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The map label for this gene is ureC

Identifier: 13474128

GI number: 13474128

Start: 3919854

End: 3921566

Strand: Reverse

Name: ureC

Synonym: mll4940

Alternate gene names: 13474128

Gene position: 3921566-3919854 (Counterclockwise)

Preceding gene: 13474131

Following gene: 13474127

Centisome position: 55.74

GC content: 64.86

Gene sequence:

>1713_bases
ATGGCCAGAATCTCGCGTGCCGCCTACGCCCAGATGTATGGGCCGACTGTTGGCGACAAGGTCAGGCTGGCCGACACCGA
ACTCTTCATCGAGGTTGAAAAGGACCTCACCATCCACGGCGAGGAGGTGAAATTCGGCGGCGGCAAGGTGATCCGCGACG
GCATGGGCCAGAGCCAGGTTTCCCGCGCCCAGGGCGCGGTCGACACCGTCATCACCAATGCGCTGGTGGTCGATGCCGGC
GCCGGCATCTTCAAGGCCGATATCGGCCTCAAGGACGGCCGCATCGCGGCAATCGGCAAGGCCGGCAATCCGGATACGCA
GGATGGCGTCACCATCATTATCGGCCCGGGCACCGAGATTATCGCCGGCGAGGGCAAGATCCTGACCGCCGGCGGCTTCG
ACGCGCATATCCACTTCATCTGCCCGCAGCAGATCGAGGAAGCGCTGATGAGCGGCATCACCACAATGCTGGGCGGCGGC
ACCGGCCCGGCGCACGGCACGCTGGCCACCACCTGCACGCCGGGGCCGTGGCACATGGCGCGCATGATCCAGTCCTTCGA
CGCCTTTCCGATGAATATCGGCCTGTCGGGCAAGGGCAATGCCTCGCTGCCGGCGGCGCTGGAAGAAATGGTGCTGGGCG
GCGCCTGCTCGCTGAAGCTGCATGAGGATTGGGGCACGACGCCGGCGGCGATCGACTGCTGCCTGTCGGTGGCCGACGAT
TACGACGTGCAGGTGATGATCCATACCGACACGCTGAACGAATCCGGCTTCGTCGAAAACACGGTAGCGGCGATCAAGGG
CCGCACCATCCACGCCTTCCATACCGAAGGCGCCGGCGGCGGCCACGCGCCCGACATCATCAAGGTTTGCGGCCTGCCCA
ACGTCATCCCGTCTTCGACCAATCCGACACGGCCCTACACGGTCAACACGCTGGCCGAGCATCTCGACATGCTGATGGTC
TGCCATCATCTGTCGCCGTCGATCCCCGAGGACATCGCCTTTGCCGAGAGCCGCATCCGCAAGGAGACGATCGCCGCCGA
GGATATCCTGCACGACATCGGCGCCTTCTCGATCATCTCGTCGGACTCACAAGCCATGGGCCGGGTCGGCGAGGTGGCGA
TCCGCACCTGGCAGACCGCCGACAAGATGAAGCGCCAGCGCGGCGCGCTGCCGCAGGAAACCGGCGACAACGACAATTTC
CGCGTTCGCCGCTACATCGCCAAATACACGATCAACCCGGCCATCGCGCATGGACTGTCGAAAGACATCGGCTCGATCGC
CGTCGGCAAACGCGCCGACCTGGTGCTGTGGAACCCGGCCTTTTTCGGCGTGAAGCCGGACATGGTGCTGGTCGGCGGGA
TGATCGCCGCCGCCCCGATGGGCGACCCGAACGCCTCGATCCCGACGCCGCAGCCGATGCACTACCGGCCGATGTTCGGC
GCCTATGGCAAGGCCAGGACCAACTCATCGGTGACCTTCGTTTCGAAAGCCGCCCTCGAGTCGGGCCTGCATGGCCGGCT
TGGCGTCGAAAAGCAATTCGTCGCCGTGGAAAACACCCGTGGCGGCATCGGCAAGCATTCCATGGTGCTCAACGACGCCA
CGCCGCATGTCGAGGTCGACCCGGAAACCTACGAGGTCCGCGCCGACGGCGAATTGCTGACCTGCGAGCCGGCGACCGTG
CTGCCGATGGCGCAAAGGTATTTCCTGTTCTGA

Upstream 100 bases:

>100_bases
GGGATCAGAAGGTGTCGCCCAGCGGGTCATTGCGTGACCATTGGATGGCGGCAATGTGCAGCCCAGCCTCAACCACACCG
CATTTCGGGAGCAATCGCTG

Downstream 100 bases:

>100_bases
GTCGGCCGGCCAAATTCCGTTGCGGCTGGTATGCGTAGGCCGCAATATGCGGTCGAGCAGAAACCCATCGTGATCAGGCA
TGGCCACCGAAATCGCCTCT

Product: urease subunit alpha

Products: NA

Alternate protein names: Urea amidohydrolase subunit alpha

Number of amino acids: Translated: 570; Mature: 569

Protein sequence:

