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The map label for this gene is ilvD [H]

Identifier: 13474506

GI number: 13474506

Start: 4319105

End: 4320910

Strand: Direct

Name: ilvD [H]

Synonym: mlr5404

Alternate gene names: 13474506

Gene position: 4319105-4320910 (Clockwise)

Preceding gene: 13474504

Following gene: 13474507

Centisome position: 61.39

GC content: 64.62

Gene sequence:

>1806_bases
ATGGCCGGCGCCCCCACCAAGAAGAAAAAATTCCGCTCGCAGGAGTGGTTCGACAACCCCGACAACCCAGGCATGACGGC
GCTCTATCTCGAGCGTTACCTGAATTACGGGCTGACGCGTGCCGAGCTGATGTCGGGCAAGCCGTTGATCGGCATCGCCC
AGACCGGCTCGGATCTGTCGCCGTGCAACCGCCACCATATCGAGCTCGCCAAGCGTGTGCGCGAAGGCATCGTCTCGATG
GGCGGCATTCCCTTCGAATTCCCCTGCCATCCGATCCAGGAGACCGGCAAGCGCCCGACCGCGGCCCTTGACCGCAACCT
TGCCTATCTCGGCCTCGTCGAGGTGCTCTATGGCTATCCGCTCGACGGCGTCGTGCTGACCATCGGTTGCGACAAGACGA
CGCCGGCGCTGCTCATGGCGGCCGCCACCGTCAACATCCCGGCCATCGCGCTGTCGGTCGGCCCGATGCTCAACGGCTGG
CACAAGGGCAAGCGCACCGGTTCCGGCACCATCGTCTGGGAATCGCGCCAGCGCCTGTCGGCCGGCGAGATCGACTATGA
CGAGTTCATGGATATCGTCGCCTCCTCGGCGCCCTCCACCGGCTACTGCAACACGATGGGCACCGCCACCACGATGAATT
CGCTGGCCGAGGCGCTCGGCATGCAGTTGCCGGGCTCGGCCGCCATCCCGGCGCCTTACCGCGAGCGCGGGCAGATCGCC
TACGAGACCGGCAAGCGCATCGTCGACATGGTGCATGAGGATTTGAAGCCGTCGGACATCATGACGCGCAAGGCCTTCGA
GAATGCCATCGTCGTCAATTCGGCGATCGGCGGCTCGACCAACGCGCCGATTCATCTCAACGCCATTGCCCGCCATCTCG
GCGTGCCGCTCGACAATGACGACTGGCAGGCGATCGGCCTCAAGGTGCCGCTCATCGTCAACCTGCAGCCGACGGGCGAG
TATCTCGGCGAGGACTACCATCACGCCGGCGGCGTGCCGGCCGTCGTGGCCGAGCTGATGAAGGGCGGGCTGTTGCCGCA
TCCCGATGCCCTGACCGCCAATGGCAAGTCGATCGGCGACAATTGCAAGGCGGCGGTGGTCGAAAACGCCGACGTAATCC
GCACCGTCGACAAGCCGCTGAAGGTCAATGCCGGCTTCATCAACCTCAGCGGCAATCTGTTCGATTCGGCGATCATGAAG
ACCAGCGGTATCTCGCCGGAGTTCCGCGAGCGCTACCTCTCCAATCCGAAGGACCCGGAAGCTTTCGAAGGCAACGCCAT
GGTCTTTGACGGCCCGGAGGATTACCACGCCCGCATCGACGATCCGGCGCAAGGCATCGATGAACACACGATCCTGTTCA
TGCGCGGCGCCGGCCCGGTCGGCTATCCCGGCGGTGCCGAGGTCGTCAACATGCAGCCGCCGGCCTATCTCATCAAGAAG
GGCATCCATGCGCTGGCCTGTATCGGCGACGGCCGCCAGTCGGGCACGTCGGGCTCGCCGTCGATCCTCAACGCCTCGCC
GGAAGCTGCCATTGGCGGCGGACTGGCGCTGCTCAAGACAGGCGACCGCGTCCGCATCGACCTGAACAAGGGCACTGCCA
ACATTCTGGTCAGCGACGAAGAGATCGCCAAGCGGCGCGCGGCGCTGCAGGGCAATGGCGGCTACCACTATCCGCAGCAC
CAGACGCCGTGGCAGGAAATCCAGCGCGGCATGGTAGACCAGTTCGACCAGGGCATGGTGTTGAAGCCGGCGGTGAAATA
CCAGGATGTCGCGCACACCAGGGGTGTGCCCAGGGACAATCACTGA

Upstream 100 bases:

>100_bases
TTGTGTCTATCGCACCAAAGTGCGGGTTGGGGACGCGCGTGCCCCTTGCTTGCATTGACGCGTTGTCATATCGATTTGTC
ATACAAATACGGAGACCGTG

Downstream 100 bases:

>100_bases
TTGCTCCCGATTACCGGCATCTGTTCGCGGATGCTTACATAACGACGAACGGCGGCCTGATCCGGATCAAGCCGCCGTTC
ATCGTCCTTGACAAGCGCGC

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 601; Mature: 600

Protein sequence:

>601_residues
MAGAPTKKKKFRSQEWFDNPDNPGMTALYLERYLNYGLTRAELMSGKPLIGIAQTGSDLSPCNRHHIELAKRVREGIVSM
GGIPFEFPCHPIQETGKRPTAALDRNLAYLGLVEVLYGYPLDGVVLTIGCDKTTPALLMAAATVNIPAIALSVGPMLNGW
HKGKRTGSGTIVWESRQRLSAGEIDYDEFMDIVASSAPSTGYCNTMGTATTMNSLAEALGMQLPGSAAIPAPYRERGQIA
YETGKRIVDMVHEDLKPSDIMTRKAFENAIVVNSAIGGSTNAPIHLNAIARHLGVPLDNDDWQAIGLKVPLIVNLQPTGE
YLGEDYHHAGGVPAVVAELMKGGLLPHPDALTANGKSIGDNCKAAVVENADVIRTVDKPLKVNAGFINLSGNLFDSAIMK
TSGISPEFRERYLSNPKDPEAFEGNAMVFDGPEDYHARIDDPAQGIDEHTILFMRGAGPVGYPGGAEVVNMQPPAYLIKK
GIHALACIGDGRQSGTSGSPSILNASPEAAIGGGLALLKTGDRVRIDLNKGTANILVSDEEIAKRRAALQGNGGYHYPQH
QTPWQEIQRGMVDQFDQGMVLKPAVKYQDVAHTRGVPRDNH

Sequences:

>Translated_601_residues
MAGAPTKKKKFRSQEWFDNPDNPGMTALYLERYLNYGLTRAELMSGKPLIGIAQTGSDLSPCNRHHIELAKRVREGIVSM
GGIPFEFPCHPIQETGKRPTAALDRNLAYLGLVEVLYGYPLDGVVLTIGCDKTTPALLMAAATVNIPAIALSVGPMLNGW
HKGKRTGSGTIVWESRQRLSAGEIDYDEFMDIVASSAPSTGYCNTMGTATTMNSLAEALGMQLPGSAAIPAPYRERGQIA
YETGKRIVDMVHEDLKPSDIMTRKAFENAIVVNSAIGGSTNAPIHLNAIARHLGVPLDNDDWQAIGLKVPLIVNLQPTGE
YLGEDYHHAGGVPAVVAELMKGGLLPHPDALTANGKSIGDNCKAAVVENADVIRTVDKPLKVNAGFINLSGNLFDSAIMK
TSGISPEFRERYLSNPKDPEAFEGNAMVFDGPEDYHARIDDPAQGIDEHTILFMRGAGPVGYPGGAEVVNMQPPAYLIKK
GIHALACIGDGRQSGTSGSPSILNASPEAAIGGGLALLKTGDRVRIDLNKGTANILVSDEEIAKRRAALQGNGGYHYPQH
QTPWQEIQRGMVDQFDQGMVLKPAVKYQDVAHTRGVPRDNH
>Mature_600_residues
AGAPTKKKKFRSQEWFDNPDNPGMTALYLERYLNYGLTRAELMSGKPLIGIAQTGSDLSPCNRHHIELAKRVREGIVSMG
GIPFEFPCHPIQETGKRPTAALDRNLAYLGLVEVLYGYPLDGVVLTIGCDKTTPALLMAAATVNIPAIALSVGPMLNGWH
KGKRTGSGTIVWESRQRLSAGEIDYDEFMDIVASSAPSTGYCNTMGTATTMNSLAEALGMQLPGSAAIPAPYRERGQIAY
ETGKRIVDMVHEDLKPSDIMTRKAFENAIVVNSAIGGSTNAPIHLNAIARHLGVPLDNDDWQAIGLKVPLIVNLQPTGEY
LGEDYHHAGGVPAVVAELMKGGLLPHPDALTANGKSIGDNCKAAVVENADVIRTVDKPLKVNAGFINLSGNLFDSAIMKT
SGISPEFRERYLSNPKDPEAFEGNAMVFDGPEDYHARIDDPAQGIDEHTILFMRGAGPVGYPGGAEVVNMQPPAYLIKKG
IHALACIGDGRQSGTSGSPSILNASPEAAIGGGLALLKTGDRVRIDLNKGTANILVSDEEIAKRRAALQGNGGYHYPQHQ
TPWQEIQRGMVDQFDQGMVLKPAVKYQDVAHTRGVPRDNH

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=600, Percent_Identity=28, Blast_Score=195, Evalue=5e-51,
Organism=Escherichia coli, GI1788157, Length=444, Percent_Identity=30.4054054054054, Blast_Score=171, Evalue=2e-43,
Organism=Escherichia coli, GI1786464, Length=543, Percent_Identity=27.9926335174954, Blast_Score=125, Evalue=9e-30,
Organism=Escherichia coli, GI2367371, Length=483, Percent_Identity=28.7784679089027, Blast_Score=123, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6322476, Length=516, Percent_Identity=29.8449612403101, Blast_Score=204, Evalue=3e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 64523; Mature: 64392

