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The map label for this gene is ghrA [H]

Identifier: 13474577

GI number: 13474577

Start: 4400981

End: 4401922

Strand: Reverse

Name: ghrA [H]

Synonym: mll5489

Alternate gene names: 13474577

Gene position: 4401922-4400981 (Counterclockwise)

Preceding gene: 13474578

Following gene: 13474573

Centisome position: 62.56

GC content: 64.01

Gene sequence:

>942_bases
ATGGAAAAAGGCCGCATCCTGCTTGCCGTCACCGGCTTTCATCCGCAGCGCTGGCGCGAGCTTTTGTCGGCCGAGCGCGA
GGTGGTGCTGGAGCCGGATGGCGCCAAGGATCCGTCGATCACCTATGCAGTGGTGTGGAAGCAGAAGCCGAACCTGTTGT
CGTCGCTGCCCAATCTGCGCGCCATCTTCTCGATCGGCGCCGGCGTCGACCATATTTTCGCTGACCCGGGCCTGCCCGAC
GTGCCGATCGTCAAGGTCGTCGCCGACAACCTCACGCAATACATGACCGAATATGTCGTCTGGCGGGTGCTCGATCATCA
TCGCCAGGGCCTGCTCTACCGGCAGCAGCAGCAAAAGAAGATCTGGCACGAGCCGCCGCAGCGGCCGGCCGGCGACATAT
CCGTCGGCATTATGGGGCTCGGCAATCTCGGCCGCGCCGCGGCCTCGGTGCTGCTGTCGCTCGGCTTCGCGGTCAATGGC
TGGTCACGCACCGAGCGGCCGATGCAAGGGGTGGCGACCTATTCCGGCGAGGCCGGGTTGATCCCCTTCCTCAAGGCCAC
CGACATCCTTGTCGTGCTTTTGCCGCTGACGCCGGACACGCAAGGCATCATCAATTACGGCGTGCTCAAGGAATTGCGCA
AACGCAACGGCCTCGGCGGTTCGGTGCTGATCAACGCCGGGCGCGGCCGCCTGCAGAAGGATGCCGACATCGTGCGGGCG
CTGGATGACGGCACGTTGAAGGAGGCGAGCCTCGACGTGTTCGAGGTCGAGCCGCTGCCGAAGACCAGCCCATTGTGGAA
CCATCCGAAAGTGTTCGTGACGCCGCACGCCGCGGCGACCTCCGATCCCATGCATCTGGCGCCGACCATGCTGCGCCAGA
TGGACGCCTTCGAGCGTGGCGAAAAACTCGAGAATCTGGTGGATCGCAAGGCGGGATATTAG

Upstream 100 bases:

>100_bases
ACTATACTCGGGCATTGATCTCGGCCGCCTTCAAGATAGAGACGGCGCCGGTCGGCATCGTCAGCGAGTAATTTGCGTAA
AGAGGGACTAGAATACCGCG

Downstream 100 bases:

>100_bases
CCAGGGTCTTACATCGCCAGATCCCAGTCCCTGAAGCACTGCTTGATTGCTCTCACGGAGGACAGCTGCAGTTTTGGCAG
GTCGAGCTCCTCGAACATCG

Product: putative 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: 2-ketoacid reductase [H]

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MEKGRILLAVTGFHPQRWRELLSAEREVVLEPDGAKDPSITYAVVWKQKPNLLSSLPNLRAIFSIGAGVDHIFADPGLPD
VPIVKVVADNLTQYMTEYVVWRVLDHHRQGLLYRQQQQKKIWHEPPQRPAGDISVGIMGLGNLGRAAASVLLSLGFAVNG
WSRTERPMQGVATYSGEAGLIPFLKATDILVVLLPLTPDTQGIINYGVLKELRKRNGLGGSVLINAGRGRLQKDADIVRA
LDDGTLKEASLDVFEVEPLPKTSPLWNHPKVFVTPHAAATSDPMHLAPTMLRQMDAFERGEKLENLVDRKAGY

Sequences:

