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The map label for this gene is fmt

Identifier: 13474064

GI number: 13474064

Start: 3857716

End: 3858669

Strand: Reverse

Name: fmt

Synonym: mll4854

Alternate gene names: 13474064

Gene position: 3858669-3857716 (Counterclockwise)

Preceding gene: 13474065

Following gene: 13474063

Centisome position: 54.84

GC content: 64.47

Gene sequence:

>954_bases
ATGCCCCTTCGCGTCATCTTCATGGGCACGCCGGAGTTTTCGGTGCCGACGCTGCGCGCGATCGCCAAGGCCGGACATGA
GATTTCCGCCGTCTACACGCAGCCGCCGCGCGCCGCCGGCCGGCGCGGACTGGAGTTGACGCCTTCACCGGTGCAGCGCG
AGGCCGAGCGGCTGGGCATCGAGGTGCGGACGCCGACATCCCTCAAGGGCGAGGCCGAACAGGCCGCTTTCAACGCCCTG
CGGGCCGATATCGCCGTGGTCGTGGCCTATGGTTTGCTGCTGCCGAAGGTAATTCTCGACGCACCCCGGCTTGGCTGCAT
CAACGGCCATGCATCGCTTCTGCCGCGCTGGCGCGGTGCCGCCCCCATCCAGCGCGCCATCATGGCTGGTGACCTGGAAA
GCGGCATGATGGTTATGCGCATGGAAGAGGGTCTCGACACCGGCCCGGTGGGATTGCTTGAAAAATGCGCCATCGACCCC
GATATGACAGCCGGCGATCTGCATGATCGGTTGATGCGCGTCGGTGCTGCCCTGATGGTGGAAGCGCTGGCGCGGCTGGC
AAAGAACACCCTGACATTTACCGCGCAAGCGGCGGAAGGGGTGACTTACGCCAGAAAAATCGATAAATCCGAGACGCGCG
TGGACTGGACGCGGCCCGCGGCCGAGGTCCACAACCACCTTCGTGGCCTGTCGCCCTTTCCCGGCGCCTGGTCCGAAATT
GACATTGGCGGCCGCATGGAACGGCTGAAACTGCTTCGCTCGACGCTGTCCGATGGCCTGTCGCCTTCGGAAGATTTGGG
CGAGTCGGGAGGAATTCTCGATGACCGGCTGACGGTCGCCTGCGGGGCAGGCGCGATCAGACTGGTCGAAGTTCAACGTG
CGGGCGGAAAGCCCGCCGCCGCGTCGGAATTCCTGCGCGGAGCCAAGATCGTAAAAGGAATGAAGTTCTCATGA

Upstream 100 bases:

>100_bases
CATCGACCACATCTCGAAGCTGAAGCGCGACATGGTGGTGAAGAAGTTCAAGAAGCTCGCCAAGGACAAGGCGCCGGGCA
AGCTGGTGGGATAGGGGAAA

Downstream 100 bases:

>100_bases
GCATGATGTCGATACGCGCGGCGACGCCGCGGGATCGCGAGGCCATTCGCCTCGTCGAGGAACACGCCTTCGGCCAGCAG
GCGGAGGCCGGGCTGGTCGA

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 317; Mature: 316

Protein sequence:

>317_residues
MPLRVIFMGTPEFSVPTLRAIAKAGHEISAVYTQPPRAAGRRGLELTPSPVQREAERLGIEVRTPTSLKGEAEQAAFNAL
RADIAVVVAYGLLLPKVILDAPRLGCINGHASLLPRWRGAAPIQRAIMAGDLESGMMVMRMEEGLDTGPVGLLEKCAIDP
DMTAGDLHDRLMRVGAALMVEALARLAKNTLTFTAQAAEGVTYARKIDKSETRVDWTRPAAEVHNHLRGLSPFPGAWSEI
DIGGRMERLKLLRSTLSDGLSPSEDLGESGGILDDRLTVACGAGAIRLVEVQRAGGKPAAASEFLRGAKIVKGMKFS

Sequences:

>Translated_317_residues
MPLRVIFMGTPEFSVPTLRAIAKAGHEISAVYTQPPRAAGRRGLELTPSPVQREAERLGIEVRTPTSLKGEAEQAAFNAL
RADIAVVVAYGLLLPKVILDAPRLGCINGHASLLPRWRGAAPIQRAIMAGDLESGMMVMRMEEGLDTGPVGLLEKCAIDP
DMTAGDLHDRLMRVGAALMVEALARLAKNTLTFTAQAAEGVTYARKIDKSETRVDWTRPAAEVHNHLRGLSPFPGAWSEI
DIGGRMERLKLLRSTLSDGLSPSEDLGESGGILDDRLTVACGAGAIRLVEVQRAGGKPAAASEFLRGAKIVKGMKFS
>Mature_316_residues
PLRVIFMGTPEFSVPTLRAIAKAGHEISAVYTQPPRAAGRRGLELTPSPVQREAERLGIEVRTPTSLKGEAEQAAFNALR
ADIAVVVAYGLLLPKVILDAPRLGCINGHASLLPRWRGAAPIQRAIMAGDLESGMMVMRMEEGLDTGPVGLLEKCAIDPD
MTAGDLHDRLMRVGAALMVEALARLAKNTLTFTAQAAEGVTYARKIDKSETRVDWTRPAAEVHNHLRGLSPFPGAWSEID
IGGRMERLKLLRSTLSDGLSPSEDLGESGGILDDRLTVACGAGAIRLVEVQRAGGKPAAASEFLRGAKIVKGMKFS

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family

Homologues:

Organism=Homo sapiens, GI21614513, Length=328, Percent_Identity=29.5731707317073, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI238814322, Length=318, Percent_Identity=29.874213836478, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI164663775, Length=229, Percent_Identity=28.3842794759825, Blast_Score=95, Evalue=1e-19,
Organism=Escherichia coli, GI1789683, Length=307, Percent_Identity=42.0195439739414, Blast_Score=233, Evalue=9e-63,
Organism=Escherichia coli, GI1788589, Length=303, Percent_Identity=26.7326732673267, Blast_Score=103, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI133930964, Length=335, Percent_Identity=27.7611940298507, Blast_Score=114, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6319458, Length=282, Percent_Identity=29.0780141843972, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45550868, Length=312, Percent_Identity=28.8461538461538, Blast_Score=121, Evalue=7e-28,
Organism=Drosophila melanogaster, GI28571984, Length=229, Percent_Identity=31.8777292576419, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24585660, Length=328, Percent_Identity=24.6951219512195, Blast_Score=78, Evalue=7e-15,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): FMT_RHILO (Q98D53)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_105632.1
- ProteinModelPortal:   Q98D53
- SMR:   Q98D53
- GeneID:   1228293
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mll4854
- NMPDR:   fig|266835.1.peg.3736
- HOGENOM:   HBG571560
- OMA:   QIRACTP
- ProtClustDB:   PRK00005
- BRENDA:   2.1.2.9
- HAMAP:   MF_00182
- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR015518
- Gene3D:   G3DSA:3.10.25.10
- Gene3D:   G3DSA:3.40.50.170
- PANTHER:   PTHR11138
- TIGRFAMs:   TIGR00460

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N; SSF50486 FMT_C_like; SSF53328 formyl_transf

EC number: =2.1.2.9

Molecular weight: Translated: 33904; Mature: 33773

Theoretical pI: Translated: 8.85; Mature: 8.85

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLRVIFMGTPEFSVPTLRAIAKAGHEISAVYTQPPRAAGRRGLELTPSPVQREAERLGI
CCEEEEEECCCCCCCHHHHHHHHCCCCEEEEEECCCHHHCCCCCCCCCCHHHHHHHHCCE
EVRTPTSLKGEAEQAAFNALRADIAVVVAYGLLLPKVILDAPRLGCINGHASLLPRWRGA
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHCCCCCCC
APIQRAIMAGDLESGMMVMRMEEGLDTGPVGLLEKCAIDPDMTAGDLHDRLMRVGAALMV
CHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
EALARLAKNTLTFTAQAAEGVTYARKIDKSETRVDWTRPAAEVHNHLRGLSPFPGAWSEI
HHHHHHHHHHHEEEEHHHCCHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCEE
DIGGRMERLKLLRSTLSDGLSPSEDLGESGGILDDRLTVACGAGAIRLVEVQRAGGKPAA
CCCCHHHHHHHHHHHHHCCCCCCHHCCCCCCCCCCCEEEEECCCCEEEEEEECCCCCCHH
ASEFLRGAKIVKGMKFS
HHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
PLRVIFMGTPEFSVPTLRAIAKAGHEISAVYTQPPRAAGRRGLELTPSPVQREAERLGI
CEEEEEECCCCCCCHHHHHHHHCCCCEEEEEECCCHHHCCCCCCCCCCHHHHHHHHCCE
EVRTPTSLKGEAEQAAFNALRADIAVVVAYGLLLPKVILDAPRLGCINGHASLLPRWRGA
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHCCCCCCC
APIQRAIMAGDLESGMMVMRMEEGLDTGPVGLLEKCAIDPDMTAGDLHDRLMRVGAALMV
CHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
EALARLAKNTLTFTAQAAEGVTYARKIDKSETRVDWTRPAAEVHNHLRGLSPFPGAWSEI
HHHHHHHHHHHEEEEHHHCCHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCEE
DIGGRMERLKLLRSTLSDGLSPSEDLGESGGILDDRLTVACGAGAIRLVEVQRAGGKPAA
CCCCHHHHHHHHHHHHHCCCCCCHHCCCCCCCCCCCEEEEECCCCEEEEEEECCCCCCHH
ASEFLRGAKIVKGMKFS
HHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968