFEDAAVDIATLGVEIVREEEKTNPNVVKIVGSPLSATRLRALYF
TRATAPWGEGPLYHHVGLYAYRRSALERFVALKPSPLERRERLEQLRALEAGMRIDAEIVRSLPLGVDTPQDLERARTIL
SN

Sequences:

>Translated_242_residues
MSTLILIPARMASTRLPGKPLADISGAPMIVHVARRAAEAGLGRVVVATDTQSVAEAVRAHGFEAVMTRIDHESGSDRIH
EALAALDPGRKVETIVNVQGDLPTIDPGIIAASLRPFEDAAVDIATLGVEIVREEEKTNPNVVKIVGSPLSATRLRALYF
TRATAPWGEGPLYHHVGLYAYRRSALERFVALKPSPLERRERLEQLRALEAGMRIDAEIVRSLPLGVDTPQDLERARTIL
SN
>Mature_241_residues
STLILIPARMASTRLPGKPLADISGAPMIVHVARRAAEAGLGRVVVATDTQSVAEAVRAHGFEAVMTRIDHESGSDRIHE
ALAALDPGRKVETIVNVQGDLPTIDPGIIAASLRPFEDAAVDIATLGVEIVREEEKTNPNVVKIVGSPLSATRLRALYFT
RATAPWGEGPLYHHVGLYAYRRSALERFVALKPSPLERRERLEQLRALEAGMRIDAEIVRSLPLGVDTPQDLERARTILS
N

Specific function: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria

COG id: COG1212

COG function: function code M; CMP-2-keto-3-deoxyoctulosonic acid synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsB family

Homologues:

Organism=Escherichia coli, GI1787147, Length=249, Percent_Identity=48.1927710843374, Blast_Score=196, Evalue=9e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KDSB_RHILO (Q98BN3)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_106153.1
- HSSP:   P04951
- ProteinModelPortal:   Q98BN3
- SMR:   Q98BN3
- GeneID:   1228814
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mlr5497
- NMPDR:   fig|266835.1.peg.4257
- HOGENOM:   HBG637773
- OMA:   IIPARLK
- ProtClustDB:   PRK05450
- BRENDA:   2.7.7.38
- GO:   GO:0005737
- HAMAP:   MF_00057
- InterPro:   IPR003329
- InterPro:   IPR004528
- TIGRFAMs:   TIGR00466

Pfam domain/function: PF02348 CTP_transf_3

EC number: =2.7.7.38

Molecular weight: Translated: 26284; Mature: 26152

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTLILIPARMASTRLPGKPLADISGAPMIVHVARRAAEAGLGRVVVATDTQSVAEAVRA
CCCEEEECCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHH
HGFEAVMTRIDHESGSDRIHEALAALDPGRKVETIVNVQGDLPTIDPGIIAASLRPFEDA
CCHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHCCCCCHHH
AVDIATLGVEIVREEEKTNPNVVKIVGSPLSATRLRALYFTRATAPWGEGPLYHHVGLYA
HHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHEECCCCCCCCCCHHHHHHHH
YRRSALERFVALKPSPLERRERLEQLRALEAGMRIDAEIVRSLPLGVDTPQDLERARTIL
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCHHHHHHHHHHH
SN
CC
>Mature Secondary Structure 
STLILIPARMASTRLPGKPLADISGAPMIVHVARRAAEAGLGRVVVATDTQSVAEAVRA
CCEEEECCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHH
HGFEAVMTRIDHESGSDRIHEALAALDPGRKVETIVNVQGDLPTIDPGIIAASLRPFEDA
CCHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHCCCCCHHH
AVDIATLGVEIVREEEKTNPNVVKIVGSPLSATRLRALYFTRATAPWGEGPLYHHVGLYA
HHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHEECCCCCCCCCCHHHHHHHH
YRRSALERFVALKPSPLERRERLEQLRALEAGMRIDAEIVRSLPLGVDTPQDLERARTIL
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCHHHHHHHHHHH
SN
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968