>570_residues
MARISRAAYAQMYGPTVGDKVRLADTELFIEVEKDLTIHGEEVKFGGGKVIRDGMGQSQVSRAQGAVDTVITNALVVDAG
AGIFKADIGLKDGRIAAIGKAGNPDTQDGVTIIIGPGTEIIAGEGKILTAGGFDAHIHFICPQQIEEALMSGITTMLGGG
TGPAHGTLATTCTPGPWHMARMIQSFDAFPMNIGLSGKGNASLPAALEEMVLGGACSLKLHEDWGTTPAAIDCCLSVADD
YDVQVMIHTDTLNESGFVENTVAAIKGRTIHAFHTEGAGGGHAPDIIKVCGLPNVIPSSTNPTRPYTVNTLAEHLDMLMV
CHHLSPSIPEDIAFAESRIRKETIAAEDILHDIGAFSIISSDSQAMGRVGEVAIRTWQTADKMKRQRGALPQETGDNDNF
RVRRYIAKYTINPAIAHGLSKDIGSIAVGKRADLVLWNPAFFGVKPDMVLVGGMIAAAPMGDPNASIPTPQPMHYRPMFG
AYGKARTNSSVTFVSKAALESGLHGRLGVEKQFVAVENTRGGIGKHSMVLNDATPHVEVDPETYEVRADGELLTCEPATV
LPMAQRYFLF

Sequences:

>Translated_570_residues
MARISRAAYAQMYGPTVGDKVRLADTELFIEVEKDLTIHGEEVKFGGGKVIRDGMGQSQVSRAQGAVDTVITNALVVDAG
AGIFKADIGLKDGRIAAIGKAGNPDTQDGVTIIIGPGTEIIAGEGKILTAGGFDAHIHFICPQQIEEALMSGITTMLGGG
TGPAHGTLATTCTPGPWHMARMIQSFDAFPMNIGLSGKGNASLPAALEEMVLGGACSLKLHEDWGTTPAAIDCCLSVADD
YDVQVMIHTDTLNESGFVENTVAAIKGRTIHAFHTEGAGGGHAPDIIKVCGLPNVIPSSTNPTRPYTVNTLAEHLDMLMV
CHHLSPSIPEDIAFAESRIRKETIAAEDILHDIGAFSIISSDSQAMGRVGEVAIRTWQTADKMKRQRGALPQETGDNDNF
RVRRYIAKYTINPAIAHGLSKDIGSIAVGKRADLVLWNPAFFGVKPDMVLVGGMIAAAPMGDPNASIPTPQPMHYRPMFG
AYGKARTNSSVTFVSKAALESGLHGRLGVEKQFVAVENTRGGIGKHSMVLNDATPHVEVDPETYEVRADGELLTCEPATV
LPMAQRYFLF
>Mature_569_residues
ARISRAAYAQMYGPTVGDKVRLADTELFIEVEKDLTIHGEEVKFGGGKVIRDGMGQSQVSRAQGAVDTVITNALVVDAGA
GIFKADIGLKDGRIAAIGKAGNPDTQDGVTIIIGPGTEIIAGEGKILTAGGFDAHIHFICPQQIEEALMSGITTMLGGGT
GPAHGTLATTCTPGPWHMARMIQSFDAFPMNIGLSGKGNASLPAALEEMVLGGACSLKLHEDWGTTPAAIDCCLSVADDY
DVQVMIHTDTLNESGFVENTVAAIKGRTIHAFHTEGAGGGHAPDIIKVCGLPNVIPSSTNPTRPYTVNTLAEHLDMLMVC
HHLSPSIPEDIAFAESRIRKETIAAEDILHDIGAFSIISSDSQAMGRVGEVAIRTWQTADKMKRQRGALPQETGDNDNFR
VRRYIAKYTINPAIAHGLSKDIGSIAVGKRADLVLWNPAFFGVKPDMVLVGGMIAAAPMGDPNASIPTPQPMHYRPMFGA
YGKARTNSSVTFVSKAALESGLHGRLGVEKQFVAVENTRGGIGKHSMVLNDATPHVEVDPETYEVRADGELLTCEPATVL
PMAQRYFLF

Specific function: Unknown

COG id: COG0804

COG function: function code E; Urea amidohydrolase (urease) alpha subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 urease domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): URE1_RHILO (Q98CY9)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_105696.1
- ProteinModelPortal:   Q98CY9
- SMR:   Q98CY9
- MEROPS:   M38.982
- GeneID:   1228357
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mll4940
- NMPDR:   fig|266835.1.peg.3800
- HOGENOM:   HBG357507
- OMA:   TIHAFHT
- ProtClustDB:   PRK13207
- BRENDA:   3.5.1.5
- GO:   GO:0005737
- HAMAP:   MF_01953
- InterPro:   IPR006680
- InterPro:   IPR011059
- InterPro:   IPR011612
- InterPro:   IPR005848
- InterPro:   IPR017951
- InterPro:   IPR017950
- PRINTS:   PR01752
- TIGRFAMs:   TIGR01792

