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The map label for this gene is fucA [C]

Identifier: 13474121

GI number: 13474121

Start: 3915351

End: 3916169

Strand: Reverse

Name: fucA [C]

Synonym: mll4933

Alternate gene names: 13474121

Gene position: 3916169-3915351 (Counterclockwise)

Preceding gene: 13474122

Following gene: 13474119

Centisome position: 55.66

GC content: 63.0

Gene sequence:

>819_bases
TTGCGGGCAGCCGTCGGTCGCGGCATTCTTGCCAAAACCGGAGGATTTTCGATGAGCATCGCCCGCCTGCAGAAGGAAAC
GCGGACCAACCTGCCCTTCTACGAAGAGCGCGTCGATCTCGCCTGTGCGTTTCGCTGGACGGCGCGGCTCAACATGCACG
AGGCGGTGGCCAACCATTTCTCGCTGGCGGTCAACGAGGACGGCACGCAGTTCCTGATGAACCCCAACCAGGTGCATTTC
TCGCGCATCAAGGCGAGCGACCTGTTGATGATCGACGCCAACGATCCGAACACGCTGTCGGGCCCCAACGCGCCCGACCC
GACGGCCTGGGGCCTGCACGGCGCCATCCATCGCAATGTGCCGCATGCGCGTTGCGTCATGCATGTCCATTCGATCCATG
CCACGGTACTGGCCTCGCTGGCCGACTCGACATTGCCGCCGATCGACCAGAATTCGGCGATGTTCTTCAACCGTCATGTC
GTCGACGCGCACTACGGCGGGCTGGCCTTCGAGGAAGAGGGCGAGCGCTGCTCGCAGCTTCTCACCGATCCCAAGGTCAA
GGTCATGGTGATGGGCAATCACGGCGTGCTGGTGATCGGCGACACCGTCGCCGATGCCTTCAACCGCATGTTCTATTTCG
AGCGCGCCGCCGAGACCTACATCAAGGCGCTGTGGACCGGCCGGCCGCTGCGCACGCTGTCCGATGCGATTGCCGAGAAG
ACGGCGAGCGAAATGGACGACTATCCCGGCCAGGCCGAACGCCATCTCGCCGAGTTGAAGGCGATCCTCGACGAGGAAGA
GCCGATCTACCGGAATTAG

Upstream 100 bases:

>100_bases
TCATCGATTTCATCGTCGAGCATGGCGGGCTGAGGGTTGGCACCGCCACCAGCACGGCGGCCTGACAGGCATCCGTTCCC
TCTGCACCAACCAAAACCCG

Downstream 100 bases:

>100_bases
AGCCCGAGCTGAGCCCGCAATTCCTCGGCGCTGTTGATGACGATGGCGCCAGGCGGGCCTTCCATCGGCTTTTCCGGCCA
GAAGATCGTCTTCATGCCCG

Product: hypothetical protein

Products: Dihydroxyacetone phosphate; L-Lactaldehyde [C]

Alternate protein names: NA

Number of amino acids: Translated: 272; Mature: 272

Protein sequence:

>272_residues
MRAAVGRGILAKTGGFSMSIARLQKETRTNLPFYEERVDLACAFRWTARLNMHEAVANHFSLAVNEDGTQFLMNPNQVHF
SRIKASDLLMIDANDPNTLSGPNAPDPTAWGLHGAIHRNVPHARCVMHVHSIHATVLASLADSTLPPIDQNSAMFFNRHV
VDAHYGGLAFEEEGERCSQLLTDPKVKVMVMGNHGVLVIGDTVADAFNRMFYFERAAETYIKALWTGRPLRTLSDAIAEK
TASEMDDYPGQAERHLAELKAILDEEEPIYRN

Sequences:

>Translated_272_residues
MRAAVGRGILAKTGGFSMSIARLQKETRTNLPFYEERVDLACAFRWTARLNMHEAVANHFSLAVNEDGTQFLMNPNQVHF
SRIKASDLLMIDANDPNTLSGPNAPDPTAWGLHGAIHRNVPHARCVMHVHSIHATVLASLADSTLPPIDQNSAMFFNRHV
VDAHYGGLAFEEEGERCSQLLTDPKVKVMVMGNHGVLVIGDTVADAFNRMFYFERAAETYIKALWTGRPLRTLSDAIAEK
TASEMDDYPGQAERHLAELKAILDEEEPIYRN
>Mature_272_residues
MRAAVGRGILAKTGGFSMSIARLQKETRTNLPFYEERVDLACAFRWTARLNMHEAVANHFSLAVNEDGTQFLMNPNQVHF
SRIKASDLLMIDANDPNTLSGPNAPDPTAWGLHGAIHRNVPHARCVMHVHSIHATVLASLADSTLPPIDQNSAMFFNRHV
VDAHYGGLAFEEEGERCSQLLTDPKVKVMVMGNHGVLVIGDTVADAFNRMFYFERAAETYIKALWTGRPLRTLSDAIAEK
TASEMDDYPGQAERHLAELKAILDEEEPIYRN

Specific function: Fucose metabolism; third step. [C]

COG id: COG0235

COG function: function code G; Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldolase class II family [H]

Homologues:

Organism=Homo sapiens, GI89276787, Length=191, Percent_Identity=28.2722513089005, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI9257190, Length=191, Percent_Identity=28.2722513089005, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI297307160, Length=191, Percent_Identity=28.2722513089005, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI297307158, Length=191, Percent_Identity=28.2722513089005, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI9257192, Length=191, Percent_Identity=28.2722513089005, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI9951927, Length=214, Percent_Identity=28.5046728971963, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI62912453, Length=214, Percent_Identity=28.5046728971963, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI9943848, Length=214, Percent_Identity=28.5046728971963, Blast_Score=81, Evalue=8e-16,
Organism=Homo sapiens, GI29826323, Length=193, Percent_Identity=25.9067357512953, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI29826325, Length=193, Percent_Identity=25.9067357512953, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI29826321, Length=193, Percent_Identity=25.9067357512953, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI29826319, Length=193, Percent_Identity=25.9067357512953, Blast_Score=71, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI71989560, Length=231, Percent_Identity=28.5714285714286, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71989541, Length=231, Percent_Identity=28.5714285714286, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71989555, Length=231, Percent_Identity=28.5714285714286, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71989550, Length=231, Percent_Identity=28.5714285714286, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71989544, Length=231, Percent_Identity=28.5714285714286, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI115533218, Length=213, Percent_Identity=27.6995305164319, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI115533216, Length=197, Percent_Identity=28.4263959390863, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI281363755, Length=193, Percent_Identity=26.4248704663212, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI281363751, Length=193, Percent_Identity=26.4248704663212, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24655690, Length=193, Percent_Identity=26.4248704663212, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24655685, Length=193, Percent_Identity=26.4248704663212, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI281363761, Length=193, Percent_Identity=26.4248704663212, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281363759, Length=193, Percent_Identity=26.4248704663212, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281363753, Length=193, Percent_Identity=26.4248704663212, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281363763, Length=193, Percent_Identity=26.4248704663212, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281363757, Length=193, Percent_Identity=26.4248704663212, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17136738, Length=193, Percent_Identity=26.4248704663212, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001303 [H]

Pfam domain/function: PF00596 Aldolase_II [H]

EC number: 4.1.2.17 [C]

Molecular weight: Translated: 30269; Mature: 30269

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAAVGRGILAKTGGFSMSIARLQKETRTNLPFYEERVDLACAFRWTARLNMHEAVANHF
CCCCCCCCCEEECCCCHHHHHHHHHHHHCCCCHHHHHHCEEEEEEHHHHCCHHHHHHHHE
SLAVNEDGTQFLMNPNQVHFSRIKASDLLMIDANDPNTLSGPNAPDPTAWGLHGAIHRNV
EEEECCCCCEEEECCCEEHHEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCCHHHHCCC
PHARCVMHVHSIHATVLASLADSTLPPIDQNSAMFFNRHVVDAHYGGLAFEEEGERCSQL
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCCCCEEEHHHHHHHHHH
LTDPKVKVMVMGNHGVLVIGDTVADAFNRMFYFERAAETYIKALWTGRPLRTLSDAIAEK
HCCCCEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
TASEMDDYPGQAERHLAELKAILDEEEPIYRN
HHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MRAAVGRGILAKTGGFSMSIARLQKETRTNLPFYEERVDLACAFRWTARLNMHEAVANHF
CCCCCCCCCEEECCCCHHHHHHHHHHHHCCCCHHHHHHCEEEEEEHHHHCCHHHHHHHHE
SLAVNEDGTQFLMNPNQVHFSRIKASDLLMIDANDPNTLSGPNAPDPTAWGLHGAIHRNV
EEEECCCCCEEEECCCEEHHEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCCHHHHCCC
PHARCVMHVHSIHATVLASLADSTLPPIDQNSAMFFNRHVVDAHYGGLAFEEEGERCSQL
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCCCCEEEHHHHHHHHHH
LTDPKVKVMVMGNHGVLVIGDTVADAFNRMFYFERAAETYIKALWTGRPLRTLSDAIAEK
HCCCCEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
TASEMDDYPGQAERHLAELKAILDEEEPIYRN
HHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Ca2+; Co2+; Mg2+; Mn2+; Zn2+ [C]

Kcat value (1/min): 19.3 [C]

Specific activity: 21.0

Km value (mM): 0.7 {L-fuculose} [C]

Substrates: L-Fuculose 1-phosphate [C]

Specific reaction: L-Fuculose 1-phosphate <==> Dihydroxyacetone phosphate + L-Lactaldehyde [C]

General reaction: Elimination of an aldehyde C-C bond; Cleavage [C]

Inhibitor: EDTA; Phosphoglycolohydroxamate [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]