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The map label for this gene is trpB

Identifier: 13474230

GI number: 13474230

Start: 4014688

End: 4015938

Strand: Direct

Name: trpB

Synonym: mlr5071

Alternate gene names: 13474230

Gene position: 4014688-4015938 (Clockwise)

Preceding gene: 13474229

Following gene: 13474231

Centisome position: 57.06

GC content: 64.51

Gene sequence:

>1251_bases
ATGGACCAGCCGGCGACGCCCAATTCCTTCCGCACCGGACCCGACGAGCAGGGCATGTTCGGCATTTTCGGCGGCCGTTT
CGTCGCAGAAACGCTGATGCCGCTGATCCTCGACCTGGAGCGGCACTGGAACGAGGTCAAGAACGATCCGGATTTCAGGG
CTGAGCTGACCGATCTTTCGACCCACTATGCCGGACGCCCGTCGAAGCTCTATTTCGCCGAGGGTCTTACGAAGCATCTT
CGCGAGGTTTCCTCGGCGAAGGGCCTCGGGGGCGGCGCCAAAGTCTATTTCAAGCGCGAGGACCTGAACCACACCGGGTC
GCACAAGATCAACAACTGCCTCGGCCAGATCCTGCTGGCCAAGCGCATGGGCAAGAAGCGCATCATCGCCGAGACAGGCG
CCGGCCAGCATGGCGTGGCATCCGCCACCGTCGCCGCCCGCTTCGGCTATCCCTGCGTCGTCTACATGGGCGCCACCGAC
GTTGCCCGGCAGAGCCCGAACGTGTTTCGCATGAAGCTGCTCGGCGCCGAAGTGCGGCCGGTCACCGCTGGCCACGGCAC
GCTGAAGGACGCCATGAACGAAGCCCTTCGCGATTGGGTCACCAATGTCGAGGACACCTATTATCTTATCGGCACAGCCG
CAGGCCCGCATCCCTATCCGGAGCTGGTGCGCGACTTCCAGTCGGTGATCGGCACCGAGGCGCGCGCGCAAATCCTCGAA
CAGGAAGGCCGGCTGCCCGACACCATCATTGCCGCTGTCGGCGGCGGCTCGAATGCCATCGGTCTGTTCCATCCCTTCCT
CGACGACAAGGACGTGCGCATCATCGGCATCGAAGCCGGCGGGCGCGGCCTCGACGGCATCGAGCACTGCGCCTCGATGA
ATGCCGGTTCTCCCGGCGTGCTGCACGGCAACCGCACCTATCTCCTGCAGAATGCCGACGGCCAGATCATGGACGGCCAT
TCGATCTCGGCCGGCCTCGACTATCCCGGCGTCGGCCCGGAGCATTCCTGGCTGCGCGATTCCGGCCGCGTCGAATATGT
GCCGATCCTCGACGACGAGGCGCTGGAAGCCTTCAAGCTGACGACGCGCGTCGAAGGCATCATCCCGGCGCTGGAATCCG
CGCACGCCATCGCCCACGCGGTGAAGATCGTGCCTGCCATGGACAAGGACCAGATCGTCATCGTCAACCTGTCCGGCCGT
GGCGACAAGGACGTGCACACGGTGGCCTCGATGCTGGGCATGGAGATCTAG

Upstream 100 bases:

>100_bases
CGGGCCGCCTAACGCCTTTAAACAAGAGTATGTCCCGGAAAAATGGGAACCGGTTTTCCGACAAGGACATGCTCAAAACA
TAAGATTTAGGAGATCGGCG

Downstream 100 bases:

>100_bases
GCCCTTTGGACAGTTTCGATTTGGGAGTTGATTATGAGCAAAATTCGTCCAAAGGGCCAGACATGACGACCCGCATCGAC
CGCCGCATGGCGAAGCTGAA

Product: tryptophan synthase subunit beta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MDQPATPNSFRTGPDEQGMFGIFGGRFVAETLMPLILDLERHWNEVKNDPDFRAELTDLSTHYAGRPSKLYFAEGLTKHL
REVSSAKGLGGGAKVYFKREDLNHTGSHKINNCLGQILLAKRMGKKRIIAETGAGQHGVASATVAARFGYPCVVYMGATD
VARQSPNVFRMKLLGAEVRPVTAGHGTLKDAMNEALRDWVTNVEDTYYLIGTAAGPHPYPELVRDFQSVIGTEARAQILE
QEGRLPDTIIAAVGGGSNAIGLFHPFLDDKDVRIIGIEAGGRGLDGIEHCASMNAGSPGVLHGNRTYLLQNADGQIMDGH
SISAGLDYPGVGPEHSWLRDSGRVEYVPILDDEALEAFKLTTRVEGIIPALESAHAIAHAVKIVPAMDKDQIVIVNLSGR
GDKDVHTVASMLGMEI

Sequences:

>Translated_416_residues
MDQPATPNSFRTGPDEQGMFGIFGGRFVAETLMPLILDLERHWNEVKNDPDFRAELTDLSTHYAGRPSKLYFAEGLTKHL
REVSSAKGLGGGAKVYFKREDLNHTGSHKINNCLGQILLAKRMGKKRIIAETGAGQHGVASATVAARFGYPCVVYMGATD
VARQSPNVFRMKLLGAEVRPVTAGHGTLKDAMNEALRDWVTNVEDTYYLIGTAAGPHPYPELVRDFQSVIGTEARAQILE
QEGRLPDTIIAAVGGGSNAIGLFHPFLDDKDVRIIGIEAGGRGLDGIEHCASMNAGSPGVLHGNRTYLLQNADGQIMDGH
SISAGLDYPGVGPEHSWLRDSGRVEYVPILDDEALEAFKLTTRVEGIIPALESAHAIAHAVKIVPAMDKDQIVIVNLSGR
GDKDVHTVASMLGMEI
>Mature_416_residues
MDQPATPNSFRTGPDEQGMFGIFGGRFVAETLMPLILDLERHWNEVKNDPDFRAELTDLSTHYAGRPSKLYFAEGLTKHL
REVSSAKGLGGGAKVYFKREDLNHTGSHKINNCLGQILLAKRMGKKRIIAETGAGQHGVASATVAARFGYPCVVYMGATD
VARQSPNVFRMKLLGAEVRPVTAGHGTLKDAMNEALRDWVTNVEDTYYLIGTAAGPHPYPELVRDFQSVIGTEARAQILE
QEGRLPDTIIAAVGGGSNAIGLFHPFLDDKDVRIIGIEAGGRGLDGIEHCASMNAGSPGVLHGNRTYLLQNADGQIMDGH
SISAGLDYPGVGPEHSWLRDSGRVEYVPILDDEALEAFKLTTRVEGIIPALESAHAIAHAVKIVPAMDKDQIVIVNLSGR
GDKDVHTVASMLGMEI

Specific function: The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine

COG id: COG0133

COG function: function code E; Tryptophan synthase beta chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpB family

Homologues:

Organism=Escherichia coli, GI1787515, Length=394, Percent_Identity=55.5837563451777, Blast_Score=443, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6321412, Length=394, Percent_Identity=54.3147208121827, Blast_Score=445, Evalue=1e-126,

Paralogues:

None

Copy number: 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 5,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): TRPB_RHILO (Q98CN7)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_105798.1
- ProteinModelPortal:   Q98CN7
- SMR:   Q98CN7
- GeneID:   1228459
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mlr5071
- NMPDR:   fig|266835.1.peg.3902
- HOGENOM:   HBG303148
- OMA:   LKREDLC
- ProtClustDB:   PRK04346
- BRENDA:   4.2.1.20
- HAMAP:   MF_00133
- InterPro:   IPR001926
- InterPro:   IPR006653
- InterPro:   IPR006654
- InterPro:   IPR023026
- TIGRFAMs:   TIGR00263

Pfam domain/function: PF00291 PALP; SSF53686 PyrdxlP-dep_enz_bsu

EC number: =4.2.1.20

Molecular weight: Translated: 44897; Mature: 44897

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00168 TRP_SYNTHASE_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQPATPNSFRTGPDEQGMFGIFGGRFVAETLMPLILDLERHWNEVKNDPDFRAELTDLS
CCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
THYAGRPSKLYFAEGLTKHLREVSSAKGLGGGAKVYFKREDLNHTGSHKINNCLGQILLA
HHCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHH
KRMGKKRIIAETGAGQHGVASATVAARFGYPCVVYMGATDVARQSPNVFRMKLLGAEVRP
HHCCCCEEEEECCCCCCCCHHHHHHHHCCCCEEEEECCHHHHHCCCCEEEEEEECCCCCE
VTAGHGTLKDAMNEALRDWVTNVEDTYYLIGTAAGPHPYPELVRDFQSVIGTEARAQILE
EECCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCHHHHHHHH
QEGRLPDTIIAAVGGGSNAIGLFHPFLDDKDVRIIGIEAGGRGLDGIEHCASMNAGSPGV
HCCCCCCEEEEEECCCCCCEEEEECCCCCCCEEEEEEECCCCCCHHHHHHHHCCCCCCCE
LHGNRTYLLQNADGQIMDGHSISAGLDYPGVGPEHSWLRDSGRVEYVPILDDEALEAFKL
EECCEEEEEECCCCCEECCCCCCCCCCCCCCCCCCHHHCCCCCEEEEECCCHHHHHHHHH
TTRVEGIIPALESAHAIAHAVKIVPAMDKDQIVIVNLSGRGDKDVHTVASMLGMEI
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MDQPATPNSFRTGPDEQGMFGIFGGRFVAETLMPLILDLERHWNEVKNDPDFRAELTDLS
CCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
THYAGRPSKLYFAEGLTKHLREVSSAKGLGGGAKVYFKREDLNHTGSHKINNCLGQILLA
HHCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHH
KRMGKKRIIAETGAGQHGVASATVAARFGYPCVVYMGATDVARQSPNVFRMKLLGAEVRP
HHCCCCEEEEECCCCCCCCHHHHHHHHCCCCEEEEECCHHHHHCCCCEEEEEEECCCCCE
VTAGHGTLKDAMNEALRDWVTNVEDTYYLIGTAAGPHPYPELVRDFQSVIGTEARAQILE
EECCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCHHHHHHHH
QEGRLPDTIIAAVGGGSNAIGLFHPFLDDKDVRIIGIEAGGRGLDGIEHCASMNAGSPGV
HCCCCCCEEEEEECCCCCCEEEEECCCCCCCEEEEEEECCCCCCHHHHHHHHCCCCCCCE
LHGNRTYLLQNADGQIMDGHSISAGLDYPGVGPEHSWLRDSGRVEYVPILDDEALEAFKL
EECCEEEEEECCCCCEECCCCCCCCCCCCCCCCCCHHHCCCCCEEEEECCCHHHHHHHHH
TTRVEGIIPALESAHAIAHAVKIVPAMDKDQIVIVNLSGRGDKDVHTVASMLGMEI
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968