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The map label for this gene is aacA4 [H]

Identifier: 13474178

GI number: 13474178

Start: 3969260

End: 3969781

Strand: Reverse

Name: aacA4 [H]

Synonym: mll5006

Alternate gene names: 13474178

Gene position: 3969781-3969260 (Counterclockwise)

Preceding gene: 13474179

Following gene: 13474177

Centisome position: 56.42

GC content: 61.11

Gene sequence:

>522_bases
ATGCCGCCTGAGAAGGTGGTGCTCTACGATTTTCGGCCGGTTACCGAAAAGGACCTGCCGATGATCGCCGGCTGGCTGGC
CGAGCCTGAAGTGGCCGAGTGGTGGAACGATCCGGACACGGAGATCGCCGAGATTCGCGATCATATCGACTCGATTTCGG
TCGAGCCGCTGATCGTCGAACTCGACGGCAAGCCGATCGCCTATCTGCAGAGCTACGACCCGCATCTGGAAGACGACCAT
CCCTATGCCGACCAGCCGTTCGGCACGCTCGGCATCGATTTGTCGATCGGCCGGCCGGAGCTGCTAGGCATCGGCCATGG
CTCGGCAATCGTGCGTCAGTTCGTCGAAGATCTGTTTAGGGAAGGCGTGCCCCGCGTCATCATCGACCCCGACCCAGCCA
ATCTCAGGGCCATCCGCGCCTATGAAAAGGCCGGATTCCGGGCCATAGACCGCAGGCAATCGGTCTATGGCGACGTCGTG
CTGATGGCGATCGATGCCGACGATGAGCAAGAGGGGGAATAA

Upstream 100 bases:

>100_bases
GACACCGACAAGGATGCCGAGGAGATCGCCCGCAAGGCGATGCAGATCGCCTCCGACATCTGTGTCTACACCAACAACAA
TTTCGTCGTCGAAACGCTCG

Downstream 100 bases:

>100_bases
TCAGATGAGCAAGCCGGCCGCGGACGATGGCTACTCGGCCTATGAAGACAGCTGGCGCATGGGTCTTCTGCTCGTCCTTG
GCCTGCTCATCTTCCAGGCC

Product: aminoglycoside 6'-N-acetyltransferase

Products: NA

Alternate protein names: AAC(6'); Amikacin resistance protein [H]

Number of amino acids: Translated: 173; Mature: 172

Protein sequence:

>173_residues
MPPEKVVLYDFRPVTEKDLPMIAGWLAEPEVAEWWNDPDTEIAEIRDHIDSISVEPLIVELDGKPIAYLQSYDPHLEDDH
PYADQPFGTLGIDLSIGRPELLGIGHGSAIVRQFVEDLFREGVPRVIIDPDPANLRAIRAYEKAGFRAIDRRQSVYGDVV
LMAIDADDEQEGE

Sequences:

>Translated_173_residues
MPPEKVVLYDFRPVTEKDLPMIAGWLAEPEVAEWWNDPDTEIAEIRDHIDSISVEPLIVELDGKPIAYLQSYDPHLEDDH
PYADQPFGTLGIDLSIGRPELLGIGHGSAIVRQFVEDLFREGVPRVIIDPDPANLRAIRAYEKAGFRAIDRRQSVYGDVV
LMAIDADDEQEGE
>Mature_172_residues
PPEKVVLYDFRPVTEKDLPMIAGWLAEPEVAEWWNDPDTEIAEIRDHIDSISVEPLIVELDGKPIAYLQSYDPHLEDDHP
YADQPFGTLGIDLSIGRPELLGIGHGSAIVRQFVEDLFREGVPRVIIDPDPANLRAIRAYEKAGFRAIDRRQSVYGDVVL
MAIDADDEQEGE

Specific function: Resistance to antibiotics containing the purpurosamine ring including gentamicin, kanamycin, tobramycin, and neomycin [H]

COG id: COG1670

COG function: function code J; Acetyltransferases, including N-acetylases of ribosomal proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 N-acetyltransferase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000182
- InterPro:   IPR016181
- InterPro:   IPR019432 [H]

Pfam domain/function: PF00583 Acetyltransf_1; PF10331 AlcB [H]

EC number: =2.3.1.82 [H]

Molecular weight: Translated: 19476; Mature: 19345

Theoretical pI: Translated: 4.03; Mature: 4.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPEKVVLYDFRPVTEKDLPMIAGWLAEPEVAEWWNDPDTEIAEIRDHIDSISVEPLIVE
CCCCCEEEEECCCCCCCCCCHHHHHCCCCHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEE
LDGKPIAYLQSYDPHLEDDHPYADQPFGTLGIDLSIGRPELLGIGHGSAIVRQFVEDLFR
ECCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEECCCHHHHHHHHHHHHH
EGVPRVIIDPDPANLRAIRAYEKAGFRAIDRRQSVYGDVVLMAIDADDEQEGE
CCCCEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHCCCEEEEEEECCCCCCCC
>Mature Secondary Structure 
PPEKVVLYDFRPVTEKDLPMIAGWLAEPEVAEWWNDPDTEIAEIRDHIDSISVEPLIVE
CCCCEEEEECCCCCCCCCCHHHHHCCCCHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEE
LDGKPIAYLQSYDPHLEDDHPYADQPFGTLGIDLSIGRPELLGIGHGSAIVRQFVEDLFR
ECCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEECCCHHHHHHHHHHHHH
EGVPRVIIDPDPANLRAIRAYEKAGFRAIDRRQSVYGDVVLMAIDADDEQEGE
CCCCEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHCCCEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2841303; 1963948 [H]