>Translated_313_residues
MEKGRILLAVTGFHPQRWRELLSAEREVVLEPDGAKDPSITYAVVWKQKPNLLSSLPNLRAIFSIGAGVDHIFADPGLPD
VPIVKVVADNLTQYMTEYVVWRVLDHHRQGLLYRQQQQKKIWHEPPQRPAGDISVGIMGLGNLGRAAASVLLSLGFAVNG
WSRTERPMQGVATYSGEAGLIPFLKATDILVVLLPLTPDTQGIINYGVLKELRKRNGLGGSVLINAGRGRLQKDADIVRA
LDDGTLKEASLDVFEVEPLPKTSPLWNHPKVFVTPHAAATSDPMHLAPTMLRQMDAFERGEKLENLVDRKAGY
>Mature_313_residues
MEKGRILLAVTGFHPQRWRELLSAEREVVLEPDGAKDPSITYAVVWKQKPNLLSSLPNLRAIFSIGAGVDHIFADPGLPD
VPIVKVVADNLTQYMTEYVVWRVLDHHRQGLLYRQQQQKKIWHEPPQRPAGDISVGIMGLGNLGRAAASVLLSLGFAVNG
WSRTERPMQGVATYSGEAGLIPFLKATDILVVLLPLTPDTQGIINYGVLKELRKRNGLGGSVLINAGRGRLQKDADIVRA
LDDGTLKEASLDVFEVEPLPKTSPLWNHPKVFVTPHAAATSDPMHLAPTMLRQMDAFERGEKLENLVDRKAGY

Specific function: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively [H]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=233, Percent_Identity=29.6137339055794, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI23308577, Length=180, Percent_Identity=27.2222222222222, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI87081824, Length=281, Percent_Identity=38.4341637010676, Blast_Score=181, Evalue=7e-47,
Organism=Escherichia coli, GI87082289, Length=235, Percent_Identity=26.3829787234043, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=154, Percent_Identity=33.1168831168831, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI28574286, Length=254, Percent_Identity=24.4094488188976, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24585516, Length=147, Percent_Identity=35.3741496598639, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI28571528, Length=265, Percent_Identity=24.5283018867925, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.79; =1.1.1.81 [H]

Molecular weight: Translated: 34536; Mature: 34536

Theoretical pI: Translated: 9.21; Mature: 9.21

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKGRILLAVTGFHPQRWRELLSAEREVVLEPDGAKDPSITYAVVWKQKPNLLSSLPNLR
CCCCCEEEEEECCCHHHHHHHHHCCCEEEECCCCCCCCCEEEEEEECCCCHHHHHCCCHH
AIFSIGAGVDHIFADPGLPDVPIVKVVADNLTQYMTEYVVWRVLDHHRQGLLYRQQQQKK
HHHHHCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
IWHEPPQRPAGDISVGIMGLGNLGRAAASVLLSLGFAVNGWSRTERPMQGVATYSGEAGL
HHCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCC
IPFLKATDILVVLLPLTPDTQGIINYGVLKELRKRNGLGGSVLINAGRGRLQKDADIVRA
CCHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHH
LDDGTLKEASLDVFEVEPLPKTSPLWNHPKVFVTPHAAATSDPMHLAPTMLRQMDAFERG
HCCCCCCCCCCCEEEECCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHH
EKLENLVDRKAGY
HHHHHHHHHCCCC
>Mature Secondary Structure
MEKGRILLAVTGFHPQRWRELLSAEREVVLEPDGAKDPSITYAVVWKQKPNLLSSLPNLR
CCCCCEEEEEECCCHHHHHHHHHCCCEEEECCCCCCCCCEEEEEEECCCCHHHHHCCCHH
AIFSIGAGVDHIFADPGLPDVPIVKVVADNLTQYMTEYVVWRVLDHHRQGLLYRQQQQKK
HHHHHCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
IWHEPPQRPAGDISVGIMGLGNLGRAAASVLLSLGFAVNGWSRTERPMQGVATYSGEAGL
HHCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCC
IPFLKATDILVVLLPLTPDTQGIINYGVLKELRKRNGLGGSVLINAGRGRLQKDADIVRA
CCHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHH
LDDGTLKEASLDVFEVEPLPKTSPLWNHPKVFVTPHAAATSDPMHLAPTMLRQMDAFERG
HCCCCCCCCCCCEEEECCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHH
EKLENLVDRKAGY
HHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA