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The map label for this gene is hisB

Identifier: 13474180

GI number: 13474180

Start: 3970560

End: 3971159

Strand: Direct

Name: hisB

Synonym: mlr5008

Alternate gene names: 13474180

Gene position: 3970560-3971159 (Clockwise)

Preceding gene: 13474174

Following gene: 13474181

Centisome position: 56.43

GC content: 64.33

Gene sequence:

>600_bases
ATGGCGCCCCGTTCCGCCGAAGCCAGCCGCAAGACCAAGGAAACCGATATCTCGGTGTCGGTCCATGTCGACGGCTCGGG
CAAATCCGATATCGCGACGGGCGTCGGCTTCTTCGACCATATGCTCGACCAGCTGTCGCGCCATTCGCTGATCGACATGA
CGGTGAGGGCCAAGGGCGACCTGCACATAGACGACCACCACACGGTCGAGGACACCGGCATCGCGCTCGGCCAGGCCTTG
ACGAAGGCGCTGGGTGAGCGGCGCGGCATCATGCGATATGCCTCGATCGACCTTGCCATGGACGAGACGCTGACACGCGC
GGCGATCGACGTGTCGGGCCGGCCGTTCCTGGTCTGGAACGTGTCTTTCTCGTCGCCCAAGATCGGCACCTTCGACACCG
AGCTGGTGCGGGAATTCTTCCAGGCGCTGGCCCAAAATGCCGGCATCACGCTGCATGTCACCAACCATTATGGCGCCAAC
AACCACCATATCGCCGAGACCTGCTTCAAGGCGGTGGCGCGCGCGTTGCGTGCCGCGCTCGAGCCCGACCCGCGCCAGCC
GGACGCGGTTCCCTCCACCAAGGGATCGTTGAAGGGATAG

Upstream 100 bases:

>100_bases
CAATCGCCGGATCATGCTGATAGAAGGCTTTCGTTTTCAAGCCGGTGAATGTTCGAAGCTCGTCCGCGGAGCTTTGAAAC
CCTGAGACAAGGACAAGGTC

Downstream 100 bases:

>100_bases
GCCATGGCCACCTATGTCGTGATGGAACCGCCCAGCCGCAGCGAAAAGGTCGATGCAACGGCCTTTGTCCGCGACGGCTT
CACCTGGCTCGGCCTGCTGG

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 199; Mature: 198

Protein sequence:

>199_residues
MAPRSAEASRKTKETDISVSVHVDGSGKSDIATGVGFFDHMLDQLSRHSLIDMTVRAKGDLHIDDHHTVEDTGIALGQAL
TKALGERRGIMRYASIDLAMDETLTRAAIDVSGRPFLVWNVSFSSPKIGTFDTELVREFFQALAQNAGITLHVTNHYGAN
NHHIAETCFKAVARALRAALEPDPRQPDAVPSTKGSLKG

Sequences:

>Translated_199_residues
MAPRSAEASRKTKETDISVSVHVDGSGKSDIATGVGFFDHMLDQLSRHSLIDMTVRAKGDLHIDDHHTVEDTGIALGQAL
TKALGERRGIMRYASIDLAMDETLTRAAIDVSGRPFLVWNVSFSSPKIGTFDTELVREFFQALAQNAGITLHVTNHYGAN
NHHIAETCFKAVARALRAALEPDPRQPDAVPSTKGSLKG
>Mature_198_residues
APRSAEASRKTKETDISVSVHVDGSGKSDIATGVGFFDHMLDQLSRHSLIDMTVRAKGDLHIDDHHTVEDTGIALGQALT
KALGERRGIMRYASIDLAMDETLTRAAIDVSGRPFLVWNVSFSSPKIGTFDTELVREFFQALAQNAGITLHVTNHYGANN
HHIAETCFKAVARALRAALEPDPRQPDAVPSTKGSLKG

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=194, Percent_Identity=50, Blast_Score=192, Evalue=9e-51,
Organism=Saccharomyces cerevisiae, GI6324776, Length=221, Percent_Identity=38.9140271493213, Blast_Score=156, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_RHILO (Q98CT7)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_105748.1
- ProteinModelPortal:   Q98CT7
- SMR:   Q98CT7
- GeneID:   1228409
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mlr5008
- NMPDR:   fig|266835.1.peg.3852
- HOGENOM:   HBG289010
- OMA:   TLHVETL
- ProtClustDB:   PRK00951
- BRENDA:   4.2.1.19
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 21575; Mature: 21443

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPRSAEASRKTKETDISVSVHVDGSGKSDIATGVGFFDHMLDQLSRHSLIDMTVRAKGD
CCCCCCCHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCC
LHIDDHHTVEDTGIALGQALTKALGERRGIMRYASIDLAMDETLTRAAIDVSGRPFLVWN
EEECCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEECCCCEEEEEE
VSFSSPKIGTFDTELVREFFQALAQNAGITLHVTNHYGANNHHIAETCFKAVARALRAAL
EECCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHC
EPDPRQPDAVPSTKGSLKG
CCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
APRSAEASRKTKETDISVSVHVDGSGKSDIATGVGFFDHMLDQLSRHSLIDMTVRAKGD
CCCCCCHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCC
LHIDDHHTVEDTGIALGQALTKALGERRGIMRYASIDLAMDETLTRAAIDVSGRPFLVWN
EEECCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEECCCCEEEEEE
VSFSSPKIGTFDTELVREFFQALAQNAGITLHVTNHYGANNHHIAETCFKAVARALRAAL
EECCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHC
EPDPRQPDAVPSTKGSLKG
CCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968