Pfam domain/function: PF01979 Amidohydro_1; PF00449 Urease_alpha; SSF51338 Metalo_hydrolase

EC number: =3.5.1.5

Molecular weight: Translated: 60517; Mature: 60386

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS01120 UREASE_1; PS00145 UREASE_2; PS51368 UREASE_3

Important sites: ACT_SITE 322-322 BINDING 221-221

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARISRAAYAQMYGPTVGDKVRLADTELFIEVEKDLTIHGEEVKFGGGKVIRDGMGQSQV
CCCCHHHHHHHHCCCCCCCEEEEECEEEEEEEECCEEEECCEEEECCCEEEECCCCHHHH
SRAQGAVDTVITNALVVDAGAGIFKADIGLKDGRIAAIGKAGNPDTQDGVTIIIGPGTEI
HHHHCHHHHHHHCEEEEECCCCEEEECCCCCCCCEEEEECCCCCCCCCCEEEEECCCCEE
IAGEGKILTAGGFDAHIHFICPQQIEEALMSGITTMLGGGTGPAHGTLATTCTPGPWHMA
EECCCEEEEECCCCEEEEEECHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCHHHHH
RMIQSFDAFPMNIGLSGKGNASLPAALEEMVLGGACSLKLHEDWGTTPAAIDCCLSVADD
HHHHHCCCCCEEEECCCCCCCCCHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHCCC
YDVQVMIHTDTLNESGFVENTVAAIKGRTIHAFHTEGAGGGHAPDIIKVCGLPNVIPSST
CEEEEEEEECCCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHCCCCCCCCCCC
NPTRPYTVNTLAEHLDMLMVCHHLSPSIPEDIAFAESRIRKETIAAEDILHDIGAFSIIS
CCCCCEEHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEC
SDSQAMGRVGEVAIRTWQTADKMKRQRGALPQETGDNDNFRVRRYIAKYTINPAIAHGLS
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHEEEEEHHHCCCHHHHHHHH
KDIGSIAVGKRADLVLWNPAFFGVKPDMVLVGGMIAAAPMGDPNASIPTPQPMHYRPMFG
HHHCCEECCCCCCEEEECCEEECCCCCEEEECCCCEECCCCCCCCCCCCCCCCCCCCCCC
AYGKARTNSSVTFVSKAALESGLHGRLGVEKQFVAVENTRGGIGKHSMVLNDATPHVEVD
CCCCCCCCCCEEEEEHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCEEEEECCCCCEEEC
PETYEVRADGELLTCEPATVLPMAQRYFLF
CCEEEEEECCCEEEECCCHHHHHHHHHHCC
>Mature Secondary Structure 
ARISRAAYAQMYGPTVGDKVRLADTELFIEVEKDLTIHGEEVKFGGGKVIRDGMGQSQV
CCCHHHHHHHHCCCCCCCEEEEECEEEEEEEECCEEEECCEEEECCCEEEECCCCHHHH
SRAQGAVDTVITNALVVDAGAGIFKADIGLKDGRIAAIGKAGNPDTQDGVTIIIGPGTEI
HHHHCHHHHHHHCEEEEECCCCEEEECCCCCCCCEEEEECCCCCCCCCCEEEEECCCCEE
IAGEGKILTAGGFDAHIHFICPQQIEEALMSGITTMLGGGTGPAHGTLATTCTPGPWHMA
EECCCEEEEECCCCEEEEEECHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCHHHHH
RMIQSFDAFPMNIGLSGKGNASLPAALEEMVLGGACSLKLHEDWGTTPAAIDCCLSVADD
HHHHHCCCCCEEEECCCCCCCCCHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHCCC
YDVQVMIHTDTLNESGFVENTVAAIKGRTIHAFHTEGAGGGHAPDIIKVCGLPNVIPSST
CEEEEEEEECCCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHCCCCCCCCCCC
NPTRPYTVNTLAEHLDMLMVCHHLSPSIPEDIAFAESRIRKETIAAEDILHDIGAFSIIS
CCCCCEEHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEC
SDSQAMGRVGEVAIRTWQTADKMKRQRGALPQETGDNDNFRVRRYIAKYTINPAIAHGLS
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHEEEEEHHHCCCHHHHHHHH
KDIGSIAVGKRADLVLWNPAFFGVKPDMVLVGGMIAAAPMGDPNASIPTPQPMHYRPMFG
HHHCCEECCCCCCEEEECCEEECCCCCEEEECCCCEECCCCCCCCCCCCCCCCCCCCCCC
AYGKARTNSSVTFVSKAALESGLHGRLGVEKQFVAVENTRGGIGKHSMVLNDATPHVEVD
CCCCCCCCCCEEEEEHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCEEEEECCCCCEEEC
PETYEVRADGELLTCEPATVLPMAQRYFLF
CCEEEEEECCCEEEECCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968