Click here to switch to the map view.

The map label for this gene is livH [H]

Identifier: 13474352

GI number: 13474352

Start: 4152312

End: 4153211

Strand: Direct

Name: livH [H]

Synonym: mlr5220

Alternate gene names: 13474352

Gene position: 4152312-4153211 (Clockwise)

Preceding gene: 13474351

Following gene: 13474353

Centisome position: 59.01

GC content: 65.67

Gene sequence:

>900_bases
ATGATCGCCGATTTCGACTACCAGTTCTTCATCGAAGTGCTCGTCGGCGGCCTGCTCTCCGGCGTCATGTACTCGCTGGT
CGCGATCGGCTTCGTGCTGATCTACAAGACATCAGGCGTGCTCAATTTCGCGCAAGGCGCGCTGCTCTTGTTCGCGGCAC
TCACCTTCGTCAGCCTCGTCGAACGCGGTGTTCCCTTCGCGCTGGCGCTGGTGGCCACCTTCGCCATCATGGTGGCGATC
GGCATCGCCATCGAGCGCACGGTGCTCAGGCCGCTCACCAACAAGCCGCCGATCACGCTCTTCATGGCCACGCTCGGCCT
GTCCTACATCATCGAGGGCGCCGCCCAGTTGATCTGGGGCACGCAGGTCCATGGCCTCGACCTCGGCATCGAGGATGTGC
CGCTGGAAGTCGGCGGTGTGCTGATCAGCCAGTTCGACATCTTCGCGGCTGTGGTCGCCGCCGGCATGGTTCTGCTGCTG
TCGCTGTTCTTCCGCTACACCCGCATCGGCCTCTCCTTCCGCGCCGTCGCCGACGATCAGTTCGCCGCCCTAGCGGTCGG
CCTCAGGCTGCCGCTGATCTGGGCGACCGTCTGGGCCGCGGCCGGCCTCGTCGCGCTGGTCGCGGGACTGCTCTGGGGCG
CCCGCCTCGGCGTGCAGTTCTCACTGTCCCTGGTGGTGCTCAAGGCGCTGCCGGTGCTGGTGCTTGGCGGCTTCGATTCG
ATCCTCGGCGCCATCGTCGGCGGCCTCTTGATCGGCGCCAGCGAGAAGCTCGCCGAGGTCTATATCGGCGACTATTTCGG
CGGCGGCATCGAGAGCTGGTTCGCCTATGTCGTGGCGCTTGCCTTCCTCCTGATCCGTCCCTCCGGCCTGTTCGGCCAGA
AGCTCGTGGAGAGGGTCTGA

Upstream 100 bases:

>100_bases
GCAAGATCGCTGACGCCACGCCCGACGAAGTCAGGAACGACCAGCGCGTTATCGATGCCTATCTCGGCGTCGCCTCCGAC
AATGAGGACGGGGCAGGCAT

Downstream 100 bases:

>100_bases
GCCATGGCCGCGATCACAAGCAATTTCTCCTCCGCGCCGGTGCTGCCGAAATGGACCGCGCCCGTGCTGCTGCTTGCCTT
CGCCTATGGCATCGTGCCGT

Product: ABC transporter, permease protein

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MIADFDYQFFIEVLVGGLLSGVMYSLVAIGFVLIYKTSGVLNFAQGALLLFAALTFVSLVERGVPFALALVATFAIMVAI
GIAIERTVLRPLTNKPPITLFMATLGLSYIIEGAAQLIWGTQVHGLDLGIEDVPLEVGGVLISQFDIFAAVVAAGMVLLL
SLFFRYTRIGLSFRAVADDQFAALAVGLRLPLIWATVWAAAGLVALVAGLLWGARLGVQFSLSLVVLKALPVLVLGGFDS
ILGAIVGGLLIGASEKLAEVYIGDYFGGGIESWFAYVVALAFLLIRPSGLFGQKLVERV

Sequences:

>Translated_299_residues
MIADFDYQFFIEVLVGGLLSGVMYSLVAIGFVLIYKTSGVLNFAQGALLLFAALTFVSLVERGVPFALALVATFAIMVAI
GIAIERTVLRPLTNKPPITLFMATLGLSYIIEGAAQLIWGTQVHGLDLGIEDVPLEVGGVLISQFDIFAAVVAAGMVLLL
SLFFRYTRIGLSFRAVADDQFAALAVGLRLPLIWATVWAAAGLVALVAGLLWGARLGVQFSLSLVVLKALPVLVLGGFDS
ILGAIVGGLLIGASEKLAEVYIGDYFGGGIESWFAYVVALAFLLIRPSGLFGQKLVERV
>Mature_299_residues
MIADFDYQFFIEVLVGGLLSGVMYSLVAIGFVLIYKTSGVLNFAQGALLLFAALTFVSLVERGVPFALALVATFAIMVAI
GIAIERTVLRPLTNKPPITLFMATLGLSYIIEGAAQLIWGTQVHGLDLGIEDVPLEVGGVLISQFDIFAAVVAAGMVLLL
SLFFRYTRIGLSFRAVADDQFAALAVGLRLPLIWATVWAAAGLVALVAGLLWGARLGVQFSLSLVVLKALPVLVLGGFDS
ILGAIVGGLLIGASEKLAEVYIGDYFGGGIESWFAYVVALAFLLIRPSGLFGQKLVERV

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=315, Percent_Identity=26.6666666666667, Blast_Score=93, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 31673; Mature: 31673

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIADFDYQFFIEVLVGGLLSGVMYSLVAIGFVLIYKTSGVLNFAQGALLLFAALTFVSLV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
ERGVPFALALVATFAIMVAIGIAIERTVLRPLTNKPPITLFMATLGLSYIIEGAAQLIWG
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
TQVHGLDLGIEDVPLEVGGVLISQFDIFAAVVAAGMVLLLSLFFRYTRIGLSFRAVADDQ
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCH
FAALAVGLRLPLIWATVWAAAGLVALVAGLLWGARLGVQFSLSLVVLKALPVLVLGGFDS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
ILGAIVGGLLIGASEKLAEVYIGDYFGGGIESWFAYVVALAFLLIRPSGLFGQKLVERV
HHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHCC
>Mature Secondary Structure
MIADFDYQFFIEVLVGGLLSGVMYSLVAIGFVLIYKTSGVLNFAQGALLLFAALTFVSLV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
ERGVPFALALVATFAIMVAIGIAIERTVLRPLTNKPPITLFMATLGLSYIIEGAAQLIWG
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
TQVHGLDLGIEDVPLEVGGVLISQFDIFAAVVAAGMVLLLSLFFRYTRIGLSFRAVADDQ
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCH
FAALAVGLRLPLIWATVWAAAGLVALVAGLLWGARLGVQFSLSLVVLKALPVLVLGGFDS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
ILGAIVGGLLIGASEKLAEVYIGDYFGGGIESWFAYVVALAFLLIRPSGLFGQKLVERV
HHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]