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: PS00886 ILVD_EDD_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGAPTKKKKFRSQEWFDNPDNPGMTALYLERYLNYGLTRAELMSGKPLIGIAQTGSDLS
CCCCCCHHHHHCCHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHCCCCEEEEECCCCCCC
PCNRHHIELAKRVREGIVSMGGIPFEFPCHPIQETGKRPTAALDRNLAYLGLVEVLYGYP
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCHHHHCCHHHHHHHHHHHCCC
LDGVVLTIGCDKTTPALLMAAATVNIPAIALSVGPMLNGWHKGKRTGSGTIVWESRQRLS
CCCEEEEEECCCCCHHHHHHHHHCCCCEEEEECCCHHCCHHCCCCCCCCEEEECCCCCCC
AGEIDYDEFMDIVASSAPSTGYCNTMGTATTMNSLAEALGMQLPGSAAIPAPYRERGQIA
CCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHCCCEE
YETGKRIVDMVHEDLKPSDIMTRKAFENAIVVNSAIGGSTNAPIHLNAIARHLGVPLDND
HHHHHHHHHHHHHCCCCHHHHHHHHHCCEEEEEECCCCCCCCCEEHHHHHHHHCCCCCCC
DWQAIGLKVPLIVNLQPTGEYLGEDYHHAGGVPAVVAELMKGGLLPHPDALTANGKSIGD
CCEEEEEEEEEEEEECCCHHHHCCCHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
NCKAAVVENADVIRTVDKPLKVNAGFINLSGNLFDSAIMKTSGISPEFRERYLSNPKDPE
CCCEEEECCCHHHHHCCCCEEECCCEEEECCCHHHHHHHHHCCCCHHHHHHHCCCCCCCC
AFEGNAMVFDGPEDYHARIDDPAQGIDEHTILFMRGAGPVGYPGGAEVVNMQPPAYLIKK
CCCCCEEEECCCCCCCCCCCCHHCCCCCEEEEEEECCCCCCCCCCCCEEECCCCHHHHHC
GIHALACIGDGRQSGTSGSPSILNASPEAAIGGGLALLKTGDRVRIDLNKGTANILVSDE
CCEEEEEECCCCCCCCCCCCCEECCCCCCCCCCCEEEEECCCEEEEEECCCCEEEEECHH
EIAKRRAALQGNGGYHYPQHQTPWQEIQRGMVDQFDQGMVLKPAVKYQDVAHTRGVPRDN
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEECCCHHHHHHHHHCCCCCCC
H
C
>Mature Secondary Structure 
AGAPTKKKKFRSQEWFDNPDNPGMTALYLERYLNYGLTRAELMSGKPLIGIAQTGSDLS
CCCCCHHHHHCCHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHCCCCEEEEECCCCCCC
PCNRHHIELAKRVREGIVSMGGIPFEFPCHPIQETGKRPTAALDRNLAYLGLVEVLYGYP
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCHHHHCCHHHHHHHHHHHCCC
LDGVVLTIGCDKTTPALLMAAATVNIPAIALSVGPMLNGWHKGKRTGSGTIVWESRQRLS
CCCEEEEEECCCCCHHHHHHHHHCCCCEEEEECCCHHCCHHCCCCCCCCEEEECCCCCCC
AGEIDYDEFMDIVASSAPSTGYCNTMGTATTMNSLAEALGMQLPGSAAIPAPYRERGQIA
CCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHCCCEE
YETGKRIVDMVHEDLKPSDIMTRKAFENAIVVNSAIGGSTNAPIHLNAIARHLGVPLDND
HHHHHHHHHHHHHCCCCHHHHHHHHHCCEEEEEECCCCCCCCCEEHHHHHHHHCCCCCCC
DWQAIGLKVPLIVNLQPTGEYLGEDYHHAGGVPAVVAELMKGGLLPHPDALTANGKSIGD
CCEEEEEEEEEEEEECCCHHHHCCCHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
NCKAAVVENADVIRTVDKPLKVNAGFINLSGNLFDSAIMKTSGISPEFRERYLSNPKDPE
CCCEEEECCCHHHHHCCCCEEECCCEEEECCCHHHHHHHHHCCCCHHHHHHHCCCCCCCC
AFEGNAMVFDGPEDYHARIDDPAQGIDEHTILFMRGAGPVGYPGGAEVVNMQPPAYLIKK
CCCCCEEEECCCCCCCCCCCCHHCCCCCEEEEEEECCCCCCCCCCCCEEECCCCHHHHHC
GIHALACIGDGRQSGTSGSPSILNASPEAAIGGGLALLKTGDRVRIDLNKGTANILVSDE
CCEEEEEECCCCCCCCCCCCCEECCCCCCCCCCCEEEEECCCEEEEEECCCCEEEEECHH
EIAKRRAALQGNGGYHYPQHQTPWQEIQRGMVDQFDQGMVLKPAVKYQDVAHTRGVPRDN
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEECCCHHHHHHHHHCCCCCCC
H
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]